Navigation Links
New human reproductive hormone could lead to novel contraceptives
Date:12/22/2009

Nearly 10 years after the discovery that birds make a hormone that suppresses reproduction, University of California, Berkeley, neuroscientists have established that humans make it too, opening the door to development of a new class of contraceptive and possible treatments for cancer or other diseases.

The hormone, gonadotropin inhibitory hormone (GnIH), has the opposite effect from gonadotropin releasing hormone, a key reproductive hormone. While GnRH triggers a cascade of hormones that prime the body for sex and procreation, GnIH puts a brake on the cascade.

"Identifying the inhibitory hormone in humans forces us to revise our understanding of the control mechanism of human reproduction," said first author Takayoshi Ubuka, a post-doctoral fellow in the UC Berkeley Department of Integrative Biology and in the Helen Wills Neuroscience Institute. "We hope this will stimulate clinical studies on people with precocious puberty or in the area of contraception."

Because reproductive hormones often promote the growth of cancer cells, GnIH might also work as an anti-cancer agent.

"Frequently, treatment of hormone-responsive cancers involves GnRH antagonists or very, very high doses of GnRH, which cause side effects," said George Bentley, UC Berkeley assistant professor of integrative biology. "Maybe we can use something that inhibits reproduction at physiological levels, so that we can bypass some of these side effects."

Ubuka, Bentley and their colleagues at UC Berkeley and in Japan and the United Kingdom report their findings in the Dec. 22 online issue of the public access journal PLoS ONE.

GnIH was discovered in 2000 in quail and has been studied in other birds, in mice and in sheep, but its role in humans has been hard to pin down. While the human genome contains the gene for GnIH, it was unclear if, when and where the protein hormone is produced, and whether it affects reproduction.

The UC Ber
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Albina du Boisrouvray Congratulates New Director of FXB Center for Health and Human Rights at Harvard University
2. U-M Study Reveals Surprising Lack of Genetic Diversity in the Most Widely Used Human Embryonic Stem Cell Lines
3. Humanic Design is Pleased to Announce Application Self Service (APSS) to its Product Suite to Empower Organizations with Automation
4. Launch of ImmortalHumans.com as a Result of Humankind's Drive to Cure Aging and Become Biologically Immortal Within this Century
5. Magnetic field measurements of the human heart at room temperature
6. PeopleStreme Human Capital Releases 'New Trends in Performance Management - 2010' Whitepaper
7. UNFPA Honoured With Human Rights Award
8. Human Rights Denied: Obama Leaves 75 Million Children Behind
9. New Report Examines the Role of Communications Technologies in Humanitarian Crises
10. Pharmacyclics, Inc. Announces Presentation of Interim Results From Phase I Trial of Its First-In-Human Btk Inhibitor PCI-32765
11. Human guinea pigs wary of high-paying medical trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Kansas City, MO (PRWEB) July 30, 2014 ... care practices have recently been awarded the Patient-Centered ... bestowed by the National Committee for Quality Assurance. ... has achieved NCQA Level I, Level 2, or ... doctors who participate in Patient-Centered Medical Home report ...
(Date:7/29/2014)... 2014 1Heart Caregiver Services’ advocacy ... focus on Brain Fitness Education brings great acceptance ... Fitness Program Director Tee Barr delivered an exceptional ... unit and the Assisted Living section of Aegis ... Director Christy Rozsa and Aegis Life Neighborhood Director ...
(Date:7/29/2014)... 2014 VogueQueen.com, a well-known online supplier, ... newest trends in garment fashion by providing graceful and ... selling an all-inclusive array of sexy dresses , ... a lot of customers take price into consideration. Worry ... makes the purchase more affordable for all clients. ...
(Date:7/29/2014)... 29, 2014 Daily Gossip indicates that ... all other disturbing symptoms that hemorrhoids commonly causes. The ... and natural medicine expert. , The author of ... the elimination of symptoms such as itching, burning, pain ... more about the H Miracle by visiting the official ...
(Date:7/29/2014)... (EA) a form of acupuncture where a ... acupuncture needles produces significant improvements in fatigue, ... weeks for early stage breast cancer patients experiencing ... inhibitors (AIs) to treat breast cancer. The results ... led by researchers at the Perelman School of ...
Breaking Medicine News(10 mins):Health News:Saint Luke’s Medical Group Awarded Patient-Centered Medical Home 2011 Level 3 Recognition 2Health News:1Heart Caregiver Services Conducts Brain Fitness Education and Brings Tee Barr to Aegis Ventura 2Health News:1Heart Caregiver Services Conducts Brain Fitness Education and Brings Tee Barr to Aegis Ventura 3Health News:1Heart Caregiver Services Conducts Brain Fitness Education and Brings Tee Barr to Aegis Ventura 4Health News:VogueQueen.com Now Provides Graceful And Sexy Lingerie Collection For August 2Health News:H Miracle Review Exposes Natural Method to Cure Hemorrhoids 2Health News:Acupuncture improves quality of life for breast cancer patients using aromatase inhibitors 2Health News:Acupuncture improves quality of life for breast cancer patients using aromatase inhibitors 3
... New research shows a link between use of two ... used either pesticide developed Parkinson,s disease approximately 2.5 times ... a collaborative effort conducted by researchers at the National ... of the National Institutes of Health, and the Parkinson,s ...
... Reinberg HealthDay Reporter , SUNDAY, Feb. 13 ... antioxidants called flavonoids, especially berries, may be protecting themselves ... In addition to berries, flavonoids are found in a ... fruits. These compounds have been touted as protective against ...
... 12 (HealthDay News) -- Winter couch potatoes who decide to ... injury if they don,t take the proper steps to safely ... an exercise program or new sport, you need to get ... fitness, advised Dr. Anders Cohen, chief of neurosurgery and spine ...
... HealthDay Reporter , FRIDAY, Feb. 11 (HealthDay ... regularly, their ability to think, to plan and even ... In addition, exercise was linked to increased activity in ... and self-control, according to brain imaging scans analyzed by ...
... 11 (HealthDay News) -- In addition to the ... one dermatologist cautions that players may be sharing ... "Outbreaks of ringworm, herpes and methicillin-resistant Staphylococcus aureus ... and professional level throughout the world," dermatologist Dr. ...
... the enzyme that gives fireflies their glow, enables researchers ... thereby track the progression of infectious diseases or cancerous ... shave their fur. Developed by researchers with the Lawrence ... California (UC) Berkeley, this new bioluminescent probe has already ...
Cached Medicine News:Health News:NIH study finds 2 pesticides associated with Parkinson's disease 2Health News:Berries May Offer Sweet Protection Against Parkinson's Disease 2Health News:Berries May Offer Sweet Protection Against Parkinson's Disease 3Health News:Get Into Shape Before Spring Activities, Doctor Advises 2Health News:Overweight Kids Who Exercise Improve Thinking, Math Skills: Study 2Health News:Overweight Kids Who Exercise Improve Thinking, Math Skills: Study 3Health News:Skin Infections Can Spread Easily Among Athletes 2Health News:Skin Infections Can Spread Easily Among Athletes 3Health News:Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin 2Health News:Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin 3
(Date:7/29/2014)... , July 29, 2014  Landauer, Inc. (NYSE: ... and environmental radiation measurement and monitoring, outsourced medical physics ... financial results for the fiscal third quarter 2014 after ... The Company will host a conference call ... a.m. Central Time (10 a.m. Eastern Time). Investors may ...
(Date:7/29/2014)... WASHINGTON , July 29, 2014 New ... in Medicare Part D by a projected $2.9 to ... by the actuarial firm Milliman released today by the ... Part D premiums could increase by as much as ... hepatitis C drugs, including Sovaldi and Olysio. ...
(Date:7/29/2014)... July 29, 2014 Numotion,s Board of Directors has ... will be the company,s new Chief Executive Officer. ... career at GE where he worked primarily for GE Healthcare ... to over $5 billion. His most recent position was as ... "I am thrilled to join Numotion," said Mike ...
Breaking Medicine Technology:Landauer, Inc. Sets Date and Time for Announcement of Fiscal Third Quarter 2014 Results 2New Milliman Study: Hepatitis C Drugs Could Increase Medicare Part D Spending by $2.9 to $5.8 Billion in 2015 2Numotion Names Mike Swinford CEO 2
... 3, 2011 Nonin Medical, Inc., the inventor of ... a leader in noninvasive physiological monitoring, announced the worldwide ... Pulse Oximeter for medical monitoring manufacturers. ... wired pulse oximeter will provide a new level of ...
... Optimer Pharmaceuticals, Inc. (NASDAQ: OPTR ) ... Senior Vice President of Research and Development, Cynthia Schwalm ... M.D., as Senior Vice President of Pharmacovigilance. These newly ... the Company prepares for the potential launch of its ...
Cached Medicine Technology:Nonin Medical Launches Low Power Xpod®, Model 3012LP, OEM Pulse Oximeter Globally 2Optimer Pharmaceuticals Expands Senior Management Team 2Optimer Pharmaceuticals Expands Senior Management Team 3Optimer Pharmaceuticals Expands Senior Management Team 4Optimer Pharmaceuticals Expands Senior Management Team 5
Molt periosteal elevator #9, 18.5 cm, 7-1/4"....
Periosteal elevator #9, 18 cm, 7"....
Full curve periosteal elevator - cervical - sharp, round tip, length 184 mm (7 1/4")....
... The Frontier Anterior Deformity System ... Kass, Moss Miami, and Isola ... thoracoscopic procedures to deliver unsurpassed versatility, ... the highest level of versatility for ...
Medicine Products: