Navigation Links
New light on the genetic basis of inflammatory diseases
Date:11/1/2012

In one of the largest studies of its kind ever conducted, an international team of scientists has thrown new light on the genetic basis of the inflammatory bowel diseases (IBD). Crohn's disease and ulcerative colitis, the two most common forms of IBD, are chronic inflammatory digestive disorders affecting 230,000 Canadians. Dr. John Rioux, researcher at the Montreal Heart Institute and Associate Professor of Medicine at the Universit de Montral, is one of the researchers who have identified 71 genetic regions newly associated with inflammatory bowel disease (IBD), increasing the total number discovered to date to 163, in one of the largest studies of its kind. Also, the study points out that these regions showed a striking overlap with those implicated in autoimmune diseases and in immune deficiencies. Even more surprising was the observation of a significant overlap with genetic regions controlling our response to microbial infections such as in the case of tuberculosis. These highlights were published in the prestigious scientific journal Nature today.

Moreover, these findings suggest that IBD results from overactive immune defence systems that evolved to fight off serious bacterial infections. In IBD, the body's immune system produces an ongoing inflammatory reaction in the intestinal tract that injures the intestinal wall, leading to diarrhea and abdominal pain. IBD patients typically require lifelong treatment with drug therapy, and often need surgery to repair tissue damage caused by the disease.

Common research

Up until this point, researchers have been studying Crohn's disease and ulcerative colitis separately. This study was based on the fact that there seems to be a vast amount of genetic overlap between the two disorders.

In the first step of the study, the researchers conducted a "meta-analysis" of 15 previous genomic studies of either Crohn's disease (CD) or ulcerative colitis (UC), the two most com
'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pesticides May Be Linked to Slightly Smaller Babies, Shorter Pregnancies
2. Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
3. Scientific session and new research highlights
4. U.S. Gives Green Light to Publish Controversial Bird Flu Research
5. Shedding light on southpaws
6. Intense light prevents, treats heart attacks
7. Triple negative breast cancer symposium highlights current advances
8. With Weights, You Can Lighten Your Load
9. Study highlights need for coordination of care in stage 2 and 3 rectal cancer treatment
10. Clinical news alert: Journal of the American Academy of Orthopaedic Surgeons May highlights
11. Study Links Antibiotic to Slight Rise in Heart Patients Death Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 24, 2014 (HealthDay News) -- The holidays can be a ... off by certain foods and drinks. "This is the ... trigger attacks of migraine," Dr. David Dodick, chair of the ... foundation. "It,s important to think through food and beverage ... attack," added Dodick, a professor of neurology at the Mayo ...
(Date:12/24/2014)... Dec. 24, 2014 (HealthDay News) -- A new, injectable ... and Drug Administration. The agency on Tuesday approved ... those who are overweight and have at least one ... 2 diabetes or high cholesterol. Patients taking the ... low-calorie diet and exercise regularly, the FDA noted. ...
(Date:12/24/2014)... Dec. 24, 2014 (HealthDay News) -- Researchers say they ... that develop into eggs and sperm. While this ... is the first time that these types of cells ... efficiently using human stem cells, according to the team ... creation of primordial germ cells is one of the ...
(Date:12/24/2014)... lab technician with the U.S. Centers for Disease Control ... virus in an agency laboratory in Atlanta earlier this ... workers are being checked for possible exposure, CDC officials ... Monday when CDC scientists doing research on Ebola mistakenly ... another CDC lab in the same building, the ...
(Date:12/24/2014)... Gluten, a protein found predominately in ... an intolerance to gluten, causing side effects that can ... joint pain and fatigue. For this reason, Diet Doc ... deliver safe and fast weight loss while teaching patients ... allergy reaction. These gluten free diet plans combine the ...
Breaking Medicine News(10 mins):Health News:Expert Offers Tips for Preventing Holiday Migraines 2Health News:FDA Approves New Weight-Loss Drug 2Health News:FDA Approves New Weight-Loss Drug 3Health News:CDC Monitors Lab Worker for Possible Ebola Exposure 2Health News:Diet Doc Adds Gluten Free Diet Plans to Their Stable of Specialized Weight Loss Programs 2Health News:Diet Doc Adds Gluten Free Diet Plans to Their Stable of Specialized Weight Loss Programs 3
... , DALLAS, Sept. 11 During its 2009 Annual Conference ... Association (PCA) will address some of the most pressing issues facing private ... be discussed during the Conference include: , , , ... Revenue Act of 1978. The program will cover PCA,s actions ...
... , Lilly to donate funds to ADA camp ... CHICAGO, Sept. 11 When the 2009 NFL season begins this ... with diabetes. , , Eli Lilly and Company (Lilly) ... help send children with diabetes to summer camps through the Touchdowns ...
... , LIBERTYVILLE, Ill., Sept. 11 They,re BAA-AACK! ... the teeny, insidious bloodsuckers--which feast on sleeping humans--are making a comeback ... spotted in hotels from coast to coast. And not just the ... recent study of 700 mid-priced hotels, 25% were found to host ...
... , DENVER, Sept. 11 Corgenix Medical ... diagnostic test kits, will host a conference call on Friday, September ... and operating performance for its fiscal year ended June 30, 2009, ... , , Corgenix invites all those interested ...
... Study found those who lived near heavy traffic noise had ... Living next to busy roads may be bad for your ... are in earshot of engines rumbling, horns honking and brakes ... report in the Sept. 9 issue of Environmental Health ...
... ... the lowest prices possible. To maintain high quality standards and ensure consumer trust, they ... product safety and efficacy. , ... Fargo, ND (Vocus) September 11, 2009 -- Last month ConsumerLab.com (CL), an ...
Cached Medicine News:Health News:Private Care Association to Tackle Major Issues Impacting Home Care Industry 2Health News:Chicago Bears Quarterback Jay Cutler, Eli Lilly and Company and the American Diabetes Association Team Up to Fund Diabetes Camp Scholarships Through "Touchdowns for Diabetes" 2Health News:Chicago Bears Quarterback Jay Cutler, Eli Lilly and Company and the American Diabetes Association Team Up to Fund Diabetes Camp Scholarships Through "Touchdowns for Diabetes" 3Health News:Chicago Bears Quarterback Jay Cutler, Eli Lilly and Company and the American Diabetes Association Team Up to Fund Diabetes Camp Scholarships Through "Touchdowns for Diabetes" 4Health News:Rest Easy, the Safe, All-Natural Bed Bug Travel Spray 2Health News:Busy Roads Boost Blood Pressure 2Health News:Swanson Health Products' Vitamin E and Acai Dietary Supplements Pass Quality Control Tests Conducted by ConsumerLab.com 2
(Date:12/24/2014)... CHAPEL HILL, N.C. , Dec. 23, 2014 /PRNewswire/ ... marketplace success. As the key link between the medical ... will grow even more in the coming years as ... relationships. According to research by benchmarking ... and MSLs can gain an important edge is by ...
(Date:12/22/2014)... , Dec. 22, 2014 Apnea Sciences ( ... offices in Aliso Viejo , California.  ... to the tremendous growth and worldwide expansion, a new ... patented SnoreRx, the anti snore cure have exceeded our ... "We are now in 23 countries and will ...
(Date:12/22/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/hmlfbq/investment ) ... Analysis of the US Medical Device Sector " ... http://photos.prnewswire.com/prnh/20130307/600769 This analysis ... identifies the key trends and rationale for undertaking ... and acquisitions. The study will be ...
Breaking Medicine Technology:Role of Medical Science Liaisons Evolving in Medical Device Sector 2Investment Analysis of the US Medical Device Sector 2
... 10, 2012 uVera Diagnostics has introduced the CR3 Keyless ... screening specimen cup provides several state-of-the-art features not available ... "This is revolutionary to the drug testing industry," said Rick ... designed for ease of use for both genders. The unique ...
...  - Agreement allows development for potential treatment of ... SHPGY ), the global specialty biopharmaceutical company, ... develop and market Resolor ® (prucalopride) in the ... N.V.  Terms of the agreement have not been disclosed. ...
Cached Medicine Technology:uVera Diagnostics Offers New Drug Screening Product 2Shire Acquires US Rights to Resolor(R) (prucalopride) 2Shire Acquires US Rights to Resolor(R) (prucalopride) 3Shire Acquires US Rights to Resolor(R) (prucalopride) 4
... the first intra-operative fluorescent imaging system ... the location of the coronary arteries ... coronary artery bypass procedures. ,The patented ... to view, record, replay, print, and ...
... When myocardial infarction is ... TROPT sensitive rapid assay allows ... marker troponin T from a ... qualitative result is available within ...
The Polygraf ID multi-parametric recorder works with POLYGRAM NET analysis software to create a unique interface that combines web-style navigation, graphical presentation and intuitive design to del...
... The White Sun light source offers the industry ... Kelvin color temperature at a lower price. A ... White Sun to be used with Olympus, Storz, ... light output LED and re-settable bulb timer. The ...
Medicine Products: