Navigation Links
New laboratory test assesses how DNA damage affects protein synthesis
Date:8/21/2012

RIVERSIDE, Calif. Transcription is a cellular process by which genetic information from DNA is copied to messenger RNA for protein production. But anticancer drugs and environmental chemicals can sometimes interrupt this flow of genetic information by causing modifications in DNA.

Chemists at the University of California, Riverside have now developed a test in the lab to examine how such DNA modifications lead to aberrant transcription and ultimately a disruption in protein synthesis.

The chemists report that the method, called "competitive transcription and adduct bypass" or CTAB, can help explain how DNA damage arising from anticancer drugs and environmental chemicals leads to cancer development.

"Aberrant transcription induced by DNA modifications has been proposed as one of the principal inducers of cancer and many other human diseases," said Yinsheng Wang, a professor of chemistry, whose lab led the research. "CTAB can help us quantitatively determine how a DNA modification diminishes the rate and fidelity of transcription in cells. These are useful to know because they affect how accurately protein is synthesized. In other words, CTAB allows us to assess how DNA damage ultimately impedes protein synthesis, how it induces mutant proteins. "

Study results appeared online in Nature Chemical Biology on Aug. 19.

Wang explained that the CTAB method can be used also to examine various proteins involved in the repair of DNA. One of his research group's goals is to understand how DNA damage is repaired knowledge that could result in the development of new and more effective drugs for cancer treatment.

"This, however, will take more years of research," Wang cautioned.

His lab has a long-standing interest in understanding the biological and human health consequences of DNA damage. The current research was supported by the National Cancer Institute, the National Institute of Environmental Health Sciences and the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health.

Wang was joined in the research by UC Riverside's Changjun You (a postdoctoral scholar and the research paper's first author), Xiaoxia Dai, Bifeng Yuan, Jin Wang and Jianshuang Wang; Philip J. Brooks of the National Institute on Alcohol Abuse and Alcoholism, Md.; and Laura J. Niedernhofer of the University of Pittsburgh School of Medicine, Penn.

Next, the researchers plan to use CTAB to investigate how other types of DNA modifications compromise transcription and how they are repaired in human cells.


'/>"/>
Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert  

Related medicine news :

1. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
2. Even Young Teens Show Signs of Sun Damage
3. Researchers Repair Damage Caused by Heart Attacks in Mice
4. New technique may help severely damaged nerves regrow and restore function
5. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
6. Stem cell sparing radiotherapy for head and neck cancer may avoid salivary gland damage
7. Breathing during radiotherapy - how to hit the treatment target without causing collateral damage
8. How to minimize stroke damage
9. Obese adolescents have heart damage
10. Obese Teens Can Have Heart Damage Without Showing Signs
11. Study: Heart damage after chemo linked to stress in cardiac cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New laboratory test assesses how DNA damage affects protein synthesis
(Date:2/23/2017)... Denver, Colorado (PRWEB) , ... February 23, 2017 ... ... Dialog Magazine, an exciting, new, interactive publication where generations converge and explore the ... to expand their worldview, Dialog Magazine enables readers to gain understanding, increase empathy, ...
(Date:2/23/2017)... ... (PRWEB) February 23, ... the nation to come together to combine its favorite springtime ... its favorite fruit – apples! To celebrate National Nutrition Month, ... the “Apple Madness” bracket tournament – a five-week, five-round online ...
(Date:2/23/2017)... ... 23, 2017 , ... Thomas Vas-Don suffered from severe injury due ... was able to successfully recover. In “ Origin & Insertion Charts for Massage Therapists ... the principals of massage, anatomy , trigger points and referral pain patterns ...
(Date:2/22/2017)... ... February 22, 2017 , ... Stem cell therapy has ... technology is so cutting edge, in fact, the U.S. Food and Drug Administration ... However, successful patient outcomes in certain clinical stem cell procedures have shown that ...
(Date:2/22/2017)... ... 2017 , ... Giving patients with diabetes customized coaching sessions, ... hospital admissions, and better blood pressure and glycemic control, a new study ... be found here . , The study comes as health plans increasingly ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... , Feb. 23, 2017 Research and ... Analysis and Strategies - 2016" report to their offering. ... The latest research ... data and benchmarks in the global Fibromyalgia market. The ... the key drugs marketed for Fibromyalgia and their clinical attributes? How ...
(Date:2/23/2017)... , Feb 23, 2017 Research and Markets ... & Trends - Industry Forecast to 2025" report to their ... The ... around 6.9% over the next decade to reach approximately $47.6 billion ... estimates and forecasts for all the given segments on global as ...
(Date:2/23/2017)...  MiMedx Group, Inc. (NASDAQ: MDXG), the leading regenerative ... to develop and market advanced products and therapies for ... and Dental sectors of healthcare, today announced its record ... December 31, 2016. Full Year 2016 Highlights ... increase over full year 2015 revenue ...
Breaking Medicine Technology: