Navigation Links
New long-acting local anesthetic derived from algae effectively blocks pain in surgical patients
Date:2/23/2011

at the incision site at both 12 hours (4 vs. 18 percent) and 24 hours (6 vs. 16 percent). Significantly more neoSTX-treated patients had complete absence of pain at 12 hours, both at rest (88 vs. 69 percent) and with movement (80 vs. 60 percent). Patients in the neoSTX group reported a full functional recovery approximately 2 days earlier. No serious adverse reactions occurred in either group.

The trial was a three-part effort led by first author Alberto Rodrguez-Navarro, MD, at Padre Hurtado Hospital (Santiago, Chile); a clinical-academic team led by Berde; and a pharmaceutical development team led by Luis Novoa, CEO of Proteus SA. "As a surgeon who specializes in abdominal surgery, I think that the future of pain treatment will benefit greatly from this type of multidisciplinary collaboration," says Rodrguez-Navarro.

The Chilean and American investigators met through their scientific publications. Berde and Daniel Kohane, MD, PhD, a clinician-researcher in Critical Care Medicine at Children's, had studied site 1 sodium-channel blockers derived from marine toxins for more than a decade. Their work in rats showed that the compounds lack the side effects of existing anesthetics and opioid analgesics. They are not addictive, have no cardiac toxicity and don't cross the blood-brain barrier, thus avoiding the risk of seizures occasionally seen with existing local anesthetics. They also cause minimal local tissue reaction, avoiding the nerve and muscle damage seen with high concentrations of existing local anesthetics.

Meanwhile, in Chile, Rodrguez-Navarro had published work examining the anesthetic potential of neoSTX, derived from local algae.

The scientists at Proteus have developed expertise in extracting, culturing and purifying large amounts of neoSTX from freshwater microalgae, and formulating the compound for medical use. The planned clinical studies at Children's, hoped to begin this year, will look for optimal doses that
'/>"/>

Contact: Erin McColgan
erin.mccolgan@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Long-acting beta-agonists most effective step-up therapy for children with poorly controlled asthma
2. Detroits urban farms could provide a majority of produce for local residents
3. Locally Grown May Mean Healthier, But Not Always
4. NYU Langone offers vascular-targeted photodynamic therapy for localized prostate cancer
5. Prediction tool helps estimate local recurrence in patients with noninvasive breast cancer
6. Civil society and local partners for XIX International AIDS Conference (AIDS 2012) announced
7. Test your Localization Abilities on globalvis.com
8. Local Murders Linked to Poor School Performance
9. “Brazilian Blowout” Blows into Local Salon
10. i98 Fm And ahm Announce Local Hero Finalists
11. Local Walgreen's Drug Stores Now Stock ZymaDerm™ The Painless Treatment for Molluscum Contagiosum
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... (PRWEB) August 22, 2014 According ... Type & Application - Global Trends & Forecast ... with an analysis and forecast of the market ... to $38,729 million by 2019, at a significant ... market data tables and 44 figures spread through ...
(Date:8/22/2014)... Hallandale Beach, Florida (PRWEB) August 22, 2014 ... treatment for Lasik in Fort Lauderdale at the most ... patients get better eyesight through their advanced Lasik treatments. ... available worldwide and the Braverman Eye Center has been ... thousands of patients live a glasses-free and contact lenses-free ...
(Date:8/22/2014)... a wide range of epigenetic changesalterations in DNA across the ... with Crohn,s disease (CD), reports Inflammatory Bowel Diseases ... Foundation of America (CCFA). The journal is published ... Wolters Kluwer Health . , The study ... of the genome in children with CD, according to Professor ...
(Date:8/22/2014)... confused with lactose intolerance. However, these are two entirely ... lactose intolerance do not digest lactose properly because they ... of the potentially much more dangerous cow milk allergy, ... its own IgE antibodies. , According to statistics, about ... from a genuine milk allergy. Less adults are diagnosed ...
(Date:8/22/2014)... Medical Oncology (ESMO), the leading pan-European organisation representing ... three outstanding individuals receiving the Society,s esteemed annual ... Bokemeyer, Heikki Joensuu and Peter Boyle on the ... Madrid, Spain. , Carsten Bokemeyer will receive the ... transition of cancer discovery into real benefit at ...
Breaking Medicine News(10 mins):Health News:Isocyanate Market An Industry Growing Steadily Projected to Grow $38,729 Million by 2019 - Report by MarketsandMarkets 2Health News:Isocyanate Market An Industry Growing Steadily Projected to Grow $38,729 Million by 2019 - Report by MarketsandMarkets 3Health News:Isocyanate Market An Industry Growing Steadily Projected to Grow $38,729 Million by 2019 - Report by MarketsandMarkets 4Health News:Braverman Eye Center Now Offers Lasik Treatment in Fort Lauderdale at the Most Affordable Fee 2Health News:Study shows epigenetic changes in children with Crohn's disease 2Health News:Scientists uncover why major cow milk allergen is actually allergenic 2Health News:ESMO honours outstanding oncology professionals 2Health News:ESMO honours outstanding oncology professionals 3
... are warned of side effect that could hamper immigration ... widely used cancer drug capecitabine can cause people to ... they,re trying to enter the United States, an oncologist ... medical oncology at the National Cancer Centre in Singapore, ...
... learned at the Canadian-run military hospital in Kandahar, Afghanistan ... a London, Ontario physician who has served two tours ... professor in the Department of Surgery at the Schulich ... Western Ontario and a general surgeon at the London ...
... Recondo Technology, a leading provider of revenue ... today announced the firm,s selection as one ... Recondo as one of the top 100 companies ... http://www.newscom.com/cgi-bin/prnh/20090527/LA23009LOGO ) , (Logo: ...
... Johnson recognized by business leaders for vision, determination and ... Search America , a part of ... health care, today announced that its president, Daniel Johnson, ... & Young Entrepreneur of the Year(R) Award in Minnesota ...
... to develop new and more effective therapies to fight ... Team" of scientists and clinicians that is co-led by ... Department of Energy,s Lawrence Berkeley National Laboratory. , The ... Entertainment Industry Foundation charitable organization aimed at moving cancer ...
... Care Reform; Mark McClellan ModeratesWASHINGTON, May 27 ... to presenting comprehensive legislation to overhaul the nation,s ... Secretary Michael Leavitt and former Senate Majority Leader ... highlight the need for transparency and inclusion in ...
Cached Medicine News:Health News:Fingerprints May Vanish With Cancer Drug 2Health News:Sharing surgical lessons from the Canadian field hospital in Afghanistan 2Health News:Recondo Technology Wins Red Herring 100 North America Award 2Health News:SearchAmerica(R) President Named as a Finalist for the Ernst & Young Entrepreneur of the Year(R) Award 2Health News:SearchAmerica(R) President Named as a Finalist for the Ernst & Young Entrepreneur of the Year(R) Award 3Health News:Berkeley Lab scientist co-leads breast cancer 'dream team' 2Health News:Berkeley Lab scientist co-leads breast cancer 'dream team' 3Health News:NPC Newsmaker Program Hosts Briefing on Health Care Reform with Former HHS Secretary Michael Leavitt and Former Senate Majority Leader Tom Daschle 2
(Date:8/21/2014)... , Aug. 21, 2014  Zacks.com announces the list ... Zacks Equity Research analysts discuss the latest news and events ... the blog include the Hewlett-Packard (NYSE: HPQ - Free Report ... Bulkers, Inc. (NYSE: SB - Free Report ), GlaxoSmithKline ... International N.V. (NYSE: FI - Free Report ). ...
(Date:8/21/2014)... 21, 2014 InfinityQS International, Inc., the ... Intelligence , today announces Infusion Chicago, its 9 ... be held Oct. 9-10, 2014, at the Chicago ... showcase the necessity for implementing a quality system ... Intelligence to gain insight into production processes. Complimentary ...
(Date:8/21/2014)... , Aug. 21, 2014  The board of directors ... leading provider of clinical trial imaging solutions, today announced ... chief financial officer, effective immediately.  Mr. Groff has held ... 2013.  He joined VirtualScopics in January 2006 as an ... 2013. "When the board of VirtualScopics asked ...
Breaking Medicine Technology:The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 2The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 3The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 4The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 5The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 6The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 7The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 8The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 9The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 10The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 11InfinityQS to Host Manufacturing Intelligence Conference in Chicago 2VirtualScopics, Inc. Names James Groff Chief Financial Officer 2VirtualScopics, Inc. Names James Groff Chief Financial Officer 3VirtualScopics, Inc. Names James Groff Chief Financial Officer 4
... FRANCISCO, June 22, 2011 Autonomy Corporation plc ... infrastructure software for the enterprise, today announced that the ... Autonomy,s flagship Web Content Management (WCM) platform, has twice ... Site Monitor performance report. The Swiss Pharma Site Monitor ...
... FALL RIVER, Mass., June 21, 2011 Millstone ... introduced an advanced version of its online inventory ... refinement, Millstone launched a new online, password-protected system ... place orders, and manage distribution.  Benefits of the ...
Cached Medicine Technology:Autonomy Powers Award-Winning Website for Leading Swiss Pharmaceutical Company 2Autonomy Powers Award-Winning Website for Leading Swiss Pharmaceutical Company 3Autonomy Powers Award-Winning Website for Leading Swiss Pharmaceutical Company 4Millstone Medical Outsourcing Introduces Advanced Version of Online Inventory Management System 2
... are designed for the retraction of ... lesions. Reduced obstruction when working within ... range of blade sizes from 2 ... change and release, malleable material allows ...
The Budde Halo Retractor Side Rail Support is designed for the adaptation and attachment of the Budde Halo Brain Retractor System to the operating room table when a conventional skull clamp is not us...
Telescopic Diamond-Dissectors for delicate sharp tissue preparation. Total/working lengths 220/240 mm with protective sleeve....
Epstein Curettes 3.0 mm, length 8" (203 mm)....
Medicine Products: