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New lymphoma therapy may be more effective with fewer side effects
Date:11/3/2010

r proteins that help lymphoma cells. The research team showed that turning on EP300 made lymphomas much more sensitive to the HDAC and Hsp90 inhibitors. Administering the drugs together is like "kicking both legs" of the lymphoma cells, so they cannot regain their balance. Thus, the combined effect of the drugs is much greater than either drug alone and has very powerful anti-tumor effects. In contrast, normal cells and tissues are not damaged by this form of combination therapy, since they are not dependent on these two "legs."

Finally, the scientists also discovered that EP300 is sometimes mutated in lymphomas, which shows that this gene may normally protect B cells from becoming cancerous. Detection of these mutations in patients is important since such tumors may not be responsive to RI-BPI. Dr. Melnick says that there is much more work to be done but he hopes that his research will lead to a better understanding of the mechanisms of cancer at the cellular level and better treatments for lymphomas and other cancers.


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Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

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