Navigation Links
New light shed on the enigma of salt intake and hypertension
Date:5/4/2009

A high salt intake has been implicated in cardiovascular disease risk for 5000 years. But salt-sensitive hypertension still remains an enigma. Now, investigators from Germany at the University of Erlangen, the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and Regensburg, collaborating with researchers from Finland and Austria have shed new light on the relationship between salt intake, bodily processes, and blood pressure regulation. Within the skin, they have detected a new storage area for salt in the body. They also found out that if the process behind this storage is defect, animals become hypertensive (Nature Medicine, doi 10.1038/nm.1960)*.

Salt (natrium chloride, NaCl) is required for life. Herbivores (plant-eating animals) risk their lives to go to "salt licks" and carnivores (meat-eating animals) go to salt licks to eat herbivores in order to obtain salt.

Salt is responsible for water regulation in the body. It is taken up by the gastro-intestinal (GI) tract and, in large part, excreted by the kidneys. However, salt is also stored in cells and in the interstitium, the area between cells in the body.

Dr. Jens Titze and colleages, among them Dominik N. Mller, Wolfgang Derer, and Friedrich C. Luft from the Experimental and Clinical Research Center at the MDC, could now show that a high-salt diet in rats leads to the accumulation of salt in the interstitium in the skin. This process is carefully regulated by special white blood cells, the macrophages.

In those macrophages, the scientists found a gene regulator (transcription factor) called TonEBP (tonicity-responsible enhancer binding protein). TonEBP is activated in these cells in response to high salt and turns on a gene (VEGF-C - vascular endothelial growth factor C) that controls the production of lymphatic blood vessels. With high-salt diet the lymphatic vessels increase.

The investigators also showed that when these macrophages ar
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Study shines more light on benefit of vitamin D in fighting cancer
3. Bacteria See the Light
4. Quantum light beams good for fast technology
5. Free will takes flight: how our brains respond to an approaching menace
6. New MRI finding sheds light on multiple sclerosis disease progressio
7. RA Drugs Linked to Slight Skin Cancer Risk
8. QUANTEL Intends to Strengthen its Dermatology/ Aesthetics Division With the Acquisition of WaveLight Aesthetic GmbH
9. REACH Registry Highlights That Patients With Peripheral Arterial Disease (PAD) Suffer High Rates of Heart Attack, Stroke, Hospitalization, and Death
10. Cardiovascular Technologies to be Highlighted at 5th Annual Cleveland Clinic Medical Innovation Summit, Oct. 1-3
11. First Circuit Court of Appeals Rules Against Philip Morris in Lights Class Action
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... ( FXS ) is a genetic disorder that causes ... autistic spectrum, as well as cognitive deficits. It is ... the most common cause of autism. , Now biomedical ... a study that sheds light on the ... (July 23) in the Journal of Neuroscience , ...
(Date:7/23/2014)... Kathleen Doheny HealthDay Reporter ... surgery appears to have an additional side benefit -- ... to a new study. The study found that ... reported having incontinence prior to the procedure. After surgery, ... improved or disappeared, said study researcher Dr. Leslee Subak, ...
(Date:7/23/2014)... the genome resulting from a combination of genetic modifications ... weak predispositions to developing certain kinds of cancer; in ... throughout our lifetime. Although the genetic origins of cancers ... not able to measure the role of non-coding regions ... from the University of Geneva (UNIGE), by studying tissues ...
(Date:7/23/2014)... 2014 A therapy combining salmon fibrin injections into ... into the brain restored voluntary motor function impaired by ... Center have found. , In a study on rodents, ... turning back the developmental clock in a molecular pathway ... and providing a scaffold so that neuronal axons at ...
(Date:7/23/2014)... Recently, Agebc.com has launched its new collection of ... a promotion of wedding dresses. According to a representative ... end of this month. , The beautiful wedding dresses ... mermaid, ball-gown, empire, and more. Agebc.com is a well-known ... for women, and the company is devoted to providing ...
Breaking Medicine News(10 mins):Health News:Study links enzyme to autistic behaviors 2Health News:Study links enzyme to autistic behaviors 3Health News:Weight Loss Surgery May Help Ease Urinary Incontinence 2Health News:Weight Loss Surgery May Help Ease Urinary Incontinence 3Health News:Genetics of cancer: Non-coding DNA can finally be decoded 2Health News:Gene inhibitor, salmon fibrin restore function lost in spinal cord injury 2Health News:Agebc.com Launched Its New Collection of Wedding Dresses 2
... ... beings need music as a form of release and expression, and now it has been ... ... stressors, stimuli, and distractions in this world, it can be difficult for the average person ...
... Huge ... ... Almac has addressed ongoing industry developments by greatly expanding their capacity in the New ... in the pharmaceutical industry, specifically the growing demand for biologics. Biologics, which are ...
... ... announced today it has acquired Canterbury International, a privately-held company based ... furnishings. The Verdin Company, based in Cincinnati, Ohio, is recognized ... and clock towers, glockenspiels, and other musical instruments.,Canterbury International, a leading ...
... ... and Profitability. , ... Manasquan, NJ, USA (PRWEB) June 21, 2010 -- Marketers with sufficient insight to estimate ... untapped profit potential, according to the 2010 Lenskold Group / emedia Lead ...
... ... industry. Anyone who can understand this contradiction, will understand the sense of urgency related to ... now, keeping BP’s oil spill and the effects of it in mind. , ... (PRWEB) June 20, 2010 -- BP’s oil ...
... ... profession will come together to share knowledge and explore innovations in one of the most ... ... unique conferences offering high-quality scientific programs, which broaden perspectives by exploring the latest innovations in ...
Cached Medicine News:Health News:Reinvent your Mental State With Brainwave Entrainment Relaxation Music 2Health News:Reinvent your Mental State With Brainwave Entrainment Relaxation Music 3Health News:Reinvent your Mental State With Brainwave Entrainment Relaxation Music 4Health News:Almac's US Headquarters Will Address Capacity Demand for Clinical Supplies 2Health News:The Verdin Company Acquires Canterbury International, an industry leader in architectural site furnishings for over 50 years 2Health News:The Verdin Company Acquires Canterbury International, an industry leader in architectural site furnishings for over 50 years 3Health News:Lead Generation Marketing ROI Study Released 2Health News:Lead Generation Marketing ROI Study Released 3Health News:Lead Generation Marketing ROI Study Released 4Health News:Wind turbines harmful for the environment and public health 2Health News:The 2nd Future Trends in Implantology International Dental Conference 2
(Date:7/23/2014)... -- Creekridge Capital, an independent vendor-focused finance company, ... far in 2014 to their portfolio of contractual ... both the healthcare and technology industries. They range ... companies. Each of these new vendors take advantage ... standard leasing products, subscription solutions, a dedicated revolving ...
(Date:7/23/2014)...  When it comes to welcoming our new robot overlords, ... out the red carpet. Healthcare is one of ... robots into our human sphere. With healthcare concerns top of ... to apply new technologies to help with old problems. That,s ... is expected to increase from $1.7 billion now to $3.7 ...
(Date:7/23/2014)... ANGELES , July 23, 2014  Researchers from ... with calcium elevates calcium levels too high, ... among other health problems. Women close to ... and vitamin D to prevent diseases such as osteoporosis, ... would recommend that women determine how much calcium they ...
Breaking Medicine Technology:Creekridge Capital Signs Several New Vendor Partners 2Women Taking Too Much Calcium Create Health Risk 2
... CHICAGO , June 2 The Female Health Company (Nasdaq: ... Condoms to be distributed for HIV/AIDS prevention to attendees at the 2010 World Cup. ... from June 11, 2010 to July 11, 2010 . , ... The month-long 2010 World Cup, which offers three million ...
... HAMILTON, N.J. , June 2 MedAvante, Inc., the leader in ... its CQC Continuous Quality Control Service for trials assessing Alzheimer,s Disease. Its CQC ... including depression, anxiety and schizophrenia in the United States , Europe ... , , , ...
Cached Medicine Technology:The Female Health Company Receives Order for 3.5 Million FC2 Female Condoms for Distribution at 2010 World Cup 2The Female Health Company Receives Order for 3.5 Million FC2 Female Condoms for Distribution at 2010 World Cup 3MedAvante Launches Service to Boost Reliability of Assessments to Reduce Risk of Failed Alzheimer's Disease Trials 2MedAvante Launches Service to Boost Reliability of Assessments to Reduce Risk of Failed Alzheimer's Disease Trials 3
Diamond Filter Tips play a critical role in preventing aerosol-borne contamination. Also available sterilized (no need to autoclave) and certified free of detectable RNase, DNase, DNA, RNA, and prote...
10 L, Racked, Pre-sterilized, 96 tips/rack Recommended for 2, 5 and 10 L pipettes....
... are ideal for PCR and ... any work where aerosol contamination ... for pipetting DNA/RNA solutions, infectious ... For applications requiring absolute sterility, ...
Avant E-Z Rack Premium Low Binding 10 l Pipet Tips are accurate, contamination free, and allow quantitative transfer of your samples without relying on silicone....
Medicine Products: