Navigation Links
New insights into salt transport in the kidney
Date:8/23/2012

Sodium chloride, better known as salt, is vital for the organism, and the kidneys play a crucial role in the regulation of sodium balance. However, the underlying mechanisms of sodium balance are not yet completely understood. Researchers of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Charit Universittsmedizin Berlin and the University of Kiel have now deciphered the function of a gene in the kidney and have thus gained new insights into this complex regulation process (PNAS Early Edition, doi/10.1073/pnas.1203834109)*.

In humans, the kidneys filter around 1700 liters of blood every day, of which 180 liters are collected as primary urine and ultimately one to two liters of urine are excreted. The kidneys thus wash toxic waste products out of the body, but retain some useful substances and reintroduce them into the body, thus simultaneously regulating the salt and water balance.

Molecular velcro

In the study just published by Dr. Tilman Breiderhoff, Prof. Thomas Willnow (both MDC), as well as Dr. Nina Himmerkus and Prof. Markus Bleich (both of the University of Kiel) and Dr. Dominik Mller (Charit) the focus is on the claudin-10 gene, which is expressed in a specific segment of the kidney, in Henle's loop. In the thick ascending limb of this loop, , a large part of the filtered sodium chloride, as well as calcium and magnesium are reabsorbed. The gene product under investigation, the claudin 10 protein, belongs to a family of proteins that connect the epithelial cells which cover the inner and outer surfaces of the body and stick them together like velcro. Claudins, however, also form pores, through which ions and substances are transported between the cells.

"If these transport processes are disturbed, this can lead to serious loss of function of the kidneys," Dr. Breiderhoff explained. As example he cited various human hereditary diseases in which either absorption of table salt (Bartter syndrome) or of calcium and magnesium (familial hypomagnesemia with hypercalciuria and nephrocalcinosis FHHNC) is disturbed. The second disease is characterized by a lack of magnesium in the blood and an excess of calcium in the urine, which leads to calcification of the kidneys. It is caused by mutations in one of two genes (claudin 16 or claudin 19), which also belong to the gene family of the claudins.

The researchers have now demonstrated in mice that the claudin-10 gene is involved in the reabsorption of salt in the kidney. If the gene in the kidney is deactivated, the reabsorption of sodium is impaired, but the reabsorption of calcium and magnesium is increased. The consequence is that the mice have elevated magnesium levels in the blood, and excess calcium is deposited in the kidney. Simultaneously, the urine volume is increased because the kidneys of the mice cannot reabsorb enough water, a sign that the recovery of salt is disturbed.


'/>"/>
Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert  

Related medicine news :

1. Researchers fish-eye view could offer insights for human vision
2. Feces fossils lend new insights into connection between Native-Americans, diabetes
3. Scientists at the Mainz University Medical Center gain new insights into Taspase1 function
4. Better treatment for brain cancer revealed by new molecular insights
5. Aggregating instead of stabilizing: New insights into the mechanisms of heart disease
6. Understanding and promoting mental health - Insights from psychological science
7. New insights into when beach sand may become unsafe for digging and other contact
8. From a Failed Vaccine, New Insights Into Fighting HIV
9. K9 CarFence™ Launches as Newest Innovation in Pet Transportation
10. Men Have a Greater Lifetime Risk for Kidney Failure: Study
11. Drinking Iced Tea Raises Kidney Stone Risk: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insights into salt transport in the kidney
(Date:5/6/2016)... ... 06, 2016 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has written ... found in the Bible about helping to stop cancer. Yisrayl says there are too many ... that the health and science industries will pay close attention and take action. The Pastor ...
(Date:5/6/2016)... ... May 06, 2016 , ... Kenneth Cochran, DSc, RN, FACHE, ... of the South announced today that Dr. Robert Menuet, Interventional Cardiologist with Cardiovascular ... Ultrasound Guided Coronary Atherectomy. , This procedure involves the removal of ...
(Date:5/5/2016)... ... 2016 , ... While the practice and profession of Aging Life Care is ... has on communities and resources. Aging Life Care plays an important role as these ... , Aging Life Care is a holistic, client-centered approach to caring for older adults ...
(Date:5/5/2016)... ... 2016 , ... The U.S. Food and Drug Administration today ... submit their products through an arduous federal approval process. The rules, which treat ... market since February 15, 2007. That would essentially ban 99 percent of all ...
(Date:5/5/2016)... CA (PRWEB) , ... May 05, 2016 , ... This weekend, from Friday, May 6 ... take on steep California terrain at the first Team Semper Fi Mountain Bike Camp, hosted ... them will be mountain bike legends Mark Weir and Jason Moeschler, who’ll share pro tips ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 6, 2016 ... of liver disorders along with rise in obesity ... drugs in the coming few years. The NASH ... last five years on account of rising number ... is a large, un-tapped market with no FDA ...
(Date:5/5/2016)... -- Replikins Ltd. today reported initial promising results in animal trials of its Zika vaccine ... ... ... ... on Pubmed. The analysis identified the highest gene Replikin Counts in Zika history back ...
(Date:5/5/2016)...  Endo International plc (NASDAQ: ENDP ... Lortie , President, U.S. Branded Pharmaceuticals, has decided ... appointment of a successor. Mr. Lortie joined Endo ... with responsibility for all strategic, commercial and operational ... development, commercial operations, managed markets, manufacturing, supply chain ...
Breaking Medicine Technology: