Navigation Links
New induced stem cells may unmask cancer at earliest stage
Date:2/3/2011

ogramming of marrow cells from a patient with chronic myeloid leukemia, a cancer of the blood that kills about 1,500 people a year in the United States. The disease, like all leukemias, starts in the cells that produce white blood cells in bone marrow.

According to Slukvin, the induced stem cells generated from the diseased tissue retain the exact same complex of genetic abnormalities found in the mature cancer cells. That means that when the induced cells are turned back into blood, scientists could, in theory, watch cancer develop from scratch as cells bearing cancer mutations become cancer stem cells.

"When we differentiate induced stem cells back to blood, we can identify the stages when the abnormality that leads to cancer manifests itself," Slukvin explains.

The ability to pinpoint the very earliest stages of cancer is a major focus of biomedical science.

"This is very important for developing new leukemia drugs," says Slukvin. "A major focus of leukemia research is to find ways to try and eliminate the most immature leukemia cells - cancer stem cells."

The work by Slukvin and his team may represent the first step in a new understanding of the cascade of events that results in blood diseases such as leukemia.

Employing the reprogramming technique developed by Thomson and his colleagues, Slukvin emphasizes, is important because it eliminates the exotic reprogramming genes, some of which are cancer-related genes, from the induced stem cell equation. In the case of chronic myeloid leukemia and other blood diseases, obtaining stem cells that do not have the genetic reprogramming factors is very important.

"When you use viruses (to ferry genes into a cell) you have chromosomal integration," the Wisconsin researcher notes. "Some of the reprogramming factors are oncogenes and would interfere with a study of chronic myeloid leukemia" whose abnormalities are also encoded on the chromosome.


'/>"/>

Contact: Igor Slukvin
islukvin@wisc.edu
608-263-0058
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related medicine news :

1. iSAEC and HMORN to use electronic medical records to research genetics of drug-induced SAEs
2. Johns Hopkins researchers develop safer way to make induced pluripotent stem cells
3. Which comes first: Exercise-induced asthma or obesity?
4. Haptoglobin as an early serum biomarker of virus-induced type 1 diabetes in rats
5. Sun-induced skin cancer: new discovery permits doctors to assess genetic risk
6. Millions Are Losing Their Hearing Unnecessarily; Noise-Induced Hearing Loss Is Always Preventable, Says HearUSA Audiologist
7. Trauma-induced changes to genes may lead to PTSD
8. Combination antibiotics effective against chlamydia-induced arthritis
9. Octreotide acetate does not prevent treatment-induced diarrhea in anorectal cancer
10. Free Seminars to Help Employers Prevent Noise-Induced Hearing Loss Among Workers Set for Phoenix, Reno, Salt Lake City, Denver in May
11. Treatment of portal hypertensive pulmonary lesions induced by schistosomiasis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... ... July 07, 2015 , ... sweetFrog Enterprises, LLC has announced the opening of its newest ... open in the Buckeye State. The premium frozen yogurt chain was listed as #22 ... is located at 3259 Maple Avenue, Zanesville, OH 43701. , “We are thrilled to ...
(Date:7/7/2015)... SACRAMENTO, Calif. (PRWEB) , ... July 07, 2015 ... ... telemedicine intervention against pediatric obesity to better understand what worked (or didn’t) and ... clinics that participated in the Healthy Eating Active Living TeleHealth Community of Practice ...
(Date:7/7/2015)... ... ... Today, the physicians at Allied Anesthesia, who provide services to Children’s Hospital of ... a series of tips to help children stay safe over the summer months. , ... unsupervised time outdoors. , The most common causes of injuries and death for ...
(Date:7/7/2015)... NY (PRWEB) , ... July 07, 2015 , ... ... in Brazil has made a mark on the cosmetic surgery industry with ... and patient satisfaction. , The VisitandCare.com partnered medical provider is committed to patient ...
(Date:7/7/2015)... (PRWEB) , ... July 07, ... ... Refining convenience stores throughout the Southwest, including Giant, Mustang, Sun Dial and ... mobile program, surpassing their original 2015 fundraising goal by nearly $100,000, to ...
Breaking Medicine News(10 mins):Health News:sweetFrog Grows in Ohio with New Store Opening 2Health News:UC Davis Study Identifies Tools, Strategies for Enhancing Obesity Prevention in Rural Communities 2Health News:UC Davis Study Identifies Tools, Strategies for Enhancing Obesity Prevention in Rural Communities 3Health News:Allied Anesthesia Physicians Release Summertime Safety Tips 2Health News:Allied Anesthesia Physicians Release Summertime Safety Tips 3Health News:Top Plastic Surgery Provider in Brazil Joins VisitandCare.com 2Health News:Top Plastic Surgery Provider in Brazil Joins VisitandCare.com 3Health News:Western Refining Raises $524,286 to Help Send Kids with Neuromuscular Disease to MDA Summer Camp 2Health News:Western Refining Raises $524,286 to Help Send Kids with Neuromuscular Disease to MDA Summer Camp 3
... CAIn stark contrast to normal cells, which only divide a ... state of growth arrest or simply die, cancer cells never ... Biological Studies have uncovered an important clue to one of ... in the April 22, 2011 issue of Molecular Cell ...
... -- Long-term use of topical corticosteroids to treat children with ... negative side effects, according to a new study. Many ... lotions applied to the skin and this can lead to ... common fear among parents is that these ointments -- which ...
... 21 (HealthDay News) -- Smoking bans in workplaces, restaurants and ... half the states, and all such venues across the country ... Indoor areas of worksites, restaurants and bars are major sources ... and older are still exposed to it each year, ...
... palpitations and anxiety due to side effects of the ... prostate cancer, according to a study published in the ... OncologyBiologyPhysics , an official journal of the American Society ... for men with metastatic prostate cancer are either surgery ...
... dead, the rare but fatal condition called "sudden death ... mystery to scientists, some young athletes especially young ... With over-exertion, their hearts stop pumping, leading to sudden ... syndrome has been prohibitively expensive. But cardiologist Dr. Sami ...
... WEDNESDAY, April 20 (HealthDay News) -- Young children who spend ... narrower eye arteries than kids who are more physically active, ... of future cardiovascular risk, and the narrower the vessels, the ... retinal vessels give a good idea of what is going ...
Cached Medicine News:Health News:A new ending to an old 'tail' 2Health News:A new ending to an old 'tail' 3Health News:Corticosteroid Creams Safe for Kids With Eczema: Study 2Health News:Smoke-Free Laws Moving Ahead in U.S. 2Health News:Acupuncture relieves hot flashes from prostate cancer treatment 2Health News:Standing up for athletes at risk 2Health News:Couch-Potato Kids: It Shows in Their Eyes, Researchers Say 2
(Date:7/7/2015)... -- Noting the need to step up federal scrutiny ... the rapidly consolidating pharmacy benefit manager (PBM) industry, the ... Ohio Governor John Kasich (R-OH) ... help pull back the curtain on PBM drug pricing ... Kasich for bringing badly-needed reform to secretive and opaque ...
(Date:7/7/2015)... July 7, 2015   Decision Resources Group ... in dialysis patient management in the U.S. versus ... by U.S. and EU5 nephrologists from approximately 1,870 ... are the most commonly used renal medications in ... differs considerably between the two regions.      ...
(Date:7/7/2015)... , July 7, 2015   InspireMD, Inc. ... a leader in embolic protection systems ("EPS"), today ... Protection System integrated with MicroNet ™ has ... Stent New Product Innovation Award.  Through active market ... analysts and consultants recognize the successful introduction of ...
Breaking Medicine Technology:National LTC Pharmacy Leader Praises Kasich Effort to Bring Transparency to PBM Drug Pricing 2National LTC Pharmacy Leader Praises Kasich Effort to Bring Transparency to PBM Drug Pricing 3Similarities And Differences Exist When Comparing U.S. Versus EU5 Dialysis Patient Management 2Similarities And Differences Exist When Comparing U.S. Versus EU5 Dialysis Patient Management 3InspireMD Receives Frost & Sullivan 2015 European Coronary Stent New Product Innovation Award 2InspireMD Receives Frost & Sullivan 2015 European Coronary Stent New Product Innovation Award 3InspireMD Receives Frost & Sullivan 2015 European Coronary Stent New Product Innovation Award 4InspireMD Receives Frost & Sullivan 2015 European Coronary Stent New Product Innovation Award 5
... 1, 2011 Reportlinker.com announces that a ... its catalogue: , The Outlook for ... http://www.reportlinker.com/p0559149/The-Outlook-for-Medical-Devices-in-North-East-Asia.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Managed_care ... Highly-detailed analysis providing comprehensive quarterly-updated reports for ...
... IntegriChain, Inc., a commercial insight provider supporting the ... the list of America,s Most Promising Companies. IntegriChain offers ... order forecasting, order monitoring, better manage their sales and ... over the past three years and plans on continuing ...
Cached Medicine Technology:The Outlook for Medical Devices in North East Asia 2The Outlook for Medical Devices in North East Asia 3The Outlook for Medical Devices in North East Asia 4The Outlook for Medical Devices in North East Asia 5Forbes Announces IntegriChain in Top 20 on List of America's Most Promising Companies 2
This set includes 2 small, 1 medium, 1 large gonad shields and a belt. The shields and belt is an interchangeable system attached by velcro....
Collars can be attach to any Pulse aprons....
... is necessary, the Two-Piece should be ... your comfort through more efficient distribution ... The vest comes with shoulder pads ... as well as an attached belt ...
... Our unique velcro design apron ... additional support and comfort. Shoulder ... velcro flaps aid in relieving ... comfortable fit is attained by ...
Medicine Products: