Navigation Links
New insights into salt transport in the kidney
Date:8/23/2012

Sodium chloride, better known as salt, is vital for the organism, and the kidneys play a crucial role in the regulation of sodium balance. However, the underlying mechanisms of sodium balance are not yet completely understood. Researchers of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Charit Universittsmedizin Berlin and the University of Kiel have now deciphered the function of a gene in the kidney and have thus gained new insights into this complex regulation process (PNAS Early Edition, doi/10.1073/pnas.1203834109)*.

In humans, the kidneys filter around 1700 liters of blood every day, of which 180 liters are collected as primary urine and ultimately one to two liters of urine are excreted. The kidneys thus wash toxic waste products out of the body, but retain some useful substances and reintroduce them into the body, thus simultaneously regulating the salt and water balance.

Molecular velcro

In the study just published by Dr. Tilman Breiderhoff, Prof. Thomas Willnow (both MDC), as well as Dr. Nina Himmerkus and Prof. Markus Bleich (both of the University of Kiel) and Dr. Dominik Mller (Charit) the focus is on the claudin-10 gene, which is expressed in a specific segment of the kidney, in Henle's loop. In the thick ascending limb of this loop, , a large part of the filtered sodium chloride, as well as calcium and magnesium are reabsorbed. The gene product under investigation, the claudin 10 protein, belongs to a family of proteins that connect the epithelial cells which cover the inner and outer surfaces of the body and stick them together like velcro. Claudins, however, also form pores, through which ions and substances are transported between the cells.

"If these transport processes are disturbed, this can lead to serious loss of function of the kidneys," Dr. Breiderhoff explained. As example he cited various human hereditary diseases in which either absorption of table salt (Bartter s
'/>"/>

Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Researchers fish-eye view could offer insights for human vision
2. Feces fossils lend new insights into connection between Native-Americans, diabetes
3. Scientists at the Mainz University Medical Center gain new insights into Taspase1 function
4. Better treatment for brain cancer revealed by new molecular insights
5. Aggregating instead of stabilizing: New insights into the mechanisms of heart disease
6. Understanding and promoting mental health - Insights from psychological science
7. New insights into when beach sand may become unsafe for digging and other contact
8. From a Failed Vaccine, New Insights Into Fighting HIV
9. K9 CarFence™ Launches as Newest Innovation in Pet Transportation
10. Men Have a Greater Lifetime Risk for Kidney Failure: Study
11. Drinking Iced Tea Raises Kidney Stone Risk: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insights into salt transport in the kidney
(Date:12/25/2014)... News) -- Among early stage breast cancer patients who ... one percent will eventually develop leukemia as a result ... finding comes from a review of more than 20,000 ... it suggests that the risk for developing treatment-related leukemia, ... thought. "The frequency of bone marrow cancers such ...
(Date:12/25/2014)... tries its best to translate the experience of dress ... introduced its new collection of 2015 prom dresses, and ... prom outfits are guaranteed to contain the perfect designs ... designed for 2015. Anyone who wants to buy ... before Jan. 26, 2015, the deadline of the promotion. ...
(Date:12/25/2014)... ” was featured on NewsWatch as part of its monthly ... the iOS, Android, and Windows markets. Andrew Tropeano, a mobile ... and shared with viewers how this is an application for ... “A picture says a thousand words.” It’s true. There are ... because each picture holds a unique and special meaning. Photos ...
(Date:12/25/2014)... December 25, 2014 Residents at ... Community, recently showed their generous spirit by providing ... Catawba County Parenting Network- Grandparents Raising Grandchildren program. ... gathered around the largest Christmas tree on the ... purchased by residents of the Abernethy Village Association ...
(Date:12/25/2014)... Phoenix, AZ (PRWEB) December 25, 2014 ... comes to outstanding customer service and affordable quality regarding ... metropolitan area announces recognition in 2014 by the “Queen ... and Sons has earned an impressive reputation over the ... pricing on a wide range of contractor services for ...
Breaking Medicine News(10 mins):Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2Health News:Retirement Community Residents Make Impact During Holiday Season 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 3
... ... to Weak Industry Performance , ... Atlanta, GA (PRWEB) March 2, 2010 -- gloStream, maker of gloEMR, gloPM and gloSuite medical ... percent success rate, even while rapidly increasing the number of medical practices it helps to ...
... , ... , ... , , , , ... ...
... ... ... , ... , , ...
... ANN ARBOR, Mich.---Only 68 percent of corporate executives took ... a new study shows. Overall, the executives ... likely to meet their cholesterol goals. The study finding ... primary factor in medication adherence. University of ...
... Film ... ... -- The United Nations Foundation and its Nothing But Nets campaign, a global ... new documentary on the deadliest plague known to humanity--malaria. The film encourages local communities to ...
... more than twofold, study suggests , TUESDAY, March 2 ... a purpose are less likely to develop Alzheimer,s disease ... suggests. , As the population ages and dementia becomes ... the causes of the disease, associated risk factors and ...
Cached Medicine News:Health News:gloStream's gloDNA Process, Partner Community and Product Lead to 100% Success Rate 2Health News:Alliance, Inc. Receives Centers of Excellence in Recovery Grant 2Health News:Alliance, Inc. Receives Centers of Excellence in Recovery Grant 3Health News:AMA Honors Washington State Secretary of Health With Top Government Service Award 2Health News:AMA Honors Washington State Secretary of Health With Top Government Service Award 3Health News:Even the boss doesn't follow the doctor's orders 2Health News:Invisible Children's Bobby Bailey Premiers a New Documentary on Malaria 2Health News:Invisible Children's Bobby Bailey Premiers a New Documentary on Malaria 3Health News:A Purposeful Life May Stave Off Alzheimer's 2Health News:A Purposeful Life May Stave Off Alzheimer's 3
(Date:12/24/2014)... DUBLIN and RALEIGH, N.C. ... subsidiary of Endo International plc (NASDAQ: ENDP ... BDSI ) announced today that they have ... Buccal Film to the U.S. Food and Drug Administration ... the management of pain severe enough to require daily, ...
(Date:12/22/2014)... , Dec. 22, 2014 NxStage ... manufacturer of innovative dialysis products, announced today that ... cleared its System One™ to perform hemodialysis overnight ... as home nocturnal hemodialysis. NxStage,s® System One is ... the FDA for this indication. ...
(Date:12/22/2014)... 2014   TRU-D SmartUVC LLC, producers of ... announced today that the General Services Administration has awarded ...   This newly formed agreement will allow ... government purchasers, including Department of Veteran Affairs and Department ... contacts purchasing solutions for the Ebola effort in ...
Breaking Medicine Technology:Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... VANCOUVER, British Columbia, Jan. 19, 2012   OncoGenex Pharmaceuticals, Inc. ... data from two studies evaluating their investigational compound OGX-427, ... the American Society of Clinical Oncology (ASCO) 2012 Genitourinary ... OGX-427 is a novel compound designed to reduce ...
... Jan. 19, 2012 /PRNewswire-iReach/ -- Today, Wireless ... 4th Annual TripleTree iAwards for Wireless Health ... mobile and wireless solutions in the healthcare industry. ... accepted through March 30, 2012.  Each application will be ...
Cached Medicine Technology:OncoGenex Announces Presentation of OGX-427 Data at the ASCO 2012 Genitourinary Cancers Symposium 2OncoGenex Announces Presentation of OGX-427 Data at the ASCO 2012 Genitourinary Cancers Symposium 3Call for Submissions: 2012 TripleTree iAwards for Wireless Health 2Call for Submissions: 2012 TripleTree iAwards for Wireless Health 3
Double-ended. Blades set at 45 and 90 degrees. Hexagonal handle....
5 mm curved blade. Round handle....
2 mm x 3 mm tapered blade. Referred to as "Number Two Knife". Angled 45 degrees. Round handle....
7 mm strong curved blade. Round handle....
Medicine Products: