Navigation Links
New hypothesis explains why drugs increase risk of heart attacks and strokes
Date:2/23/2011

CLEVELAND February 21, 2011 New research shows that medications which have raised safety concerns over heart attack and stroke risks may not have gotten approval from the Food and Drug Administration (FDA) if the cardiovascular effects of fluid retention had been better understood. Fluid retention may explain the increased risk of heart attacks and strokes of medications such as Vioxx, Bextra, and Avandia.

The research published in Clinical Hemorheology and Microcirculation (IOS Press, ISSN 1386-0291), calculates the effects of fluid retention upon the velocity of blood flow and the turbulence of flowing blood. These calculations demonstrate that fluid retention increases the risk of heart attacks and strokes. Since numerous medications cause fluid retention, the paper's findings have implications to ensure drugs on the market are safe. The pain medications Vioxx and Bextra, and the anti-diabetic medication Avandia, cause fluid retention. Vioxx and Bextra, known as cyclo-oxygenase-2 (COX-2) inhibitors, were withdrawn from the market because of safety concerns over heart attacks and strokes, and Avandia has been suspected in some reports of increasing the risk of heart attacks.

The paper's author, Robert P. Blankfield, MD, MS, clinical professor of family medicine at Case Western Reserve University School of Medicine, and a member of the Department of Family Medicine at University Hospitals Case Medical Center, used several basic cardiovascular and hydraulic equations to demonstrate that fluid retention is detrimental for the cardiovascular system.

Fluid retention increases the likelihood that blood will flow in a turbulent manner. Turbulent blood flow accelerates atherosclerosis (hardening of the arteries), thereby increasing the risk of heart attacks and strokes. Many medications cause fluid retention, which raises blood pressure in some, but not all, individuals. Physicians worry about fluid retention if it does raise blood pressure
'/>"/>

Contact: Jessica Studeny
Jessica.studeny@case.edu
216-368-4692
IOS Press
Source:Eurekalert

0

GOOD

Page: 1 2 3 4

Related medicine news :

1. The protective brain hypothesis is confirmed
2. New studies question vascular multiple sclerosis hypothesis and treatment
3. Personal Injury Attorney David Perecman Explains the Possible Legal Consequences of Fatal 911 Operator Error in New York
4. Feedback loop explains inflammatory effect on intestinal lining
5. Book explains how focus on strengths, not failures, helps teens succeed in school
6. PCI Compliance and Data Security Requires Private Key Management – New Industry White Paper Explains
7. Drug Rehab Treatment Center Explains Rehabilitation Program Using YouTube
8. New E-Book Explains the Facts About Dental Implants
9. Brain Cell Study Explains Eureka Moment
10. Texas A&M researcher explains how embryo fights retroviral infection
11. The private sale of drugs in public hospitals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Nashville, TN (PRWEB) May 23, 2013 ... to enhance nurse understanding of the professional role and ... , Roland Joy, vice president of patient care services ... explains, "TAMC nurses are excellent clinicians, and we want ... profession, teach them that to lead they must follow, ...
(Date:5/23/2013)... Portland, Oregon (PRWEB) May 23, 2013 Better ... touches as it prepares to launch its one of ... Final training of management staff will be completed May 29th, ... Chris and Heather Richardson completed on site training in Portland ... the 29th to complete operational training. , "It really is ...
(Date:5/23/2013)... PhD Box has introduced a service ... research process by offering assistance for Thesis Proposals. The proposal ... services that the company provides for research consultation in various ... proposal writing service is that this is the stage where ... process find it difficult to draft a proposal as it ...
(Date:5/23/2013)... Sunnyvale, CA (PRWEB) May 23, 2013 Footwear ... Dansko Vista Collection of sandals containing cork footbeds. ... Dansko has had consistently good sales for many years, and ... this spring and summer. , Dansko Shoes ... and the Vista Collection is no exception. Containing leather and ...
(Date:5/23/2013)... 23, 2013 Following the recent outbreak ... internet users, the security team at idcloak Technologies has ... against this or any web-born malware. Gill-Chris Welles ... provides far better privacy and security than ... that even the best AV software cannot be depended ...
Breaking Medicine News(10 mins):Health News:OnSomble, Inc. Partners with The Aroostook Medical Center to Enhance Nurse Understanding of the Professional Role 2Health News:Better Life Maids of Portland Oregon Prepares For a Summer of 2013 Launch 2Health News:PhD Box Unveils Proposal Writing Services for Research Scholars 2Health News:Footwear etc. Announces the New Collection of Dansko Cork Sandals 2Health News:Effective virus protection without anti-virus software, identifies idcloak 2
... American Board of Internal Medicine,(ABIM) will offer ... SimSuite(R) technology, for credit toward,completion of Maintenance ... ABIM is,incorporating medical simulation technology into its ... replicates a real-life catheterization lab, and the,five ...
... clinical nomogram tool, the Sunnybrook Prostate Cancer Risk Calculator ... for prostate cancer is available online to help ... their primary care physician. A nomogram is a ... risk factors using a table and chart format. , ...
... half a million women around the world, including an ... planning methods developed by Georgetown University Medical Centers Institute ... of others use CycleBeads a visual aid developed by ... plan or prevent pregnancy. , Now CycleBeads are ...
... joint study on The Burden of Rheumatoid Arthritis and ... School of Economics (Sweden), the University of Lund (Sweden) ... that the highest cost in rheumatoid arthritis results from ... the disease. The study has just been published ...
... Living Communities Provide Insight ... into Their 50+-year Relationships, MCLEAN, Va., Feb. 4 Sunrise ... senior living services with,more than 450 communities worldwide, shared the results ... years and spent more than,five decades of special Valentine,s Days together., ...
... The American Academy of,Pediatrics (AAP) and its 60,000 member ... Cancer Day initiative Monday, February 4,to promote smoke-free environments ... of tobacco smoke exposure," said Renee R.,Jenkins, MD, FAAP, ... way,to smoke around children. Smoking in another room is ...
Cached Medicine News:Health News:Medical Simulation Corporation and the American Board of Internal Medicine Introduce New Simulation for Physician Assessment and Evaluation 2Health News:Online tool supports more dialogue on prostate cancer risk 2Health News:CycleBeads help women manage their fertility 2Health News:Rheumatoid arthritis sends many into early retirement 2Health News:Secrets to Long-Lasting Marriages Revealed in Senior Survey 2Health News:Secrets to Long-Lasting Marriages Revealed in Senior Survey 3Health News:AAP Calls for Smoke-Free Environments for World Cancer Day 2
(Date:5/22/2013)... , May 22, 2013 Advanced Prenatal ... medical device that will help alleviate the high blood ... apheresis cartridge is expected to be the first medical ... of maternal and fetal death. Every year, ... the United States . It is characterized by ...
(Date:5/22/2013)... 2013 Attorney Advertising -- Bronstein, Gewirtz & ... of purchasers of the securities of AMAG Pharmaceuticals, ... The investigation focuses on whether the Company and ... On May 22, 2013, Shares of AMAG dropped ... company announced in regulatory filing that it has ...
(Date:5/22/2013)... WHITE PLAINS, N.Y. , May 22, 2013 /PRNewswire/ ... $6 million to Valor Biotherapeutics, LLC, a ... completion of pre-clinical development, manufacturing, and a Phase I ... change the poor outcomes faced by many patients with ... with rituximab. Valor,s protein, IGN002, is ...
Breaking Medicine Technology:Advanced Prenatal Therapeutics - Using Targeted Apheresis to Treat Preeclampsia 2Bronstein, Gewirtz & Grossman, LLC Announces Investigation of AMAG Pharmaceuticals, Inc. 2The Leukemia & Lymphoma Society, Valor Biotherapeutics and ImmunGene Create Partnership to Advance Novel Therapy for Non-Hodgkin Lymphoma Patients 2The Leukemia & Lymphoma Society, Valor Biotherapeutics and ImmunGene Create Partnership to Advance Novel Therapy for Non-Hodgkin Lymphoma Patients 3The Leukemia & Lymphoma Society, Valor Biotherapeutics and ImmunGene Create Partnership to Advance Novel Therapy for Non-Hodgkin Lymphoma Patients 4
... Stop Aging Now has been selected ... one of America,s fastest-growing private companies. Stop Aging ... sells high-quality anti-aging vitamins and supplements. (Logo: ... Stop Aging Now was placed ...
... ZMH ; SIX: ZMH), a global leader in musculoskeletal care, ... Natural Nail Cephalomedullary Nail in the United States since ... Natural Nail system features an innovative design focused on restoring ... Nail Cephalomedullary Nail is designed to help address fractures of ...
Cached Medicine Technology:Stop Aging Now Named to Prestigious Inc. 5000 List 2Zimmer® Announces 1000th Implantation of Its Natural Nail™ Cephalomedullary Nail 2Zimmer® Announces 1000th Implantation of Its Natural Nail™ Cephalomedullary Nail 3
Effective adhesive, may be removed from plate without residue Easy to pierce, without pipette tip becoming tacky...
... A soft, heat-resistant, aluminum foil film ... AlumaSeal II minimizes evaportaion and vapor ... need for heat-sealing devices or mats. ... sovents and reagents. Compared to other ...
Aluminium tape featuring 3M adhesive technology. Enhanced heat transfer. Easy to pierce with a metal probe or a plastic pipette. Needles may clog with adhesive over time....
Inquire...
Medicine Products: