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New hope in fight against Huntington's disease
Date:1/10/2011

ongst these genes, which has shed light on the mechanisms underlying this disorder."

Using the approach above, the scientists found that many of the protective genes are involved in translation a cellular process in which messenger RNA (mRNA) is decoded by the ribosome to produce specific proteins. This is particularly intriguing as this process has not been implicated in Huntington's disease in the past.

This is important because recent work indicates that pharmacological modulation of translation may represent a promising avenue for treatment of Parkinson's disease. Therefore, this new research strongly dovetails with these observations and suggests that similar drug treatment may be beneficial in Huntington's disease.

Dr Giorgini, of the Department of Genetics, said: "Our research has taken advantage of cutting edge genomics approaches using a simple model organism to identify a novel area for potential therapeutic intervention for Huntington's disease.

"If our findings are validated by further studies, it might suggest a novel therapeutic approach for this devastating disorder - which is critical as currently there are no treatments for onset or progression of symptoms."


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Contact: Flaviano Giorgini
fg36@le.ac.uk
44-011-625-23485
University of Leicester
Source:Eurekalert  

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