Navigation Links
New genomic marker for tuberculosis may help identify patients who will develop the disease
Date:8/29/2010

fy a unique 'signature' for each infectious agent."

Drs. Ramilo and Mejias' also faculty members at The Ohio State University College of Medicine research has shown that gene expression microarray technology can be used to help develop blood transcriptional signatures.

"This technology allows us to see the whole picture of infection using a single blood sample, which is a really powerful tool for the clinic," said Dr. Mejias.

It's this gene expression microarray technology that allowed an international group of investigators, of which Drs. Ramilo and Mejias are part of, to provide the first complete description of the blood transcriptional signature of TB.

The study examined and compared blood drawn from patients in London, England and Cape Town, South Africa who had active TB, latent TB or who did not have TB. The team developed genome-wide transcriptional profiles for each of the patients and discovered a distinct characteristic, or "signature," of the blood from patients with active TB. X-rays of patients with this signature were consistent with signs of active TB.

"The study shows for the first time that the transcriptional signature in blood correlates with extent of disease in active TB patients," said Dr. Ramilo. "It validates the idea that this transcriptional signature is an accurate marker of TB infection."

The team also found that a subset of latent TB patients had signatures similar to those in active TB patients.

"The signature of active TB, which was observed in 10 to 20 percent of latent TB patients, may identify those individuals who will develop disease, but longitudinal studies are needed to assess this," said Dr. Ramilo.

The transcriptional signature was diminished in active TB patients after two months and completely extinguished by 12 months after treatment.

"These findings suggest that the blood transcriptional signature of active TB patients could be u
'/>"/>

Contact: Mary Ellen Peacock
MaryEllen.Peacock@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Large-scale genomic analysis of prostate cancer unveiled
2. Genentech uses Complete Genomics human genome sequencing service to compare tumor and normal genome in patient with non-small cell lung cancer; results published in Nature
3. Breast Cancer Patients Often Confused by Genomic Testing
4. Improvements needed in genomic test result discussions
5. Lawrence Berkeley National Laboratory and OpenHelixTM Announce an Updated Free Tutorial Suite for VISTA: Tools for Comparative Genomics
6. SeqWright Advances Genomic Discovery With Isilon IQ
7. Researchers chart genomic map spanning over 2 dozen cancers
8. The cancer biomarker conundrum: Too many false discoveries
9. NIH launches effort to define markers of human immune responses
10. Biomarkers Could Spot Alzheimers Disease Early, Studies Suggest
11. A New Marker to Spot Aggressive Breast Cancers?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... The Alaska Center for Dentistry ... dentist Dr. Jonathan Oudin, DDS, who will begin working ... Barrow, Alaska, for three years. According to Teresa Wallace, ... Oudin to help take on new patients. , "This ... growing and serving the greater Anchorage metro community," Wallace ...
(Date:7/31/2014)... ROCHESTER, Minn. Implementation of an algorithm aimed ... the utilization of computed tomography (CT) scans, without ... have found. The study was recently published in ... is the most common cause of acute abdominal ... becomes inflamed and filled with pus. CT scans ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Setting goals for ... on blogs on successful tips to weight loss. Fitness on ... for over 8 years, and has worked with 6000 customers ... “We have had the chance to monitor why customers start ... exercising, how long they stick to their program, whether or ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Women in ... take charge of their financial future. The Independent ... has opened registration for 6 upcoming Los Angeles area ... for women, and with input from Kim Kiyosaki, a ... It’s Rising Time) who is passionate about women’s financial ...
(Date:7/31/2014)... NV (PRWEB) July 31, 2014 ... helping independent pharmacies enhance patient care by kicking ... and medication adherence. The first of many education ... opening of ThoughtSpot 2014, Good Neighbor Pharmacy and ... Medicare and Medicaid Services (CMS) Star Measures were ...
Breaking Medicine News(10 mins):Health News:Dr. Jonathan Oudin to Join Alaska Center for Dentistry at Wasilla Location 2Health News:Fitness on the Go's Rewards Program Helps Clients Reach Their Goals 2Health News:The Independent Woman to Offer Financial Workshops in the Los Angeles Area - Developed by Women for Women 2Health News:Good Neighbor Pharmacy Reinforces Commitment to Helping Enhance Patient Care 2Health News:Good Neighbor Pharmacy Reinforces Commitment to Helping Enhance Patient Care 3
... August 2, 2011 Engaging in physical activity after ... of survival. In a study published in the September ... , researchers from the Israel Study Group on First ... who lived in low socioeconomic status (SES) neighborhoods engaged ...
... 29, 2011) − In a recent study published in ... University of Kentucky College of Nursing and Mark Pyles, ... at the College of Charleston, found smoke-free legislation does ... urban communities. This is true regardless of whether the ...
... , MONDAY, Aug. 1 (HealthDay News) -- Teens are much ... or go to school in neighborhoods with many fast food ... finds. Researchers compared 2007 data on junk food consumption ... junk food outlets, such as fast food restaurants, convenience stores, ...
... Reporter , MONDAY, Aug. 1 (HealthDay News) -- Take the stairs ... tag with your kids at the park. New research shows ... 2.5 hours, of moderate activity a week -- can reduce the ... did more -- about 300 minutes a week, or five hours ...
... in a form of T cell leukemia, according to a ... of Experimental Medicine ( www.jem.org ). Approximately half ... carry genetic mutations in a cellular signaling pathway called Notch, ... by Andrew Weng and colleagues at the British Columbia Cancer ...
... Reston, Va. (August 1, 2011) Two new studies ... of Nuclear Medicine (JNM) provide insight into the ... types of dementia and to identify pharmaceuticals to slow ... Aging (NIA) and the Alzheimer,s Association guidelines for detecting ...
Cached Medicine News:Health News:Heart attack survivors from poorer neighborhoods get less exercise 2Health News:Study finds smoke-free laws don't impact rural or urban economies 2Health News:With Junk Food Stores Nearby, Teens May Eat More of It 2Health News:Even a Little Exercise Helps the Heart, Study Finds 2Health News:Even a Little Exercise Helps the Heart, Study Finds 3Health News:New JNM research supports upcoming Alzheimer's disease guidelines 2
(Date:7/31/2014)... , July 31, 2014 Touro University ... has been selected as the recipient of a $150,000 ... will allow the University to increase research and classroom ... creating state-of-the-art technology for the study of health sciences, ... the diverse needs and interests of our students," said ...
(Date:7/31/2014)... SAN FRANCISCO , July 31, 2014 /PRNewswire/ ... ) and Aspira Scientific ( Milpitas, California ... joint venture to develop and commercialize new fluorination ... biologically active molecules has benefited from the use ... metabolism, and combine lipophilicity with polarity to improve ...
(Date:7/31/2014)... ANTWERP, Belgium and LONDON , July ... Organization (CRO) and services provider for the medical industries, announced today ... The United Kingdom has one ... valued at USD 8.9 billion in 2012 and it is projected ... was estimated at USD 234 billion in 2012, equal to 9.5% ...
Breaking Medicine Technology:Touro University California Garners Grant From Long Foundation 2Catylix, Inc. and Aspira Scientific Announce Joint Venture to Commercialize New Fluorination Technologies 2genae Opens Offices in London 2
... 22, 2011 MedVantx, Inc., today announced the deployment ... medication and adherence reporting engine across its ... in the Company,s integrated program of initial free medication ... program utilizes the Company,s proprietary automated ATM like sample ...
... NEW YORK, Nov. 22, 2011 ... research report is available in its ... - Global Pipeline Analysis, Competitive Landscape ... http://www.reportlinker.com/p0685953/MRI-Systems---Global-Pipeline-Analysis-Competitive-Landscape-and-Market-Forecasts-to-2017.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Imaging ...
Cached Medicine Technology:MedVantx Launches Patient Profile™, A Proprietary Closed-Loop Pharmaceutical Adherence Management Program for Medical Home, Accountable Care and Population Health Management 2MedVantx Launches Patient Profile™, A Proprietary Closed-Loop Pharmaceutical Adherence Management Program for Medical Home, Accountable Care and Population Health Management 3MRI Systems - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 2MRI Systems - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 3MRI Systems - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 4MRI Systems - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 5MRI Systems - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 6MRI Systems - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 7MRI Systems - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 8MRI Systems - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 9MRI Systems - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 10MRI Systems - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 11MRI Systems - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 12