Navigation Links
New insights into how brain responds to viral infection
Date:3/31/2009

March 31, 2009, New York, NYScientists at Columbia University Mailman School of Public Health have discovered that astrocytes, supportive cells in the brain that are not derived from an immune cell lineage, respond to a molecule that mimics a viral infection using cellular machinery similar to that used by classical immune cells in the blood. While scientists have been aware of the capacity of astrocytes to trigger an innate immune response when encountering a foreign agent, this work provides a new understanding of the complex mechanisms responsible for induction and regulation of inflammation in the brain and has significant implications for both the diagnosis and treatment of brain infections. The study is published as the cover article in the April 2009 issue of The FASEB Journal (http://www.fasebj.org).

In the course of trying to contain and neutralize a virus that has breached the protective barrier of the central nervous system, immune mediators secreted by astrocytes may injure other cells and tissues in the vicinity and cause additional life-threatening inflammation.

By defining the nature of inflammatory responses by brain astrocytes, this study has implications for both the diagnosis of chronic infections of the central nervous system, as well as the treatment of acute and chronic brain infections. Viral infections of the brain are associated with extremely high morbidity and mortality; in most cases, the specific microbial cause is unknown. Even when a viral cause is clear, the specific antiviral tools at our disposal remain limited. This work provides a means for implementation of a more general therapeutic approach to viral brain infections that may be effective across a wide range of viruses, or even where a virus is suspected but the offending agent cannot be identified.

"Studies such as this take us one step closer to understanding both the risk and benefit associated with antiviral immune response and may lead to new trea
'/>"/>

Contact: Randee Sacks Levine
rs363@columbia.edu
212-305-8044
Columbia University's Mailman School of Public Health
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Insights Give New Hope Against Cystic Fibrosis
2. New Research Released at Annual Society for Adolescent Medicine Meeting Provides Vital Insights into Adolescent Health Issues
3. United Spinal Association Report Reveals the Importance of Studying Multiple Sclerosis in Children: Developing New Insights into MS in Adults
4. Recovery Audit Contractor HealthDataInsights Licenses Milliman Care Guidelines(R)
5. New insights into growth factors role in brain development
6. Gene Insights May Improve Psoriasis Care
7. Researchers Gain Insights Into Aging in Mice
8. Analog Devices Healthcare Team Participates in MIT Forum on Medical Device Industry : ADI's healthcare technology experts Patrick O'Doherty and Tom O'Dwyer offer insights on trends impacting next-generation medical electronic systems.
9. HIV Vaccine Failure Still Brings Insights
10. Genetic Research Offers Insights Into Form of Malaria
11. New insights could lead to a better pneumococcal vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... The report “Industrial Enzymes Market by Types ... Agents, Bio-Fuel, Animal Feed), & Geography - Global ... the global industrial enzymes market with analysis and ... It also identifies driving and restraining factors for ... trends, opportunities, burning issues, winning imperatives, and challenges. ...
(Date:7/28/2014)... 2014 "Fist bumping" transmits significantly fewer bacteria ... the cultural expectation of hand-to-hand contact between patients ... the August issue of the American Journal ... the Association for Professionals in Infection Control and ... Institute of Biological, Environmental, and Rural Sciences at ...
(Date:7/28/2014)... Qualis Health, one of the ... has published a complimentary, online toolkit that provides ... and families in infection control. Tested and ... toolkit provides a step-by-step roadmap for implementing an ... families early in a hospital stay. , “Across ...
(Date:7/28/2014)... July 28, 2014 Recent research has ... all day for years can lead to a range ... disease. But using a standing desk, or an adjustable ... often driving office workers back to a seated position. ... are designed to alleviate this leg pain and fatigue ...
(Date:7/28/2014)... Thompson HealthDay Reporter ... prematurely appear to have a slightly increased risk of ... adulthood, Swedish researchers report. Doctors have previously suspected ... a raised risk of deep vein thrombosis and pulmonary ... the veins, the researchers noted in background information. ...
Breaking Medicine News(10 mins):Health News:Industrial Enzymes Market Worth $5,987.5 Million by 2018 - Report by MarketsandMarkets 2Health News:Industrial Enzymes Market Worth $5,987.5 Million by 2018 - Report by MarketsandMarkets 3Health News:Industrial Enzymes Market Worth $5,987.5 Million by 2018 - Report by MarketsandMarkets 4Health News:Fist-bumping beats germ-spreading handshake, study reports 2Health News:Patient Engagement in Hospital Infection Control: Online Toolkit Provides a New Solution 2Health News:New Standing Desk Anti-fatigue Mats from Martinson-Nicholls Reduce Leg Fatigue and Discomfort Working at Standing and Sit-to-Stand Desks 2Health News:Preemies May Have Higher Risk of Blood Clots, Even as Adults 2Health News:Preemies May Have Higher Risk of Blood Clots, Even as Adults 3
... in 10 men is affected, and a depressed partner can ... News) -- Although many people know that new moms are ... child, new research suggests that about 10 percent of new ... the researchers found that if the mother experiences postpartum depression, ...
... Tomography (PET) scanning and a new probe developed by ... of the immune system, providing a non-invasive and much ... The probes, the commonly used FDG that measures cellular ... measures the activity of a distinct biochemical pathway, work ...
... release is available in German . ... there are a large class of reports by eyewitnesses having ... of these apparent fire balls for a long time. Now ... magnetic field of long lightning strokes may produce the image ...
... identified an important cancer gene that could lead to more ... a disease which currently has a poor prognosis. The ... was one of a number of significant genetic differences found ... are the most common brain tumour in children. Clinicians ...
... ... at Clinicians’ Fingertips at the Point of Care or Anywhere, , ... Little Falls, NJ (PRWEB) May 18, ... medical education (CME/CE) activities, has achieved new status as an approved iPhone application developer. ...
... to ongoing health risks , TUESDAY, May 18 ... smoke, dust, fumes and gases among those involved in ... Center ultimately compromised the workers, sense of smell, new ... ability to detect odors and irritants, researchers at the ...
Cached Medicine News:Health News:Postpartum Depression Can Strike New Dads 2Health News:Postpartum Depression Can Strike New Dads 3Health News:PET scanning probes reveal different cell function within the immune system 2Health News:Mysterious ball lightning: Illusion or reality? 2Health News:Genetics of children's brain tumor unlocked 2Health News:Projects In Knowledge Launches Free iPhone App of Living Medical Textbook Neurology: Multiple Sclerosis 2010 Edition 2Health News:Projects In Knowledge Launches Free iPhone App of Living Medical Textbook Neurology: Multiple Sclerosis 2010 Edition 3Health News:Lost Sense of Smell Noted Among Ground Zero Workers Post-9/11 2
(Date:7/25/2014)... , July 25, 2014  Corporate libraries are ... understanding new advancements in technology and how to cope ... libraries in the pharmaceutical and medical device industries are ... the information and services they provide. ... LLC there are many forces of change that leading ...
(Date:7/25/2014)... /PRNewswire-iReach/ -- "Australia Capsule Endoscopy Systems Market Outlook to ... Endoscopy Systems market. The report provides value, in millions ... (in US dollars) within market segments: Photo ... Endoscopes , Capsule Endoscopy Data Recorders , ... provides company shares and distribution shares data for each ...
(Date:7/25/2014)...  Smile Train and its technology partner BioDigital have ... Simulator among leading global health innovations in The Hive ... Washington, D.C. at The John F. ... "Smile Train is honored to be represented through our ... in health and medicine that TEDMED unites each year," ...
Breaking Medicine Technology:Forces of Change Reshaping Corporate Libraries & Information Services 2Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 2Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 3Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 4Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 5Smile Train and BioDigital Selected to Showcase Virtual Surgery Simulator in The Hive at TEDMED 2014 2Smile Train and BioDigital Selected to Showcase Virtual Surgery Simulator in The Hive at TEDMED 2014 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: