Navigation Links
New insights could lead to a better pneumococcal vaccine
Date:9/22/2008

Discovery of a new, previously unknown mechanism of immunity suggests that there may be a better way to protect vulnerable children and adults against Streptococcus pneumoniae (pneumococcal) infection, say researchers at Children's Hospital Boston and Harvard School of Public Health (HSPH). The findings, published in the open-access journal PLoS Pathogens on September 19, may aid the development of novel pneumococcal vaccines. (The current vaccine, Prevnar, is expensive and covers only 7 of the 91 known pneumococcal strains.)

Pneumococcus causes serious infections in children and the elderly, including pneumonia and meningitis (inflammation of the brain). Since 2000, U.S. infants have been routinely immunized against pneumococcus, but most developing countries (where nearly one million children die from pneumococcal infections annually) cannot afford the existing vaccine.

Richard Malley, MD, of Children's Division of Infectious Diseases, and Marc Lipsitch, D. Phil., of HSPH have been studying how natural immunity against pneumococcus develops, and have shown that in addition to antibodies, T-cells can provide broad protection against this pathogen. In this new study, Malley and Lipsitch identify the specific protective T-cells so-called TH17 cells and show that they protect against infection by releasing IL-17, a protein that enables human blood cells to kill pneumococcus in the nose more efficiently. This is significant, since colonizing a person's nose is the first necessary step of infection.

Researchers had known that children, as they get older, carry pneumococcus in the nose for shorter periods of time and have less risk of disease, but it hadn't been known how this resistance develops. Malley, Lipsitch and their colleagues now show that adults and older children, but not newborn babies, have TH17 cells that target pneumococci, suggesting that exposure to pneumococcus normally leads to production of these cells. In mi
'/>"/>

Contact: Keri Stedman
keri.stedman@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study offers new insights into teenagers and anxiety disorders
2. Baird Hosts Small Cap Health Care Conference : Senior Healthcare Distribution & Services Research Analyst Eric Coldwell Shares Insights on Sector
3. Mayo Clinic Experts Offer Insights on Olympians
4. MedInsights, Inc. Selects Douglas Young as VP - Sales & Product Development
5. Circulating Tumor Cells Reveal Insights Into Lung Cancers
6. Leaders Develop Leaders: Insights from Global Benchmarking Councils 10th Annual Human Resources Conference
7. CVS Caremark to Present Insights on Redefining the Consumer Health Care Experience at AHIP Institute 2008
8. Parks Associates Analysts Present Insights on Broadband, Digital Content, Advertising, Home Systems, and Digital Health at CONNECTIONS(TM)
9. Chemstar Corporation Publishes New Insights on Fresh Produce Safety From CFP Workshop
10. Insights into cancer earn Premiers Award Commendation
11. Health Care Leaders Gather to Gain New Safety, Risk Management Insights From Aviation Industry Experts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Oxnard, CA (PRWEB) July 29, 2014 ... of the Anacapa Dental Art Institute in Oxnard and Woodland ... that have fallen out or been removed due to dental ... disease, and the two prosthodontists (experts in restoring and replacing ... of not using implant specialists to perform their dental work ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 Gout was one ... lifestyles have proven that last statement essentially moot since ... many people still do not have are the resources to ... is it costly to maintain treatment for it, but the ... daily activities to a grinding halt. , Alternative ...
(Date:7/29/2014)... Staffing, Your Partner in Locum Tenens, is reporting a forty ... strong indications the Irving, Texas-based firm will reach sixty percent ... is a great time to be at Consilium,” says Matt ... are proud of what we have accomplished in the first ... about how things are shaping up for the next six ...
(Date:7/29/2014)... Guests at Napa Valley's quintessential luxury resort, Auberge du ... The top of each luxurious resort bed is adorned with ... crafted, 100% Egyptian cotton white duvets and pillow shams have ... look, words are woven in the linens that serve as ... , Intentional breathing and visualization are keys to relaxing body, ...
(Date:7/29/2014)... 2014 A Forever Recovery , an ... to a great start and gives them a solid foundation ... of the National Cherry Festival kickoff concert held on July ... was co-sponsored by Miller Lite and in partnership with WKLT ... Bay Side Music Stage presented by Blue Cross Blue Shield ...
Breaking Medicine News(10 mins):Health News:Oxnard Dental Implant Experts Warn of Infections Around Dental Implants 2Health News:Oxnard Dental Implant Experts Warn of Infections Around Dental Implants 3Health News:Oxnard Dental Implant Experts Warn of Infections Around Dental Implants 4Health News:Gout Natural Remedy Report Review | The Ultimate Secret to Eliminating Gout Naturally – Vinamy.com 2Health News:Consilium Staffing Experiences Significant Revenue Growth 2Health News:Auberge Du Soleil Offers INTENTIONS™ by Peacock Alley on Guests' Beds Providing a Unique Sleep Experience 2Health News:A Forever Recovery Sponsors National Cherry Festival Kickoff Concert Featuring Collective Soul on July 5 in Traverse City, MI 2
... With daylight savings comes an extra,hour of sleep, ... morning? In,addition to the daily cup of coffee, ... video from the Flower Promotion Organization at:, http://media.medialink.com/WebNR.aspx?story=34055 ... General Hospital,confirmed that study participants reported being happier ...
... Stryker Corporation,(NYSE: SYK ) announced today that it will participate in the ... 8:30 a.m. Mountain Standard Time Credit ... November 27, 2007 - 12:30 p.m. ... Care Conference New York, New York ...
... Chewing Gum During Exam, CHICAGO, Nov. 1 ... students as they struggle to balance,their homework load with ... "It,s common practice for students to try to ... for exams," says Adrinda,Kelly, senior editor of The Princeton ...
... General Nutrition Centers, Inc.,("GNC" or the "Company"), announced ... to report its third quarter 2007 financial,results at 11 ... this call inside the U.S., dial 1-888-895-5479, and,outside the ... is 19663288. A webcast of the call will also ...
... North American Riding for the Handicapped Association (NARHA) awards,Ashaway,s horse-assisted ... ... Accreditation, ASHAWAY, R.I., Nov. 1 ... Premier Accredited Center,Program by North American Riding for the Handicapped ...
... Nov. 1 The Tobacco-Free Kids,Indiana Action ... campaign,today in several Indiana communities supporting local ... In Indianapolis, Angela,Mansfield (District 2 - D) ... are being,endorsed for their leadership in passing ...
Cached Medicine News:Health News:Stryker to Present at Investor Conferences 2Health News:As Exams Loom, Students Find Hope in a 'Stick' 2Health News:As Exams Loom, Students Find Hope in a 'Stick' 3Health News:As Exams Loom, Students Find Hope in a 'Stick' 4Health News:Turning Pointe Therapeutic Riding Recognized for Excellence in Providing Equine-Assisted Therapies to People with Disabilities 2Health News:Tobacco-Free Kids Indiana Action Fund Launches Campaign in Support of Angela Mansfield and Scott Keller for Indianapolis City-County Council 2Health News:Tobacco-Free Kids Indiana Action Fund Launches Campaign in Support of Angela Mansfield and Scott Keller for Indianapolis City-County Council 3
(Date:7/28/2014)... 28, 2014  Array BioPharma Inc. (Nasdaq:   ... fourth quarter and full year of fiscal ... discuss those results on Tuesday, August 12, ... Michael Carruthers , Chief Financial Officer ... 12, 2014Time:9:00 a.m. Eastern TimeToll-Free:(800) 708-4540Toll:(847) 619-6397Pass ...
(Date:7/28/2014)... , July 28, 2014  Houston dentist ... he offers orthodontic treatment with Invisalign. With access ... can have their teeth straightened without feeling self-conscious ... benefits associated with other types of braces, but ... looks in addition to better support for their ...
(Date:7/28/2014)... MONACO , 28 luglio 2014 ResMed ... sviluppo di prodotti per la cura dei disturbi respiratori ... respiratorio, ha avuto un,ingiunzione permanente in Germania contro il ... che proibisce la vendita di apparecchiature da indossare in ... 210 e le maschere 220. La sentenza della Corte ...
Breaking Medicine Technology:Houston Cosmetic Dentist, Dr. Behzad Nazari, Now Offers Orthodontic Treatment with Invisalign 2ResMed riceve un'ingiunzione permanente contro APEX in Germania, continua a far valere i propri diritti per i brevetti in Europa 2
... ( www.fuisz.com ) today announced the issuance of U.S. ... Access to On-Line Vendor Information"). Joseph Matus ... a system that allows a customer or potential customer ... database through the on-line vendor,s system to provide the ...
... The American Academy of Family Physicians Foundation is ... Immunization Award winners. These awards recognize family medicine ... in their communities through creative solutions. Monetary grants ... were presented to 16 residents from the following ...
Cached Medicine Technology:Family Medicine Residency Programs Recognized for Improving Childhood and Adult Immunizations Rates in Underserved Communities 2Family Medicine Residency Programs Recognized for Improving Childhood and Adult Immunizations Rates in Underserved Communities 3
... advanced motorized inverted microscope from Olympus. , ... provides 9 access ports for multiple input ... can have simultaneous access to a primary ... 6-position nosepiece and light path selector, the ...
... Designed to provide exceptional performance ... SteREO Lumar has unrivaled fluorescence ... light microscopy instruments. Developed for ... SteREO Lumar offers first-class optical ...
... TIRF slider, which allows laser coupling via ... for observing rapid membrane processes even ... times extremely short. The easy ... and the effective laser safety equipment of ...
... The MicroFire is a 2-megapixel, 12-bit FireWire digital camera. ... be acquired effortlessly. Imaging has never been this easy! ... CCD - 2/3" Color ... Time - 500 microseconds - 60 seconds ...
Medicine Products: