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New long-acting local anesthetic derived from algae effectively blocks pain in surgical patients
Date:2/23/2011

block pain while avoiding toxicity.

Groups of young adult volunteers will receive neoSTX injections under the skin in gradually increasing doses. Although NeoSTX has appeared very safe in over 400 patients in clinical trials so far, the upcoming study will more precisely determine the margin of safety. Subjects will be closely monitored for numbness at the injection sites, as well as whole-body effects.

The team believes that even more prolonged local anesthesia is possible. They have data from animals and exploratory studies in humans showing that combining Site-1 sodium channel blockers with existing local anesthetics can produce nerve blockade for up to 2 to 4 days with minimal local or systemic side effects.

"We think that the demand for a long-acting local anesthetic will vast," says Novoa of Proteus. "Our initial estimates suggest a market greater than 1 billion dollars."

Children's holds a U.S. patent on site 1 sodium-channel toxins as prolonged-duration local anesthetics. The clinical trial was supported by an Innova Corfo Project.


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Contact: Erin McColgan
erin.mccolgan@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

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