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New insights contradict promising Alzheimer's research
Date:5/23/2013

Approximately a year ago, the leading journal Science published an article about bexarotene as a potential Alzheimer's drug. A significant breakthrough and an important starting point for further Alzheimer's research. The research group of Bart De Strooper Alzheimer's researcher at VIB and KU Leuven in collaboration with the group of Rudi D'Hooge KU Leuven and scientists at Janssen Pharmaceutica, Beerse, also tested this candidate drug in various Alzheimer's animal test models. Their results were different, as were those of two American study groups. Therefore, they have recommended in a "technical comment" in Science that bexarotene should not be tested on patients.

Bart De Strooper (Department Director VIB/KU Leuven): "Science is a learning process and one learns by trial and error and by starting again and correcting mistakes. Therefore, it is logical that conclusions from scientific research even in prestigious journals need to be re-evaluated from time to time. If results cannot be reproduced, it is very important that this is mentioned so that other scientists can also determine the value of a publication (reproducible science is the only true science). This is the only way that we can learn from our mistakes and hopefully one day develop a drug."

Jo Bury (Managing Director VIB): "VIB places great value on thorough checks and balances of scientific results. This is the most important condition for leading research that could benefit our society. It is good news that Science is also prepared to publish negative results."

Scientific research, a process of ups and downs

Scientific findings do not simply fall into someone's lap; they are the result of years of dogged research. The icing on the cake is a publication in a scientific journal, as this is the way that scientists announce their results to the world. Before a publication is accepted, a journal will submit the document to a panel of leading sc
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Contact: Kris Van der Beken
kris.vanderbeken@vib.be
0032-473-783-435
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

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