Navigation Links
New inflammation hormone link may pave way to study new drugs for Type 2 diabetes
Date:5/15/2012

A new link between obesity and type 2 diabetes found in mice could open the door to exploring new potential drug treatments for diabetes, University of Michigan Health System research has found.

Drugs for type 2 diabetes commonly target insulin, which lowers blood glucose levels. But the U-M study suggests that glucagon a pancreas-produced hormone that has the opposite effect of insulin by raising blood glucose levels may also provide a powerful pathway to preventing and treating the increasingly prevalent disease.

Findings of the study were published this week ahead of print in Nature Medicine.

"Reducing sugar levels is the biggest goal for people with type 2 diabetes," says senior author Liangyou Rui, Ph.D., associate professor in the Department of Molecular and Integrative Physiology at the U-M Medical School. "We've mostly focused on controlling insulin production and action to treat diabetes but there has been very little study on the opposite hormone glucagon.

"Our study shows for the first time that obesity also affects glucagon action and that this hormone also contributes to high glucose levels found in type 2 diabetes."

Authors identified the NIK/NF-B2 pathway, which promotes glucagon responses in obesity. NIK was abnormally activated in mice with dietary or genetic obesity and the inhibition of liver NIK was found to cure diabetes in obese mice.

Insulin resistance which reduces the body's ability to decrease blood glucose has been the main hallmark of type 2 diabetes, which is the most common form of diabetes in the United States afflicting millions of Americans.

"There is a common theory that inflammation in liver and fat tissue associated with obesity causes insulin resistance and that leads to the biggest problem for type 2 diabetes: high blood glucose levels," Rui says.

"But blood glucose is also controlled by this other hormone glucagon, which signals to the liver to produce glucose. Inflammation may enhance the ability of glucagon to increase blood sugar.

"Obesity is a growing problem worldwide, leading to more cases of type 2 diabetes," Rui adds. "We hope to offer more data that can help expand options to treat this rampant disease."


'/>"/>

Contact: Shantell M. Kirkendoll
smkirk@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Novel drug candidates offer new route to controlling inflammation
2. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
3. Bacteria From Mouth Can Lead to Heart Inflammation: Study
4. Inflammation Might Play Role in Heart Disease: Study
5. New class of compounds stops disease-fueling inflammation in lab tests
6. The balancing act between protection and inflammation in MS
7. NIH grant targets inflammation in link between obesity and disease
8. UIC researchers discover how cells limit inflammation in lung injury
9. BUSM researchers find link between pulmonary inflammation, diesel exhaust, house dust
10. Major cause of chronic kidney disease-related inflammation is identified
11. Titanium Joint Debris May Trigger Painful Inflammation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/14/2019)... ... November 14, 2019 , ... EMulate Therapeutics, ... serious diseases, announced it will have 5 poster presentations related to its medical ... Society for Neuro-Oncology SNO Meeting in Phoenix, beginning on November 20 . ...
(Date:11/12/2019)... Ind. (PRWEB) , ... November 12, 2019 , ... ... a select group of individuals/organizations who have truly impacted those diagnosed with infertility. ... received RESOLVE’s prestigious Hope Award for Achievement, presented at the Night of Hope ...
(Date:11/12/2019)... ... November 12, 2019 , ... Raintree Rehab, a division ... therapy and rehabilitation operators throughout the United States and Physitrack, an Apple Mobility ... today announces a joint venture to develop and market clinical outcomes data solutions. ...
(Date:11/11/2019)... NEW COLUMBIA, Pa. (PRWEB) , ... November 11, ... ... thermal processing equipment, announced the shipment of two (2) Gruenberg Depyrogenation Sterilizers ... equipment. , These pharmaceutical sterilizers have maximum temperature ratings of 280°C with work ...
(Date:11/11/2019)... ... 2019 , ... PracticeLink Live! Atlanta Physician Career Fair will take place Thursday, ... p.m. and continue until 8:00 p.m. A free, optional seminar for job-seeking physicians, residents ... p.m. , Both the career fair and seminar are open to residents and fellows, ...
Breaking Medicine News(10 mins):
(Date:11/11/2019)... ... 11, 2019 , ... Windsor Care Centers (Windsor) across California ... The Society of Corporate Compliance and Ethics & Health Care Compliance Association (SCCE ... 3 through 9, 2019. This is the third year Windsor participated. , Corporate ...
(Date:11/11/2019)... (PRWEB) , ... November 11, 2019 , ... Over 60 ... new telehealth service in place. The program is designed to provide virtual mental health ... 5 storm that struck the region in October of 2018 [1]. , “This initiative ...
(Date:11/11/2019)... ... November 11, 2019 , ... ... coordination and implementation of joint projects for the benefit of biomedical professionals ... empower biomedical professionals to leverage their roles in the research, development, and ...
Breaking Medicine Technology: