Navigation Links
New genetic risk factors of lupus found in study of African-American women
Date:6/24/2011

(Boston) - Researchers from Boston University's Slone Epidemiology Center have found four new genetic variants in the major histocompatibility complex (MHC) that confer a higher risk of systemic lupus erythemathosus ("lupus") in African American women. The study, which currently appears on-line in Human Genetics, is believed to be the first to comprehensively assess the association between genetic variants in the MHC region and risk of lupus in African American women.

The findings were based on the ongoing Black Women's Health Study, a prospective study of the health of 59,000 African American women conducted by the researchers since 1995.

African American women have a higher risk of lupus compared with white US women. It has been known that the MHC region in chromosome 6 carries genetic factors associated with several auto-immune disease, and recent studies have reported several genetic variants in the MHC region associated with risk of lupus. However, these previous studies were carried out in European and Asian ancestry populations.

The researchers genotyped more than 1,500 genetic variants single nucleotide polymorphisms (SNPs) in 400 lupus cases and 800 controls. They found four independent SNPs associated with higher risk of lupus. Through the construction of a genetic score consisting of those four SNPs, the researchers found that risk of lupus increased by almost 70 percent for each extra high risk allele. One of the SNPs reported in the present study was also found in a study in Chinese women, and the researches were also able to replicate some previous findings from a study in women of European ancestry.

According to the researchers, their results show the presence of several independent genetic risk factors in the MHC region in African American women. Some of those genetic variants may be shared among women of different genetic ancestries.

"Taken together, our results and previous genome-wide association studies in European and east Asian ancestry populations show that women of different ancestral origins may share some genetic components for the risk of lupus," said lead author Edward A. Ruiz-Narvaez, ScD, an assistant professor of epidemiology at Boston University School of Medicine. "The identity of the causal variants that are being tagged by the reported SNPs is still unknown. Further studies are needed to narrow the position of the potential causal variants," he added.

The researchers point out that the identified genetic variants are not necessarily the ones directly involved in the pathogenesis of lupus, and further research is needed to identify the true causal genetic variants. Identification of the true causal genetic variants should lead to a better understanding of the biology of lupus.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Obstructive Sleep Apnea in Kids May Have Genetic Cause
3. Epigenetic signals differ across alleles
4. Study reveals genetic link between mammographic density and breast cancer
5. Genetic Risk Score Doesnt Spot Heart Trouble in Women
6. Penn researchers find genetic link to leukemias with an unknown origin
7. Scientists Spot Genetic Fingerprints of Individual Cancers
8. Genetic health risks in children of assisted reproductive technology
9. Genetic Mutation Linked to Prostate Cancer in Blacks
10. Protecting the brain from of a deadly genetic disease
11. Protecting the brain from a deadly genetic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... will be giving viewers the lowdown on sciatica in a new episode of ... that focuses on current events and innovation and investigates each subject in-depth with ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a ... “The Journey: From the Mountains to the Mission Field” is the creation of published ... all ages and currently teaches a class of ladies at her church, which she ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), an ... showcase a range of technology and learning solutions at the 68th Annual American ... to be held October 14–18, 2017 at the Mandalay Bay Resort in Las ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
(Date:10/2/2017)... 2017  AllianceRx Walgreens Prime, the combined central specialty ... pharmacy benefit manager Prime Therapeutics LLC (Prime), today officially ... the unveiling of new signage at its headquarters in ... at a few other company-owned facilities across the country. ... some of whom will begin to see the AllianceRx ...
(Date:10/2/2017)... COPENHAGEN, Denmark , Oct. 2, 2017 The ... tool in the struggle to reverse the tide of prescription ... plan for regulating their medicine intake and stepping down their ... is set to launch in December 2017; the first 100,000 ... access. Learn more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology: