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New influenza virus from seals highlights the risks of pandemic flu from animals
Date:7/31/2012

A new strain of influenza virus found in harbor seals could represent a threat to wildlife and human health, according to the authors of a study appearing July 31 in mBio, the online open-access journal of the American Society for Microbiology. It is crucial to monitor viruses like this one, which originated in birds and adapted to infect mammals, the authors say, so that scientists can better predict the emergence of new strains of influenza and prevent pandemics in the future.

"There is a concern that we have a new mammalian-transmissible virus to which humans haven't been exposed yet. It's a combination we haven't seen in disease before," says Anne Moscona of Weill Cornell Medical College in New York City, the editor of the report.

The authors, who hail from several different institutions, including Columbia University and the National Oceanic and Atmospheric Administration Outbreaks, say transmissible and pathogenic flu viruses in mammals, like the one in this study, clearly pose a concern for human health. In 2009, for instance, the H1N1 "swine flu" virus that emerged in humans apparently originated from a reassortment of flu viruses found in birds, pigs, and humans. The H3N8 strain in New England harbor seals may come to represent the first sighting of a new group of influenza viruses with the potential to persist and move between species.

The mBio study analyzed the DNA of a virus associated with a die-off of 162 New England harbor seals in 2011. Autopsies of five of the seals revealed they apparently died from infection with a type of influenza called H3N8, which is closely related to a flu strain that has been circulating in North American birds since 2002. Unlike the strain in birds, this virus has adaptations to living in mammals and has mutations that are known to make flu viruses more transmissible and cause more severe disease. The virus also has the ability to target a receptor called SAα-2,6, a protein found in t
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Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

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