Navigation Links
New insights into why humans are more susceptible to cancer and other diseases
Date:8/23/2012

Chimpanzees rarely get cancer, or a variety of other diseases that commonly arise in humans, but their genomic DNA sequence is nearly identical to ours. So, what's their secret? Researchers reporting in the September issue of the American Journal of Human Genetics, a Cell Press journal, have found that differences in certain DNA modifications, called methylation, might play a role.

The researchers discovered hundreds of genes that display different patterns of methylation between the two species. These different patterns of methylation lead to different levels of expression, and many of the genes involved are linked to specific human diseases. Given that environmental factors can affect DNA methylation, these results might help researchers to better understand how differences in genetics and environmental exposure contribute to differences, including different disease vulnerabilities, between the two species.

DNA methylation doesn't change a cell's underlying genetic information, but it does affect gene activity and can have a profound impact on processes such as aging and the development of disease. By using new state-of-the-art techniques to look at methylation maps and gene expression in the brains of chimpanzees and humans, the investigators found that changes in DNA methylation at least partially explain the divergence of gene-expression patterns between these species.

In addition, differentially methylated genes showed striking links with specific neurological and psychological disorders and cancers to which modern humans are particularly susceptible, suggesting that changes in DNA methylation might be linked to the evolution of humans' vulnerability to certain diseases.

"Our results hint, but by no means provide proof, that epigenetic divergenceor changes of chemical properties of DNAmay be particularly important for some disease-related phenotypes that are pertinent to modern humans," says senior author Dr. S
'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New insights into salt transport in the kidney
2. Researchers fish-eye view could offer insights for human vision
3. Feces fossils lend new insights into connection between Native-Americans, diabetes
4. Scientists at the Mainz University Medical Center gain new insights into Taspase1 function
5. Better treatment for brain cancer revealed by new molecular insights
6. Aggregating instead of stabilizing: New insights into the mechanisms of heart disease
7. Understanding and promoting mental health - Insights from psychological science
8. New insights into when beach sand may become unsafe for digging and other contact
9. From a Failed Vaccine, New Insights Into Fighting HIV
10. First evidence from humans on how alcohol may boost risk of cancer
11. New Seal Flu Could Pose Threat to Humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... ... ... assistPoint Partners, LLC is proud to announce a ... Through a secure web portal, assistPoint connects Life Sciences, Patients and Providers together ... and workflow solution. This provides cancer center patient advocates, financial counselors and business ...
(Date:8/4/2015)... FL (PRWEB) , ... August 04, 2015 , ... ... testing organization which provides vascular, electrocardiogram (EKG), echocardiogram, and NCV testing, announced their ... has been successfully identifying previously undiagnosed cardiovascular abnormalities one program at a time. ...
(Date:8/4/2015)... ... ... Bayco Products, Inc. announces a new industrial-grade LED Dual-LightTM headlamp in a ... have a flip-up face shield. The sleek contours of the new Nightstick NSP-4614B ... their headlamp when raising or lowering their face shield or visor. The 4614 will ...
(Date:8/4/2015)... ... 2015 , ... Worldwide Power Products acquires new assets, certifying ... in Texas. Effective July 1st of this year, Worldwide Power Products acquired operations ... the North Texas acquisition, Worldwide Power Products (“WPP”) now services 1000 generators in ...
(Date:8/4/2015)... VEGAS, Nevada (PRWEB) , ... August 04, 2015 , ... ... of radio interviews to discuss his new book, The Pain Antidote , which ... Medical Director of Las Vegas Recovery Center’s Chronic Pain Treatment Program, wrote the book ...
Breaking Medicine News(10 mins):Health News:assistPoint.com Web Site Launched 2Health News:Colleges and High Schools Across the Country Are Joining the Wimbledon U Team Uncovering Unknown Cardiac Conditions and Promoting Heart Healthy Athletes 2Health News:Colleges and High Schools Across the Country Are Joining the Wimbledon U Team Uncovering Unknown Cardiac Conditions and Promoting Heart Healthy Athletes 3Health News:New Nightstick® NSP-4614B Dual-LightTM Headlamp fits more functionality into more places 2Health News:New Nightstick® NSP-4614B Dual-LightTM Headlamp fits more functionality into more places 3Health News:North Texas Acquisition Press Release 2Health News:Medical Expert's New Book Offers Help for Chronic Pain Sufferers 2Health News:Medical Expert's New Book Offers Help for Chronic Pain Sufferers 3
... specialist makes a difference, study finds , WEDNESDAY, Aug. 22 ... to see the doctor who diagnoses their melanoma, the more ... -- skin cancer at the time of diagnosis, a new ... poorer patients getting diagnosed with thicker melanomas, the researchers said. ...
... the brain, study suggests , , WEDNESDAY, Aug. 22 (HealthDay ... frightening, traumatic memories go so deep and linger so ... rats shows that a powerful neurochemical called norepinephrine is ... but it also "imprints" an emotional fear tagged to ...
... weak or unsubstantiated, review finds , TUESDAY, Aug. 21 (HealthDay ... disease often lack proper documentation or validation, experts report in ... American Medical Association . , A team of researchers in ... They found that 286 (66.2 percent) of these claims were ...
... Fried, baked food compound poses no threat, major study finds ... be little or no link between breast cancer and acrylamide, ... to the largest epidemiological study on the subject conducted to ... acrylamide in the diet does not appear to be an ...
... in Taiwan has shown that an 800-year-old formula, Four-Agents ... pain after three cycles of treatment; however, a beneficial ... dosage regimen and treatment length used in this study ... published in the August 15 issue of the online, ...
... A computer bug infected Web gamers, with ominous results, ... Online role-playing games could provide insight into how infectious ... the real world, American researchers report. , A programming ... ("corrupted blood") among virtual characters in the popular online ...
Cached Medicine News:Health News:Melanoma Diagnosis Often Delayed for Rural Poor 2Health News:Study Probes Roots of Fearful Memories 2Health News:Gene Studies of Male-Female Differences Often Flawed 2Health News:Acrylamide Won't Raise Breast Cancer Risk 2Health News:Acrylamide Won't Raise Breast Cancer Risk 3Health News:Acrylamide Won't Raise Breast Cancer Risk 4Health News:Is 4 agents decoction (Si Wu Tang) efficacious in treating primary dysmenorrhea? 2Health News:Online 'Epidemic' Gives Clues to Bird Flu Spread 2
(Date:8/4/2015)... 4, 2015  Eli Lilly and Company (NYSE: ... Diego (UCSD) of its intent to end its contract ... Treatment in Asymptomatic Alzheimer,s disease (A4) study. The A4 ... the preclinical stage of Alzheimer,s disease in older individuals ... a PET scan, but do not show symptoms of ...
(Date:8/4/2015)... 2015  Sangamo BioSciences, Inc. (NASDAQ: SGMO ) ... Sangamo,s executive vice president, research and development, will provide ... ® development programs and an overview of the ... 11, 2015, at the 2015 Wedbush Pacgrow Healthcare Conference. ... York, NY . The presentation will ...
(Date:8/4/2015)... -- Xencor, Inc. (NASDAQ: XNCR ), a clinical-stage ... treatment of autoimmune diseases, asthma and allergic diseases, ... second quarter ended June 30, 2015 and provided a ... eight XmAb® antibody candidates are in clinical testing, ... momentum of this pipeline of antibodies is a ...
Breaking Medicine Technology:Lilly to End Contract with the University of California, San Diego for A4 Alzheimer's Study 2Lilly to End Contract with the University of California, San Diego for A4 Alzheimer's Study 3Sangamo BioSciences Announces Presentation At The 2015 Wedbush Pacgrow Healthcare Conference 2Xencor Reports Second Quarter 2015 Financial and Operating Results 2Xencor Reports Second Quarter 2015 Financial and Operating Results 3Xencor Reports Second Quarter 2015 Financial and Operating Results 4Xencor Reports Second Quarter 2015 Financial and Operating Results 5Xencor Reports Second Quarter 2015 Financial and Operating Results 6Xencor Reports Second Quarter 2015 Financial and Operating Results 7Xencor Reports Second Quarter 2015 Financial and Operating Results 8Xencor Reports Second Quarter 2015 Financial and Operating Results 9
... specialty Eraser instruments have been designed ... the right tool for situations requiring ... series of 25 gauge intraocular, bipolar, ... treatment of target tissues for fine-tip ...
Wet-Field Hemostatic Eraser bipolar tip, packsize is 10/box....
Wet-Field Hemostatic Eraser bipolar tip, packsize is 10/box....
... explanation of foldable intraocular lenses. The instrument ... placed under the implant and divides the ... helps support both halves of the lens ... in the anterior chamber is avoided. The ...
Medicine Products: