Navigation Links
New inflammation hormone link may pave way to study new drugs for Type 2 diabetes
Date:5/15/2012

A new link between obesity and type 2 diabetes found in mice could open the door to exploring new potential drug treatments for diabetes, University of Michigan Health System research has found.

Drugs for type 2 diabetes commonly target insulin, which lowers blood glucose levels. But the U-M study suggests that glucagon a pancreas-produced hormone that has the opposite effect of insulin by raising blood glucose levels may also provide a powerful pathway to preventing and treating the increasingly prevalent disease.

Findings of the study were published this week ahead of print in Nature Medicine.

"Reducing sugar levels is the biggest goal for people with type 2 diabetes," says senior author Liangyou Rui, Ph.D., associate professor in the Department of Molecular and Integrative Physiology at the U-M Medical School. "We've mostly focused on controlling insulin production and action to treat diabetes but there has been very little study on the opposite hormone glucagon.

"Our study shows for the first time that obesity also affects glucagon action and that this hormone also contributes to high glucose levels found in type 2 diabetes."

Authors identified the NIK/NF-B2 pathway, which promotes glucagon responses in obesity. NIK was abnormally activated in mice with dietary or genetic obesity and the inhibition of liver NIK was found to cure diabetes in obese mice.

Insulin resistance which reduces the body's ability to decrease blood glucose has been the main hallmark of type 2 diabetes, which is the most common form of diabetes in the United States afflicting millions of Americans.

"There is a common theory that inflammation in liver and fat tissue associated with obesity causes insulin resistance and that leads to the biggest problem for type 2 diabetes: high blood glucose levels," Rui says.

"But blood glucose is also controlled by this other hormone glucagon, which signals to t
'/>"/>

Contact: Shantell M. Kirkendoll
smkirk@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Novel drug candidates offer new route to controlling inflammation
2. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
3. Bacteria From Mouth Can Lead to Heart Inflammation: Study
4. Inflammation Might Play Role in Heart Disease: Study
5. New class of compounds stops disease-fueling inflammation in lab tests
6. The balancing act between protection and inflammation in MS
7. NIH grant targets inflammation in link between obesity and disease
8. UIC researchers discover how cells limit inflammation in lung injury
9. BUSM researchers find link between pulmonary inflammation, diesel exhaust, house dust
10. Major cause of chronic kidney disease-related inflammation is identified
11. Titanium Joint Debris May Trigger Painful Inflammation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... Hopkins University School of Medicine researchers have been awarded ... diabetes, Novo Nordisk announced this month. Of the 110 ... Obesity Biologics Science Forum Program, only four projects were ... researchers. They are Jonathan Powell, M.D., Ph.D.; G. William ... Jonathan Powell, a professor of oncology, will use his ...
(Date:4/18/2014)... Benaroya Research Institute at Virginia Mason (BRI) recently received ... in metastatic breast cancer reduces both the growth of ... scientists have found in models of the disease that ... 80 percent and can keep the tumor from metastasizing ... grant comes from the National Cancer Institute of the ...
(Date:4/18/2014)... 2014) ― A new study in the American ... health-related Google searches reveals a recurring pattern that could ... , Investigators from San Diego State University, the Santa ... analyzed "healthy" Google searches (searches that included the term ... in the U.S. from 2005 to 2012. They found ...
(Date:4/18/2014)... scientists could lead to potential new treatments for breaking ... , Fibrosis, or scarring, is a hallmark of ... lungs can lead to serious organ damage and, in ... options centers on findings made by Swati Bhattacharyya, PhD, ... that a specific protein plays in promoting fibrosis. ...
(Date:4/17/2014)... of chronic inflammation in non-cancerous prostate tissue may have ... than those with no inflammation, according to results of ... Hopkins Kimmel Cancer Center. , The link between persistent ... so-called high-grade prostate cancer those with a Gleason ... of the most aggressive and rapidly growing prostate cancers. ...
Breaking Medicine News(10 mins):Health News:Benaroya Research Institute evaluates immunology approach to blocking breast cancer 2Health News:New research shows people are thinking about their health early in the week 2Health News:New clues on tissue scarring in scleroderma 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3
... claiming that the she admitted to being an alcoholic. ... was made up and not written by her. ... Contactmusic quoted Allen, as saying. ,The Smile singer revealed ... was misinterpreted by someone and was spread wrongly. ,"I ...
... smoking rate has shown a decline, thanks to the comprehensive ... statistics in the 2006 report shows a decline in ... ,Over the past year, smoking decreased among men (from ... These large declines followed a year-long ad campaign aimed at ...
... detecting and measuring all known forms of hepatitis B ... patient therapy. ,Abbott and Celera, an Applera ... marking for a real-time PCR (polymerase chain reaction) test ... allowing the test to be marketed in the European ...
... Purdue university researchers has found a new modified drug for ... clinical trials. ,Millions of people suffer from ... Arun Ghosh, the Purdue professor who led the creation of ... could be the first disease-modifying therapy. It may be able ...
... Pennsylvania School of Medicine have identified proteins in the rod ... discovery of the genetic causes of a host of ... understanding of what goes wrong at the most basic level ... ,Specifically, they have identified and measured the types and ...
... study, published in The American Journal of Gastroenterology, indicates ... and 304 patients has confirmed that polyethylene (PEG) ... even elderly patients can use the drug safely for ... few data were available regarding the long term treatment ...
Cached Medicine News:Health News:New York Records Decline in Smoking Rate 2Health News:Abbott's RealTime Hepatitis B Viral Load Test Receives CE Marking in Europe 2Health News:Abbott's RealTime Hepatitis B Viral Load Test Receives CE Marking in Europe 3Health News:Modified Drug Therapy for Alzheimers Disease 2Health News:Genetic Cause of Inherited Eye Diseases Identified 2
(Date:1/14/2014)... , a manufacturer of ergonomically designed laboratory equipment for ... Japan to sell and service the Hitachi ... will utilize its network of sales professionals throughout the ... offer assistance in application use, product benefits and features, options and ...
(Date:1/14/2014)... 2014   Oligomerix, Inc. , a privately held company ... disease (AD) and related neurodegenerative disorders, announced today the ... NY as of January 15, 2014 and ... York Medical College. Oligomerix, which is focused ...
(Date:1/14/2014)... 2014   Evidera , a leading provider of evidence-based ... for Drug Evaluation and Research (CDER), U.S. Food and ... document for a patient-reported outcome (PRO) measure in drug ... Tool [EXACT] for Measurement of Symptoms of Acute Bacterial ...
Breaking Medicine Technology:NuAire announces sales and service of Hitachi Koki centrifuges in North America 2Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2Evidera Announces Release of FDA Draft Guidance on Use of the "EXACT" to Measure Symptoms of COPD Exacerbations 2Evidera Announces Release of FDA Draft Guidance on Use of the "EXACT" to Measure Symptoms of COPD Exacerbations 3Evidera Announces Release of FDA Draft Guidance on Use of the "EXACT" to Measure Symptoms of COPD Exacerbations 4
... Feb. 9, 2011 Telik, Inc. (Nasdaq: TELK ... will provide a corporate overview at the 13th Annual BIO ... February 15 at 3:00 p.m. Eastern time (12:00 p.m. Pacific ... archived webcast of the presentation will be available on the ...
... With its governmental markets still depressed, Allied Healthcare Products (Nasdaq: ... of fiscal year 2011 and improvement in its year-over-year performance. ... $117,000, or 1 cent per basic and diluted share, compared to ... For the first two quarters of the fiscal year, net income ...
Cached Medicine Technology:Allied Healthcare Products Reports Modest Profit for Quarter 2Allied Healthcare Products Reports Modest Profit for Quarter 3Allied Healthcare Products Reports Modest Profit for Quarter 4
For the quantitative determination of total cholesterol in serum....
Intended for the quantitative determination of total cholesterol in serum. Reaction: Endpoint. Reaction complete within five minutes. Wavelength: 500 nm. Linearity: 700 mg/dL (18.1 mmol/L). Single st...
... determination of Cholesterol in serum. ... 520 nm. Linearity: 500 mg/dl. ... simple 1:25 dilution and is ... 2-8 C. Liquid kit stability: ...
This 16-bit integrated and cooled system is a completely self contained unit built with a long list of standard features including all-electronic-variable transilluminator and EPI lighting....
Medicine Products: