Navigation Links
New grant awards aim to prevent autoimmune diseases
Date:9/11/2012

SEATTLE (Sept. 11, 2012) - Benaroya Research Institute at Virginia Mason (BRI) recently received two major grant awards to explore how to regulate the immune system, as part of a nationwide collaborative program to prevent autoimmune diseases. The awards will provide BRI scientists with $4.7 million from the National Institutes of Health to discover molecular mechanisms and new therapy targets through in-depth studies of immune function in cells from research participants in the BRI autoimmunity biorepositories.

"We're committed to working with NIAID (National Institute of Allergy and Infectious Diseases) and the U01 Cooperative Study Group to identify and address key gaps in current research in autoimmunity prevention," said BRI Director Gerald Nepom, MD, PhD. "We're pleased that reviewers and funders of this program have confidence in BRI's ability to play a pivotal role in this initiative, and are looking forward to this important research collaboration."

BRI Associate Director Jane Buckner, MD, will lead a $2.6 million grant to understand how the immune system becomes unbalanced in individuals with autoimmune diseases in order to determine how the immune response might be manipulated to prevent autoimmunity in people.

"Our growing understanding of the genetics of autoimmune diseases has led us to study how alterations in several immune pathways, common to individuals with Type 1 diabetes, multiple sclerosis and Crohn's disease, contribute to a loss of immune balance," said Dr. Buckner. "If we can suppress the components that contribute to these diseases and enhance the correct immune system responses early in the diseases, we can work toward preventing them."

BRI Principal Investigator Paul Bollyky, MD, PhD, will head up a $2.1 million grant to look at how the extracellular matrix (the natural substance that holds cells together in every tissue) affects Type 1 diabetes. "We know little about how the tissue environment contributes to immune regulation," said Dr. Bollyky. "This knowledge is essential if we are to devise strategies that effectively suppress autoimmunity and prevent Type 1 diabetes." Together with his BRI collaborators on the grant, Thomas Wight, PhD, and Alice Long, PhD, Dr. Bollyky will test whether interventions directed at the extracellular matrix can prevent autoimmunity and promote immune tolerance.


'/>"/>
Contact: Kay Branz
kbranz@benaroyaresearch.org
206-342-6903
Immune Tolerance Network
Source:Eurekalert

Related medicine news :

1. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
2. Washingtons Life Sciences Discovery Fund awards commercialization grants
3. University of Cincinnati researchers win $3.7M grant from US Department of Defense
4. $9 million grant awarded to UH to study, treat learning disabilities
5. Louisiana Tech University professor earns NSF Early Career Development grant
6. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
7. Grant awarded to help improve problem-solving skills for deaf and hard-of-hearing students
8. 2 Grand Challenges Explorations grants for global health
9. Clemson professor awarded nearly $600,000 4-year grant to study language of plants
10. LA BioMed receives Grand Challenges Explorations grant
11. UC San Diego Superfund Research Program receives $15 million grant renewal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... PITTSBURGH, Pa. (PRWEB) , ... October 13, 2017 , ... ... the dark poses a problem. Fortunately, an inventor from Austin, Texas, has identified a ... access to medication in darkness or restricted lighting. As such, it eliminates the need ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a ... utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the ... a CBD form that can be easily incorporated into liquid products, while reducing costs ...
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of ... part of a disaster drill on October 3rd. , Apple Rehab participated with the ... as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The ...
(Date:10/13/2017)... ... , ... Ellevate Network, the leading network for professional women, brought together some ... at their inaugural Summit in New York City in June. The event was livestreamed ... over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical ... device is now successfully helping those with the widespread ... Fibromyalgia diagnosed Amanda in Essex, England ... and washing my hair, experiencing no sleep at all, ... painful spasm… I cannot recommend [the AVACEN 100] enough, ...
(Date:9/18/2017)... , Sept. 18, 2017  PMD Healthcare of ... Pharmacy of Kalamazoo, Mich. , have ... service that expedites and streamlines patient and provider access ... 2.0, and wellness management services.  ... used to measure lung function for a variety of ...
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform for ... the first annual edition of its Global CSR Risk and Performance Index. ... by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points ... ... ...
Breaking Medicine Technology: