Navigation Links
New imaging technique captures brain activity in patients with chronic low back pain
Date:7/27/2011

Boston, MA Research from Brigham and Women's Hospital (BWH) uses a new imaging technique, arterial spin labeling, to show the areas of the brain that are activated when patients with low back pain have a worsening of their usual, chronic pain. This research is published in the August issue of the journal Anesthesiology.

"This study is a first step towards providing tools to objectively describe someone's chronic pain which is a subjective experience. We've found that when a patient has worsening of their usual pain, there are changes in the activity of the brain," said Ajay Wasan, MD, MSc, lead author of the paper and a researcher in the Pain Management Center at BWH. "These changes occur in the network of areas in the brain that process pain and mood."

Researchers compared 16 patients with chronic low back pain (CLBP) to 16 healthy subjects. Participants underwent three imaging sessions. The first was for a characterization and training session. During the second session, researchers used clinical maneuvers, such as pelvic tilting or straight leg raising , to temporarily exacerbate back pain. In the third session, heat was applied to the skin at an intensity that matched the pain levels during the second session. Patients rated their pain levels before and after the sessions and after each stimulation during the sessions.

During the last two sessions, researchers used the arterial spin labeling technique, which allows them to quantify the blood flow to specific regions of the brain over time. The amount of blood flow is indicative of neuron activity in that region of the brain. They found that there was increased activity in the brain of CLBP patients only when they experienced a worsening of their chronic pain and not during the heat pain session or in the healthy participants. Researchers also note that some of the areas of the brain that were activated when participants experienced a worsening of chronic pain have been shown to be associated with other types of pain found in other studies. However, researchers also observed activation of some areas, including the superior parietal lobule, which have been less frequently associated with pain in previous research.

"While this study begins to uncover some of the basic physiology of the brain as it processes pain, more studies are needed to help us understand how the brain function may change over the course of treatment of pain and to examine the brain mechanisms by which pain improves," Wasan said. "We are getting closer to describing, on an objective level, how the body and brain are reacting when a patient reports having more pain. We are hopeful that this could lead to an understanding of an individual patient's neurocircuitry and that knowledge could lead to therapies that would be tailored to the individual."


'/>"/>

Contact: Lori J. Shanks
ljshanks@partners.org
617-534-1604
Brigham and Women's Hospital
Source:Eurekalert

Related medicine news :

1. Neuroimaging study may pave way for effective Alzheimers treatments
2. SNMs Conjoint Mid-Winter Meetings continue to advance molecular imaging
3. Medical Imaging Northwest Completes Phase I of Its Healthcare IT Integration to Maintain Patient Care Improvements
4. Less is more in cancer imaging
5. Imaging manufacturers: Plan to reduce unnecessary radiation exposure and medical errors
6. National Council on Aging Releases Survey on Medical Imaging Safety
7. Artists, Product Designers, Printing Gurus, Game Developers, Manufacturing Engineers Will Converge at RAPID 2010/3D IMAGING Conference/Expo, May 18-20 in LA
8. Promega - TOP srl Agreement Enables Live Animal Imaging for Cancer Studies
9. Imaging fat layer around heart can help predict disease
10. ModiFace Launches VuMe in Southern Florida – the World's First Full-Featured Touch-Screen Cosmetic Surgery Imaging System
11. Midroog Ltd., an Affiliate of Moodys Investors Services, Rates Potential new Debt of Elbit Imaging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the Law ... organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our ... a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... , ... Ellevate Network, the leading network for professional women, brought together some ... at their inaugural Summit in New York City in June. The event was livestreamed ... over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) will ... during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual ... F. Collen, a pioneer in the field of medical informatics, this prestigious award is ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 Diplomat Pharmacy, Inc. ... Day Software and Consulting, LLC , and named its ... Software, based in Tennessee , will ... Day expands EnvoyHealth,s service offerings for health care partners ... "In an interoperable world, ...
(Date:9/28/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will host its ... on Friday, November 3, 2017, beginning at 7:00 a.m. ... 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... and guidance for 2018, Hill-Rom executives will also highlight ... and long-range financial outlook through 2020. ...
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
Breaking Medicine Technology: