Navigation Links
New insight into factors that drive muscle-building stem cells
Date:1/8/2008

A report in the January issue of Cell Metabolism, a publication of Cell Press, provides new evidence explaining how stem cells known as satellite cells contribute to building muscles up in response to exercise. These findings could lead to treatments for reversing or improving the muscle loss that occurs in diseases such as cancer and AIDS as well as in the normal aging process, according to the researchers.

The researchers showed that a transient and local rise in an inflammatory signal, the cytokine known as interleukin-6 (IL-6), is essential for the growth of muscle fibers. The findings offer the first clear mechanism for the stem cells incorporation into muscle and the first evidence linking a cytokine to this process, said Pura Muoz-Cnoves of Universitat Pompeu Fabra in Barcelona, Spain. As we learn more about how muscles grow in adults, we may uncover new methods for restoring lost muscle mass in the elderly and ill, she added.

Skeletal muscles are made up of individual myofibers, each with many nuclei containing genetic material. As muscles are made to work harder, they adapt by bulking up each of those individual fibers, the researchers explained, but the mechanisms responsible have largely remained elusive.

Mounting evidence has shown that the growth of myofibers is limited by the need to maintain an equilibrium between the number of nuclei and the fibers overall volume. Because mature myofibers are incapable of cell division, new nuclei must be supplied by satellite cells (muscle stem cells). Once activated, satellite cells follow an ordered set of events, including proliferation, migration, and incorporation into the myofiber, leading to its growth.

Now, the researchers have found that IL-6 is an essential regulator in that process. While IL-6 was virtually undetectable in the muscles of control mice, animals whose muscles were made to work harder showed an increase in IL-6 after one day. That cytokine rise was maintained for two weeks before it declined again.

Interestingly, systemically high levels of IL-6 had earlier been implicated in the muscle wasting process, Muoz-Cnoves noted. Having excess IL-6 is bad, but its local translation is required for muscle growth.

The researchers further found that IL-6 was produced both within myofibers and in their associated satellite cells, leading to muscle growth. In contrast, the muscles of mice lacking IL-6 did not show any significant increase in size after several weeks of overloading. The researchers also showed that IL-6 exerts its effects by inducing the proliferation of satellite cells.

While Muoz-Cnoves said that the findings are just the beginning of a new line of investigation into how adult muscle grows, she added that they might ultimately provide a new avenue for muscle-building therapies.

Treatments could be designed to compensate for or block the pathways leading to muscle loss, she said. In muscles that have already lost mass, you might also be able to stimulate muscle growth.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. Insights into cell movement likely to aid immune study, cancer research
2. Patient-Centric Healthcare Study Reveals Key Insights for Pharmaceutical Marketers
3. New insights into deadly heart rhythm disorder
4. Neural Insights Could Bring Better Cochlear Implants
5. New technique reveals insights into lung disease
6. MDs reactions to pharma marketing influenced by brand, side effects: Management Insights
7. Elbit Imaging Ltd. Announces US$19,829,643 Investment in its Subsidiary InSightec Ltd., in an Internal Round of Financing
8. InSightec Ltd. Announces US$30 Million Investment Round
9. Cell Insights May Predict Breast Cancers Spread
10. Physics provides new insights on cataract formation
11. Aetna HSA Online Video Wins 2007 Insight Award for Customer Advocacy in Healthcare
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... , ... May 26, 2017 , ... Yisrayl Hawkins, Pastor ... publication this week that is focusing on the Peace Agreements being discussed by President ... East sprint in a race to try to speed up peace talks in the ...
(Date:5/26/2017)... ... ... Lowe acts as host and helps educate and inform the public using the “Informed” ... reconnect with America as it explores some of the best places to hike and ... inventive new place for a family vacation, and have discovered hiking. Many will agree ...
(Date:5/26/2017)... ... May 26, 2017 , ... “When the Stars Lead Home”: ... the creation of published author Laura Weigel Douglas, an avid reader who lives in ... house that sometimes feels like Green Hills Adventure Camp. She couldn’t be more grateful. ...
(Date:5/26/2017)... ... May 26, 2017 , ... ... recipient of proceeds from its 14th Annual Clays for Kids fundraiser, to be ... 30, Bennett, Colorado. , As part of BluSky’s partnership with The Adoption ...
(Date:5/26/2017)... ... ... “Cactus Jack: Against All Odds”: the story of Coach Cactus Jack and the impact ... the creation of published author, Walter Hubbard, a retired wildlife and fisheries biologist and ... Walter. Walter and Jane have three adult children and a granddaughter. Walter ...
Breaking Medicine News(10 mins):
(Date:5/23/2017)... May 23, 2017  Leaf Healthcare, recognized for ... devices for pressure ulcer prevention, will unveil its ... of Critical Care Nurses, National Teaching Institute and ... The Leaf Patient Monitoring System is the ... hospital environment.  The system seamlessly tracks patient movement ...
(Date:5/22/2017)... , May 22, 2017  As the specialty ... whole continue to make the revolutionary shift from ... important for ensuring positive patient outcomes and shaping ... are shifting focus away from clinical trials and ... of long-term specialty drug therapy utilization in precise ...
(Date:5/18/2017)... , May 17, 2017  Bayer announced today that ... will be presented at the 53 rd Annual ... taking place June 2-6 in Chicago ... ASCO span prostate, colorectal, liver and thyroid cancers, as ... the Phase II CHRONOS-1 trial of copanlisib in patients ...
Breaking Medicine Technology: