Navigation Links
New insight into the cause of common dementia found by researchers at Mayo Clinic
Date:11/17/2010

JACKSONVILLE, Fla. Researchers at the Mayo Clinic campus in Florida have found a clue as to how some people develop a form of dementia that affects the brain areas associated with personality, behavior, and language.

In the Nov. 17 online issue of the American Journal of Human Genetics, the scientists write that they discovered a link between two proteins progranulin and sortilin they say might open new avenues for the treatment of frontotemporal lobar degeneration (FTLD), which occurs in the frontal lobe and temporal lobe of the brain. This form of dementia, which is currently untreatable, generally occurs in younger people, compared to other common neurodegenerative disorders such as Alzheimer's disease.

"We now can look for a direct link between these two proteins and the development of FTLD," says the study's lead author, neuroscientist Rosa Rademakers, Ph.D. "The hope is that if we do find a strong association, it might be possible to manipulate levels of one or both of these proteins therapeutically."

Coincidentally, a research group from Yale University led by Stephen Strittmatter, M.D., Ph.D., has also pinpointed sortilin's association with progranulin thus confirming Mayo's results. Their study is being published in Neuron, also on Nov. 17.

FTLD is a family of brain diseases that are believed to share some common molecular features. One is the presence of mutations in the gene that produces tau protein in neurons. The other is mutations in the progranulin gene that Mayo Clinic researchers and their colleagues discovered in 2006. They found that 5 to 10 percent of patients with FTLD have a mutation in this gene, and that these mutations lead to a substantial loss of normal progranulin protein production, and development of FTLD.'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New Insights on Who Should Take Erbitux for Colon Cancer
2. Scientists unwrap DNA packaging to gain insight into cells
3. K-State research project offers insight into superstitious behavior
4. Sodium MRI gives new insights into detecting osteoarthritis, NYU researchers find
5. Snake venom studies yield insights for development of therapies for heart disease and cancer
6. Cell symposia meeting, Influenza: Translating basic insights, to be held Dec. 2-4, 2010
7. Suite 101.com Provides Insight Into Consumer Reading Behavior Online
8. SAGE Insight shines spotlight on research
9. From head to toe: Deep insights from whole body MRI
10. Flies offer insight into human metabolic disease
11. Emerald Express International to be Featured on ‘Insights' with Hugh Downs this Spring in a Segment that Spotlights Glutathione and Anti-Aging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... September 03, 2015 , ... ... applications are open for spring 2016. Scholarships are awarded two times each year ... The Warriors® is a national nonprofit dedicated to restoring a sense of self, ...
(Date:9/3/2015)... PEACHTREE CITY, GA (PRWEB) , ... September 03, ... ... does not cover the cost of graduated compression garments. However, graduated compression garments ... management. , Wound care and lymphedema specialist, Robyn Bjork, was recently sponsored by ...
(Date:9/3/2015)... CA (PRWEB) , ... September 03, 2015 , ... ... the real estate investment landscape by connecting accredited and institutional investors to real ... financing products designed to meet demand from both investors and sponsoring real ...
(Date:9/3/2015)... St. Louis, MO (PRWEB) , ... September 03, 2015 , ... ... NBC Nightly News*, covering the allegations made by IVC filter lawsuits filed ... allege they were harmed when a Bard IVC filter broke or failed, have recently ...
(Date:9/3/2015)... ... September 03, 2015 , ... The Linda Hall Library ... of a comet, the IceCube observatory at the South Pole, and the interior of ... Fall Lecture Series for the world's foremost independently funded research library devoted to science, ...
Breaking Medicine News(10 mins):Health News:Hope For The Warriors Spouse/Caregiver Scholarships Now Open for Spring 2016 2Health News:SIGVARIS Supports the Lymphedema Treatment Act to Help Patients with Lymphedema 2Health News:SIGVARIS Supports the Lymphedema Treatment Act to Help Patients with Lymphedema 3Health News:RealtyShares Announces Mezzanine Financing Products 2Health News:RealtyShares Announces Mezzanine Financing Products 3Health News:Bard IVC Lawsuit Allegations Reach National Prime Time News 2Health News:Bard IVC Lawsuit Allegations Reach National Prime Time News 3Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 2Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 3Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 4Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 5
... dose of phenylephrine works. , , FRIDAY, Dec. 14 (HealthDay ... popular over-the-counter cold medicines is effective at its current ... , The panel of advisers to the U.S. Food ... OTC cold medicines containing the decongestant phenylephrine really provide ...
... Think Twice Before Leaving Your Luggage On A Hotel Bed And Other ... ... Briggs & Riley Travelware, a,leader in innovative, high quality luggage, reports ... health and sanitation,at tourist attractions and travel hotspots, according to a poll ...
... Dec. 14 /PRNewswire-FirstCall/ - Cardiome Pharma Corp.,(NASDAQ: CRME/TSX: COM) ... held on Friday, December 14, 2007 at 2:00pm Eastern,(11:00am ... To access the conference call, please dial 416-340-8010 ... analysts on which,we will respond to questions at the ...
... Dec. 14 The U.S. Conference of,Catholic Bishops ... Pregnant Women,s Support Act (S. 2407), a bill ... "By providing practical resources and information, the bill ... themselves and their,children, born and unborn," said Ms. ...
... Calif., Dec. 14 Watson,Pharmaceuticals, Inc. (NYSE: ... confirmed today that Duramed Pharmaceuticals, Inc., a ... filed a patent lawsuit,against Watson and certain ... tablets USP), Watson,s generic version of,Seasonale(R), an ...
... have a history of abuse by intimate partners have higher ... of abuse, according to a study conducted at Group Health, ... terms of the cost of providing care and use of ... children were born, the research team found. Scientists from ...
Cached Medicine News:Health News:FDA Panel Finds OTC Cold Remedies Effective 2Health News:FDA Panel Finds OTC Cold Remedies Effective 3Health News:Briggs & Riley Reports That More Travelers Focus on Health and Sanitation This Holiday Season 2Health News:Briggs & Riley Reports That More Travelers Focus on Health and Sanitation This Holiday Season 3Health News:Cardiome to Hold Investor Update Call 2Health News:Cardiome to Hold Investor Update Call 3Health News:Cardiome to Hold Investor Update Call 4Health News:Bishops' Conference Praises Senate Introduction of 'Pregnant Women Support Act' 2Health News:Watson Confirms Patent Litigation With Barr Related to Seasonale(R) 2Health News:Health needs higher for kids of abused moms 2Health News:Health needs higher for kids of abused moms 3
(Date:9/3/2015)... , Sept. 3, 2015 Nevro Corp. (NYSE: ... is providing innovative evidence-based solutions for the treatment of ... presenting at the Morgan Stanley Global Healthcare Conference on ... Nevro management is scheduled to present at ... a live audio webcast, accessible in the "Investors" section ...
(Date:9/3/2015)... 2015  As part of its ongoing commitment to ... Marc R. Katz , MD, MPH, cardiac surgeon and ... Vascular Institute implanted the first HeartMate 3 left ventricular ... selected as part of the prestigious MOMENTUM 3™ Clinical ... in the United States—and the first in central Virginia—chosen ...
(Date:9/3/2015)... , Novel ideas for ... for translation of findings into practice ...   , On occasion of the 9 th ... scientists from across Europe presented the latest ... potential for achieving major advances in pain management. All presenters were ...
Breaking Medicine Technology:Bon Secours' Patient FIRST in Central Virginia to receive New Life-saving Care 2Bon Secours' Patient FIRST in Central Virginia to receive New Life-saving Care 3Bon Secours' Patient FIRST in Central Virginia to receive New Life-saving Care 4Results of Pain Research Projects Raise Aspiration for Advanced Pain Treatment 2Results of Pain Research Projects Raise Aspiration for Advanced Pain Treatment 3Results of Pain Research Projects Raise Aspiration for Advanced Pain Treatment 4Results of Pain Research Projects Raise Aspiration for Advanced Pain Treatment 5
DSL-10-49300 is a rapid, direct enzyme immunoassay (EIA) kit that provides materials for the quantitative measurement of testosterone in saliva. This assay requires no sample extraction or pretreat...
... Only 1-2% of circulating testosterone exists ... approximately 60%, is bound to SHBG with ... loosely bound to albumin. Both the albumin-bound ... while SHBG effectively inhibits testosterone action. Measurement ...
RIA kit for the quantitative determination of autoantibodies to steroid 21-hydroxylase (21-OH) in serum....
6700 Reagent Reservoirs, 120 mL...
Medicine Products: