Navigation Links
New insights into growth factor's role in brain development
Date:2/2/2009

NEW YORK (Feb. 2, 2009) -- New research sheds light on a neural growth factor called proBDNF, finding that it is present and potentially active during the perinatal period when the brain's circuitry and memory-encoding regions are being refined. Led by Weill Cornell Medical College investigators with those at the National Institutes of Health (NIH) and Memorial Sloan-Kettering Cancer Center (MSKCC), and reported in the Jan. 11 issue of the journal Nature Neuroscience, the study could lead to a better understanding of brain development and the formation of memories.

ProBDNF is the precursor form of mature brain-derived neurotrophic growth factor (BDNF), and both are active in the hippocampus and cortex -- areas key to learning, memory and higher thinking. Intriguingly, proBDNF and BDNF encourage different actions; BDNF promotes the differentiation of new neurons and their constituent parts (axons, dendrites and synapses), and proBDNF the pruning of synapses -- a process that occurs particularly in the early stages of life.

"Our results suggest that the nervous system plays an active role in both potentiating and dampening its own activity as necessary," says senior author Dr. Barbara Hempstead, the O. Wayne Isom Professor of Medicine at Weill Cornell Medical College and a leader in the field of neurotrophin research.

Dr. Hempstead and her research team, including lead authors Dr. Jianmin Yang and Dr. Chia-Jen Siao of Weill Cornell Medical College, developed new techniques that enabled them to observe when and where proBDNF and mature BDNF were being made in a mouse model. They found that proBDNF is most highly expressed in the hippocampus during the postnatal period of the mouse at about days 3 to 21, when large numbers of axons and synapses are being formed. They also found that p75 receptors, a class of receptors that encode a "death domain" in which neurons are killed or pruned, are also active during this period. These r
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New insights into common knee injuries
2. SIV infection of natural hosts provides new insights into HIV disease complexity
3. Mothers Blood Could Offer Insights Into Fetal Health
4. Study Offers Insights Into Sensory Perceptions
5. Uncover Key Competitive Intelligence Insights in Webinars Hosted by Best Practices
6. Studies lend insights into colorectal cancer screening
7. Influenza: Insights into cell specificity of human vs. avian viruses
8. Cell Insights Could Bring Better Drugs
9. New insights into inflammation in osteoarthritis
10. Physics provides new insights on cataract formation
11. Cell Insights May Predict Breast Cancers Spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... Richey, FL (PRWEB) , ... June 30, 2015 , ... ... nearly doubled from 2007 to 2013 while heroin-related deaths more than tripled in the ... drug threat (1). Novus Medical Detox Center , a leading Florida-based drug treatment ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... that they have been awarded the exclusive billing agreements with Jackson Radiology Associates ... billing services encompassing their proprietary suite of billing process software functionality called Experience ...
(Date:6/30/2015)... ... June 30, 2015 , ... On June 26, 2015, Harper’s Bazaar Magazine ... triggers that most people would not expect to cause acne flare-ups. The ... causes of acne are clogged pores and bacteria and each of the ...
(Date:6/30/2015)... FL (PRWEB) , ... June 30, 2015 , ... ... Jacksonville, reported today it has more than doubled the size of its medical ... The center’s medical staff -- which includes physicians, nurse practitioners and physician assistants ...
(Date:6/30/2015)... ... , ... Family and professional dementia caregivers are invited to ... 2015 at the Hyatt Regency Denver Tech Center from 7:30 am-4:30 pm. The ... the wife and daughter of singer Glen Campbell, who will discuss their experiences ...
Breaking Medicine News(10 mins):Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 2Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 3Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 4Health News:ADVOCATE Wins Billing Agreements with Jackson Radiology Associates 2Health News:A List of 5 Surprising Acne Triggers and the Latest Acne Treatment Options 2Health News:Lakeview Health, a Nationally Recognized Drug Rehabilitation Center in Florida, Doubles Size of Medical Staff 2Health News:Family of Singer Glen Campbell to Discuss Living with Dementia at the Alzheimer's Association of Colorado's 26th Annual Education Symposium 2
... initiatives can pay,off for organizations, although developing reliable ... But the more mature the quality,programs, the greater ... quality metrics, according to recent research from benchmarking,leader ... percent of the firms that described their quality,programs ...
... could be a vital indicator for treating narrowing of lung ... research shows that people with chronically high blood pressure in ... levels have a very high mortality rate. , ... a known indicator of advanced left heart failure, but the ...
... Travel Advantage Network manager shaves head in fundraising ... Advantage,Network (TAN), a nationwide leader in wholesale vacation ... funds for juvenile alopecia,areata, an autoimmune disorder that ... body, usually the scalp., TAN,s Total Vacation ...
... CLARA, Calif., June 20 The Continua Health,Alliance ... at 2:30 p.m. at the Santa,Clara Convention Center, ... Conference and Showcase., The session, "The next ... three use cases -- chronic disease management, aging,independently, ...
... Cash Security of $5.2 Million Lifted, SALT ... SNCI ), the only U.S.-based publicly traded ... company,s German subsidiary,successfully negotiated an amendment with Commerzbank ... the 2003 acquisition of the German subsidiary. The,amendment ...
... York, NY -- The Damon Runyon Cancer Research ... at its May 2008 Clinical Investigator Award Committee ... award are outstanding early career physician-scientists conducting patient-oriented ... mentorship of the nation,s leading scientists and clinicians. ...
Cached Medicine News:Health News:Measuring and Demonstrating the Value of Quality Initiatives 2Health News:Low Blood Sodium Predicts Mortality in PAH Patients 2Health News:TAN Employees Shave the Way for the Fight Against Alopecia 2Health News:Continua Health Alliance to Host Open Meeting at CONNECTIONS(TM) Tuesday, June 24th at 2:30 pm 2Health News:Sonic Innovations Announces Loan Amendment With German Bank 2Health News:Sonic Innovations Announces Loan Amendment With German Bank 3Health News:Damon Runyon Cancer Research Foundation awards $2.25M to 5 top young clinical investigators 2Health News:Damon Runyon Cancer Research Foundation awards $2.25M to 5 top young clinical investigators 3
(Date:6/30/2015)... June 30, 2015 Nortek Security & ... NTK ) and a leader in the residential ... announced it acquired mobile personal emergency response system ... Numera, Inc. Headquartered in ... implemented, mobile PERS products and cloud-based software platforms ...
(Date:6/30/2015)... 2015   Millar, Inc. , a leader in ... 2016 retirement of Craig Thummel , President/CEO and ... of service to the Company. The Company also announced ... of the Executive Management team as his successors. The ... currently Director of Sales and Marketing, as President, and ...
(Date:6/30/2015)... , June 24, 2015 ... announced the addition of the "Global Array ... The global array instruments market to ... the period 2014-2019 The global array instruments ... microarrays, protein microarrays, and others including tissue microarrays ...
Breaking Medicine Technology:Nortek Security & Control Acquires Health and Wellness Technology Business from Numera 2Nortek Security & Control Acquires Health and Wellness Technology Business from Numera 3Nortek Security & Control Acquires Health and Wellness Technology Business from Numera 4Millar, Inc. Announces Leadership Changes 2Millar, Inc. Announces Leadership Changes 3Global Array Instruments Market 2015-2019 - Advances in Personalized Medicines with Affymetrix, Agilent Technologies & Illumina Dominating 2
... Jan. 27, 2011 /PRNewswire-Asia/ -- China Sky One ... Company") (Nasdaq: CSKI ), a leading ... of China ("PRC"), today announced that Heilongjiang Tianlong ... subsidiary, was named a "Top Ten Branded Company ...
... Cetero Research, the leading early-stage contract research organization ... industry milestone with the completion of its 20,000th ... as the unmatched leader in early-phase clinical development ... therapeutic expertise that Cetero offers to pharmaceutical, biotechnology ...
Cached Medicine Technology:China Sky One Medical Receives Medical Industry Awards 2China Sky One Medical Receives Medical Industry Awards 3Cetero Research Announces Completion of 20,000th Early-Phase Clinical Study 2
... Integra II SP MRI-Compatible Anesthesia System is perfect ... more than one type of anesthetic agent. ... and due to its wider stance, has a ... ventilator bellows assembly is utilized in both the ...
... Market leader in soft tissue repair in ... has developed the latest evolution in orthopedic ... ORTHOCORD Suture is as strong as any ... importantly, ORTHOCORD Suture handles like ETHIBOND®., ,ORTHOCORD ...
... PURPLE NITRILE* product family offers a comprehensive ... gloves were designed as an alternative for ... hypersensitivity to natural rubber latex proteins. The ... from latex and other synthetic gloves. Custom ...
... and the distinctive COLOR PURPLE* distinguish ... them for sterile clinical procedures when ... required. Theyre designed as an alternative ... Type 1 hypersensitivity to natural rubber ...
Medicine Products: