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New lymphoma therapy may be more effective with fewer side effects
Date:11/3/2010

NEW YORK (Nov. 3, 2010) -- Diffuse large B-cell lymphoma (DLBCL) is a type of aggressive non-Hodgkin's lymphoma that accounts for approximately 40 percent of lymphomas among adults. If left untreated, it is fatal. The existing treatments have a cure rate that is slightly over 50 percent but destroy healthy cells along with the cancer cells.

Researchers at Weill Cornell Medical College have found a combination therapy that is more effective than traditional treatments and is able to kill the cancer cells without harm to surrounding tissues. In a paper published in the Journal of Clinical Investigation on Nov. 1, they report that by targeting a key lymphoma-causing factor called BCL6 with a specific inhibitor called RI-BPI in combination with either a histone deacetylases (HDAC) inhibitor or with a heat shock protein (Hsp90) inhibitor, they were able to suppress and in some cases eradicate human DLBCL in mice. The researchers said their findings provide the basis for rational, targeted combinational therapy for patients with DLBCL.

Dr. Ari Melnick, associate professor of medicine and director of the Raymond and Beverly Sackler Center for Biomedical and Physical Sciences at Weill Cornell Medical College, and his colleagues have been studying ways to kill lymphoma cancer cells more effectively and efficiently than standard treatments.

"Lymphomas are not easy to treat. The standard treatment using monoclonal antibodies and chemotherapy does not work for all patients and can cause undesirable side effects," says Dr. Melnick.

B cells are a type of white blood cell that produces antibodies to fight infections. BCL6 is a master regulatory factor that plays a critical role in keeping lymphoma cells alive. Dr. Melnick's study showed that therapeutic targeting of BCL6 with RI-BPI turned on another factor called EP300, a molecular switch that itself can turn on proteins that can restrain lymphoma cell growth and turn off othe
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Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

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