Navigation Links
New inflammation hormone link may pave way to study new drugs for Type 2 diabetes
Date:5/15/2012

A new link between obesity and type 2 diabetes found in mice could open the door to exploring new potential drug treatments for diabetes, University of Michigan Health System research has found.

Drugs for type 2 diabetes commonly target insulin, which lowers blood glucose levels. But the U-M study suggests that glucagon a pancreas-produced hormone that has the opposite effect of insulin by raising blood glucose levels may also provide a powerful pathway to preventing and treating the increasingly prevalent disease.

Findings of the study were published this week ahead of print in Nature Medicine.

"Reducing sugar levels is the biggest goal for people with type 2 diabetes," says senior author Liangyou Rui, Ph.D., associate professor in the Department of Molecular and Integrative Physiology at the U-M Medical School. "We've mostly focused on controlling insulin production and action to treat diabetes but there has been very little study on the opposite hormone glucagon.

"Our study shows for the first time that obesity also affects glucagon action and that this hormone also contributes to high glucose levels found in type 2 diabetes."

Authors identified the NIK/NF-B2 pathway, which promotes glucagon responses in obesity. NIK was abnormally activated in mice with dietary or genetic obesity and the inhibition of liver NIK was found to cure diabetes in obese mice.

Insulin resistance which reduces the body's ability to decrease blood glucose has been the main hallmark of type 2 diabetes, which is the most common form of diabetes in the United States afflicting millions of Americans.

"There is a common theory that inflammation in liver and fat tissue associated with obesity causes insulin resistance and that leads to the biggest problem for type 2 diabetes: high blood glucose levels," Rui says.

"But blood glucose is also controlled by this other hormone glucagon, which signals to the liver to produce glucose. Inflammation may enhance the ability of glucagon to increase blood sugar.

"Obesity is a growing problem worldwide, leading to more cases of type 2 diabetes," Rui adds. "We hope to offer more data that can help expand options to treat this rampant disease."


'/>"/>

Contact: Shantell M. Kirkendoll
smkirk@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Novel drug candidates offer new route to controlling inflammation
2. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
3. Bacteria From Mouth Can Lead to Heart Inflammation: Study
4. Inflammation Might Play Role in Heart Disease: Study
5. New class of compounds stops disease-fueling inflammation in lab tests
6. The balancing act between protection and inflammation in MS
7. NIH grant targets inflammation in link between obesity and disease
8. UIC researchers discover how cells limit inflammation in lung injury
9. BUSM researchers find link between pulmonary inflammation, diesel exhaust, house dust
10. Major cause of chronic kidney disease-related inflammation is identified
11. Titanium Joint Debris May Trigger Painful Inflammation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2017)... PA (PRWEB) , ... May 21, 2017 , ... Following ... 2012, New York became the first state to require that hospitals follow a protocol ... controversy in the medical community as to whether such steps would have saved Rory ...
(Date:5/19/2017)... ... 19, 2017 , ... DMG Productions is proud to announce ... Ed Begley, Jr., airing fourth quarter 2017 on FOX Business. , Based in ... supplement made from naturally occurring ingredients. Innovations will enlighten viewers on RawTrition’s all-in-one ...
(Date:5/19/2017)... ... May 19, 2017 , ... The Miller Agency, ... to families and business owners in the region, is embarking on a cooperative ... and their families. , Multiple sclerosis (MS) is a demyelinating disease that affects ...
(Date:5/19/2017)... ... May 18, 2017 , ... ML Billing, 2016 ... specialties and sizes and specializes in large group practices, is pleased to announce their ... it has also set the standard in all aspects of full-service medical billing. This ...
(Date:5/18/2017)... ... 18, 2017 , ... Dr. Kim Ross supports Stroke Awareness Month by now ... link between this condition and serious systemic health conditions including heart disease and stroke. ... in Annapolis, MD, and seeking treatment with Dr. Ross immediately may prevent bacteria from ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... 2017  A new tight-tolerance microextrusion medical tubing ... materials, is being launched by Natvar, a Tekni-Plex ... in recent years to service a wide variety ... More expensive materials such as glass and fluoropolymers ... to their ability to consistently hold tolerances. This ...
(Date:5/3/2017)... Calif. , May 3, 2017 ... of any hospital or healthcare facility. Commonly referred ... room is equipped with diagnostic imaging technology to ... of the heart. In these spaces, a team ... catheterization, balloon angioplasty, percutaneous coronary intervention, congenital heart ...
(Date:5/3/2017)... , May 3, 2017  Getinge, a ... contribute to quality enhancement and cost efficiency within ... a study of contemporary practice demonstrating that intra-aortic ... therapy for critically ill patients. The single-center, retrospective, ... newer large volume MEGA ® 50cc intra-aortic ...
Breaking Medicine Technology: