Navigation Links
New insight into selective binding properties of infectious HIV
Date:12/15/2009

Free infectious HIV-1 is widely thought to be the major form of the virus in the blood of infected persons. U.S. Military HIV Research Program (MHRP) researchers, however, have demonstrated that essentially all of the infectious virus particles can bind to the surface of red blood cells isolated from each of 30 normal (non-infected) human donors. The results were published today in PLoS ONE, and can be accessed here.

The lead investigators, Dr. Zoltan Beck and Dr. Carl Alving, researchers with MHRP in the Division of Retrovirology, Walter Reed Army Institute of Research (WRAIR), explain that the data show that although infectious HIV-1 virus particles that bind to red blood cells comprise only a small amount, perhaps as little as a mean of 2.3% of a typical HIV-1 preparation, erythrocyte-bound HIV-1 is then approximately 100-fold more infectious than free (non-cell-bound) HIV-1 for infection of target cells.

The study concludes that infectious virions constitute only a small fraction of a typical HIV-1 preparation and that, in a laboratory setting, all of the infectious virions can bind to red blood cells and other non-permissive cells (i.e., cells that cannot be infected). If this is true in HIV-infected humans it could mean that red blood cell-bound HIV-1 might be more important than free virus for transmission of infectious HIV-1 to target cells that can be infected.

Dr. Alving says, "If the same behavior of binding of infectious HIV-1 to red blood cells occurs in humans, it might be possible that red blood cell-bound infectious virions are protected from degradation or immune attack."

Dr. Beck adds, "This study suggests that erythrocytes might serve as an important, and perhaps hidden, reservoir for infectious HIV-1 virions."


'/>"/>

Contact: Lisa Reilly
lreilly@hivresearch.org
301-251-5070
Henry M. Jackson Foundation for the Advancement of Military Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. University HealthSystem Consortium Offers Value Analysis Professionals Insightful New Resources
2. New model of skin cancer provides insights on second-most common type of cancer
3. Wellness Cruise Offers Crystal Guests Indian Ocean Insight
4. Insightra Medical Launches the Freedom(TM) Ventral Hernia Repair, an Innovative New Way to Deploy Sublay Implants for Ventral Hernias Without Suturing
5. ECRI Institute Issues Health Plan Watch List: 2010 Top 7 Technologies; Exclusive Insights in White Paper, Available for Free Download
6. Reportlinker Adds North America Negative Pressure Wound Therapy (NPWT) Market: Strategic Market Analysis and Insight to 2012
7. Neuroimaging provides insights into new treatment options for Alzheimers disease
8. Former House Speaker Newt Gingrich Shares Insights on Healthcare Reform and the Federal Pay Czar with BulletproofBlog.com
9. Sg2 Announces Its INSIGHT System to Improve Hospitals' Clinical Performance and Bottom Line Results
10. New Advances and Insights in Gastroenterology Presented at Colleges 74th Annual Meeting
11. Detailed Results from RV 144 HIV Vaccine Trial Published Today in The New England Journal of Medicine and Presented at the AIDS Vaccine 2009 Conference Provide Insight for Future Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... Those ... deal with these feelings, many turn to unhealthy avenues, such as drug or alcohol ... of Marne, Michigan, has released tools for healthy coping following a traumatic event. , ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with ... Latin America . ... ... ... ...
(Date:6/23/2016)... 23, 2016  Experian Health, the healthcare ... the patient payment and care experience, today ... products and services that will enhance the ... offerings. These award-winning solutions will enable healthcare ... compliant in an ever-changing environment and redefine ...
Breaking Medicine Technology: