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New insights into common knee injuries
Date:8/29/2007

found that as they increased the amounts of the proteins, the meniscus tissue was less able to repair itself. The range of concentrations of IL-1 and TNF used in the experiment match those found in the joint fluid of humans with rheumatoid arthritis and osteoarthritis, providing further evidence that these proteins could play a role in the disease process.

According to Farshid Guilak, Ph.D., senior member of the research team and director of orthopedic research at Duke, these findings should theoretically help physicians repair knee joints damaged by injury or osteoarthritis.

There already is a drug that blocks the effects of TNF that is used widely and effectively in patients with rheumatoid arthritis, the form of the disease caused by bodys own immune system attacking the joint, Guilak said. Another drug also exists that blocks IL-1 that is being used for rheumatoid arthritis and is currently undergoing clinical trials for osteoarthritis.

These drugs are administered to the entire body. However, the key to the possible new approach would be to deliver these agents directly into the site of meniscus damage, Guilak said.


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Contact: Richard Merritt
Merri006@mc.duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

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