Navigation Links
New investigation supports correlation between XMRV and prostate cancer
Date:4/5/2010

Philadelphia, PA, April 5, 2010 The recently discovered retrovirus, xenotropic murine leukemia virus-related virus (XMRV), has been identified in some prostate cancer patients. In light of conflicting data concerning XMRV, standardized diagnostic testing is important to identify patients in which XMRV is present and to determine whether it plays a role in the incidence of prostate cancer. An article published in the April issue of Urology is a step in this direction as researchers from Emory University report the successful development of an experimental clinical test for XMRV.

"We cannot as a scientific community begin to answer the basic questions of XMRV transmission, frequency in the population, association with disease, etc. until we can effectively test for infection," according to lead investigator John A. Petros, MD, Associate Professor of Urology, Emory University School of Medicine and Veterans Administration Hospital.

Dr. Petros and co-investigators adapted technology developed in the HIV arena (neutralizing antibody assay) and have developed a serum test that can identify patients who have previously been infected with the virus. This assay has been rigorously confirmed by two independent labs and two independent technologies (PCR and FISH), thus confidence in the accuracy of the test is high.

The mode of transmission of the virus is unknown. No method is available to screen either blood or tissue donors for infection and no data are available regarding whether the virus can be transmitted by blood transfusion or tissue transplantation. Dr. Petros comments, "The public deserves to know if the next blood transfusion or organ donation will give them XMRV retrovirus, an infection which lasts for life, and could possibly be related to prostate cancer. The failure to develop accurate tests for this virus is a serious public health oversight."

Although the assay used in the present report involved the inhibition of infection of target cells by viral-like particles with the XMRV envelope protein expressed on their surface, results also suggest that more standard serologic tests for antibodies against specific viral antigens can be developed in the future.

The authors conclude that "our report adds to the growing body of evidence that XMRV is indeed a novel gamma-retrovirus capable of infecting humans and that at least some patients with prostate cancer have been infected with XMRV. We have reported serologic evidence of infection and that the serology correlated with tissue-based assays. The concordance of 3 independent methods of detecting infection added confidence to the assertion that this recently discovered virus is real and possibly related to human disease. Robust clinical assays are needed to detect XMRV infection, and much work remains to be done in determining whether XMRV is indeed an oncogenic virus or simply an associated epiphenomenon."


'/>"/>

Contact: Sarah Kane
s.kane@elsevier.com
215-239-3798
Elsevier Health Sciences
Source:Eurekalert

Related medicine news :

1. Dr. Jay Calvert MD Announces Details on New Patent-Protected Investigational Breast Implants
2. Cardiome Announces Investigational Candidate, Vernakalant, Meets Primary Endpoint in European Comparator Study
3. BHR Pharma Files Investigational New Drug Application, Receives Orphan Drug Designation, for Traumatic Brain Injury Treatment
4. MJFF Funds Two Investigations of Placebo Effect in Parkinsons Disease
5. Scott & White Healthcare researchers studying investigational agent that targets breast cancer
6. Sunquest Information Systems Supports New Meaningful Use Guidelines for Laboratories Transferring H1N1 Results
7. Verizon Wireless Supports Text4baby Program
8. Life Line Screening Supports the American Heart Association's 'Go Red for Women' Event in Denver, Colorado
9. Life Line Screening Proudly Supports NBC's Skate for the Heart in Honor of Longtime Partner, Peggy Fleming
10. European Cancer Organization supports a revision of the EU Clinical Trials Directive
11. Society of Interventional Radiology Supports Treatment for Painful Spine Fractures: Patient Selection Key
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... TAMPA, Fla. (PRWEB) , ... January 19, 2017 ... ... dozens of faculty and staff members in 2017 who are passionate about making ... , Founded in 1994 and headquartered in Tampa, UMA, a nonprofit healthcare educational ...
(Date:1/19/2017)... ... January 19, 2017 , ... Sam & Associates Insurance ... commercial and residential clients in the California Bay Area, is launching a charity drive ... the region. , Heart disease is the primary killer of adult men and women ...
(Date:1/19/2017)... ... ... Tribble Insurance Agency, a family owned and operated firm offering asset protection ... to honor Chad Phillip Dermyer, a local police trooper who was shot and killed ... fellow officers were conducting routine stops of suspects when one of them, a violent ...
(Date:1/19/2017)... ... January 19, 2017 , ... St. Catherine’s Village announced that a limited ... a skilled nursing facility on the grounds of the St. Catherine’s Village campus in ... voted the best nursing home in Mississippi for the second year in a row ...
(Date:1/19/2017)... ... January 19, 2017 , ... Creative ... Create Real Impact contest from Impact Teen Drivers and California Casualty. Entries from ... , Educational grants totaling $15,000 will be awarded for the best peer-to-peer ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , Marks E-QURE , s ... following similar agreements in Israel and Argentina ... 5 billion global market ... in medical devices for the treatment of advanced wound care, announced today it ... Colombia for the Company,s patented Bio-electrical Signal Therapy device ...
(Date:1/19/2017)... , Jan. 18, 2017   Synthetic ... clinical company developing therapeutics designed to preserve the ... patients, today confirmed plans to initiate a Phase ... modified-release reformulation of lovastatin lactone designed to reduce ... in the gut to treat the underlying ...
(Date:1/18/2017)... 18, 2017  EnteroMedics Inc. (NASDAQ: ... neuroblocking technology to treat obesity, metabolic diseases and ... an underwritten public offering of units for gross ... discounts and commissions and offering expenses payable by ... Class A Units, priced at a public offering ...
Breaking Medicine Technology: