Navigation Links
New insights into how brain responds to viral infection
Date:3/31/2009

March 31, 2009, New York, NYScientists at Columbia University Mailman School of Public Health have discovered that astrocytes, supportive cells in the brain that are not derived from an immune cell lineage, respond to a molecule that mimics a viral infection using cellular machinery similar to that used by classical immune cells in the blood. While scientists have been aware of the capacity of astrocytes to trigger an innate immune response when encountering a foreign agent, this work provides a new understanding of the complex mechanisms responsible for induction and regulation of inflammation in the brain and has significant implications for both the diagnosis and treatment of brain infections. The study is published as the cover article in the April 2009 issue of The FASEB Journal (http://www.fasebj.org).

In the course of trying to contain and neutralize a virus that has breached the protective barrier of the central nervous system, immune mediators secreted by astrocytes may injure other cells and tissues in the vicinity and cause additional life-threatening inflammation.

By defining the nature of inflammatory responses by brain astrocytes, this study has implications for both the diagnosis of chronic infections of the central nervous system, as well as the treatment of acute and chronic brain infections. Viral infections of the brain are associated with extremely high morbidity and mortality; in most cases, the specific microbial cause is unknown. Even when a viral cause is clear, the specific antiviral tools at our disposal remain limited. This work provides a means for implementation of a more general therapeutic approach to viral brain infections that may be effective across a wide range of viruses, or even where a virus is suspected but the offending agent cannot be identified.

"Studies such as this take us one step closer to understanding both the risk and benefit associated with antiviral immune response and may lead to new trea
'/>"/>

Contact: Randee Sacks Levine
rs363@columbia.edu
212-305-8044
Columbia University's Mailman School of Public Health
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Insights Give New Hope Against Cystic Fibrosis
2. New Research Released at Annual Society for Adolescent Medicine Meeting Provides Vital Insights into Adolescent Health Issues
3. United Spinal Association Report Reveals the Importance of Studying Multiple Sclerosis in Children: Developing New Insights into MS in Adults
4. Recovery Audit Contractor HealthDataInsights Licenses Milliman Care Guidelines(R)
5. New insights into growth factors role in brain development
6. Gene Insights May Improve Psoriasis Care
7. Researchers Gain Insights Into Aging in Mice
8. Analog Devices Healthcare Team Participates in MIT Forum on Medical Device Industry : ADI's healthcare technology experts Patrick O'Doherty and Tom O'Dwyer offer insights on trends impacting next-generation medical electronic systems.
9. HIV Vaccine Failure Still Brings Insights
10. Genetic Research Offers Insights Into Form of Malaria
11. New insights could lead to a better pneumococcal vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... ... Tina Wilcoxson, owner of Freeport Maine’s Royal River Natural Foods, was named one ... Federation, the largest retail trade association in the world, for her “advocacy and engagement” ... named as such. According to the NRF’s website, Retail Champions are “Main Street business ...
(Date:8/1/2015)... CT (PRWEB) , ... August 01, 2015 , ... ... Point Partners I, L.P. (“GPP”) portfolio company has acquired Premier Physical Therapy & ... it into its portfolio of state-of-the-art clinics. , “Our acquisition of Premier Physical ...
(Date:8/1/2015)... ... ... Lume Wellness creators Alex, Robert, and Sam have announced update 3.0.1 to this ... The app is designed to track various metrics of wellness, including physical activity, diet, ... and use this information for positive behavior modification. Lume Wellness keeps track of both ...
(Date:8/1/2015)... ... 2015 , ... “ reTXT ” was featured on NewsWatch as part of ... the market for iOS, Android, and Windows. Joe Toohey, the host of AppWatch and ... edit and delete any message including ones already sent. , While text messaging has ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... High Times magazine. What are the STASH awards? The Significant Technological Achievements ... by the cannabis-cultivation community as well as tried-and-true products that have stood the ...
Breaking Medicine News(10 mins):Health News:Local Retail Advocate Wins National Recognition 2Health News:Professional Physical Therapy Now Largest Outpatient Physical Therapy Provider in Northeast With Acquisition of Premier Physical Therapy & Wellness 2Health News:Lume Wellness Launches Health and Fitness Tracker iPhone App 2Health News:Correct Auto-Correct and Clarify the Unclear with reTXT Messaging App 2Health News:The High Times S.T.A.S.H. Awards Are in, Guess Who Took Home the Prize for “Best Grow System” 2
... tablets such as pain killers are packaged today in ... some form of desiccant to protect the contents against ... the contents from rattling around. , However, such caps ... two hands to manipulate. Customers and,suppliers of vitamin pills ...
... an army of plant viruses to their cause, materials ... (NIST) have identified a small biomolecule that binds specifically ... bodythe calcium compound that is the basic building block ... the new molecule can be a highly discriminating probe ...
... American Tradition -- What,s the Problem?, ... Seniors Ask, WASHINGTON, ... the sight of seniors attending a,seminar about Medicare Advantage-Part D, asking questions, and ... some federal regulators,get their way., A proposed prohibition on free meals is ...
... ... Troops, BOSTON, July ... the most underserved and,at-risk groups in our country, today announced the launch ... those soldiers,who have been wounded in conflict in the Middle East and ...
... Hot Water & Healthy Living, reviews scientific findings about warm-water ... ... For those who have,wondered how warm water makes them feel so good, ... Swimming Pool Foundation,(NSPF), "Hot Water & Healthy Living" provides a thorough review ...
... ... Care, BREA, ... owners are recalculating their,household budgets. The average pet owner typically budgets for ... as,preventive health checks and vaccinations. However, most assume that their,pet,s youth or ...
Cached Medicine News:Health News:Integrated tube cap design simplifies access to medication 2Health News:Toothpick: New molecular tag IDs bone and tooth minerals 2Health News:Proposed Medicare Regulations Threaten to End Millions of Free Meals Offered to Seniors During Education Seminars 2Health News:Purple Dog Tag Launches; Provides Hope and Healing to Thousands of US Servicemen & Veterans 2Health News:New Book Reveals Warm Water Benefits for Heart, Lungs and Mind 2Health News:Veterinary Pet Insurance Reports Pet Emergencies a Costly Reality 2Health News:Veterinary Pet Insurance Reports Pet Emergencies a Costly Reality 3Health News:Veterinary Pet Insurance Reports Pet Emergencies a Costly Reality 4
(Date:7/30/2015)... 30, 2015  Amgen (NASDAQ: AMGN ) today announced ... director of Warburg Pincus LLC, to the Amgen Board of ... Fred Hassan and the deep, global experience he brings ... Robert A. Bradway , chairman and chief executive officer of Amgen. ... serve Amgen well." Mr. Hassan has been Partner ...
(Date:7/30/2015)... LAKE, N.J. , July 30, 2015 ... simultaneously in the United States , ... the FDA, EMA and MHLW, respectively) for eribulin, for ... (STS) who have received prior chemotherapy for advanced or ... based on data from a pivotal global Phase 3 ...
(Date:7/30/2015)... 2015 P&S Market ... market overview, trends, DRO analysis, market segmentation, ... developments, competitive scenario and top competitor profiles ... Market Development and Demand Forecast to 2020  ... Explore more about global biosensors ...
Breaking Medicine Technology:Amgen Announces Appointment Of Fred Hassan To Board Of Directors 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 3Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 2Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 3Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 4Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 5Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 2Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 3Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 4Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 5
... Aug. 30, 2011 Luminex Corporation (Nasdaq: ... two upcoming investment conferences, the Morgan Stanley Global Healthcare ... scheduled to take place in New York City. ... Patrick J. Balthrop, president and chief executive officer, will ...
... REDWOOD CITY, Calif., Aug. 30, 2011 Pearl ... randomized, double-blind, Phase 2b, dose-ranging study of its ... a long-acting beta-2 agonist (LABA) compared to placebo ... All doses of FF MDI tested produced highly ...
Cached Medicine Technology:Luminex Corporation to Present at Upcoming Investment Conferences In September 2Pearl Therapeutics Announces Positive Results for Phase 2b Dose-Ranging Study of Formoterol MDI 2Pearl Therapeutics Announces Positive Results for Phase 2b Dose-Ranging Study of Formoterol MDI 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: