Navigation Links
New light on the genetic basis of inflammatory diseases
Date:11/1/2012

mon forms of IBD, creating a large dataset that combined genetic information from some 34,000 individuals who took part in those studies. The results then formed part of a second meta-analysis that included data from new genome-wide scans of more than 41,000 DNA samples from CD/UC patients and healthy comparison subjects collected at 11 centers around the world by the International IBD Genetics Consortium.

"We have greatly expanded the map of genetic regions that are associated with IBD", agreed Dr. John Rioux, co-lead author of this study and chair of the Consortium, with Jeffrey Barrett of the Wellcome Trust Sanger Institute in Cambridge, England, lead author of the study. "Each of these regions only increases a person's chance of developing IBD by a fraction of a per cent and even taken together they cannot tell us who will or will not develop the disease. But they each tell a small story about the biology of this disorder, and by combining them we find biological pathways that, if disrupted, can lead to IBD."

Immune system: a major factor

Dr. Rioux and the international team of researchers also studied the activity of genes in their IBD regions in hundreds of different types of cells involved in the immune system. They found that certain cells tended to produce more of these IBD genes, including many that are involved in the body's first line defence against invasion. This illustrates that an immune response seems to be a major factor in IBD: when a bacterium is detected, these cells are not just activated, but become overactive.

"We see a genetic balancing act between defending against bacterial infection and attacking the body's own cells," said Dr. Barrett. "Many of the regions we found are involved in sending out signals and responses to defend against bad bacteria. If these responses are over-activated, we found it can contribute to the inflammation that leads to IBD."

Nearly 100 scientists in 15 countries
'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pesticides May Be Linked to Slightly Smaller Babies, Shorter Pregnancies
2. Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
3. Scientific session and new research highlights
4. U.S. Gives Green Light to Publish Controversial Bird Flu Research
5. Shedding light on southpaws
6. Intense light prevents, treats heart attacks
7. Triple negative breast cancer symposium highlights current advances
8. With Weights, You Can Lighten Your Load
9. Study highlights need for coordination of care in stage 2 and 3 rectal cancer treatment
10. Clinical news alert: Journal of the American Academy of Orthopaedic Surgeons May highlights
11. Study Links Antibiotic to Slight Rise in Heart Patients Death Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... According to a recent report from NIDCR (National ... pain, TMJ disorders are the second most prevalent ... addition, the report revealed that TMJ disorders affect about ... estimated 4 billion dollars annually. , These estimates suggest ... symptoms such as headaches, neck pain, tenderness of the ...
(Date:4/27/2015)... April 27, 2015 Beckman Coulter is ... sequencing to study the evolution of neural circuitry and ... will review the mechanisms by which analogous forms of ... body flexions, evolved independently in certain sea slug clades. ... broadcast live April 30, 2015 at 8:00am PT. , ...
(Date:4/27/2015)... 2015 As ISO 27001 has quickly ... companies of all sizes and in all industries, Pivot ... prepare for ISO 27001 certification. The information security audit ... them for ISO 27001 certification. Pivot Point's commitment to ... the number of Lead Implementers and Auditors the company ...
(Date:4/27/2015)... (PRWEB) April 27, 2015 Doctors on ... working on a lien basis for over twenty years. So ... find the best doctor in the Fresno area , ... Dilanchian, DC and his team of medical specialists. With ... a massage therapist, Dilanchian Chiropractic is now helping ...
(Date:4/27/2015)... Guided by the extensive work of its community ... collaboration with organizations around the world to identify proven ... essential actions for organizations committed to patient experience ... systems committed to providing the best in experience will:, ... with committed time and focused intent to shape and ...
Breaking Medicine News(10 mins):Health News:Dentist in Graham NC Reveals that a Jaw Disorder May Be the Cause of Chronic Headaches and Back Pain 2Health News:Beckman Coulter Genomics Presents Using Next-Gen Sequencing to Study the Evolution of Neural Circuitry 2Health News:Beckman Coulter Genomics Presents Using Next-Gen Sequencing to Study the Evolution of Neural Circuitry 3Health News:Six Additional New ISO 27001 Lead Implementers Certified for Pivot Point Security 2Health News:Eminent Doctor Joins Forces with Doctors on Liens in Fresno 2Health News:Guiding Principles for Patient Experience Excellence Identified by The Beryl Institute 2
... significant reduction in the teaching hours for medical subjects ... in a pathetic state where medical students are unable ... end up confusing one organ with another. In addition ... considerable reduction in the teaching hours for biochemistry, pathology, ...
... launched the Female Condom (FC) in India. It has partnered ... to market// their female condoms in India under the brand ... research before being able to launch the condom in India. ... first year. A pair of Confidom will cost Rs.250/-., ...
... among the teenagers in the recent years. But a new ... that they ever took such vows. // ,The ... good way of gauging how well they adhere to these ... form of public or written declarations to remain a virgin ...
... Mountain View, Calif.-based company is one of the leading ... Hence Long Island politician sued Google. He said that ... child pornography. Jeffrey Toback, a member of the Nassau ... contains pornography involving minors. In regard to this a ...
... used brain scans to try and study the biology of ... the brain pays to the expected pain // determines and ... suggesting that simple diversions could alleviate the misery. ... a new field called neuroeconomics that uses brain imaging to ...
... study undertaken by Ohio State University that chose to study the ... men have no compunctions opening up to others about their ... of the study Julianne Serovich says, “I was very surprised at ... HIV-positive men who deliberate very carefully on whether or not to ...
Cached Medicine News:Health News:Australian Medical Students Lack Anatomy Knowledge 2Health News:Teenagers Often Deny Taken ‘Virginity Pledges 2
(Date:4/27/2015)... -- Novira Therapeutics, Inc., a privately held, clinical-stage biopharmaceutical company ... B virus (HBV) infection, today announced the presentation of ... candidate, NVR 3-778, at the 2015 annual meeting of ... (EASL) in Vienna, Austria . ... performed in a humanized UPA/SCID mouse model was described ...
(Date:4/27/2015)... BRH Medical, Ltd., today announced ... Notification Application (510k) with the US Food and Drug ... Medical expects feedback from the FDA during the next ... following FDA pre-market clearance. Additional pre-market regulatory filings are ... CEO for BRH Medical, commented, "We are thrilled to ...
(Date:4/27/2015)... 27, 2015 Endo International plc (NASDAQ: ENDP ... results before the open of the U.S. financial markets on ... will host a conference call and webcast at 9:00 a.m. ... access the call is U.S./ Canada (866) ... Please dial in 10 minutes prior to the scheduled start ...
Breaking Medicine Technology:Novira Therapeutics Announces Presentation of Preclinical Antiviral Data for NVR 3-778 at EASL 2Novira Therapeutics Announces Presentation of Preclinical Antiviral Data for NVR 3-778 at EASL 3BRH Medical, Ltd., Announces Filing of a Pre-Market Submission with the US Food and Drug Administration (FDA) for the BRH-A2 Tissue Management System 2
... Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ) announced today that it ... , before the U.S. financial markets open. , ... Anadys will hold a conference call and webcast on Thursday, July ... its second quarter 2010 financial results and to provide an update on the ...
... SAN DIEGO , July 22 Neurocrine Biosciences, Inc. (Nasdaq: ... financial results after the Nasdaq market closes on Wednesday, July 28, 2010 ... its financial results and provide a Company update Thursday morning, July 29, ... Time ). , , , ...
Cached Medicine Technology:Anadys Pharmaceuticals to Report Second Quarter 2010 Financial Results 2Neurocrine Biosciences Announces Conference Call and Webcast to Report Second Quarter 2010 Financial Results 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: