Navigation Links
New genetic risk factors of lupus found in study of African-American women
Date:6/24/2011

(Boston) - Researchers from Boston University's Slone Epidemiology Center have found four new genetic variants in the major histocompatibility complex (MHC) that confer a higher risk of systemic lupus erythemathosus ("lupus") in African American women. The study, which currently appears on-line in Human Genetics, is believed to be the first to comprehensively assess the association between genetic variants in the MHC region and risk of lupus in African American women.

The findings were based on the ongoing Black Women's Health Study, a prospective study of the health of 59,000 African American women conducted by the researchers since 1995.

African American women have a higher risk of lupus compared with white US women. It has been known that the MHC region in chromosome 6 carries genetic factors associated with several auto-immune disease, and recent studies have reported several genetic variants in the MHC region associated with risk of lupus. However, these previous studies were carried out in European and Asian ancestry populations.

The researchers genotyped more than 1,500 genetic variants single nucleotide polymorphisms (SNPs) in 400 lupus cases and 800 controls. They found four independent SNPs associated with higher risk of lupus. Through the construction of a genetic score consisting of those four SNPs, the researchers found that risk of lupus increased by almost 70 percent for each extra high risk allele. One of the SNPs reported in the present study was also found in a study in Chinese women, and the researches were also able to replicate some previous findings from a study in women of European ancestry.

According to the researchers, their results show the presence of several independent genetic risk factors in the MHC region in African American women. Some of those genetic variants may be shared among women of different genetic ancestries.

"Taken together, our results and previous genome-wide association studies in European and east Asian ancestry populations show that women of different ancestral origins may share some genetic components for the risk of lupus," said lead author Edward A. Ruiz-Narvaez, ScD, an assistant professor of epidemiology at Boston University School of Medicine. "The identity of the causal variants that are being tagged by the reported SNPs is still unknown. Further studies are needed to narrow the position of the potential causal variants," he added.

The researchers point out that the identified genetic variants are not necessarily the ones directly involved in the pathogenesis of lupus, and further research is needed to identify the true causal genetic variants. Identification of the true causal genetic variants should lead to a better understanding of the biology of lupus.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Obstructive Sleep Apnea in Kids May Have Genetic Cause
3. Epigenetic signals differ across alleles
4. Study reveals genetic link between mammographic density and breast cancer
5. Genetic Risk Score Doesnt Spot Heart Trouble in Women
6. Penn researchers find genetic link to leukemias with an unknown origin
7. Scientists Spot Genetic Fingerprints of Individual Cancers
8. Genetic health risks in children of assisted reproductive technology
9. Genetic Mutation Linked to Prostate Cancer in Blacks
10. Protecting the brain from of a deadly genetic disease
11. Protecting the brain from a deadly genetic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... report to their offering. ... failure, it replaces the function of kidneys by removing the ... the treatment helps to keep the patient body,s electrolytes such ... Increasing number of ESRD patients & substantial healthcare expenditure on ...
Breaking Medicine Technology: