Navigation Links
New hope for setback-dogged cancer treatment
Date:11/26/2012

Several drugs companies have ineffectively tried to produce antibodies that bind to the IGF-1 receptor on the cell surface, which has a critical part to play in the development of cancer. Scientists at Karolinska Institutet in Sweden have now ascertained how these antibodies work, and can explain why only some cancer patients are helped by IGF-1 blockers during clinical tests. The researchers also present a means by which drugs of this kind could help more cancer patients.

Every cell contains thousands of tiny receptors that help it communicate with other cells. These receptors are involved in countless physiological processes, such as taste and smell perception and heart rate. A couple of dozen of these receptors form their own family the kinase receptors (RTKs), which are implicated in cancer. The so-called IGF-1 receptor is particularly important for cancer cell survival, and as soon as this receptor encounters the right hormone (type 1 insulin-like growth factor, or IGF-1) into the cancer cell open a number of communication channels, helping it to grow, rapidly divide and protect itself against treatment.

Blocking this receptor with an antibody that binds to it and makes it inaccessible to IGF-1 has long been regarded as the key to a potential cancer therapy, the idea being that it will eventually lead to the death of the tumour cell. Several drugs companies have therefore been developing such antibodies in order to treat the most aggressive forms of cancer, and after some promising laboratory tests, have tested a number of these preparations on patients. However, the drugs have generally given disappointing results and helped only a small minority of patients (including children with Ewing's sarcoma), leading some companies to discontinue clinical trials focusing on the IGF-1 receptor.

The Karolinska Institutet team has now systematically analysed the different IGF-1-related triggered communication channels within a cancer ce
'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. New Stool Test Might Aid in Early Detection of Colon Cancer
3. Study reveals how cancer drug causes diabetic-like state
4. How a cancer drug leads to diabetes
5. You Survived Cancer: Now Pay Attention to Your Overall Health
6. New drug prevents spread of human prostate cancer cells
7. Eliminating the good cholesterol receptor may fight breast cancer
8. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
9. Experimental Chemo Combo for Colon Cancer Disappoints
10. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
11. Targeted therapeutics for colon cancer to be presented at AACR meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... New York, New York (PRWEB) May 18, 2013 ... Inc.’s Gynecare pelvic mesh products continue to move forward ... County Superior Court, Bernstein Liebhard LLP reports. According to ... Management Conference in the Ethicon pelvic mesh litigation will ... indicate that 2,755 complaints have been filed in the ...
(Date:5/18/2013)... FL (PRWEB) May 18, 2013 TheBeautyPlace.com ... Nioxin. Pattern hair loss is not a result of ... According to Men’s Fitness Magazine, 70% of men suffer ... Professional Strength is renowned for hair transplant surgery, ... fights male pattern baldness known as Bosley Professional Strength. ...
(Date:5/18/2013)... Simple changes in a person’s every day routine, ... water can lead to substantial health benefits, the proven ... Diet Doc understands that overcoming significant weight ... difficult and often requires the use of prescription strength ... get over initial weight loss hurdles. In addition to ...
(Date:5/18/2013)... 2013 The Ayurvedic practitioner program will ... in the West. Program is available in Mexico via ... a healing modality practiced for over 5,000 years. In ... that health begins when an individual lives in harmony ... individual needs. Ayurveda aims to heal an individual in ...
(Date:5/18/2013)... Dr. Robert Tracey, an area leader in dental laser ... of the root causes of sleep apnea to provide and ... Sleep Month, Dr. Tracey points out estimates revealing that 40 ... sleep apnea is one of the most common of all. ... breathing at different times while sleeping. When this happens, the ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuits: Bernstein Liebhard LLP Notes Upcoming Case Management Conference in New Jersey Ethicon Pelvic Mesh Litigation 2Health News:Transvaginal Mesh Lawsuits: Bernstein Liebhard LLP Notes Upcoming Case Management Conference in New Jersey Ethicon Pelvic Mesh Litigation 3Health News:TheBeautyPlace.com Features the Two New Best-Selling Hairloss Products: Bosley Professional Strength and Nioxin Systems 2Health News:TheBeautyPlace.com Features the Two New Best-Selling Hairloss Products: Bosley Professional Strength and Nioxin Systems 3Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announce the Best Weight Loss Through New Whole Foods, Healthy Snacks and Prescription Strength hCG Treatments 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announce the Best Weight Loss Through New Whole Foods, Healthy Snacks and Prescription Strength hCG Treatments 3Health News:Ayurveda Training in Mexico Offered by Escuela de Ayurveda de California, a Leading Institution in the West 2Health News:Pomona, NY Dentist, Dr. Robert Tracey of General & Laser Assisted Dentistry (GLAD) Highlights Sleep Apnea Dentistry Services for Better Sleep Month 2Health News:Pomona, NY Dentist, Dr. Robert Tracey of General & Laser Assisted Dentistry (GLAD) Highlights Sleep Apnea Dentistry Services for Better Sleep Month 3
... ... force to promote interest of oil rig crews and other maritime industry employees. , ... Houston, Texas (PRWEB) April 22, 2010 ... illustrates the hazardous and sometimes deadly work conditions that maritime workers face on a daily ...
... new options to treat type 1 diabetes, , WEDNESDAY, April ... kind, a wounded soldier whose damaged pancreas had to be ... transplanted back into him, sparing him from a life with ... In November 2009, 21-year-old Senior Airman Tre Porfirio was serving ...
... have varying opinions on how much control a person has ... of Iowa researchers suggests that when doctor and patient attitudes ... of taking their medications. Published online and in the ... the study is part of a growing body of ...
... can cause pneumonia and meningitis, researchers point out , WEDNESDAY, ... of the PCV7 vaccine to battle bacteria that causes ... notable changes in strains that cause these illnesses, researchers report. ... covered by the vaccine, the team aid. , Immunizations with ...
... young viewing audience* and their ideas about gender and violence. ... . Film theorists believe that the action character Lt. ... 1979, paved the way for a new type of female ... see female action characters take part in hand-to-hand combat, wield ...
... likely to be screened, study finds , WEDNESDAY, April 21 ... are being screened for skin cancer, a particular problem among ... common cancer screenings, a new study has found. , Researchers ... and older, who took part in the 2005 National Health ...
Cached Medicine News:Health News:Explosion on Gulf Coast Oil Rig Underscores Daily Dangers for Maritime Workers, Say Houston Maritime Injury Lawyers Arnold & Itkin LLP 2Health News:Wounded Soldier Spared Diabetes With Emergency Transplant 2Health News:Wounded Soldier Spared Diabetes With Emergency Transplant 3Health News:Wounded Soldier Spared Diabetes With Emergency Transplant 4Health News:Patient-physician compatibility increases odds of following doctor's orders 2Health News:Patient-physician compatibility increases odds of following doctor's orders 3Health News:Vaccine Now Misses Many Pneumococcal Infections in Kids 2Health News:Tough girl or sidechick? 2Health News:Few Over 50 Get Skin Cancer Screenings 2
(Date:5/17/2013)... , May 17, 2013  Sony Biotechnology Inc. ("Sony") ... Spectral Analyzer (SP6800).  Sony will be exhibiting and taking ... be held at the San Diego ... , from May 20 - 22.  ... system, incorporating commercial audio-visual technologies into new and novel ...
(Date:5/17/2013)... May 17, 2013 /PRNewswire-iReach/ -- The escalation of ... is placing renewed emphasis on alternate delivery technologies. ... a number of factors are converging to create ... and their delivery device partners . These include ... the growing trend toward self-administration for chronic diseases, ...
(Date:5/17/2013)... May 17, 2013  Atossa Genetics, Inc. (NASDAQ: ... Kyle Guse , Chief Financial Officer & General ... Conference on Thursday, May 30, 2013, in New ... The Company,s presentation is scheduled to begin at ... webcast. To access the webcast, go to www.atossagenetics.com . ...
Breaking Medicine Technology:Sony Biotechnology Inc.'s New Technology for Science Provides Researchers Results in Color 2Pharmaceutical Makers and Delivery Device Partners Rethink Delivery Technologies - New Report Examines this Evolving Segment 2Pharmaceutical Makers and Delivery Device Partners Rethink Delivery Technologies - New Report Examines this Evolving Segment 3Atossa Genetics to Present at the Second Annual Marcum LLP MicroCap Conference 2Atossa Genetics to Present at the Second Annual Marcum LLP MicroCap Conference 3
... FRISCO, Texas and SPOKANE, Wash., May 31, 2011 A ... family in Spokane, Wash. after becoming lost on the way ... mother, the police and a life-saving wearable locator device called ... adults with cognitive conditions. Stephanie Lund purchased the ...
... May 31, 2011 Genetic Technologies Limited (ASX: GTG; ... its first BREVAGen ™ clinical sample from a ... of its Australian laboratory under the US Clinical Laboratories ... sample was received by Phenogen Sciences, the Company,s new ...
Cached Medicine Technology:EmSeeQ® Locator Device Aids in Returning Lost Spokane Boy with Autism Safely Back Home in Minutes 2EmSeeQ® Locator Device Aids in Returning Lost Spokane Boy with Autism Safely Back Home in Minutes 3Genetic Technologies Processes First BREVAGen™ Patient Sample 2Genetic Technologies Processes First BREVAGen™ Patient Sample 3
... tool for the Humphrey Field Analyzer, ... and shows less inter-test variability than ... degree of reproducibility as Full Threshold ... correlate with the earlier glaucoma damage ...
... is the smartest, toughest and most technologically ... on-board artificial intelligence algorithm, DiogenesTM, the Decipher ... while on the patient. The Decipher was ... the rigorous tests required to monitor the ...
... is a top quality Carl Zeiss Meditec ... vision defects even safer, more patient-friendly and ... work platform are oriented towards increasing efficiency, ... recovery of vision. Key factors here are ...
The Vivid e delivers everything you need in a compact echo system, like complete cardiovascular functionality, a comprehensive cardiac measurement and analysis package, and full shared service capabi...
Medicine Products: