Navigation Links
New insight into factors that drive muscle-building stem cells
Date:1/8/2008

A report in the January issue of Cell Metabolism, a publication of Cell Press, provides new evidence explaining how stem cells known as satellite cells contribute to building muscles up in response to exercise. These findings could lead to treatments for reversing or improving the muscle loss that occurs in diseases such as cancer and AIDS as well as in the normal aging process, according to the researchers.

The researchers showed that a transient and local rise in an inflammatory signal, the cytokine known as interleukin-6 (IL-6), is essential for the growth of muscle fibers. The findings offer the first clear mechanism for the stem cells incorporation into muscle and the first evidence linking a cytokine to this process, said Pura Muoz-Cnoves of Universitat Pompeu Fabra in Barcelona, Spain. As we learn more about how muscles grow in adults, we may uncover new methods for restoring lost muscle mass in the elderly and ill, she added.

Skeletal muscles are made up of individual myofibers, each with many nuclei containing genetic material. As muscles are made to work harder, they adapt by bulking up each of those individual fibers, the researchers explained, but the mechanisms responsible have largely remained elusive.

Mounting evidence has shown that the growth of myofibers is limited by the need to maintain an equilibrium between the number of nuclei and the fibers overall volume. Because mature myofibers are incapable of cell division, new nuclei must be supplied by satellite cells (muscle stem cells). Once activated, satellite cells follow an ordered set of events, including proliferation, migration, and incorporation into the myofiber, leading to its growth.

Now, the researchers have found that IL-6 is an essential regulator in that process. While IL-6 was virtually undetectable in the muscles of control mice, animals whose muscles were made to work harder showed an increase in IL-6 after one day. That cytokine rise was maintained for two weeks before it declined again.

Interestingly, systemically high levels of IL-6 had earlier been implicated in the muscle wasting process, Muoz-Cnoves noted. Having excess IL-6 is bad, but its local translation is required for muscle growth.

The researchers further found that IL-6 was produced both within myofibers and in their associated satellite cells, leading to muscle growth. In contrast, the muscles of mice lacking IL-6 did not show any significant increase in size after several weeks of overloading. The researchers also showed that IL-6 exerts its effects by inducing the proliferation of satellite cells.

While Muoz-Cnoves said that the findings are just the beginning of a new line of investigation into how adult muscle grows, she added that they might ultimately provide a new avenue for muscle-building therapies.

Treatments could be designed to compensate for or block the pathways leading to muscle loss, she said. In muscles that have already lost mass, you might also be able to stimulate muscle growth.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. Insights into cell movement likely to aid immune study, cancer research
2. Patient-Centric Healthcare Study Reveals Key Insights for Pharmaceutical Marketers
3. New insights into deadly heart rhythm disorder
4. Neural Insights Could Bring Better Cochlear Implants
5. New technique reveals insights into lung disease
6. MDs reactions to pharma marketing influenced by brand, side effects: Management Insights
7. Elbit Imaging Ltd. Announces US$19,829,643 Investment in its Subsidiary InSightec Ltd., in an Internal Round of Financing
8. InSightec Ltd. Announces US$30 Million Investment Round
9. Cell Insights May Predict Breast Cancers Spread
10. Physics provides new insights on cataract formation
11. Aetna HSA Online Video Wins 2007 Insight Award for Customer Advocacy in Healthcare
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... ... July 20, 2017 , ... The ... Architecture Body of Knowledge (BIZBOK® Guide )v 6.0 is now available for member ... effort through Guild collaborative teams. , Non-members may download the Part 1 ...
(Date:7/20/2017)... , ... July 20, 2017 , ... LINET, an international ... innovation to their product line: the AVE 2 birthing bed. , Perfectly suitable for ... a new level of comfort and efficiency to every phase of childbirth. The AVE ...
(Date:7/20/2017)... ... July 19, 2017 , ... At Creekwood Dental Arts, Drs. ... joint (TMJ) treatment and dental implants in Waco, TX, using the latest ... the T-Scan™ by Tekscan®, they can capture details in the oral cavity for accurate ...
(Date:7/20/2017)... ... July 19, 2017 , ... Adolfson & Peterson Construction (AP) ... Christensen. As a leader in healthcare construction, AP has successfully built several well-known ... the Midwest with Josh now on board. , Josh brings over nine ...
(Date:7/20/2017)... ... July 20, 2017 , ... “Fidget”: a fun-filled, action-packed ... retired public high school music and drama teacher who was a summa cum laude ... including a “Teacher of the Year” award. After her retirement from public school, Lynn ...
Breaking Medicine News(10 mins):
(Date:7/5/2017)... 5, 2017 Wolfmet 3D  printed tungsten collimator manufactured by ... and manufacturing combine to progress molecular radiotherapy imaging. ... are unable to accurately quantify the radiation absorbed by those ... the success of this radiotherapy treatment has been available — ... ...
(Date:6/30/2017)... 30, 2017 In vitro diagnostics market firm ... May, at least ten diagnostic companies have successfully completed ... offerings and a loan facility.  The size of these ... million.  Kalorama Information provides a monthly IVD Market ... Knowledge Center. ...
(Date:6/20/2017)... LAGUNA HILLS, Calif. , June 20, ... data that validate the use of MMprofiler with SKY92, ... multiple myeloma (MM). In a poster presentation at the ... (EHA) in Madrid, Spain , SkylineDx ... identifying high-risk elderly patients. In a ...
Breaking Medicine Technology: