Navigation Links
New grant to study how pediatric brain tumor, ependymoma, develops
Date:6/1/2011

Armed with new grant support, investigators at Nationwide Children's Hospital plan to examine how a common gene of the nervous system leads to the development of a devastating brain tumor, ependymoma. Robert A. Johnson, PhD, principal investigator in the Center for Childhood Cancer at The Research Institute at Nationwide Children's, has received a one-year $75,000 grant from the Matthew Larson Foundation for this research.

Ependymoma, an aggressive tumor that affects the central nervous system, is the first most common brain tumor in children. Ependymoma is chemo-resistant and is incurable in up to 40 percent of cases.

Previously, Dr. Johnson and colleagues at St. Jude Children's Research Hospital discovered that elevated levels of the Ephb2 gene cause embryonic neural stem cells to transform into one of the nine subgroups of ependymoma. The Ephb2 gene normally plays a critical role in cell development throughout the nervous system.

With the Matthew Larson Foundation grant, Dr. Johnson will be able to directly investigate just how the Ephb2 receptor is able to alter normal neural cells and cause ependymoma.

"Many studies have described Ephb2's ability to regulate cellular development in different cell types, but we don't yet know this receptor's role in transforming neural cells," said Dr. Johnson. "It seems that ependymoma develops when Ephb2 inhibits the ability of neural cells to differentiate and complete their cellular development."

During in vitro studies, Dr. Johnson plans to overexpress the Ephb2 receptor in neural stem cells to determine the receptor's role in these cells and to understand whether this overexpression halts cell progression. He also plans to examine the effects different types of mutations in the Ephb2 gene have on neural cell differentiation.

Future studies using a mouse model will help clarify these questions and also help determine if specific Ephb2 mutations can model ano
'/>"/>

Contact: Erin Pope
Erin.Pope@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH grant for the move toward clinical trials targeting the lysosomal storage disease MPSIIIB
2. MetLife Foundations grant bolsters media coverage for aging issues
3. UTMB researcher receives $3 million NIH grant to study aging in Mexico
4. NIH awards Salk Institute $5.5 million grant to study Williams syndrome
5. Grant extends funding for the Broads Stanley Center for Psychiatric Research
6. Cedars-Sinais mobile medical clinics receive $500,000 grant from California Community Foundation
7. Immigrants Eat American Junk Food to Fit In: Study
8. Gates Foundation awards Ben-Gurion U. researcher grant for malaria detection using cell phones
9. Grant funds next phase in bringing healthier sorghum closer to underserved communities
10. K-RITH awards grants to foster teamwork among South African TB/HIV scientists
11. $4.5 million grant creates transdisciplinary program to train scholars in child obesity prevention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... The Fit Body Boot Camp franchise is known throughout ... and their community outreach. The new Rockville Fit Body Boot ... of the company’s new fitness boot camp in ... is excited about the grand opening, because of the opportunity ... honor the memory of emergency workers who sacrificed their lives ...
(Date:9/23/2014)... 2014 Maturo Medical Weight and ... announced Dr. Lisa Maturo has received certification in ... Worldlink Medical Academy. Dr. Maturo is one of ... this credential. , World-renowned bioidentical hormone replacement ... the rigorous training course, which trained participants in ...
(Date:9/23/2014)... 23, 2014 Wohl Associates ... packaging equipment, has recently taken delivery of used industrial ... include mixers, sheeters, and equipment for producing gnocchi and ... Toresani unit and a La Parmigiana mixer/extruder. With a ... a mixing tank that is 17” wide, 28” long ...
(Date:9/23/2014)... 23, 2014 Hope For The Warriors® ... Celebration to be hosted in Boston, Massachusetts on Sunday, ... Amphitheater. This signature event honors the courage of our ... the fallen. Proceeds from the evening will benefit Hope ... a sense of self, restoring the family unit, and ...
(Date:9/23/2014)... Los Angeles, CA (PRWEB) September 23, 2014 ... launched sales funnel building software application has created a ... commotion surrounding the launch of this new software has ... published an investigative review for her readers. ... such as site design, programming and development can be ...
Breaking Medicine News(10 mins):Health News:Rockville Fit Body Boot Camp Invites Community to Fitness Boot Camp Grand Opening 2Health News:Rockville Fit Body Boot Camp Invites Community to Fitness Boot Camp Grand Opening 3Health News:Doctor Lisa Maturo of Maturo Medical Obtains Expert Certification in BioIdentical Hormone Replacement Therapy from World Link Medical 2Health News:Used Industrial Pasta Machinery Now Available at Wohl Associates 2Health News:Hope For The Warriors Announces Got Heart, Give Hope Celebration in Boston 2Health News:Hope For The Warriors Announces Got Heart, Give Hope Celebration in Boston 3Health News:ClickFunnels 2.0 – Review Of Russell Brunson’s Sales Funnel Building Software Released 2
... Group,Inc. (Amex: QGP ) (http://www.QuantumMD.com ), ... Noel J. Guillama, President &,CEO, will present at ... p.m. (Pacific) on Monday, August 18, 2008 at ... Guillama will give a 23-minute presentation regarding The ...
... a national survey,of adults, 60 percent of Hispanic American ... is the #1 fatal disease among women.,Further, nearly half ... greater than that of Caucasian women. Dania Rich-Spencer, Vice,President ... the Go,Red For Women, founded by the American Heart ...
... getting infected cells to drop their guard according to ... a catalyst to a cancer-busting reaction which calls up an ... Cancer adapts quickly to traditional drugs which attack infected cells ... of defence using ruthenium as a catalyst to a reaction ...
... School of Medicine, Fox Chase Cancer Center and ... that will speed the translation of medical and ... , As part of the agreement, the ... Translational Medicine, based at Temple, to design and ...
... Program to Increase Breast and ... Cervical Cancer Screening Rates, COLUMBIA, ... care guidance company, today announced the,launch of their Women,s Health ... to help increase the,prevention and early detection of breast and ...
... all evidence of disease in selected patients with cancer ... the first published report from an ongoing clinical trial. ... Clinical Cancer Research, (published online August 12) researchers ... targeted radiation therapy had completely controlled all signs of ...
Cached Medicine News:Health News:The Quantum Group to Present at the Noble Financial Equity Conference 2Health News:The Quantum Group to Present at the Noble Financial Equity Conference 3Health News:Temple, Fox Chase and Geisinger create Keystone Institute for Translational Medicine 2Health News:Resolution Health Introduces Women's Health and Wellness Action Campaign 2Health News:Resolution Health Introduces Women's Health and Wellness Action Campaign 3Health News:Resolution Health Introduces Women's Health and Wellness Action Campaign 4Health News:Targeted radiation therapy can control limited cancer spread 2Health News:Targeted radiation therapy can control limited cancer spread 3
(Date:9/23/2014)... FRANCISCO , Sept. 23, 2014 Today, ... (ORS), announced the formation of the DripDrop Foundation, ... to preventable dehydration worldwide. Utilizing scientific advancements in ... introduce solutions to reduce dehydration and healthcare costs ... relief missions. "DripDrop has been ...
(Date:9/23/2014)... --  BioLife Solutions , Inc. (NASDAQ: BLFS ... clinical grade hypothermic storage and cryopreservation ... for cells and tissues  ("BioLife" or the "Company"), ... Board.  The new members are Jason Acker , ... Dr. Acker is a Senior Development Scientist with the ...
(Date:9/22/2014)... -- , La tecnología basada en ... satisfagan el creciente rigor de las autoridades sanitarias en ... permanentes de ensayo (TMF, por sus siglas en inglés) ... el sector de las ciencias biológicas hasta la fecha ... ensayos clínicos que planean proporcionar a los auditores acceso ...
Breaking Medicine Technology:DripDrop Forms Foundation To Scale Relief Efforts 2BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 2BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 3BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 4BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 5BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 6BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 7El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 2El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 3El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 4El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 5
... Colo., June 21, 2011 Medivance® Inc . ... the Ernst & Young Entrepreneur Of The Year ® ... & Life Sciences category. According to Ernst & Young ... and extraordinary success in such areas as innovation, financial ...
... a leader in global healthcare primary market research and influence ... 50 market research firms in the United States. ... to be part of the Honomichl 50, and a testament ... panel of physicians and allied health professionals, and innovative technology. ...
Cached Medicine Technology:Robert Kline, President & CEO, Medivance Named Ernst & Young Entrepreneur Of The Year® 2011 Regional Award Winner 2Robert Kline, President & CEO, Medivance Named Ernst & Young Entrepreneur Of The Year® 2011 Regional Award Winner 3AlphaDetail, Healthcare Market Research Specialist, Named to the Honomichl Top 50 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: