New insight into factors that drive muscle-building ... (for two weeks before it declined again. ...)

New insight into factors that drive muscle-building stem cells

Date:1/8/2008

for two weeks before it declined again.

Interestingly, systemically high levels of IL-6 had earlier been implicated in the muscle wasting process, Muoz-Cnoves noted. Having excess IL-6 is bad, but its local translation is required for muscle growth.

The researchers further found that IL-6 was produced both within myofibers and in their associated satellite cells, leading to muscle growth. In contrast, the muscles of mice lacking IL-6 did not show any significant increase in size after several weeks of overloading. The researchers also showed that IL-6 exerts its effects by inducing the proliferation of satellite cells.

While Muoz-Cnoves said that the findings are just the beginning of a new line of investigation into how adult muscle grows, she added that they might ultimately provide a new avenue for muscle-building therapies.

Treatments could be designed to compensate for or block the pathways leading to muscle loss, she said. In muscles that have already lost mass, you might also be able to stimulate muscle growth.

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Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

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GOOD

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