Navigation Links
New insights contradict promising Alzheimer's research
Date:5/23/2013

Approximately a year ago, the leading journal Science published an article about bexarotene as a potential Alzheimer's drug. A significant breakthrough and an important starting point for further Alzheimer's research. The research group of Bart De Strooper Alzheimer's researcher at VIB and KU Leuven in collaboration with the group of Rudi D'Hooge KU Leuven and scientists at Janssen Pharmaceutica, Beerse, also tested this candidate drug in various Alzheimer's animal test models. Their results were different, as were those of two American study groups. Therefore, they have recommended in a "technical comment" in Science that bexarotene should not be tested on patients.

Bart De Strooper (Department Director VIB/KU Leuven): "Science is a learning process and one learns by trial and error and by starting again and correcting mistakes. Therefore, it is logical that conclusions from scientific research even in prestigious journals need to be re-evaluated from time to time. If results cannot be reproduced, it is very important that this is mentioned so that other scientists can also determine the value of a publication (reproducible science is the only true science). This is the only way that we can learn from our mistakes and hopefully one day develop a drug."

Jo Bury (Managing Director VIB): "VIB places great value on thorough checks and balances of scientific results. This is the most important condition for leading research that could benefit our society. It is good news that Science is also prepared to publish negative results."

Scientific research, a process of ups and downs

Scientific findings do not simply fall into someone's lap; they are the result of years of dogged research. The icing on the cake is a publication in a scientific journal, as this is the way that scientists announce their results to the world. Before a publication is accepted, a journal will submit the document to a panel of leading scientists in that field of research. The publication is only given the go-ahead following a positive evaluation by these experts.

Built-in control mechanisms

Is this an absolute guarantee? Unfortunately not.

Fellow scientists try to reproduce results. They are usually successful, but sometimes similar experiments lead to different results. And this needs to be reported and examined in more detail. These built-in control mechanisms in the scientific process are therefore very important. It is a normal part of the scientific process. Scientific journals also sometimes offer scientists the opportunity to comment on certain publications after they have been published. The journal Science does this in the form of "technical comments". This is often the source of more extensive research.

New insights sometimes invalidate existing theories

Scientists want to get to the bottom of phenomena, usually with a certain hypothesis in mind. Research leads to new knowledge and insights, which results in refinement of the existing theories. However, sometimes this results in a completely new theory and the rejection of an existing theory. The history of science is littered with examples of this: think of Copernicus who was the first to assert that the sun and not the earth is the centre of our solar system. The Flemish contribution to Science is an excellent example of the self-monitoring process in the scientific world.


'/>"/>

Contact: Kris Van der Beken
kris.vanderbeken@vib.be
0032-473-783-435
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Related medicine news :

1. BroadConnect’s Latest Video Solution Sets Aimed at Providing Technical Insights for Businesses Hoping to Gain Greater Returns from their Investment in Communication and Security Solutions
2. NexTec Group Named to Bob Scott’s Insights Top 100 VAR’s for 2013
3. Julia Desmond Talks Deeksha Dynamics and 108 Insights to Empowerment in New Book
4. Gaspari Nutrition Sponsors Renzo Gracie Jiu Jitsu’s Weekly Insights Video Series
5. Monkey Research Gives Insights Into New SARS-Like Virus
6. RazorInsights Hires Former Siemens RVP Karl Kiss to Drive Sales
7. More Genetic Insights Into 3 Types of Cancer
8. Research from the 2013 Genitourinary Cancers Symposium highlights new insights on high-risk prostate cancer prevalence and treatment, compares benefit of surveillance and surgery for management of small kidney tumors
9. Pulmonary & Allergy Update highlights insights and advances
10. Study of cancer cell metabolism yields new insights on leukemia
11. Studies provide new insights into brain-behavior relationships
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... Advanced Inc., a leading provider of travel therapy ... MBA to serve as Advanced Inc.’s Chief Financial Officer, effective December 1, 2016. Jason ... extensive financial and operational leadership experience to Advanced Inc. He began his career in ...
(Date:12/2/2016)... ... December 02, 2016 , ... With the number of pain management programs ... patients must find the one that works for them. When an inventor from Suisun ... that worked and decided to share it with others. , He developed a prototype ...
(Date:12/2/2016)... Delaware (PRWEB) , ... December 02, 2016 , ... ... released a new version of its SaaS LIMS, CloudLIMS Lite. CloudLIMS Lite helps ... sample entry through labeling, storing, shipping and disposal. The new version is a ...
(Date:12/2/2016)... ... December 02, 2016 , ... Yisrayl Hawkins, at The ... how this current generation fits into Bible Prophecy. Yisrayl says this generation, known as ... to this conclusion, showing how the details line up exactly with Bible Prophecy – ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... Technologist/Clinical Laboratory Scientist & Author of Type 2 Diabetes: The Owner’s Manual, ... The Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... , December 2, 2016 - bioLytical lanza el ... directrices de la OMS     Continue Reading ... ... , , ... infecciosas, ha anunciado hoy que está expandiendo el lanzamiento de su INSTI HIV ...
(Date:12/2/2016)... , December 2, 2016 ... global cardiac pacemaker market in its upcoming report titled, "Global Market Study ... a Declining CAGR of -1.4% between 2016 and 2024". The ... Mn in 2015 and this is likely to decline ... revenue, the global cardiac pacemaker market is anticipated to ...
(Date:12/2/2016)... , Dec. 2, 2016  LifeVac, the revolutionary device ... in the Emergency Response Training and Support Services (ERTSS) ... to have LifeVac become part of the ERTSS mission ... and CEO of LifeVac. "Having an established network of ... effectively will help leverage our efforts to spread LifeVac,s ...
Breaking Medicine Technology: