Navigation Links
New genomic marker for tuberculosis may help identify patients who will develop the disease
Date:8/29/2010

It may soon be possible to identify patients who will develop tuberculosis, as scientists have identified changes in the blood specific to the disease. These findings are from an international study published in the August 19 issue of Nature and conducted by doctors and researchers at Nationwide Children's Hospital using blood profiling techniques to understand infections.

Tuberculosis (TB) is caused by the bacterium Mycobacterium tuberculosis, which usually attacks the lungs and can be fatal if not treated properly. Although TB is no longer a leading cause of death in the United States, it remains an epidemic in much of the world. One third of the world's total population is infected with the microbes that cause TB; however, most people infected with M. tuberculosis remain asymptomatic with latent TB. People with latent TB have a 10 percent lifetime risk of developing active TB, but current tests can not identify which individuals will develop the disease.

"Tools to diagnose infections like TB, bronchiolitis and pneumonia have been developed and are actively used to classify patients as being infected with specific pathogens, but we are still unable to predict how each person is going to react to the infection," said one of the study's authors Octavio Ramilo, MD, chief of Infectious Diseases at Nationwide Children's Hospital. "It's difficult to predict patient outcomes, and this is a real problem."

To combat this problem, Dr. Ramilo and Asuncion Mejias, MD, investigators at the Center for Vaccines and Immunity in The Research Institute at Nationwide Children's Hospital, are using microarray technology to develop blood profiles in patients specific to infectious diseases.

"Each infectious agent, be it a virus or a bacterium, interacts with human immune cells in unique ways by triggering proteins on white blood cells," said Dr. Mejias. "We can identify patterns among the white blood cell's activated proteins and identi
'/>"/>

Contact: Mary Ellen Peacock
MaryEllen.Peacock@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Large-scale genomic analysis of prostate cancer unveiled
2. Genentech uses Complete Genomics human genome sequencing service to compare tumor and normal genome in patient with non-small cell lung cancer; results published in Nature
3. Breast Cancer Patients Often Confused by Genomic Testing
4. Improvements needed in genomic test result discussions
5. Lawrence Berkeley National Laboratory and OpenHelixTM Announce an Updated Free Tutorial Suite for VISTA: Tools for Comparative Genomics
6. SeqWright Advances Genomic Discovery With Isilon IQ
7. Researchers chart genomic map spanning over 2 dozen cancers
8. The cancer biomarker conundrum: Too many false discoveries
9. NIH launches effort to define markers of human immune responses
10. Biomarkers Could Spot Alzheimers Disease Early, Studies Suggest
11. A New Marker to Spot Aggressive Breast Cancers?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... FRIDAY, Nov. 21, 2014 (HealthDay News) -- Many young ... smoke, but a new study finds fumes from the ... been linked to an increased risk for leukemia in ... 21 in the journal Cancer Epidemiology, Biomarkers & ... hookah tobacco smoking is not a safe alternative to ...
(Date:11/22/2014)... Steven Reinberg HealthDay Reporter ... better when patients are treated in an ambulance by a ... researchers report. The sooner patients get the clot dissolver ... after a stroke, the researchers noted. For the best outcome, ... after stroke symptoms start, the researchers said. "The so-called ...
(Date:11/22/2014)... HealthDay Reporter FRIDAY, Nov. 21, ... homes may commonly deal with aggressive or inappropriate behavior from ... 10 centers in New York state found that, in the ... were involved in some type of incident with a fellow ... someone yelling or cursing at another resident. In other cases, ...
(Date:11/21/2014)... Los Angeles, CA (PRWEB) November 21, 2014 ... is now creating picture-perfect smiles for patients in preparation ... are bonded to the fronts of teeth, look completely ... flaws. In certain situations, veneers are also valued for ... for most patients and can be used on one ...
(Date:11/21/2014)... 2014 (HealthDay News) -- Seeking to make it tougher ... and Drug Administration on Thursday approved a new hydrocodone ... -- best known by the brand name Vicodin -- ... to a surge in dangerous addictions across the United ... ER (hydrocodone bitartrate) is an extended-release tablet to treat ...
Breaking Medicine News(10 mins):Health News:Hookahs Deliver Toxic Benzene in Every Puff, Study Shows 2Health News:Special Ambulance Delivers Vital Stroke Care More Quickly 2Health News:Special Ambulance Delivers Vital Stroke Care More Quickly 3Health News:Senior-to-Senior Aggression Common in U.S. Nursing Homes 2Health News:Senior-to-Senior Aggression Common in U.S. Nursing Homes 3Health News:Los Angeles Porcelain Veneers Dentist, Dr. Kevin Sands, Now Creates Picture-Perfect Smiles for Patients for the Holiday Season 2Health News:FDA Approves 'Abuse-Resistant' Narcotic Painkiller 2Health News:FDA Approves 'Abuse-Resistant' Narcotic Painkiller 3
... A study has indicated that inflammatory bowel disease in women ... two times.// , ,Diseases such as Crohn's disease and ... weight babies or premature babies. Yet, the 'silver lining' exists ... has certainly reduced the risks. ,The St. ...
... by a US research company has highlighted the overriding ... health// problem facing society and their children today. , ... adults, found that nearly 27% named 'obesity', as the ... followed next with 16% strongly advocating action, while ...
... that could be used as a bioterrorist tool eludes ... better understood, University of Iowa// researchers report in the ... ,This bacterium, Francisella tularensis, is found naturally in ... insect bites, contact with infected rabbits or ingesting contaminated ...
... Food Technology Plant Special Research Centre (CeRPTA) is a ... called as gluten sensitive enteropathy. This product was successfully ... enhanced nutritive value and increased shelf life. ... sufferers to follow a strictly gluten-free diet for their ...
... of Texas M. D. Anderson Cancer Center suggest that the ... 40 years reduced the tumor growth in the// human pancreas ... ,The Journal of the National Cancer Institute issued on Dec.20 ... is three times more effective than just the administration of ...
... resonance imaging technique developed at the University of ... of neurological problems, such as// Chiari malformations, hydrocephalus ... use through a $1.4 million National Institutes of ... project, which draws on bioengineering, radiology and neurosurgery, ...
Cached Medicine News:Health News:Clues Found On How Deadly Bacterium Gains Foothold 2Health News:Clues Found On How Deadly Bacterium Gains Foothold 3Health News:Gluten Free Bread: Boon for Celiac Disease 2Health News:Anti Allergy Drugs Reduce Tumor Growth 2Health News:Anti Allergy Drugs Reduce Tumor Growth 3Health News:New MRI Technique Measures Intracranial Pressure in Brain Disorder 2
(Date:11/22/2014)... HILL, N.C. , Nov. 21, 2014 /PRNewswire/ ... healthcare system. Undoubtedly, the growing influence of patients ... spend for marketing interactions. Now, more than ever, ... retain patients for medical products is essential. ... firm, Best Practices, LLC, benchmarked companies spent about ...
(Date:11/21/2014)... SAN CLEMENTE, Calif. , Nov. 21, 2014 /PRNewswire/ ... Lab Coats and Performance Scrubs carried out a new ... the medical industry,s very first "limited edition" lab ... the first female professors of surgery in the world. ... departure from its unisex predecessors, with a sleek envelope ...
(Date:11/21/2014)... 2014  PTC Therapeutics, Inc. (NASDAQ: PTCT ) ... Award for Vision, Innovation, and Leadership has been awarded to ... award recognizes an individual who has had a significant impact ... for several decades. "I am honored to ... Peltz , Ph.D., CEO of PTC Therapeutics, Inc. "When I ...
Breaking Medicine Technology:New Report Details Importance of Adopting a "Patient Journey" Framework in Marketing 2Medelita Introduces Medical Industry's First Limited Edition Women's Designer Lab Coat 2PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 2PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 3
For the quantitative in vitro determination of Lipase in human serum and plasma....
Enzymatic Clearance assay for the in vitro quantitative determination of HDL-cholesterol in human serum and plasma....
For the quantitative in vitro determination of Ammonia in plasma...
For the quantitative in vitro determination of Potassium in serum or plasma....
Medicine Products: