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New genetic risk factors of lupus found in study of African-American women
Date:6/24/2011

(Boston) - Researchers from Boston University's Slone Epidemiology Center have found four new genetic variants in the major histocompatibility complex (MHC) that confer a higher risk of systemic lupus erythemathosus ("lupus") in African American women. The study, which currently appears on-line in Human Genetics, is believed to be the first to comprehensively assess the association between genetic variants in the MHC region and risk of lupus in African American women.

The findings were based on the ongoing Black Women's Health Study, a prospective study of the health of 59,000 African American women conducted by the researchers since 1995.

African American women have a higher risk of lupus compared with white US women. It has been known that the MHC region in chromosome 6 carries genetic factors associated with several auto-immune disease, and recent studies have reported several genetic variants in the MHC region associated with risk of lupus. However, these previous studies were carried out in European and Asian ancestry populations.

The researchers genotyped more than 1,500 genetic variants single nucleotide polymorphisms (SNPs) in 400 lupus cases and 800 controls. They found four independent SNPs associated with higher risk of lupus. Through the construction of a genetic score consisting of those four SNPs, the researchers found that risk of lupus increased by almost 70 percent for each extra high risk allele. One of the SNPs reported in the present study was also found in a study in Chinese women, and the researches were also able to replicate some previous findings from a study in women of European ancestry.

According to the researchers, their results show the presence of several independent genetic risk factors in the MHC region in African American women. Some of those genetic variants may be shared among women of different genetic ancestries.

"Taken together, our results and previous genome-wide a
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Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

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