Navigation Links
New insights into how brain responds to viral infection
Date:3/31/2009

March 31, 2009, New York, NYScientists at Columbia University Mailman School of Public Health have discovered that astrocytes, supportive cells in the brain that are not derived from an immune cell lineage, respond to a molecule that mimics a viral infection using cellular machinery similar to that used by classical immune cells in the blood. While scientists have been aware of the capacity of astrocytes to trigger an innate immune response when encountering a foreign agent, this work provides a new understanding of the complex mechanisms responsible for induction and regulation of inflammation in the brain and has significant implications for both the diagnosis and treatment of brain infections. The study is published as the cover article in the April 2009 issue of The FASEB Journal (http://www.fasebj.org).

In the course of trying to contain and neutralize a virus that has breached the protective barrier of the central nervous system, immune mediators secreted by astrocytes may injure other cells and tissues in the vicinity and cause additional life-threatening inflammation.

By defining the nature of inflammatory responses by brain astrocytes, this study has implications for both the diagnosis of chronic infections of the central nervous system, as well as the treatment of acute and chronic brain infections. Viral infections of the brain are associated with extremely high morbidity and mortality; in most cases, the specific microbial cause is unknown. Even when a viral cause is clear, the specific antiviral tools at our disposal remain limited. This work provides a means for implementation of a more general therapeutic approach to viral brain infections that may be effective across a wide range of viruses, or even where a virus is suspected but the offending agent cannot be identified.

"Studies such as this take us one step closer to understanding both the risk and benefit associated with antiviral immune response and may lead to new trea
'/>"/>

Contact: Randee Sacks Levine
rs363@columbia.edu
212-305-8044
Columbia University's Mailman School of Public Health
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Insights Give New Hope Against Cystic Fibrosis
2. New Research Released at Annual Society for Adolescent Medicine Meeting Provides Vital Insights into Adolescent Health Issues
3. United Spinal Association Report Reveals the Importance of Studying Multiple Sclerosis in Children: Developing New Insights into MS in Adults
4. Recovery Audit Contractor HealthDataInsights Licenses Milliman Care Guidelines(R)
5. New insights into growth factors role in brain development
6. Gene Insights May Improve Psoriasis Care
7. Researchers Gain Insights Into Aging in Mice
8. Analog Devices Healthcare Team Participates in MIT Forum on Medical Device Industry : ADI's healthcare technology experts Patrick O'Doherty and Tom O'Dwyer offer insights on trends impacting next-generation medical electronic systems.
9. HIV Vaccine Failure Still Brings Insights
10. Genetic Research Offers Insights Into Form of Malaria
11. New insights could lead to a better pneumococcal vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014 Dynamic health trends, changing ... in the Bread Production industry over the past ... moderate their consumption of a variety of industry ... shrunk the market for white loaf bread and ... by introducing more nutritious products to attract health-conscious ...
(Date:9/30/2014)... September 30, 2014(BRONX, NY)Medications are the leading cause of ... analysis of death certificates from 1999 to 2010, conducted ... and Albert Einstein College of Medicine of Yeshiva ... Journal of Allergy and Clinical Immunology , also ... was particularly high among older people and African-Americans and ...
(Date:9/30/2014)... NV (PRWEB) September 30, 2014 Fat ... nutrition specialist and best-selling author Mike Geary that is helping ... transform their body into a fat-burning machine in less than ... an investigative review. , “In our culture that is ... be hard to decipher what is really fact and fiction ...
(Date:9/30/2014)... Eagan, Minn. (PRWEB) September 30, 2014 ... trips to the apple orchard, pumpkin patch or annual ... season for fast-spreading viruses – like the respiratory infection ... cold in most children, a small percentage – especially ... severe symptoms. Increased concern about the Enterovirus is prompting ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 A group of ... to combat an epidemic that, left unchecked, could create a ... are not headed to Africa. John Rogers, the Executive Director ... North Korea to fight a disease most think mankind conquered ... some 80 years ago is on the comeback in several ...
Breaking Medicine News(10 mins):Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Comprehensive Study of allergic deaths in US finds medications are main culprit 2Health News:Fat Burning Kitchen: Review Exposes Mike Geary’s 24-Hour Diet Transformation for Helping the Body Burn Fat Through a Natural Diet 2Health News:Fat Burning Kitchen: Review Exposes Mike Geary’s 24-Hour Diet Transformation for Helping the Body Burn Fat Through a Natural Diet 3Health News:As Hospitals Combat Enterovirus Outbreaks, Patients and Families Turn to “Virtual Visits” with CaringBridge 2Health News:US Delegation Heads to North Korea to Combat Tuberculosis Epidemic 2
... Assembly elected new officers and members of its national board of ... Conference in Washington, D.C.New officers include:, , ... Director of YWCA York, Pennsylvania , ... Chicago, Illinois , Secretary: ...
... is standing up against insurance companies and big business , ... New ... lawyers can have a tough time against large pocketed companies such ... these monsters want the public to believe it is they who are ...
... and experts will gather in New Orleans on June ... health and property damage controversy involving building materials: ... for two teleconferences dealing with the insurance implications on ... According to the Consumer Product Safety Commission, at least ...
... For 7-year-old Alexander, it,s meant orthotics and physical therapy ... 7-year-old Rebecca, it,s an insulin pump for her Type ... cerebral palsy, it,s a wheelchair.All these children and more ... the UnitedHealthcare Children,s Foundation (UHCCF) in recent years to ...
... CME LL C ... Initiatives. In her new role, DeMatteo will guide the ... through activities founded on proven learning adult principles, delivered ... CME LLC more ...
... Pa., May 12 The Pennsylvania Department of Aging and ... a 15-member Quality Council that will advise on new policies ... services. "Many older citizens and those with disabilities prefer to ... nursing facility -- so we want to make sure that ...
Cached Medicine News:Health News:YWCA USA Elects New National Leadership Team 2Health News:Manhattan Personal Injury Attorney Blames Insurance Industry For Negative Perception Of Civil Justice System 2Health News:Chinese Drywall Litigation Subject of Conference and Two Teleconferences 2Health News:UnitedHealthcare Children's Foundation To Award More Medical Grants for Child Health Care Needs in Connecticut 2Health News:Ann Marie DeMatteo Joins CME LLC as Vice President of Educational Initiatives, Drives Innovative Programming Approaches 2Health News:Pennsylvania Council Formed to Advise on Improving Services to Older Adults, People with Disabilities 2
(Date:9/30/2014)... 2014   Acutus Medical, Inc. (ACM), ... 3D Cardiac Chamber Imaging and Dipole Density Mapping system ... sustain complex cardiac arrhythmias, including atrial fibrillation, announced it ... its imaging/mapping system as well as bring to market ... Medical to complete work on the AcQMap TM ...
(Date:9/30/2014)... In 2011, approximately 5.1 million people in ... pain relievers (e.g. opioids). 1 Clinical treatments for ... the use of buprenorphine, buprenorphine/naloxone, naltrexone or methadone. The ... developing and improving care management programs, according to ... Therapeutics LLC (Prime). Cost trends ...
(Date:9/30/2014)... Calif. , Sept. 30, 2014  Life ... group focused on supporting promising emerging biotech, medical ... been named the Top Angel Investment Group in ... as the best performer out of 370 angel ... historical performance, network strength (connections), selection aptitude and ...
Breaking Medicine Technology:Acutus Medical, Inc. Completes Additional $26.2M Series B Financing to Fund Portfolio Expansion 2Acutus Medical, Inc. Completes Additional $26.2M Series B Financing to Fund Portfolio Expansion 3Studies show cost and use of opioid dependence treatment are increasing, spurring the need for care management programs 2Studies show cost and use of opioid dependence treatment are increasing, spurring the need for care management programs 3Life Science Angels Ranked the Top Angel Investment Group in the U.S. 2Life Science Angels Ranked the Top Angel Investment Group in the U.S. 3
... Top Line Data Is Expected to Be Presented in ... VIA Pharmaceuticals,(Nasdaq: VIAP ), a biotechnology company focused ... disease, announced today that,it has completed patient enrollment in ... 2 trials investigating VIA-2291, the,company,s lead product candidate., ...
... Effects are not the Only Way We Suffer - ... Allergies Impact Mood and Self-Perception, KENILWORTH, ... allergies affect about 50,million people in the United States.(1)(2) Yet, ... often,disregarded as a nuisance: in today,s society allergies get little ...
Cached Medicine Technology:VIA Pharmaceuticals Completes Enrollment In Phase 2 Carotid Endarterectomy (CEA) Trial 2VIA Pharmaceuticals Completes Enrollment In Phase 2 Carotid Endarterectomy (CEA) Trial 3VIA Pharmaceuticals Completes Enrollment In Phase 2 Carotid Endarterectomy (CEA) Trial 4VIA Pharmaceuticals Completes Enrollment In Phase 2 Carotid Endarterectomy (CEA) Trial 5New Survey Suggests Cultural Ambivalence to Allergies Leaves Many Suffering Needlessly 2New Survey Suggests Cultural Ambivalence to Allergies Leaves Many Suffering Needlessly 3New Survey Suggests Cultural Ambivalence to Allergies Leaves Many Suffering Needlessly 4New Survey Suggests Cultural Ambivalence to Allergies Leaves Many Suffering Needlessly 5New Survey Suggests Cultural Ambivalence to Allergies Leaves Many Suffering Needlessly 6New Survey Suggests Cultural Ambivalence to Allergies Leaves Many Suffering Needlessly 7
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: