Navigation Links
New intranasal influenza vaccine triggers robust immunity with significantly less antigen
Date:10/28/2008

Washington, DC (October 26, 2008) A single administration of a novel, nasally delivered influenza vaccine elicited immune responses in ferrets that were more than 20 times higher than those generated by two injections of the currently approved vaccines, according to a study by NanoBio Corporation. The new vaccine used only half the standard antigen dose to produce this effect.

Results of the study are being presented today at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)/Infectious Diseases Society of America (IDSA) 46th annual meeting in Washington, D.C.

The company's nasal vaccines exert adjuvant activity without the need for pro-inflammatory materials, toxins or cytokines.

"Our nanoemulsion-based intranasal vaccine adjuvant system represents a paradigm shift in vaccinology. It can be used to safely deliver multiple antigen types directly into the lining of the nasal mucosa, which is rich in dendritic cells that present the antigen(s) to the immune system," said James R. Baker, Jr., M.D., founder and chairman of NanoBio Corp. "The nanoemulsion adjuvant uniquely interacts with these cells to trigger unparalleled mucosal and systemic immunity."

In the study, ferrets received 7.5, 15 and 45 micrograms of nanoemulsion-adjuvanted influenza vaccine (n=12 ferrets/dose). All three doses produced antibody responses substantially higher than those triggered by the standard intramuscular vaccine. The ferrets, which represent the most relevant influenza animal model for humans, were then challenged with live influenza virus, and all were protected.

"A large, unmet medical need still exists for protecting people from influenza infection," Baker said. "The robust immunity and antigen-sparing capability demonstrated in this study are especially important for addressing this unmet need, as are the demands for a vaccine that would protect people in the face of a flu pandemic."

NanoBio plans to begin a phase 1 clinical study for seasonal influenza in the first half of 2009 and is currently initiating preclinical studies in pandemic flu.


'/>"/>

Contact: Becky Levine
blevine@medthink.com
919-786-4918
MedThink Communications
Source:Eurekalert

Related medicine news :

1. FDA approves expanded label for FluMist (influenza virus vaccine live, intranasal) to include childr
2. Nanoemulsion-Based Intranasal Influenza Vaccine Adjuvant Triggers Robust Immunity Using Significantly Less Antigen
3. Bioniche Responds to Australian Equine Influenza Outbreak
4. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
5. NIH scientists describe ways to better assess benefits of influenza vaccine in the elderly
6. Launch of New Educational Campaign, Spread the Word - NOT the Flu!, Aims to Highlight Importance of Influenza Vaccination
7. Novartis Vaccines Launches National Gift-Giving Program to Help Protect Loved Ones by Reserving an Influenza Vaccination
8. Influenza: Insights into cell specificity of human vs. avian viruses
9. Childhood Influenza Immunization Coalition Issues New Report to Help Improve Low Childhood Influenza Immunization Rates
10. Health Department Reports States First Lab-Confirmed Influenza Case of the Season
11. Colorado Influenza and Pneumococcal Alert Coalition (CIPAC) Partners with Novartis Vaccines for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... ... ... From the Speaker Podium to the Exhibit Floor at Booth#514, Worldwide Leading Contact Center ... at SpeechTek 2016 Event, taking place May 23-25 at the Omni Shoreham in Washington ... “5 Customer Engagement Strategies to improve Customer Satisfaction in your Contact Center” on May ...
(Date:5/6/2016)... ... May 06, 2016 , ... Multiple award winning ... and operated for over 35 years. Maintaining core values of exceptional customer service, quality ... and made them a leading name in San Diego plumbing, and other services including ...
(Date:5/6/2016)... ... May 06, 2016 , ... This Mother’s Day kicks off the ... 17th annual National Women’s Health Week takes place May 8-May 14. , ... combining forces to empower women to make their health a top priority. Women everywhere ...
(Date:5/5/2016)... Viejo, CA (PRWEB) , ... May 05, 2016 , ... ... in Final Cut Pro X. Drag and drop a TransWipe preset between two video ... Choose from smooth corner wipes to colored panels with customizable color and orientation options. ...
(Date:5/5/2016)... Lubbock, Texas (PRWEB) , ... May 05, 2016 , ... ... of the Responsible Wool Standard (RWS) for public stakeholder review. The stakeholder review is ... ensure that it meets its goals and delivers value to the wool industry., The ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... 5, 2016 ... of the  "Europe Thrombocythemia Market and ... to their offering.       ... ,The latest research Europe Thrombocythemia Market ... provides comprehensive insights into Thrombocythemia pipeline ...
(Date:5/4/2016)... May 4, 2016  Compass Diversified Holdings (NYSE: ... an owner of leading middle market businesses, announced today ... March 31, 2016. First Quarter 2016 Highlights ... Reinvestment ("CAD" or "Cash Flow") of $13.6 million for ... loss of $15.0 million for the first quarter of ...
(Date:5/4/2016)... May 4, 2016 According to market ... and Demand Forecast to 2022 - Industry Insights by Slice ... Center and Others)" by P&S Market Research, the global ... 2015, and it is expected to grow at a CAGR ... slice type segment is expected to witness the faster growth, ...
Breaking Medicine Technology: