Navigation Links
New insight into selective binding properties of infectious HIV
Date:12/15/2009

Free infectious HIV-1 is widely thought to be the major form of the virus in the blood of infected persons. U.S. Military HIV Research Program (MHRP) researchers, however, have demonstrated that essentially all of the infectious virus particles can bind to the surface of red blood cells isolated from each of 30 normal (non-infected) human donors. The results were published today in PLoS ONE, and can be accessed here.

The lead investigators, Dr. Zoltan Beck and Dr. Carl Alving, researchers with MHRP in the Division of Retrovirology, Walter Reed Army Institute of Research (WRAIR), explain that the data show that although infectious HIV-1 virus particles that bind to red blood cells comprise only a small amount, perhaps as little as a mean of 2.3% of a typical HIV-1 preparation, erythrocyte-bound HIV-1 is then approximately 100-fold more infectious than free (non-cell-bound) HIV-1 for infection of target cells.

The study concludes that infectious virions constitute only a small fraction of a typical HIV-1 preparation and that, in a laboratory setting, all of the infectious virions can bind to red blood cells and other non-permissive cells (i.e., cells that cannot be infected). If this is true in HIV-infected humans it could mean that red blood cell-bound HIV-1 might be more important than free virus for transmission of infectious HIV-1 to target cells that can be infected.

Dr. Alving says, "If the same behavior of binding of infectious HIV-1 to red blood cells occurs in humans, it might be possible that red blood cell-bound infectious virions are protected from degradation or immune attack."

Dr. Beck adds, "This study suggests that erythrocytes might serve as an important, and perhaps hidden, reservoir for infectious HIV-1 virions."


'/>"/>

Contact: Lisa Reilly
lreilly@hivresearch.org
301-251-5070
Henry M. Jackson Foundation for the Advancement of Military Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. University HealthSystem Consortium Offers Value Analysis Professionals Insightful New Resources
2. New model of skin cancer provides insights on second-most common type of cancer
3. Wellness Cruise Offers Crystal Guests Indian Ocean Insight
4. Insightra Medical Launches the Freedom(TM) Ventral Hernia Repair, an Innovative New Way to Deploy Sublay Implants for Ventral Hernias Without Suturing
5. ECRI Institute Issues Health Plan Watch List: 2010 Top 7 Technologies; Exclusive Insights in White Paper, Available for Free Download
6. Reportlinker Adds North America Negative Pressure Wound Therapy (NPWT) Market: Strategic Market Analysis and Insight to 2012
7. Neuroimaging provides insights into new treatment options for Alzheimers disease
8. Former House Speaker Newt Gingrich Shares Insights on Healthcare Reform and the Federal Pay Czar with BulletproofBlog.com
9. Sg2 Announces Its INSIGHT System to Improve Hospitals' Clinical Performance and Bottom Line Results
10. New Advances and Insights in Gastroenterology Presented at Colleges 74th Annual Meeting
11. Detailed Results from RV 144 HIV Vaccine Trial Published Today in The New England Journal of Medicine and Presented at the AIDS Vaccine 2009 Conference Provide Insight for Future Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... September 23, 2014 Ale Gicqueau, President ... on Advanced Data Visualization for Clinical Trials at the ... in San Francisco on Friday, September 26, 2014. ... volunteers. Since its inception, PhUSE has expanded from its ... a global platform for the discussion of topics encompassing ...
(Date:9/23/2014)... 23, 2014 WetKeys Washable Keyboards announces ... in their industrial keyboards line. Labeled ... to last longer in heavy-duty industrial computing for the ... where grease and oil can destroy usability or cause ... constant threat to the longevity of computer equipment and ...
(Date:9/23/2014)... September 23, 2014 With the emergence ... sale of all tobacco products, retail chains are transforming ... services to patients, customers, and shoppers. In this capacity, ... of retail pharmacy healthcare to share their knowledge on ... to know to coordinate care with other colleagues inside ...
(Date:9/23/2014)... Névo takes a bold step forward in fitness ... activity tracking and phone notifications for a fashion conscious ... and more. , http://www.nevowatch.com , “Today, ... their busy lives to look and feel better. The ... results, but until now, style played a distance second ...
(Date:9/23/2014)... 23, 2014 Published by Nationwide Lifts, the ... to take charge of their mobility in a new way, ... impactful. Stair lifts are that equipment and can ... in the elevator business, I’ve seen so many ... or a loved one with mobility issues,” said Andy Darnley, ...
Breaking Medicine News(10 mins):Health News:Clinovo Sponsors and Presents at Pharmaceutical Users Software Exchange (PhUSE) SDE in San Francisco 2Health News:WetKeys Announces New Oil Resistant Keyboard for Industrial Computing, Food Processing Plants, Automotive Factories and Machine Shops 2Health News:WetKeys Announces New Oil Resistant Keyboard for Industrial Computing, Food Processing Plants, Automotive Factories and Machine Shops 3Health News:WetKeys Announces New Oil Resistant Keyboard for Industrial Computing, Food Processing Plants, Automotive Factories and Machine Shops 4Health News:WetKeys Announces New Oil Resistant Keyboard for Industrial Computing, Food Processing Plants, Automotive Factories and Machine Shops 5Health News:Retail Pharmacies at the Forefront of Primary Care Innovation 2Health News:Nevo changes the face of fitness wearables with an analogue watch combining activity tracking, phone notifications, and LED goal progress indicators for active lifestyles 2Health News:Nevo changes the face of fitness wearables with an analogue watch combining activity tracking, phone notifications, and LED goal progress indicators for active lifestyles 3Health News:Nationwide Lifts, America’s Leader in Home Elevators, Is Proud to Announce the Release of Its First Book, “Stair Lifts: Move Up, Not Out!” 2
(Date:9/22/2014)... Sept. 22, 2014 Decision Resources Group finds that ... expected to be worth $2 billion (U.S. dollars), increasing at ... next five years (to 2018). This growth comes as ... in 2013 and 4.9 percent expected over the next three ... is small but highly competitive. The pharmaceutical market is dominated ...
(Date:9/22/2014)... -- Persistence Market Research ( http://www.persistencemarketresearch.com/ ) ... Ophthalmic Devices: Asia to Witness ... at USD 29,171.5 million in 2014 and is expected ... to 2020, to reach an estimated value of USD ... Market Study on Ophthalmic Devices:  Asia  to ...
(Date:9/22/2014)... , Sept. 22, 2014  AVT, Inc. (OTC ... retailing systems and custom vending machines, announced today that ... Unit. This new, smaller sized unit is designed for ... practices. According to industry statistics, there are ... Opticwash is the world,s first automated kiosk ...
Breaking Medicine Technology:Despite Its Limited Size, Chile's Pharmaceutical Market Offers Growing Opportunity for Drug Industry 2Despite Its Limited Size, Chile's Pharmaceutical Market Offers Growing Opportunity for Drug Industry 3Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 2Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 3Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 4Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 5Opticwash Pro Enables Optical Retailers to Generate New Revenues and Customer Traffic through a Unique Eyeglass Cleaning System 2
... LAKES, N.J., Dec. 29 BD (Becton, Dickinson and Company) (NYSE: ... would present at the following investor healthcare conferences in January: , , ... 6, 2010, 9:15 a.m. ET, 28th ... 6:30 p.m. ET, , A live webcast of BD,s ...
... PALM CITY, Fla., Dec. 29 Connectyx Technologies Holdings Group, ... a National RV Owners Community as a marketing partner to ... over one million members and more than 3,400 individual club ... The RV Club provides its membership with essential services ranging ...
Cached Medicine Technology:BD to Present at Investor Healthcare Conferences 2Connectyx Announces MedFlash Sales Partnership with National Recreational Vehicle Club 2Connectyx Announces MedFlash Sales Partnership with National Recreational Vehicle Club 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: