Navigation Links
New grant to study how pediatric brain tumor, ependymoma, develops
Date:6/1/2011

Armed with new grant support, investigators at Nationwide Children's Hospital plan to examine how a common gene of the nervous system leads to the development of a devastating brain tumor, ependymoma. Robert A. Johnson, PhD, principal investigator in the Center for Childhood Cancer at The Research Institute at Nationwide Children's, has received a one-year $75,000 grant from the Matthew Larson Foundation for this research.

Ependymoma, an aggressive tumor that affects the central nervous system, is the first most common brain tumor in children. Ependymoma is chemo-resistant and is incurable in up to 40 percent of cases.

Previously, Dr. Johnson and colleagues at St. Jude Children's Research Hospital discovered that elevated levels of the Ephb2 gene cause embryonic neural stem cells to transform into one of the nine subgroups of ependymoma. The Ephb2 gene normally plays a critical role in cell development throughout the nervous system.

With the Matthew Larson Foundation grant, Dr. Johnson will be able to directly investigate just how the Ephb2 receptor is able to alter normal neural cells and cause ependymoma.

"Many studies have described Ephb2's ability to regulate cellular development in different cell types, but we don't yet know this receptor's role in transforming neural cells," said Dr. Johnson. "It seems that ependymoma develops when Ephb2 inhibits the ability of neural cells to differentiate and complete their cellular development."

During in vitro studies, Dr. Johnson plans to overexpress the Ephb2 receptor in neural stem cells to determine the receptor's role in these cells and to understand whether this overexpression halts cell progression. He also plans to examine the effects different types of mutations in the Ephb2 gene have on neural cell differentiation.

Future studies using a mouse model will help clarify these questions and also help determine if specific Ephb2 mutations can model another one of the nine ependymoma subgroups.

"I expect that our findings will shed light on the biology of these tumors and therefore allow us to develop more effective, targeted therapies," said Dr. Johnson.


'/>"/>

Contact: Erin Pope
Erin.Pope@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Related medicine news :

1. NIH grant for the move toward clinical trials targeting the lysosomal storage disease MPSIIIB
2. MetLife Foundations grant bolsters media coverage for aging issues
3. UTMB researcher receives $3 million NIH grant to study aging in Mexico
4. NIH awards Salk Institute $5.5 million grant to study Williams syndrome
5. Grant extends funding for the Broads Stanley Center for Psychiatric Research
6. Cedars-Sinais mobile medical clinics receive $500,000 grant from California Community Foundation
7. Immigrants Eat American Junk Food to Fit In: Study
8. Gates Foundation awards Ben-Gurion U. researcher grant for malaria detection using cell phones
9. Grant funds next phase in bringing healthier sorghum closer to underserved communities
10. K-RITH awards grants to foster teamwork among South African TB/HIV scientists
11. $4.5 million grant creates transdisciplinary program to train scholars in child obesity prevention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... ... newest advanced absorption cannabidiol (CBD) serum, “NANOCALM 300” Microemulsified Hemp Extract. This ... instant absorption from the mouth into the bloodstream. Far outpacing the ...
(Date:2/22/2017)... ... 22, 2017 , ... The Centers for Medicare & Medicaid ... in Delaware, New Jersey, Pennsylvania and West Virginia prepare for and participate in ... Act of 2015 (MACRA). , This technical assistance, authorized and funded under ...
(Date:2/22/2017)... NJ (PRWEB) , ... February 22, 2017 , ... ... healthcare communications company, launched a new media platform connecting healthcare technology professionals and ... will be followed by a quarterly publication starting on March 1, announced Michael ...
(Date:2/22/2017)... ... February 22, 2017 , ... Pet obesity in the U.S. continued ... according to the Association for Pet Obesity Prevention (APOP). During the ninth annual survey, ... such as the benefits of corn and grains, value of raw and organic diets, ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... so many different solutions on the market, it is easy to start feeling ... Premier Locksmith offers a complimentary security consultation. , Home Security Hardware Choices, ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... , Feb. 22, 2017 Henry ... an exclusive distribution agreement with Rijuven, which develops ... diagnostic device to medical practitioners. ... electrocardiogram (ECG) and heart sound signals, transmits real-time ... and offers cloud-based analysis to help physicians provide ...
(Date:2/22/2017)... Calif. , Feb. 22, 2017  Bioness, Inc., ... therapies, today announced the first series of successful StimRouter ... at Radboud University Medical Center (Nijmegen, Netherlands ... ( Cork, Ireland ), and Kliniek Park ... the successful launch continuing, Bioness plans to further support ...
(Date:2/22/2017)... , Feb. 22, 2017 Oncternal Therapeutics, ... for both rare and common malignancies, today announced ... financing. The company intends to use the proceeds ... TK216, and to advance preclinical development of a ... Cirmtuzumab is a first-in-class anti-ROR1 monoclonal antibody being ...
Breaking Medicine Technology: