Navigation Links
New genomic marker for tuberculosis may help identify patients who will develop the disease
Date:8/29/2010

fy a unique 'signature' for each infectious agent."

Drs. Ramilo and Mejias' also faculty members at The Ohio State University College of Medicine research has shown that gene expression microarray technology can be used to help develop blood transcriptional signatures.

"This technology allows us to see the whole picture of infection using a single blood sample, which is a really powerful tool for the clinic," said Dr. Mejias.

It's this gene expression microarray technology that allowed an international group of investigators, of which Drs. Ramilo and Mejias are part of, to provide the first complete description of the blood transcriptional signature of TB.

The study examined and compared blood drawn from patients in London, England and Cape Town, South Africa who had active TB, latent TB or who did not have TB. The team developed genome-wide transcriptional profiles for each of the patients and discovered a distinct characteristic, or "signature," of the blood from patients with active TB. X-rays of patients with this signature were consistent with signs of active TB.

"The study shows for the first time that the transcriptional signature in blood correlates with extent of disease in active TB patients," said Dr. Ramilo. "It validates the idea that this transcriptional signature is an accurate marker of TB infection."

The team also found that a subset of latent TB patients had signatures similar to those in active TB patients.

"The signature of active TB, which was observed in 10 to 20 percent of latent TB patients, may identify those individuals who will develop disease, but longitudinal studies are needed to assess this," said Dr. Ramilo.

The transcriptional signature was diminished in active TB patients after two months and completely extinguished by 12 months after treatment.

"These findings suggest that the blood transcriptional signature of active TB patients could be u
'/>"/>

Contact: Mary Ellen Peacock
MaryEllen.Peacock@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Large-scale genomic analysis of prostate cancer unveiled
2. Genentech uses Complete Genomics human genome sequencing service to compare tumor and normal genome in patient with non-small cell lung cancer; results published in Nature
3. Breast Cancer Patients Often Confused by Genomic Testing
4. Improvements needed in genomic test result discussions
5. Lawrence Berkeley National Laboratory and OpenHelixTM Announce an Updated Free Tutorial Suite for VISTA: Tools for Comparative Genomics
6. SeqWright Advances Genomic Discovery With Isilon IQ
7. Researchers chart genomic map spanning over 2 dozen cancers
8. The cancer biomarker conundrum: Too many false discoveries
9. NIH launches effort to define markers of human immune responses
10. Biomarkers Could Spot Alzheimers Disease Early, Studies Suggest
11. A New Marker to Spot Aggressive Breast Cancers?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... adults in Athens, GA who find that they have a problem ... call the new helpline which can offer support and guidance for ... Athens is a wonderful resource for an adolescent drug or alcohol ... end substance abuse once and for all. When a young person ... when really they should put their faith in a youth rehab ...
(Date:8/23/2014)... Summer vacation is almost over and before we know it ... for school supplies and a new wardrobe might take precedence ... to also spend some time brushing up on bed bug ... in heavily populated places,” said Randy Rupert, Bed Bug Team ... settings for bed bugs to take up residence.” , An ...
(Date:8/22/2014)... (PRWEB) August 23, 2014 Recently, Skmen.com, ... new collection of 2014 bohemian dresses in its online ... deeply discounted prices, up to 28% off. All the ... before August 31, 2014. , The company’s ... Skmen.com wants to show worldwide customers more the latest ...
(Date:8/22/2014)... a leading online supplier of wedding dresses and women’s special ... bridesmaid dresses to its product line. In addition to ... high quality items. All of them are now available at ... , The company’s new items can definitely add beauty for ... It is true that all its products are more and ...
(Date:8/22/2014)... 2014 Millennium Treatment Group has recently noticed ... high level of drug use among teenagers. The treatment facility ... addiction and work to minimize drug abuse. , America is ... drug addiction in history. According to the National Institute ... Americans aged 12 or older—or 9.2 percent of the population—had ...
Breaking Medicine News(10 mins):Health News:Teenagers in Athens, GA are Locating Addiction Recovery Thanks to New Helpline 2Health News:Expert Advice for a Bed Bug-Free School Year 2Health News:Cheap Bohemian Dresses Unveiled by Experienced Supplier Skmen.com 2Health News:Discounted Empire Bridesmaid Dresses Online At UWDress.com 2Health News:Millennium Treatment Group Sees Increase in Marijuana Use Among Youth 2
... in the August issue of the journal Neuron, published ... Ivan de Araujo and colleagues,// have mapped the activity ... in multiple feeding-related brain areas. Until now studies ... been only fragmentary measuring brain regions only at specific ...
... country's only tuberculosis hospital that was shut for the ... ,The 37-bed hospital in the capital of Nepal, ... of August, with 25 beds having been made available ... Minister and Minister for Health and Population, Amik Sherchan, ...
... Thai news agency reported that Thailand’s Public Health Ministry ... to help screen patients in an attempt// to prevent ... Health Minister Pinij Charusombat said, the blue-collar workers used ... may be left out from the ministry's bird flu ...
... at gunpoint were freed shortly after their abduction after ... // They abduction took place in Kandahar province of ... carrying the 15 medical staff, but released the hostages ... Outlook newspaper quoted Abdul Hayee Razmal, deputy director of ...
... Ghosh’s film “Sunglass” was unfortunately bought to a halt today ... right eye swelling// up forcing the production crew to pack ... the swollen area. ,But the Bengali director is ... of schedule and left for Chennai! ,"'Sunglass' is ...
... TG Hospital gave a B.C. youngster a bowel, liver, pancreas and ... for the death of her son. She said, "They were telling ... that page." , ,Her son Gairett, 18, is now recovering ... General Hospital. He now has a new bowel, stomach, liver and ...
Cached Medicine News:Health News:Hunger Mapping 2Health News:A sty in Actress Konkona Sharma Disrupts the Shooting of Bi- Lingual movie 'Sunglass' 2Health News:Rare Transplant Gives B.C Youngster 4 New Organs 2Health News:Rare Transplant Gives B.C Youngster 4 New Organs 3
(Date:8/22/2014)... COLUMBUS, Ohio , Aug. 22, 2014 MC ... Devices Inc. (MID), a Columbus, OH ... to distribute the FloShield laparoscopic and robotic visualization system in ... will be approved for sale in Japan ... has a long-time experience and an extensive product portfolio in ...
(Date:8/22/2014)... 2014  Mark Riccio, director of Cornell University,s ... using the online crowd-funding platform Kickstarter to bring ... researchers and would-be superheros everywhere: "for FREE." Riccio,s ... do if you had Superman,s X-ray vision?" The ... everywhere, from elementary through high school students, academic ...
(Date:8/22/2014)... , Aug. 22, 2014  WaferGen Bio-systems, Inc. ... public offering of units of common stock and warrants ... proceeds of $20 million, prior to deducting underwriting discounts ... The shares and warrants are immediately separable and will ... expected to begin trading on The NASDAQ Stock Market ...
Breaking Medicine Technology:MC Medical agrees to be the exclusive distributor of FloShield products in Japan 2Cornell's X-ray Imaging Lab Director Uses Kickstarter Campaign to "Democratize" Advanced 3D Imaging 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 3WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 4
... to superior immobilization and cervical spine care, one ... already know that the most important function of ... But what you may not know is that ... provides superior immobilization over the leading one-piece rigid ...
... support and stabilization for non-operable hip disorders ... hip arthroplasty. Neoprene padding is secured to ... interface. This brace may be ordered with ... joints. , ,POSTERIOR PANEL: The ...
... Bledsoe Simple Pelvic Brace is the solution ... control. This off-the-shelf brace fits like a ... than 10 minutes. The Bledsoe Simple Pelvic ... as abduction and adduction in 15 increments ...
... A Pavlik-type harness with greatly improved ... of congenital hip dysplasia. Color-coded straps, ... antislip foot pieces.,Color-coded anterior straps help ... be made while the child lies ...
Medicine Products: