Navigation Links
New insights into why humans are more susceptible to cancer and other diseases
Date:8/23/2012

Chimpanzees rarely get cancer, or a variety of other diseases that commonly arise in humans, but their genomic DNA sequence is nearly identical to ours. So, what's their secret? Researchers reporting in the September issue of the American Journal of Human Genetics, a Cell Press journal, have found that differences in certain DNA modifications, called methylation, might play a role.

The researchers discovered hundreds of genes that display different patterns of methylation between the two species. These different patterns of methylation lead to different levels of expression, and many of the genes involved are linked to specific human diseases. Given that environmental factors can affect DNA methylation, these results might help researchers to better understand how differences in genetics and environmental exposure contribute to differences, including different disease vulnerabilities, between the two species.

DNA methylation doesn't change a cell's underlying genetic information, but it does affect gene activity and can have a profound impact on processes such as aging and the development of disease. By using new state-of-the-art techniques to look at methylation maps and gene expression in the brains of chimpanzees and humans, the investigators found that changes in DNA methylation at least partially explain the divergence of gene-expression patterns between these species.

In addition, differentially methylated genes showed striking links with specific neurological and psychological disorders and cancers to which modern humans are particularly susceptible, suggesting that changes in DNA methylation might be linked to the evolution of humans' vulnerability to certain diseases.

"Our results hint, but by no means provide proof, that epigenetic divergenceor changes of chemical properties of DNAmay be particularly important for some disease-related phenotypes that are pertinent to modern humans," says senior author Dr. S
'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New insights into salt transport in the kidney
2. Researchers fish-eye view could offer insights for human vision
3. Feces fossils lend new insights into connection between Native-Americans, diabetes
4. Scientists at the Mainz University Medical Center gain new insights into Taspase1 function
5. Better treatment for brain cancer revealed by new molecular insights
6. Aggregating instead of stabilizing: New insights into the mechanisms of heart disease
7. Understanding and promoting mental health - Insights from psychological science
8. New insights into when beach sand may become unsafe for digging and other contact
9. From a Failed Vaccine, New Insights Into Fighting HIV
10. First evidence from humans on how alcohol may boost risk of cancer
11. New Seal Flu Could Pose Threat to Humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Cash House 's contributions to Horizons for ... of the shelter including new initiatives and a wide range ... lives of each youth who walk through their door. , ... youth ages 16-25. Not only does Horizons operate as a ... the youth who come through their doors. Horizons has a ...
(Date:8/27/2014)... Dallas, TX (PRWEB) August 27, 2014 ... professional and in-depth study on the current state of ... The report provides a basic overview of the industry, ... analysis and Chinese domestic market analysis are provided with ... of the market. A comparison between the international and ...
(Date:8/27/2014)... Many patients believe mental illness is not life ... mortality rate of about 15%. The suicide rate ... it's offset by an alarming homicide rate (including attempted ... treat and manage symptoms of mental illnesses like depression, ... directed. Missed dosages or cutting pills in half ...
(Date:8/27/2014)... August 27, 2014 Do brands know what ... about to shed some light on the topic Sept. 16 ... of the Brand Activation Association and the ... polled hundreds of consumers to learn what types of marketing ... on influencing a potential buying decision. While the survey focuses ...
(Date:8/27/2014)... Aspirus Wausau Hospital today announced the ... Buzz™ Digital O.R. at Aspirus Wausau Hospital, in Wausau, ... operating rooms will be Buzz, a centralized surgical hub ... supports planning, navigation, imaging and communications connectivity. , ... software and hardware all controlled from the full HD ...
Breaking Medicine News(10 mins):Health News:Cash House a Major Supporter of Horizons for Youth 2Health News:Cash House a Major Supporter of Horizons for Youth 3Health News:Maleic Anhydride Industry & Isoprene Market Global and China Analysis Now Available at ReportsnReports.com 2Health News:Maleic Anhydride Industry & Isoprene Market Global and China Analysis Now Available at ReportsnReports.com 3Health News:Maleic Anhydride Industry & Isoprene Market Global and China Analysis Now Available at ReportsnReports.com 4Health News:Maleic Anhydride Industry & Isoprene Market Global and China Analysis Now Available at ReportsnReports.com 5Health News:MedicationDiscountCard.com now Makes Brintellix and Mental Illness Medications More Affordable with Discount Cards 2Health News:CRN Set To Release Poll Results On What Marketing Tactics Prompt Consumers To Buy 2Health News:Aspirus Wausau Hospital Announces First Large Scale Digital Operating Room Integration Project in the US 2Health News:Aspirus Wausau Hospital Announces First Large Scale Digital Operating Room Integration Project in the US 3
... HOUSTON - A vaccine that turns the immune system ... drives the most aggressive form of glioblastoma multiforme improved ... researchers at Duke University and The University of Texas ... Journal of Clinical Oncology . Eighteen newly diagnosed ...
... Oct. 6, 2010 A set of proteins found in ... to diagnose Alzheimer,s disease, researchers at UT Southwestern Medical Center ... An analysis of the proteins, plus a clinical exam, proved ... accurate in ruling it out in people without the disease, ...
... Reinberg HealthDay Reporter , TUESDAY, Oct. 5 (HealthDay ... young adults admit they are binge drinkers, health officials said ... as having four or more drinks for women, and five ... -- numbers that are different because men and women metabolize ...
... to a discovery by a Saint Louis University researcher, scientists ... better control cholesterol levels in blood. Led by ... at Saint Louis University and published in a recent issue ... of the United States of America, the study found that ...
... New neuroscience research by life scientists from UCLA and Australia may ... to brain injury or disease. By examining how ... way the brain first captures and encodes a situation or event ... The study is published in the Sept. 29 edition ...
... By Randy Dotinga HealthDay Reporter , ... study is the latest to suggest that testosterone may ... causing serious side effects. Researchers aren,t yet ready ... to female patients. However, the treatment does hold some ...
Cached Medicine News:Health News:Vaccine extends glioblastoma patients' survival in phase II trial 2Health News:Blood test could diagnose Alzheimer's disease, UT Southwestern researchers find 2Health News:1 in 4 U.S. Teens and Young Adults Binge Drink: CDC 2Health News:1 in 4 U.S. Teens and Young Adults Binge Drink: CDC 3Health News:Better cholesterol drugs may follow Saint Louis University researcher's breakthrough 2Health News:Neuroscience research may help patients recover from brain injury 2Health News:Testosterone Could Boost Health of Heart Failure Patients 2
(Date:8/27/2014)... Aug. 27, 2014 Reportlinker.com announces that ... its catalogue: Global Animal Health Market ... About Animal Health Animal health refers to ... treat animals to enhance their quality of life, ... animal food. The Global Animal Health market covers ...
(Date:8/27/2014)... NEW YORK , Aug. 27, ... a new market research report is ... Latest Chinese Guidebook for Application and ... From Regulations to Practices (2014 Edition) ... .html  Now, Chinese ...
(Date:8/27/2014)... 2014 Amgen (NASDAQ: AMGN ) ... has granted priority review designation for ivabradine for the ... oral drug that inhibits the I f ... body,s cardiac pacemaker. 1 Ivabradine works to slow ... or ventricular repolarization. 1 Heart failure is a ...
Breaking Medicine Technology:Global Animal Health Market 2014-2018 2Global Animal Health Market 2014-2018 3Global Animal Health Market 2014-2018 4Global Animal Health Market 2014-2018 5Global Animal Health Market 2014-2018 6Global Animal Health Market 2014-2018 7Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 2Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 3Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 4Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 5Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 6Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 7Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 8Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 9Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 10FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 2FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 3FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 4FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 5FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 6FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 7
... Bulletin Board: SNKTY), a life sciences company engaged ... of healthy aging,announced today the launch of a ... to consumers and medical,professionals about Pyratine-6, Senetek,s advanced ... website ( http://www.Pyratine-6.com ) is a comprehensive and ...
... Supports Use of Fujirebio Diagnostics, , HE4 Test with ... CancerMALVERN, Pa., Jan. 26 A pivotal clinical trial ... Gynecologic Oncology demonstrated the utility of combining ... aid in estimating the risk of epithelial ovarian cancer ...
Cached Medicine Technology:Senetek PLC Launches Dedicated Pyratine-6(TM) Website 2Pivotal Data Published For First Biomarker Combination Test to Determine Risk of Ovarian Cancer in Women Who Present With Pelvic Mass 2Pivotal Data Published For First Biomarker Combination Test to Determine Risk of Ovarian Cancer in Women Who Present With Pelvic Mass 3Pivotal Data Published For First Biomarker Combination Test to Determine Risk of Ovarian Cancer in Women Who Present With Pelvic Mass 4
... two and four ounce bottles ... the needs of procedural kit ... itself has been custom molded ... the cap perfectly. This product ...
A patient skin prepping solution in a self-contained applicator combining two proven broad-spectrum antimicrobials: alcohol for fast kill and fast drying (3 minutes on skin), and an iodophor for pers...
Idophor PVP Scrub Winged Sponges...
... can be a valuable tool in standardizing ... items necessary for a procedure are supplied ... continuum of care are easier to be ... sequence of use, allowing the clinician to ...
Medicine Products: