Navigation Links
New instrument helps researchers see how diseases start and develop in minute detail
Date:10/21/2011

Magnetic resonance imaging (MRI) is an established technique which over the years has made it possible for researchers and healthcare professionals to study biological phenomena in the body without using ionising radiation, for example X-rays.

The images produced by normal MRI are, to put it simply, pictures of water in the body, since the body is largely made up of water. MRI produces images of the hydrogen nuclei in water molecules. It can also be used to study other types of nuclei in many other interesting molecules. The only problem is that the concentration of molecules that are interesting to track is so low that they are not visible on a normal MRI scan. It is this problem that the researchers have now solved by constructing a 'polariser'.

In the polariser, the researchers make these molecules visible to the MRI scanner by hyperpolarising them. The molecules are then injected into their natural body tissue.

"Then we can follow the specific molecule and see the reactions in which it is involved. This gives us a unique opportunity to see and measure enzymatic reactions directly in the living tissue", explains Professor Deniz Kirik.

The technology could be used to study molecules in many different types of tissue in the body. Deniz Kirik, who is a Professor of Neuroscience, will focus on developing this technology to study the brain something which has not been done before.

"The brain is not an easy target!" he observes. "When we look inside the brain today using MRI, we see the molecules that are most numerous. However, it is rarely these common molecules we want to study. We want to study how molecules that have a low concentration in the tissue behave, for example how signal substances are produced, used and broken down. It is when these processes don't work that we become ill.

"This technology has the potential to help us do just that. If we can make it work, it will be a breakthrough not only for neuroscience but also for other research fields such as diabetes, cancer and inflammation, where similar obstacles limit our understanding of the basic molecular processes which lead to disease."

Professor Hindrik Mulder is one of the co-applicants for the project and he will develop and use the technology in diabetes research. Dr Vladimir Denisov from the Lund University Bioimaging Centre is leading the technical development within the project.

At present there are only a few polarisers in the world and Lund's newly built device is the only one in Scandinavia to be fully available for academic research.

"All the other equivalent instruments are purchased commercially and come with restrictions placed by the manufacturer. We therefore chose to take the longer and more complicated route of building the instrument ourselves", explains a pleased and proud Deniz Kirik.

Now that the instrument has become operational, the researchers have started on the first experiments. "This is the first of two steps", says Deniz Kirik. "The next step in this frontline research is to develop the unique technology by constructing an even more sophisticated polariser which will enable advanced experiments on animal models for various diseases."


'/>"/>

Contact: Deniz Kirik
Deniz.Kirik@med.lu.se
46-733-822-586
Lund University
Source:Eurekalert

Related medicine news :

1. ANT+ and Texas Instruments connect proven ultra low power sensors to smartphones
2. Thomas E. Mower And Karl Malone Instrumental To Success Of Sportsmen For Fish And Wildlife Organization
3. New from Cole-Parmer — An expanded line of H-B Instrument Thermometers
4. PHSI LLC Announces the Addition of New Technology from Audina Hearing Instruments
5. Spectrum Surgical Instruments Corp. Announces: Cleanables™ Instrument Cleaning Brushes
6. Spectrum Surgical Instruments Appoints President, Chief Operating Officer
7. NASAs Webb telescope MIRI instrument takes one step closer to space
8. Surgical instruments with electronic serial numbers
9. Musical Instruments a Breeding Ground for Germs: Study
10. UNT Health Science Centers Roby Helps Identify Bodies of Chiles Patio 29
11. MarquisNet Co-Location Agreement with MessageBroadcast Helps Message Delivery Provider Expand World-Class Network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2017)... ... April 26, 2017 , ... Infertility may be a ... and has helped many women become pregnant upon treating their diagnosis. ... simple outpatient evaluations. We can provide the necessary information to diagnose and ...
(Date:4/26/2017)... ... 2017 , ... New SUPRO® XT55 Isolated Soy Protein ... helping beverage manufacturers more effectively manage protein costs. “Soy protein has always been ... as more stable pricing over time. Now it’s even more relevant as plant ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... Mirroring360 Pro . This new addition to the Mirroring360 product family combines ... and business. , Mirroring360 Pro enables educators, business professionals and individuals to stream ...
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... ... CEOs, CFOs and HR decision-makers are preparing for how his administration could impact ... will provide insight into what changes are most likely to make it through ...
(Date:4/25/2017)... ... 25, 2017 , ... Patients who would like to straighten ... fraction of the time as traditional braces – Wilckodontics®. Dr. Victoria Chen, an ... this revolutionary treatment with or without a referral. , Wilckodontics is also ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... NEW YORK , April 19, 2017 ... Surgical drainage devices are tubes used to remove excess ... include, blood, serum, pus, urine, bile or lymph. Surgical ... types of surgery such as orthopedics surgery, cardiovascular surgery, ... device is prophylactic post-surgery to prevent accumulation of fluid ...
(Date:4/19/2017)... 2017 Companion animal ... in pets such as canine, avian and feline. ... types such as Attenuated Live Vaccines, Conjugate Vaccines, ... and Recombinant Vaccines. Attenuated live vaccines are derived ... which have been weakend under laboratory conditions. Conjugate ...
(Date:4/18/2017)... 2017 Cogentix Medical, Inc. (NASDAQ: CGNT), a ... Uro/Gyn and Gynecology markets with innovative and proprietary products, ... March 31, 2017 after the market close on Tuesday, ... host a conference call and webcast to discuss its ... 2017 at 4:30 p.m. Eastern Time (3:30 p.m. Central ...
Breaking Medicine Technology: