Navigation Links
New lymphoma therapy may be more effective with fewer side effects
Date:11/3/2010

NEW YORK (Nov. 3, 2010) -- Diffuse large B-cell lymphoma (DLBCL) is a type of aggressive non-Hodgkin's lymphoma that accounts for approximately 40 percent of lymphomas among adults. If left untreated, it is fatal. The existing treatments have a cure rate that is slightly over 50 percent but destroy healthy cells along with the cancer cells.

Researchers at Weill Cornell Medical College have found a combination therapy that is more effective than traditional treatments and is able to kill the cancer cells without harm to surrounding tissues. In a paper published in the Journal of Clinical Investigation on Nov. 1, they report that by targeting a key lymphoma-causing factor called BCL6 with a specific inhibitor called RI-BPI in combination with either a histone deacetylases (HDAC) inhibitor or with a heat shock protein (Hsp90) inhibitor, they were able to suppress and in some cases eradicate human DLBCL in mice. The researchers said their findings provide the basis for rational, targeted combinational therapy for patients with DLBCL.

Dr. Ari Melnick, associate professor of medicine and director of the Raymond and Beverly Sackler Center for Biomedical and Physical Sciences at Weill Cornell Medical College, and his colleagues have been studying ways to kill lymphoma cancer cells more effectively and efficiently than standard treatments.

"Lymphomas are not easy to treat. The standard treatment using monoclonal antibodies and chemotherapy does not work for all patients and can cause undesirable side effects," says Dr. Melnick.

B cells are a type of white blood cell that produces antibodies to fight infections. BCL6 is a master regulatory factor that plays a critical role in keeping lymphoma cells alive. Dr. Melnick's study showed that therapeutic targeting of BCL6 with RI-BPI turned on another factor called EP300, a molecular switch that itself can turn on proteins that can restrain lymphoma cell growth and turn off other proteins that help lymphoma cells. The research team showed that turning on EP300 made lymphomas much more sensitive to the HDAC and Hsp90 inhibitors. Administering the drugs together is like "kicking both legs" of the lymphoma cells, so they cannot regain their balance. Thus, the combined effect of the drugs is much greater than either drug alone and has very powerful anti-tumor effects. In contrast, normal cells and tissues are not damaged by this form of combination therapy, since they are not dependent on these two "legs."

Finally, the scientists also discovered that EP300 is sometimes mutated in lymphomas, which shows that this gene may normally protect B cells from becoming cancerous. Detection of these mutations in patients is important since such tumors may not be responsive to RI-BPI. Dr. Melnick says that there is much more work to be done but he hopes that his research will lead to a better understanding of the mechanisms of cancer at the cellular level and better treatments for lymphomas and other cancers.


'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Related medicine news :

1. New class of drug kills lymphoma cells
2. Vitamin K may protect against developing non-Hodgkins lymphoma, say Mayo Clinic researchers
3. Scott & White Healthcare clinical trials target lymphoma, leukemia
4. Lifestyle factors significantly impact survival of non-Hodgkins lymphoma patients, study finds
5. Lifestyle Affects Survival in Non-Hodgkins Lymphoma
6. Study identifies promising treatment for aggressive lymphoma
7. Study shows Hodgkin lymphoma survivors lack post-treatment screening for other cancers
8. Lymphoma Survivors Often Miss Out on Follow-Up
9. Lymphoma patients with cardiovascular disease have increased risk of cardiac hospitalization
10. Study makes exciting progress in elucidating the mechanisms of bortezomib in lymphoma
11. Scott & White Healthcare study aimed at T-cell lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 2016 , ... Quality metrics are proliferating in cancer care, and are derived ... eye of the beholder, according to experts who offered insights and commentary in the ... Care. For the full issue, click here . , For the American Society ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
Breaking Medicine Technology: