Navigation Links
New light shed on the enigma of salt intake and hypertension
Date:5/4/2009

A high salt intake has been implicated in cardiovascular disease risk for 5000 years. But salt-sensitive hypertension still remains an enigma. Now, investigators from Germany at the University of Erlangen, the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and Regensburg, collaborating with researchers from Finland and Austria have shed new light on the relationship between salt intake, bodily processes, and blood pressure regulation. Within the skin, they have detected a new storage area for salt in the body. They also found out that if the process behind this storage is defect, animals become hypertensive (Nature Medicine, doi 10.1038/nm.1960)*.

Salt (natrium chloride, NaCl) is required for life. Herbivores (plant-eating animals) risk their lives to go to "salt licks" and carnivores (meat-eating animals) go to salt licks to eat herbivores in order to obtain salt.

Salt is responsible for water regulation in the body. It is taken up by the gastro-intestinal (GI) tract and, in large part, excreted by the kidneys. However, salt is also stored in cells and in the interstitium, the area between cells in the body.

Dr. Jens Titze and colleages, among them Dominik N. Mller, Wolfgang Derer, and Friedrich C. Luft from the Experimental and Clinical Research Center at the MDC, could now show that a high-salt diet in rats leads to the accumulation of salt in the interstitium in the skin. This process is carefully regulated by special white blood cells, the macrophages.

In those macrophages, the scientists found a gene regulator (transcription factor) called TonEBP (tonicity-responsible enhancer binding protein). TonEBP is activated in these cells in response to high salt and turns on a gene (VEGF-C - vascular endothelial growth factor C) that controls the production of lymphatic blood vessels. With high-salt diet the lymphatic vessels increase.

The investigators also showed that when these macrophages ar
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Study shines more light on benefit of vitamin D in fighting cancer
3. Bacteria See the Light
4. Quantum light beams good for fast technology
5. Free will takes flight: how our brains respond to an approaching menace
6. New MRI finding sheds light on multiple sclerosis disease progressio
7. RA Drugs Linked to Slight Skin Cancer Risk
8. QUANTEL Intends to Strengthen its Dermatology/ Aesthetics Division With the Acquisition of WaveLight Aesthetic GmbH
9. REACH Registry Highlights That Patients With Peripheral Arterial Disease (PAD) Suffer High Rates of Heart Attack, Stroke, Hospitalization, and Death
10. Cardiovascular Technologies to be Highlighted at 5th Annual Cleveland Clinic Medical Innovation Summit, Oct. 1-3
11. First Circuit Court of Appeals Rules Against Philip Morris in Lights Class Action
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... Targeted ... and improve the lives of patients, according to a newly published report. Surviving ... read the full article. , The authors of the new paper focus ...
(Date:8/29/2015)... ... 2015 , ... Brands like Toppik , Eau Thermale Avene and Bliss ... a threshold of $49.00 was required to qualify for free standard shipping,” said Jennifer ... shipping for customers regardless of the item’s selling price.” , With competitive pricing in ...
(Date:8/29/2015)... ... , ... ProDrop Particles includes over 40 particle backdrops designed for use in ... that users can shrink and stretch in the Final Cut Pro X timeline. Choose ... brightness, scale, speed, range, and flare attributes with intuitive controls found in the top-right ...
(Date:8/29/2015)... ... August 29, 2015 , ... ... localized area with stretching, soft tissue manipulation. Platelet rich plasma injections also have ... through research to improve treatment outcomes. This localized treatment seems to address ...
(Date:8/29/2015)... TX (PRWEB) , ... August 29, 2015 , ... ... allows the company to freely market and sell Arterosil and Arterosil HP, and ... Health Sciences, LLC (DHS) sued Vascular Health Sciences, LLC (VHS) in the United ...
Breaking Medicine News(10 mins):Health News:Top Mesothelioma Researchers Highlight Targeted Therapies in New Report, According to Surviving Mesothelioma 2Health News:TheBeautyPlace.com Discounts Shipping on Select Brands 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 3
... women,s risk of recurrent or new tumors by more than ... -- There,s good news for the 60 percent of ... taking the aromatase inhibitor (AI) drug letrozole (Femara) can cut ... benefit was seen even when women initiated the drug one ...
... Johnson &,Johnson will participate in the Eleventh Annual ... at the Loews Miami Beach Hotel,in Miami, Florida. ... will represent the Company in a session scheduled ... be available to investors and other interested parties,by ...
... University School of Medicine and Children,s Healthcare of Atlanta ... to find new ways to make kidney transplants more ... partner with UCLA,s Mattel Childrens Hospital in Los Angeles ... Alto for a study of kidney transplants in children. ...
... Disease Control has awarded the Indiana University School of ... of nearly $10 million in funding over 5 years ... regional entities to share data and information to enhance ... disease outbreaks and other public health emergencies. , The ...
... Two Hospitals in Central Pennsylvania Earn Designation, ... Shield is,pleased to announce the recognition of Penn ... Blue Distinction Centers for Complex and Rare,Cancers., ... of new,cancer cases each year, making it difficult ...
... March 11 Granite State Manufacturing (GSM),a ... and,commercial markets, acquired Scandia Manufacturing Company Inc. ... mechanical marine systems,for the Department of Defense. ... the United States Navy., Granite State ...
Cached Medicine News:Health News:Late Use of Aromatase Inhibitor Still Effective Against Breast Cancer 2Health News:Late Use of Aromatase Inhibitor Still Effective Against Breast Cancer 3Health News:NIH grant to Emory and pediatric partners aims to improve kidney transplants for children 2Health News:Regenstrief Institute tapped by CDC to combat potentially catastrophic disease outbreaks 2Health News:Highmark Blue Shield and National Association Name Area Hospitals as Blue Distinction Centers for Complex and Rare Cancers 2Health News:Highmark Blue Shield and National Association Name Area Hospitals as Blue Distinction Centers for Complex and Rare Cancers 3Health News:Granite State Manufacturing Acquires Scandia Manufacturing Company Inc. 2
(Date:8/27/2015)... , Aug. 27, 2015 ieCrowd™ ... in the commercial development of the company,s supplemental ... Smart Oxygen device, being developed by ieCrowd,s subsidiary ... a patient,s changing demand for oxygen based on ... 510 (k) submission for the Smart Oxygen device ...
(Date:8/27/2015)... Pa. , Aug. 27, 2015  Now that ... the Da Vinci S™ surgical robot, hospitals with robotic ... plans. They also need to see where they stand ... on the right patients? Have they adopted best practices ... surgery program in the future? ECRI Institute, ...
(Date:8/27/2015)... MARIETTA, Ga. , Aug. 27, 2015  MiMedx ... regenerative medicine company utilizing human amniotic tissue and ... and therapies for the Wound Care, Surgical, Orthopedic, ... healthcare, responded today and corrected the multiple inaccuracies ... Transplant Foundation ("MTF") regarding the recent rulings from ...
Breaking Medicine Technology:Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 2Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 3Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 4ECRI Institute's New Robotic Surgery Service Helps Hospitals Brace for Change 2ECRI Institute's New Robotic Surgery Service Helps Hospitals Brace for Change 3MiMedx Corrects Inaccuracies In MTF Press Release Regarding The Recent Rulings From The Patent Trial And Appeal Board 2MiMedx Corrects Inaccuracies In MTF Press Release Regarding The Recent Rulings From The Patent Trial And Appeal Board 3MiMedx Corrects Inaccuracies In MTF Press Release Regarding The Recent Rulings From The Patent Trial And Appeal Board 4
... Lasers, a global developer, manufacturer and provider of laser, ... applications, announced today that it will launch a nationwide ... Breast Cancer Awareness Month.  The Declare Your Freedom program ... month of October 2011. Radiation therapists ...
... Oct. 5, 2011 Hill-Rom Holdings, Inc. (NYSE: ... and 2012 financial guidance on Wednesday, October 26, 2011.  You ... on Thursday, October 27, 2011, at 8 a.m. ET. ... Earnings and 2012 Financial Guidance release will be issued to ...
Cached Medicine Technology:In Honor of National Breast Cancer Awareness Month, Alma Lasers Launches Nationwide Radiation Tattoo Removal Program, Declare Your Freedom 2Hill-Rom Holdings, Inc. Invites You to Join Its Fiscal 2011 Fourth Quarter Earnings and 2012 Financial Guidance Webcast 2
... 3D Signature is a state of ... that integrates blood, sterile body fluid ... powerful microbiology workstation with comprehensive capabilities. ... identification and where expanded flexibility in ...
The Vitek 2 is a fully automated bacteriology system that performs bacterial identification and susceptibility testing analysis using a standard inoculum. It detects resistance and helps combat bacte...
IDS Rapid ANA II System, a microbial identification system....
IDS Rapid SS/u, a microbial identification system....
Medicine Products: