Navigation Links
New lung cancer drug shows dramatic results for shrinking tumors
Date:6/22/2010

Media Contact: Karen Shea 61

Patients with a specific kind of lung cancer may benefit from a Phase III clinical trial offered by the Moores UCSD Cancer Center. The new drug, crizotinib, under development by Pfizer, showed dramatic results in reducing lung cancer tumors in some patients during Phase I and II clinical trials.

"The results of the first two trials have been very encouraging," said Lyudmila Bazhenova, MD, assistant clinical professor at UC San Diego School of Medicine and a member of the Moores UCSD Cancer Center. "The Phase III clinical trials will be critical in determining if this drug goes to market."

According to a preliminary study presented at the 2010 meeting of the American Society of Clinical Oncology, Phase I/II clinical trials demonstrated that 57% of patients had their tumors reduced and at eight weeks of the treatment, 87% showed disease stabilization.

In some patients with non-small cell lung cancer (NSCLC), the anaplastic lymphoma kinase (ALK) gene may move and fuse with another gene, EML4. The resultant fusion produces an enzyme that promotes lung cancer cell growth. This fusion happens in approximately four percent of NSCLC patients. The chances of a patient having the fusion gene increases if they have the adenocarcinoma subtype of lung cancer, or are non-smokers or former light smokers, among other characteristics. Those patients have an approximate 20% chance of having this mutation. Crizotinib inhibits the enzyme, allowing the cancer cells to die off.

The Phase III clinical trial will compare crizotinib with standard-of-care chemotherapy in the treatment of ALK-positive recurrent NSCLC. Through a randomized selection process, patients will either be treated with chemotherapy or crizotinib. If the patients who are given the chemotherapy do not respond to treatment, they will be given crizotinib at the end of the trial.


'/>"/>

Contact: Karen Shea
kshea@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1

Related medicine news :

1. Scripps Announces Plans for Region's First Proton Therapy Center; $185 Million Facility to Offer Advanced Care to Cancer Patients
2. Chlordecone exposure and risk of prostate cancer
3. Kids Into Safe Skin (K.I.S.S) Officially Launches Today with a Mission to Create Awareness About Skin Cancer Detection and Prevention
4. Cancer and Multiple Sclerosis Survivor Martin Smith's 3,000-mile Bicycle Ride Benefits Cancer Research
5. Cancers of sweat glands, other skin-related structures may be increasing in United States
6. New drugs to relieve cancer pain
7. Hematology-Oncology Associates of Northern New Jersey (HOANNJ) Joins Effort to Improve Cancer Care with Via Oncology™ Pathways
8. Coffee Might Guard Against Head, Neck Cancers
9. Surveillance may be suitable treatment option for patients with low-risk prostate cancer
10. Watchful Waiting Often Best Strategy for Slow-Moving Prostate Cancer
11. Second Ohio State cancer drug begins clinical trials testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2020)... , ... May 30, 2020 , ... ... technology and virtual solutions that can meet the needs of a COVID-riddled world, ... HashCash’s healthcare solutions abide by the necessary compliances and augment the caregiving ...
(Date:5/27/2020)... ... May 27, 2020 , ... Productive Plastics, a leading ... face shields to be used as personal protective equipment (PPE) to combat ... single use, made to be worn by frontline healthcare professionals and for any ...
(Date:5/26/2020)... ... May 26, 2020 , ... ... through which certain infections can impact the brain causing post infectious encephalitis. ... Associated with Streptococcal Infections) and PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) could adversely ...
(Date:5/26/2020)... ... 2020 , ... As much of the country continues to ... joining forces to start a country-wide movement of physical activity to honor and ... is a national fitness challenge beginning Tuesday, May 26 and culminating on Sunday, ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... its first milestone to deliver over one million FDA-compliant face shields — designed, ... Face Shields meet the critical need for personal protective equipment (PPE) for both ...
Breaking Medicine News(10 mins):
(Date:6/2/2020)... TAMPA, Fla. (PRWEB) , ... June 02, 2020 ... ... non-clinical healthcare, Harmony Healthcare announced today that in response to COVID-19 it is ... job security, updated remote and on-site solutions, reimbursements, and a host of digital ...
(Date:5/30/2020)... ... May 29, 2020 , ... Impiger ... and web based solution People1 Care to help organizations safely return ... into the 'new normal’ through daily wellness screenings, social distancing support, and contact ...
(Date:5/30/2020)... (PRWEB) , ... May 30, 2020 , ... During a ... is not an inherent trait - it is developed and strengthened through hardship. Recent ... type of mindset, and engage in certain practices in order to stay strong in ...
Breaking Medicine Technology: