Navigation Links
New light on the genetic basis of inflammatory diseases
Date:11/1/2012

In one of the largest studies of its kind ever conducted, an international team of scientists has thrown new light on the genetic basis of the inflammatory bowel diseases (IBD). Crohn's disease and ulcerative colitis, the two most common forms of IBD, are chronic inflammatory digestive disorders affecting 230,000 Canadians. Dr. John Rioux, researcher at the Montreal Heart Institute and Associate Professor of Medicine at the Universit de Montral, is one of the researchers who have identified 71 genetic regions newly associated with inflammatory bowel disease (IBD), increasing the total number discovered to date to 163, in one of the largest studies of its kind. Also, the study points out that these regions showed a striking overlap with those implicated in autoimmune diseases and in immune deficiencies. Even more surprising was the observation of a significant overlap with genetic regions controlling our response to microbial infections such as in the case of tuberculosis. These highlights were published in the prestigious scientific journal Nature today.

Moreover, these findings suggest that IBD results from overactive immune defence systems that evolved to fight off serious bacterial infections. In IBD, the body's immune system produces an ongoing inflammatory reaction in the intestinal tract that injures the intestinal wall, leading to diarrhea and abdominal pain. IBD patients typically require lifelong treatment with drug therapy, and often need surgery to repair tissue damage caused by the disease.

Common research

Up until this point, researchers have been studying Crohn's disease and ulcerative colitis separately. This study was based on the fact that there seems to be a vast amount of genetic overlap between the two disorders.

In the first step of the study, the researchers conducted a "meta-analysis" of 15 previous genomic studies of either Crohn's disease (CD) or ulcerative colitis (UC), the two most com
'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pesticides May Be Linked to Slightly Smaller Babies, Shorter Pregnancies
2. Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
3. Scientific session and new research highlights
4. U.S. Gives Green Light to Publish Controversial Bird Flu Research
5. Shedding light on southpaws
6. Intense light prevents, treats heart attacks
7. Triple negative breast cancer symposium highlights current advances
8. With Weights, You Can Lighten Your Load
9. Study highlights need for coordination of care in stage 2 and 3 rectal cancer treatment
10. Clinical news alert: Journal of the American Academy of Orthopaedic Surgeons May highlights
11. Study Links Antibiotic to Slight Rise in Heart Patients Death Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2015)... York, NY (PRWEB) May 02, 2015 ... when a deadly natural disaster strikes anywhere on this ... to leverage human sympathy and compassion for their own ... (United States Computer Emergency Readiness Team) issued an ... users “of potential email scams citing the earthquake in ...
(Date:5/2/2015)... 02, 2015 On Tuesday April 7th, ... (ELCH) gathered to celebrate improvements in patient care. In ... Partners (RVHP), had zero acquired ventilator associated infections, zero ... infections. ELCH was also recently named a Top Performer ... at ELCH credited the teamwork of staff from all ...
(Date:5/2/2015)... 2015 ZoomCare, the Portland-based innovator of ... to offer its new healthcare insurance to individuals and ... Health Insurance System is the nation’s first health insurance ... performance. ZOOM+ Personal Health Insurance was ZoomCare’s first such ... are subject to review and regulation by the Oregon ...
(Date:5/1/2015)... Islands, BWI (PRWEB) May 02, 2015 ... It is http://www.thevenetiangracebay.com , and it is ... incorporates the stunning white and attractive turquoise hues of ... of Google, sixty seven percent of leisure travelers used ... showed that smartphones were used in the planning and ...
(Date:5/1/2015)... (PRWEB) May 01, 2015 Royal River ... Freeport, Maine, reports on a new study that found ... joint swelling and improved physical function as well as ... severe osteoarthritis of the knee. , The report is ... Insights for Well Being® ,” which Royal River Natural ...
Breaking Medicine News(10 mins):Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2Health News:ZoomCare Applies to be on Oregon Exchange 2Health News:Turks and Caicos Resort, The Venetian on Grace Bay, Launches New Web Presence 2Health News:New Study Finds Nutrients Ease Arthritis Pain, Retailer Reports 2
... , , , ... you could tell people,s personalities based on the types of drink they ... be described as sweet and indulgent, while someone who likes fruity drinks ... of Los Angeles-based BLD & Grace Restaurants says the same could be ...
... divorce and widowhood to poorer health , MONDAY, July 27 (HealthDay ... your health, but it has been less clear how you will ... Now, a new study shows that scenario spells trouble, even if ... who ceased being married at some point in their lives were ...
... 29,000 patients in the United States with metastatic colorectal cancer, ... shown to improve survival. But for more than one in ... that this treatment could result in a severe reduction in ... of bacterial infection and possible subsequent death. A new ...
... , , , N ew ... t ions S ho w W ays ... WASHINGTON, July 27 The health cost of obesity in the United States is as high as ... Control and Prevention. The study, which appears online today in the journal Health Affairs, was released at ...
... , , Web Site, Ad Campaign, e-Activism ... WASHINGTON, July 27 Teamsters General President Jim Hoffa on Monday announced ... new Web site, an ad campaign, call-in days, e-activism and events planned ... will kick off with a new Web site today, teamstersforhealthcarereformnow.com, to mobilize ...
... , , HARRISBURG, Pa., July 27 ... neglect of an older adult by calling the state,s Elder Abuse Hotline at ... Older individuals who are being abused or neglected are also urged ... the right to live a life free from abuse and neglect, which can ...
Cached Medicine News:Health News:Personality in a Cup 2Health News:Personality in a Cup 3Health News:Marriage Ends, Health Declines 2Health News:Marriage Ends, Health Declines 3Health News:Genetic testing may be valuable in treating colorectal cancer 2Health News:Study Estimates Medical Cost of Obesity May Be As High as $147 Billion Annually 2Health News:Study Estimates Medical Cost of Obesity May Be As High as $147 Billion Annually 3Health News:Teamsters Launch Campaign To Support Health Care Reform 2Health News:Department of Aging Urges Citizens to Report Abuse and Neglect of Older Adults 2
(Date:5/1/2015)... May 1, 2015 The breakthrough hepatitis C ... price but manufacturer Gilead Sciences overcame initial market resistance ... effective public relations campaigns. Sovaldi,s high cure ... side effects propelled the drug to $2.3 billion in ... first quarter on the market. But Sovaldi,s price tag ...
(Date:5/1/2015)... 2015 CANTEL MEDICAL CORP. (NYSE: CMN ) ... Officer, will be presenting at the Bank of America Merrill ... in Las Vegas, NV. The formal ... AM PT/1:00 PM ET. In addition, management will be available ... An audio webcast will be available via the investor relations ...
(Date:5/1/2015)... May 01, 2015 Research and Markets ... "US ACO IT Spending Outlook 2018" report ... number of lives covered by ACO would grow at ... report, the ACO IT spending has been studied on ... software and spending on services. Our research provides current ...
Breaking Medicine Technology:New Study Examines Success Lessons of Sovaldi's and Harvoni's Blockbuster Launches 2United States ACO IT Spending Outlook 2014-2018 2
... level of injury is key to treating MCLs nonsurgically, ... to the knee,s medial cruciate ligament (MCL) may be ... published in the March 2009 issue of The ... (JAAOS) . The key, the review,s authors found, ...
... 2 Aerovance Inc. today announced that it ... Drug Administration (FDA) and the U.K. Medicines and ... Phase IIb clinical trial, AeroTrial(TM), of inhaled dry ... begins today in the United States for AeroTrial, ...
Cached Medicine Technology:Treating Knee Ligament Injuries 2Treating Knee Ligament Injuries 3Aerovance Initiates Phase IIb Clinical Trial with Aerovant(TM) for the Treatment of Uncontrolled Asthma 2Aerovance Initiates Phase IIb Clinical Trial with Aerovant(TM) for the Treatment of Uncontrolled Asthma 3
High viscosity bone cement without antibiotics for digital use with an average setting time of approx. 6-8 Min., 40g of powder and 14.4g of liquid....
... The Videoscopes provide superior image ... connecting to the camera head with ... density ensures more light at the ... provide optimum image clarity and reliability.,The ...
... Nail System sports a 2mm mid-shaft ... support and stability of a large ... preserves diaphyseal bone stock in the ... fracture routinely associated with the use ...
... is the second generation of the lens ... technology allows one-handed delivery of the C11UB ... colored plunger allows better visualization and is ... insertion. The modified 55-degree beveled tip eases ...
Medicine Products: