Navigation Links
New immunotherapy for malignant brain tumors
Date:11/25/2013

This news release is available in German.

Animal experiments show that it is relatively easy to treat cancer in the early stages. However, it is far more difficult to successfully treat advanced cancer. Treatment of brain tumors is particularly challenging because regulatory T-cells accumulate in brain tumors and suppress an immune attack.

In several steps using a new strategy and a novel drug, Burkhard Becher's team from the Institute of Experimental Immunology at the University of Zurich has now succeeded in doing exactly this in the case of glioblastoma, one of the most dangerous brain tumors. First step, they stimulated the body's own immune system in such a way that it recognised and then killed the brain tumor cells even in advanced stages of the disease.

The initial objective of their new study was to break through the tumor's protective shield. "We wanted to establish whether we can actually elicit an immune response to a tumor growing within the brain", explains Burkhard Becher. To this end, the team used the immune messenger substance, Interleukin-12. When Interleukin-12 is produced in the tumor, immune cells are stimulated locally in such a manner that the tumor is attacked and rejected. Once this procedure had worked well in the early stages of the tumor, the researchers waited in the next stage until the tumor was very large and the life expectancy of the untreated test animals was less than three weeks. "We only began treatment when it was, in fact, already too late", says the first author of the study Johannes vom Berg. The success rate was low, Berg adds. "We then injected biopharmaceutical Interleukin-12 into the large brain tumor. This did induce an immune response but only led to tumor rejection in one-quarter of the animals."

From
'/>"/>

Contact: Burkhard Becher, Ph.D.
becher@immunology.uzh.ch
41-446-353-703
University of Zurich
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Immunotherapy for elderly cancer patients finds new promise in drug combination
2. Antibodies reverse type 1 diabetes in new immunotherapy study
3. Moffitt researchers say effective immunotherapy for melanoma hinges on blocking suppressive factors
4. Sublingual immunotherapy shows promise as treatment for peanut allergy
5. Immunotherapy reduces allergic patients sensitivity to peanuts
6. 2-step immunotherapy attacks advanced ovarian cancer
7. Study by Allegheny General Hospital Physicians Shows Oral Immunotherapy is a Safe, Effective Alternative to Allergy Shots for Ragweed Sufferers
8. Researchers to develop next generation immunotherapy for children with deadly solid tumors
9. 2-step ovarian cancer immunotherapy made from patients own tumor shows promise
10. Cancer Research Institute Announces June Cancer Immunotherapy Awareness Month; 1-800-FLOWERS.COM® and The Fund for Park Avenue to Support and Promote Awareness
11. Researchers provide rationale for use of targeted immunotherapy in sarcomatoid lung carcinomas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... 23, 2014 A team of New York ... longer when preceded by surgery and delivered by an experienced ... new study. Click here to read it now . ... cases of mesothelioma patients who underwent hemithoracic (one ... dose to the shape of a tumor. Patients who ...
(Date:8/23/2014)... Board of Directors voted on Monday, August 18th to approve ... for commercial and industrial properties. This was accomplished with ... in Carmel, California. , This is a historical moment, ... the State of California has approved this technology for use ... can now be used as a sole source of water ...
(Date:8/23/2014)... TX (PRWEB) August 23, 2014 Youth ... of Texas. It’s no different in Houston, TX. Substance ... are falling victim to drug and alcohol dependency in ... are looking to beat substance abuse, but don’t know ... juvenile treatment facility can be a challenge because most ...
(Date:8/22/2014)... 23, 2014 The IT manager of ... hosting for several years. He has recently announced that ... hosting suppliers in 2014. , GoDaddy is a popular ... features and great hosting solutions at affordable rates. It ... for shared hosting plans depend on the length of ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 AWeber, ... services that currently helps more than 120,000 small ... caught the attention of Shane Michaels, prompting an investigative ... crucial element for any online marketing campaign, despite what ... in the marketing world,” reports Michaels. “AWeber is a ...
Breaking Medicine News(10 mins):Health News:New Study Links Hospital Experience and Prior Surgery with Mesothelioma Radiation Success, According to Surviving Mesothelioma 2Health News:Historical Moment in the Monterey Peninsula, Brings Drought Relief Solution to California, with the Help of EcoloBlue and AWG Technology 2Health News:New Houston Hotline Assisting Juveniles in Locating Dependable Rehabilitation Help 2Health News:AWeber: Review Exposes Affordable Provider of Opt-In Email Marketing Services 2
... Mass., Nov. 25 Gene Network Sciences, Inc.,(GNS) ... company, Fina,Technologies, Inc. (Fina) to leverage its proprietary ... new arena -- that of,quantitative financial trading and ... raw clinical and genomics data to identify drug,targets, ...
... Season , , ROSELAND, N.J., ... during the busy holiday season. Unfortunately many get drawn into buying ... At airports, it,s easy to wind up eating unhealthy foods ... a rush or have time to spend before a flight, you ...
... Pharmaceuticals, Inc.,(Nasdaq: ARNA ) announced today that the ... Health Care Conference on December 3, 2008 at 2:30,p.m. Eastern ... Hotel in,New York City. Jack Lief, Arena,s President and Chief ... including its clinical,development and discovery programs. , ...
... /PRNewswire-FirstCall/ - Nuvo Research Inc. (TSX: NRI), a Canadian ... of drug products delivered to and through the skin, ... and development subsidiary, has signed a research and development ... develops and markets skin care products. Financial details of ...
... 25 Hillenbrand, Inc.,(NYSE: HI ) -- ... United States,District Court in the Southern District of Texas ... denied in,two previously disclosed antitrust lawsuits against Batesville Casket ... As previously reported, a purported consumer ...
... WELLINGTON, Fla., Nov. 25 The Quantum Group,Inc. ... solutions provider for,the healthcare industry, announced today that ... approval and a Certificate,of Authority from the State ... RASI has been established to provide administrative ...
Cached Medicine News:Health News:Gene Network Sciences Announces Creation of Spin-off Entity Focused on Quantitative Finance and E-Commerce 2Health News:Gene Network Sciences Announces Creation of Spin-off Entity Focused on Quantitative Finance and E-Commerce 3Health News:Nutritionist Claudia Gonzalez Shares Tips for Eating Well On-the-Go During the Busy Holiday Rush 2Health News:Arena Pharmaceuticals to Present at the Piper Jaffray 20th Annual Health Care Conference 2Health News:Arena Pharmaceuticals to Present at the Piper Jaffray 20th Annual Health Care Conference 3Health News:Nuvo Research subsidiary signs collaboration agreement with Fortune Global 500 company 2Health News:Nuvo Research subsidiary signs collaboration agreement with Fortune Global 500 company 3Health News:Magistrate Judge Recommends Denial of Class Certification in Funeral Industry Antitrust Litigation 2Health News:The Quantum Group Announces State Approval of TPA Application for Subsidiary Company Renaissance Administrative Solutions, Inc. 2Health News:The Quantum Group Announces State Approval of TPA Application for Subsidiary Company Renaissance Administrative Solutions, Inc. 3Health News:The Quantum Group Announces State Approval of TPA Application for Subsidiary Company Renaissance Administrative Solutions, Inc. 4
(Date:8/21/2014)... 2014  Aptuit LLC announces that Aptuit SSCI, ... , has enhanced its capabilities in the areas ... large molecules, including biologic drugs, metabolites, and polymers, ... mass spectrometer. In making the announcement, ... "The expanded large molecule capability enhances our early ...
(Date:8/21/2014)... Aug. 21, 2014  Vermillion, Inc. (NASDAQ: ... cancers and women,s health, has appointed Holly B. ... Markets. Ms. Bauzon has a proven track ... coverage for laboratory services companies. She has more than ... Inc., where she held the position of Director, Lab ...
(Date:8/21/2014)... 21, 2014  eRelevance Corporation ( www.erelevancecorp.com ), ... that it has completed integration with Nextech, a ... Surgery and Dermatology practices. "Integration allows ... healthcare practices using Nextech," stated Bob Fabbio ... information from the EMR we are able to ...
Breaking Medicine Technology:Aptuit SSCI Adds Ultra High Resolution Q-TOF Mass Spectrometer for Large & Small Molecule Analyses 2Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2eRelevance Corporation Integrates with Nextech Electronic Medical Records 2
... , FORT COLLINS, Colo., Dec. 14 Manchester Pharmaceuticals, ... (chenodiol tablets). On October 22, 2009, the US ... therapy for patients suffering from gallstones in whom surgery ... advanced age. , Chenodal prescriptions have started to be ...
... 14 Oxygen Biotherapeutics, Inc. (OTC Bulletin Board: OXBT) today ... the addition of Lt. Gen. Ronald R. Blanck, DO, U.S. ... Associates, a federal health services consulting firm based in Falls ... nine members. , Dr. Blanck began his military career in ...
Cached Medicine Technology:Manchester Announces Availability of Chenodal(TM) 2Oxygen Biotherapeutics, Inc. Expands Board of Directors 2
Katena ophthalmic burr for polishing pterygiums, includes one round diamond burr and has an storage case....
Illuminated Trial Lens Set is an attractive set of trial lenses worked to a high standard of accuracy....
Trial Lens Sets....
... is the first ... to offer two kinds ... and taurine. Cleans, rinses, ... and conditions any soft ...
Medicine Products: