Navigation Links
New light on the genetic basis of inflammatory diseases
Date:11/1/2012

mon forms of IBD, creating a large dataset that combined genetic information from some 34,000 individuals who took part in those studies. The results then formed part of a second meta-analysis that included data from new genome-wide scans of more than 41,000 DNA samples from CD/UC patients and healthy comparison subjects collected at 11 centers around the world by the International IBD Genetics Consortium.

"We have greatly expanded the map of genetic regions that are associated with IBD", agreed Dr. John Rioux, co-lead author of this study and chair of the Consortium, with Jeffrey Barrett of the Wellcome Trust Sanger Institute in Cambridge, England, lead author of the study. "Each of these regions only increases a person's chance of developing IBD by a fraction of a per cent and even taken together they cannot tell us who will or will not develop the disease. But they each tell a small story about the biology of this disorder, and by combining them we find biological pathways that, if disrupted, can lead to IBD."

Immune system: a major factor

Dr. Rioux and the international team of researchers also studied the activity of genes in their IBD regions in hundreds of different types of cells involved in the immune system. They found that certain cells tended to produce more of these IBD genes, including many that are involved in the body's first line defence against invasion. This illustrates that an immune response seems to be a major factor in IBD: when a bacterium is detected, these cells are not just activated, but become overactive.

"We see a genetic balancing act between defending against bacterial infection and attacking the body's own cells," said Dr. Barrett. "Many of the regions we found are involved in sending out signals and responses to defend against bad bacteria. If these responses are over-activated, we found it can contribute to the inflammation that leads to IBD."

Nearly 100 scientists in 15 countries
'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pesticides May Be Linked to Slightly Smaller Babies, Shorter Pregnancies
2. Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
3. Scientific session and new research highlights
4. U.S. Gives Green Light to Publish Controversial Bird Flu Research
5. Shedding light on southpaws
6. Intense light prevents, treats heart attacks
7. Triple negative breast cancer symposium highlights current advances
8. With Weights, You Can Lighten Your Load
9. Study highlights need for coordination of care in stage 2 and 3 rectal cancer treatment
10. Clinical news alert: Journal of the American Academy of Orthopaedic Surgeons May highlights
11. Study Links Antibiotic to Slight Rise in Heart Patients Death Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... The Latinos In Action Festival 2014 is being ... Florida State Fair Grounds from 9am - 9pm. Latinos ... from around the world. Latinos in Action Festival is ... and Univision Mobile, a service provided by T-Mobile company. ... 4,000 people from different backgrounds, cultures and nationalities. Come ...
(Date:8/27/2014)... of hormone therapy has spawned a prevalent but preventable ... hot flashes, according to a study by a Yale ... the study published in the Aug. 27 online issue ... that moderate to severe hot flashes also called ... women. Women with VMS experience more than feeling hot; ...
(Date:8/27/2014)... Line: Photodynamic therapy (PDT, which uses topical agents and ... keratoses (AKs, a common skin lesion caused by sun ... uses liquid nitrogen to freeze lesions). , ... California Davis Medical Center, in Sacramento, and colleagues. ... the skin typically found on individuals with fair complexions ...
(Date:8/27/2014)... 2014 Michigan Head & Neck Institute is ... a local elementary school by ensuring they have everything they ... year-round attendance, and Michigan Head & Neck Institute wants to ... school year. , "There are a lot of military families ... way to give back to our community," said Lauren Taylor, ...
(Date:8/27/2014)... Dr. Stewart Shofner and Dr. Kevin ... suffering from impaired vision. Some of the most common ... . Recently, Dr. Shofner has noticed a significant increase ... and also online. To help patients understand the facts, ... , 1)    Myth: People with perfect vision won’t develop glaucoma. ...
Breaking Medicine News(10 mins):Health News:Marc Anthony to Perform at "Nieves Productions" Latinos in Action Festival 2Health News:The high cost of hot flashes: Millions in lost wages preventable 2Health News:Photodynamic therapy vs. cryotherapy for actinic keratoses 2Health News:Michigan Head & Neck Institute is Conducting Their 2nd Annual School Supplies Drive at Their Facility to Benefit Local Year-Round Elementary School Students 2Health News:Renowned Eye Surgeon Dr. Stewart Shofner Debunks Top Five Myths About Glaucoma 2Health News:Renowned Eye Surgeon Dr. Stewart Shofner Debunks Top Five Myths About Glaucoma 3Health News:Renowned Eye Surgeon Dr. Stewart Shofner Debunks Top Five Myths About Glaucoma 4
... protein well known for its crucial role in regulating gene ... it a key player in the immune system. But SATB1 ... contributing factor in the most aggressive forms of breast cancer. ... metastasis -- the stage when cells break away from the ...
... in Montana, FORT HARRISON, Mont., March 12 ... to Department of Veterans Affairs (VA),benefits information and ... program using,video-conferencing technology and staffing support., "Access ... them receive,the benefits they have earned through their ...
... senior director for drug discovery at Scripps Florida, will ... Scripps Florida in 2005, previously held positions at Merck ... fund research to develop a compound to treat neurodegeneration ... to bring the potential treatment to the point where ...
... Include Prescription Drug Marketing and,Purchasing Reform, ALBANY, ... AARP, NYSUT, BALCONY, CSEA, PEF, Consumers Union,NYPIRG and ... elected,officials and leaders to make prescription drugs more ... purchasing reform., Among the proposals supported for ...
... earlier treatments, better patient outcomes , , WEDNESDAY, March 12 ... identify patients at risk of developing acute kidney injury ... the problem would otherwise be detected, a pilot study ... and better patient outcomes, the researchers say. , The ...
... First-of-its-kind workshop to convene at Northwestern Memorial June,19-21, ... about anyone,about their healthcare experiences in America and ... medical error, or expected outcomes gone,wrong. In fact, ... error is between the fourth and eighth leading ...
Cached Medicine News:Health News:A protein that triggers aggressive breast cancer 2Health News:A protein that triggers aggressive breast cancer 3Health News:A protein that triggers aggressive breast cancer 4Health News:A protein that triggers aggressive breast cancer 5Health News:VA to Pilot Innovative Remote Benefits Delivery Program 2Health News:Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinson's disease 2Health News:Coalition of Consumer, Business, Union and Advocacy Groups Call for Increased Rx Affordability and Accessibility 2Health News:Coalition of Consumer, Business, Union and Advocacy Groups Call for Increased Rx Affordability and Accessibility 3Health News:Coalition of Consumer, Business, Union and Advocacy Groups Call for Increased Rx Affordability and Accessibility 4Health News:New Test Predicts Risk of Post-Surgery Kidney Injury 2Health News:Northwestern Memorial Hospital, CAPS, and p4ps Host Consumer Forum to Advance Partnerships to Improve Healthcare Patient Safety 2Health News:Northwestern Memorial Hospital, CAPS, and p4ps Host Consumer Forum to Advance Partnerships to Improve Healthcare Patient Safety 3Health News:Northwestern Memorial Hospital, CAPS, and p4ps Host Consumer Forum to Advance Partnerships to Improve Healthcare Patient Safety 4
(Date:8/27/2014)... BOSTON , Aug. 27, 2014  Columbia Laboratories, ... Company"), a provider of pharmaceutical development, clinical trial manufacturing, ... industry, today announced that it will participate at the ... Investment Conference, to be held in New ... conference at 11:15am on September 9, 2014 at the ...
(Date:8/27/2014)... and NINGBO, China , ... the Ningbo Menovo Pharmaceutical Co., Ltd, ("Menovo") today announced ... development of generic pharmaceuticals, primarily targeting the ... the agreement, Amerigen and Menovo will jointly develop products ... States . Menovo will be responsible for manufacturing ...
(Date:8/27/2014)... 2014 /CNW/ - Covalon Technologies Ltd. (the "Company" or "Covalon") ... financial results for its third quarter of fiscal 2014: ... , Revenue of $1,291,378, a 13% decrease over the ... for the quarter of $240,156 compared to net income of ... For the nine months ended June 30, 2014: ...
Breaking Medicine Technology:Amerigen Pharmaceuticals Limited and the Ningbo Menovo Pharmaceutical Co., Ltd, today announced they had entered into a collaboration agreement regarding the development of generic pharmaceuticals, primarily targeting the United States market 2Covalon Announces Third Quarter Results 2Covalon Announces Third Quarter Results 3
...   GP Strategies Corporation (NYSE: GPX ... and technical training, e-Learning solutions, management consulting and engineering ... Capital") has agreed to purchase 350,000 shares in a ... of the transaction is subject to customary conditions and ...
...  Boston Scientific Corporation (NYSE: BSX ) is ... Healthcare Conference in San Francisco. Hank Kucheman, ... Company on Wednesday, January 11, 2012, beginning at approximately ... President, and Jeff Capello, Executive Vice President and Chief ...
Cached Medicine Technology:Sagard Capital Increases Ownership in GP Strategies by 350,000 Shares in a Private Transaction with Bedford Oak Partners, L.P. 2Sagard Capital Increases Ownership in GP Strategies by 350,000 Shares in a Private Transaction with Bedford Oak Partners, L.P. 3Boston Scientific to Participate in 30th Annual J.P. Morgan Healthcare Conference 2
... Designs ROM post-operative knee braces are designed ... rehabilitation. , ,Adjustable and versatile, ROM ... for health care professionals. The braces are ... feature quick dial combination hinges that allow ...
... Neuroprene™ soft supports are a convenient, ... proprioceptive taping for common orthopedic conditions/instabilities. ... provide specific compression and lateral to ... (proprioceptors) in the skin and soft ...
... The Deluxe Heavy Duty Drop Lock Post Operative ... pin hinge with a spring loaded drop lock ... arms and contoured plates prevent the brace from ... a tibial offset for anatomical alignment that controls ...
... might just be the world's most versatile ... support, post-op/rehab support, or both, Flex is ... Accutrac™ ROM hinges control flexion and extension ... durability while being heat-moldable to accommodate changes ...
Medicine Products: