Navigation Links
New long-acting local anesthetic derived from algae effectively blocks pain in surgical patients
Date:2/23/2011

Boston, MA -- A U.S.-Chile collaboration is bringing surgical patients closer to having a long-acting local anesthetic. In a randomized, double-blind trial, patients given neosaxitoxin, a new local anesthetic derived from algae, had significantly less postoperative pain and recovered about two days sooner than those given the commonly used local anesthetic bupivacaine. Based on this finding, Children's Hospital Boston, a co-investigator on the study, has signed a collaboration agreement with biotech start-up company Proteus SA (Santiago, Chile) to move the new anesthetic toward clinical adoption.

Tens of millions of patients have operations requiring local anesthesia each year. Current local anesthetics act for less than 8 hours; when they wear off, patients generally need opioid analgesics, which cause substantial side effects, including nausea, sedation, shallow breathing, sleepiness, constipation and itching. These side effects often delay recovery and can result in prolonged hospitalization.

Neosaxitoxin (neoSTX) provides local anesthesia for more than 24 hours. It is a site 1 sodium-channel blocker, part of a larger class of emerging anesthetics based on molecules derived from aquatic organisms.

"In my opinion, there has not been a truly innovative new local anesthetic medication in the last 40 to 50 years," notes study coauthor Charles Berde, MD, PhD, chief of the Division of Pain Medicine at Children's Hospital Boston. "Most drugs introduced over that time period have represented only minimal advances. There have been candidate drugs that went in novel directions, but they've had shortcomings, and none have made it to market."

The neoSTX trial, the first of its kind, involved 137 Chilean patients having laparoscopic removal of their gall bladders. As reported in the March-April issue of Regional Anesthesia and Pain Medicine, significantly fewer patients randomized to neoSTX reported severe postoperative pain
'/>"/>

Contact: Erin McColgan
erin.mccolgan@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Long-acting beta-agonists most effective step-up therapy for children with poorly controlled asthma
2. Detroits urban farms could provide a majority of produce for local residents
3. Locally Grown May Mean Healthier, But Not Always
4. NYU Langone offers vascular-targeted photodynamic therapy for localized prostate cancer
5. Prediction tool helps estimate local recurrence in patients with noninvasive breast cancer
6. Civil society and local partners for XIX International AIDS Conference (AIDS 2012) announced
7. Test your Localization Abilities on globalvis.com
8. Local Murders Linked to Poor School Performance
9. “Brazilian Blowout” Blows into Local Salon
10. i98 Fm And ahm Announce Local Hero Finalists
11. Local Walgreen's Drug Stores Now Stock ZymaDerm™ The Painless Treatment for Molluscum Contagiosum
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... ... August 04, 2015 , ... Healthcare ... executives and technology professionals in healthcare and technology markets, today announced significant spikes ... of Defense’s recently-announced Electronic Health Record (EHR) decision. The DOD related numbers solidify ...
(Date:8/3/2015)... ... ... of the economic recovery since the 2008 has been subject to much debate, the fact ... six years. Unemployment has dropped from a 2009 high of 10 percent to 5.9 percent, ... the U.S. stock market is at an all time high, and interest rates at near ...
(Date:8/3/2015)... ... August 04, 2015 , ... The American ... , The new internationally peer-reviewed Guidelines were prepared by members of the AAT ... imaging, in evaluating patients with dental-oral and systemic health-related complaints. , Thermography ...
(Date:8/3/2015)... ... , ... Sutter Health’s California Pacific Medical center announces the appointment of Hamila ... in her role effective immediately and will have responsibility for all aspects of operations ... Health for about 15 years, including the past 7 years as vice president of ...
(Date:8/3/2015)... Mich (PRWEB) , ... August 03, 2015 , ... Since ... country has declined, according to a new publication released today by the AAMC (Association ... black male college graduates over the past three decades, the number of black male ...
Breaking Medicine News(10 mins):Health News:Coverage of DOD’s EHR Decision Reinforces Healthcare IT News’ Leadership 2Health News:Newport Board group, an Advisory Firm Serving the Middle Market, Cautions Businesses on How to Survive the Coming Recession 2Health News:Newport Board group, an Advisory Firm Serving the Middle Market, Cautions Businesses on How to Survive the Coming Recession 3Health News:Newport Board group, an Advisory Firm Serving the Middle Market, Cautions Businesses on How to Survive the Coming Recession 4Health News:American Academy of Thermology (AAT) Publishes First-Ever Guidelines for Oral-Systemic Thermography 2Health News:American Academy of Thermology (AAT) Publishes First-Ever Guidelines for Oral-Systemic Thermography 3Health News:Hamila Kownacki, RN Appointed as New Chief Operating Officer at CPMC 2Health News:New Publication Focuses on the Decline of Black Males in Medicine 2Health News:New Publication Focuses on the Decline of Black Males in Medicine 3Health News:New Publication Focuses on the Decline of Black Males in Medicine 4
... to identify the agricultural areas with the greatest potential for ... ), which is at risk of extinction. The study shows ... Park of the Sierra de Cardea y Montoro, in Crdoba ... this species lives are the most appropriate sites ...
... , , , ... Healthcare, one of the nation,s first and leading providers of kidney ... the recipients of the 2009 Norman S. Coplon Extramural Grant Program. ... and medical centers in the United States and Canada who are ...
... , , , SAN DIEGO, ... company, today announced that the U.S. Court of Appeals for the ... over the validity of its patents that cover the methods for ... thiopurines to reach and maintain desired therapeutic levels (U.S. Patent Nos. ...
... , , Stable Medicare ... Quality Report , , WASHINGTON, Sept. ... Alliance for Quality Nursing Home Care (Alliance) characterized the health care ... as a step in the right direction, and said the process ...
... , WASHINGTON, Sept. 17 More than ... joint Open Letter to Congress declaring that the health care ... act now on meaningful reforms. They state that Congress has a ... , , The Open Letter identifies eight ...
... , , , ... advanced medical and aesthetic devices, introduces Smooth Cool HR/SR, a world-class ... the light based hair removal market. Smooth Cool HR/SR will make ... first thru third. "Smooth Cool HR/SR is designed for the practitioner ...
Cached Medicine News:Health News:Proposal to reintroduce Iberian lynx on abandoned agricultural land 2Health News:Satellite Healthcare Announces the Recipients of the 2009 Norman S. Coplon Extramural Grants 2Health News:Satellite Healthcare Announces the Recipients of the 2009 Norman S. Coplon Extramural Grants 3Health News:Appeals Court Rules in Favor of Prometheus, Upholds the Patentability of Its Claims for Methods of Thiopurine Metabolite Testing 2Health News:Baucus Approach to Financing Health Care Reform Step in Right Direction 2Health News:Leading American Healthcare Experts Press Congress to Act Quickly on Health Reform 2Health News:Leading American Healthcare Experts Press Congress to Act Quickly on Health Reform 3Health News:Leading American Healthcare Experts Press Congress to Act Quickly on Health Reform 4Health News:Eclipse Introduces Smooth Cool HR/SR with Unique Chilling Technology 2
(Date:8/3/2015)... BOULDER, Colo., Aug. 3, 2015  Array BioPharma ... for the fourth quarter and full year of ... Ron Squarer, Chief Executive Officer of Array, noted, ... Phase 3, are on track for regulatory submissions ... in BRAF-mutant melanoma and BRAF-mutant colorectal cancer further ...
(Date:8/3/2015)... Aug. 3, 2015  Charleston Laboratories, Inc., an ... second clinical development program with a Phase 1 ... CL-H1T contains fast-dissolving promethazine and sumatriptan.  ... a treatment for migraine headache pain and migraine-induced ... patients with migraine headaches also suffer from nausea ...
(Date:8/3/2015)... FLORHAM PARK, N.J. , Aug. 3, ... met its primary and secondary endpoints in a phase ... constipation (OIC) in adult patients with chronic non-cancer pain. ... antagonist (PAMORA). This is the third Phase III trial ... endpoints. Study results showed that a 0.2 ...
Breaking Medicine Technology:Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 2Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 3Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 4Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 5Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 6Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 7Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 8Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 9Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 10Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 11Array BioPharma Reports Financial Results For The Fourth Quarter And Full Year Of Fiscal 2015 12Charleston Laboratories, Inc. Initiates Patient Enrollment in a Phase 1 Study of Charleston's Second Product, CL-H1T 2Naldemedine Meets Primary Endpoint In Phase 3 Study For The Treatment Of Opioid-Induced Constipation 2Naldemedine Meets Primary Endpoint In Phase 3 Study For The Treatment Of Opioid-Induced Constipation 3Naldemedine Meets Primary Endpoint In Phase 3 Study For The Treatment Of Opioid-Induced Constipation 4
... SenSage, Inc., a leading provider of ... that it has been selected as Cerner Corporation,s (Nasdaq: ... for its ability to demonstrate significant speed to value ... announced today an expanded alliance with Cerner to offer ...
... Codexis, Inc. (Nasdaq: CDXS ) ... with Teva Pharmaceutical Industries Ltd., the world,s largest ... technology transfer of custom biocatalysts for manufacture of ... have been transferred to pilot manufacturing and a ...
Cached Medicine Technology:SenSage Named Cerner Corporation's 'Accelerate Partner of the Year' 2SenSage Named Cerner Corporation's 'Accelerate Partner of the Year' 3SenSage Named Cerner Corporation's 'Accelerate Partner of the Year' 4Codexis Achieves Development Milestones With Teva 2
CO 2 SMO-Capnograph/Pulse Oximeter...
A software program for simple, efficient pulse oximetry analysis, which enables easy viewing, analysis and report generation for pulse rate and SpO 2 ....
... the next generation in pulse oximetry monitoring ... current family of "digital pulse oximeters, MARSpO ... breakthroughs in signal processing. This provides improved ... superior performance during challenging clinical conditions such ...
The NPB-40 Handheld Pulse Oximeter is both compact and affordable. It is simple to operate, provides spot-check monitoring of SpO 2 and pulse rate, and is compact enough to fit in your pocket....
Medicine Products: