Navigation Links
New grant awards aim to prevent autoimmune diseases
Date:9/11/2012

SEATTLE (Sept. 11, 2012) - Benaroya Research Institute at Virginia Mason (BRI) recently received two major grant awards to explore how to regulate the immune system, as part of a nationwide collaborative program to prevent autoimmune diseases. The awards will provide BRI scientists with $4.7 million from the National Institutes of Health to discover molecular mechanisms and new therapy targets through in-depth studies of immune function in cells from research participants in the BRI autoimmunity biorepositories.

"We're committed to working with NIAID (National Institute of Allergy and Infectious Diseases) and the U01 Cooperative Study Group to identify and address key gaps in current research in autoimmunity prevention," said BRI Director Gerald Nepom, MD, PhD. "We're pleased that reviewers and funders of this program have confidence in BRI's ability to play a pivotal role in this initiative, and are looking forward to this important research collaboration."

BRI Associate Director Jane Buckner, MD, will lead a $2.6 million grant to understand how the immune system becomes unbalanced in individuals with autoimmune diseases in order to determine how the immune response might be manipulated to prevent autoimmunity in people.

"Our growing understanding of the genetics of autoimmune diseases has led us to study how alterations in several immune pathways, common to individuals with Type 1 diabetes, multiple sclerosis and Crohn's disease, contribute to a loss of immune balance," said Dr. Buckner. "If we can suppress the components that contribute to these diseases and enhance the correct immune system responses early in the diseases, we can work toward preventing them."

BRI Principal Investigator Paul Bollyky, MD, PhD, will head up a $2.1 million grant to look at how the extracellular matrix (the natural substance that holds cells together in every tissue) affects Type 1 diabetes. "We know little about how the tissue environment contributes to immune regulation," said Dr. Bollyky. "This knowledge is essential if we are to devise strategies that effectively suppress autoimmunity and prevent Type 1 diabetes." Together with his BRI collaborators on the grant, Thomas Wight, PhD, and Alice Long, PhD, Dr. Bollyky will test whether interventions directed at the extracellular matrix can prevent autoimmunity and promote immune tolerance.


'/>"/>
Contact: Kay Branz
kbranz@benaroyaresearch.org
206-342-6903
Immune Tolerance Network
Source:Eurekalert

Related medicine news :

1. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
2. Washingtons Life Sciences Discovery Fund awards commercialization grants
3. University of Cincinnati researchers win $3.7M grant from US Department of Defense
4. $9 million grant awarded to UH to study, treat learning disabilities
5. Louisiana Tech University professor earns NSF Early Career Development grant
6. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
7. Grant awarded to help improve problem-solving skills for deaf and hard-of-hearing students
8. 2 Grand Challenges Explorations grants for global health
9. Clemson professor awarded nearly $600,000 4-year grant to study language of plants
10. LA BioMed receives Grand Challenges Explorations grant
11. UC San Diego Superfund Research Program receives $15 million grant renewal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Dr. Alan ... surgery in New York City. He is known for his distinguished expertise and ... vascular surgery, Dr. Benvenisty holds sub-specialty training in treating renovascular disease and aortic ...
(Date:5/24/2017)... ... May 24, 2017 , ... Drs. Nicholas Rallis and Chris ... spent 10 years as clinical instructors for the reputable Full Mouth Rehabilitation continuing ... the program, private practitioners receive cutting-edge clinical training and learn how to perform ...
(Date:5/24/2017)... ... May 24, 2017 , ... STATEMENT OPPOSING PRESIDENT DONALD TRUMP’S ... Donald Trump’s budget, “A New Foundation for American Greatness—President's Budget FY 2018,” because ... marginalizes underserved populations, undermines productivity, and destroys the social safety net needed by ...
(Date:5/24/2017)... (PRWEB) , ... May 24, ... ... affecting the female reproductive tract in which the endometrial lining of the ... causing inflammation and pain. Patients experiencing painful intercourse, painful periods, pelvic pain, ...
(Date:5/24/2017)... ... ... If you are thinking of a visit to San Francisco , fall is a ... time to visit. , Business Architecture Associates is pleased to offer 5 days of training ... 4-½ day package for individuals, and as 4-½ day corporate package for up to 3 ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... , May 10, 2017 Radiology has become ... its costs have also spiraled to the number one ... to radiology than ever before as the most complete ... a patient with lower back pain an MRI may ... reason for pain, resulting in entirely different treatment protocols.  ...
(Date:5/9/2017)...  Semler Scientific, Inc. (OTCQB: SMLR), an emerging ... the clinical effectiveness and efficiency of healthcare providers, ... ended March 31, 2017. "We ... identify when preventive care options are appropriate, which ... attacks or strokes occur," said Doug Murphy-Chutorian ...
(Date:5/6/2017)...  Hill-Rom Holdings, Inc. (NYSE: HRC), has begun a ... to its Welch Allyn campus. The ... more than 100 new jobs to Central ... a significant presence for more than 100 years. Hill-Rom,s ... large portion of which will be R&D and engineering ...
Breaking Medicine Technology: