Navigation Links
New genetic risk factors of lupus found in study of African-American women
Date:6/24/2011

(Boston) - Researchers from Boston University's Slone Epidemiology Center have found four new genetic variants in the major histocompatibility complex (MHC) that confer a higher risk of systemic lupus erythemathosus ("lupus") in African American women. The study, which currently appears on-line in Human Genetics, is believed to be the first to comprehensively assess the association between genetic variants in the MHC region and risk of lupus in African American women.

The findings were based on the ongoing Black Women's Health Study, a prospective study of the health of 59,000 African American women conducted by the researchers since 1995.

African American women have a higher risk of lupus compared with white US women. It has been known that the MHC region in chromosome 6 carries genetic factors associated with several auto-immune disease, and recent studies have reported several genetic variants in the MHC region associated with risk of lupus. However, these previous studies were carried out in European and Asian ancestry populations.

The researchers genotyped more than 1,500 genetic variants single nucleotide polymorphisms (SNPs) in 400 lupus cases and 800 controls. They found four independent SNPs associated with higher risk of lupus. Through the construction of a genetic score consisting of those four SNPs, the researchers found that risk of lupus increased by almost 70 percent for each extra high risk allele. One of the SNPs reported in the present study was also found in a study in Chinese women, and the researches were also able to replicate some previous findings from a study in women of European ancestry.

According to the researchers, their results show the presence of several independent genetic risk factors in the MHC region in African American women. Some of those genetic variants may be shared among women of different genetic ancestries.

"Taken together, our results and previous genome-wide a
'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Obstructive Sleep Apnea in Kids May Have Genetic Cause
3. Epigenetic signals differ across alleles
4. Study reveals genetic link between mammographic density and breast cancer
5. Genetic Risk Score Doesnt Spot Heart Trouble in Women
6. Penn researchers find genetic link to leukemias with an unknown origin
7. Scientists Spot Genetic Fingerprints of Individual Cancers
8. Genetic health risks in children of assisted reproductive technology
9. Genetic Mutation Linked to Prostate Cancer in Blacks
10. Protecting the brain from of a deadly genetic disease
11. Protecting the brain from a deadly genetic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... feelings are personal and subjective, the human brain ... represents emotions across different senses, situations and even ... neuroscientist Adam Anderson. , "We discovered that fine-grained ... an area of the brain associated with emotional ... an individual,s subjective feeling," says Anderson, associate professor ...
(Date:7/9/2014)... There has been a sharp increase in the ... using MyChart, the online, interactive service that allows patients ... healthcare providers, schedule appointments, and renew prescriptions. , Over ... MyChart each year increased five-fold, while the ... 10-fold, according to a study by Dr. David ...
(Date:7/9/2014)... declines and extinctions around the world have been ... but new research from the National Institute for ... pathogen, ranavirus, may also contribute. , In ... ranavirus, which causes severe hemorrhage of internal organs ... of wood frogs if they are exposed to ...
(Date:7/9/2014)... flatulence and have a reputation for being highly toxic, but ... now being being found to offer potential health benefits in ... and dementia. A new compound (AP39), designed and made at ... therapies, by targeting delivery of very small amounts of the ... , Scientists in Exeter have already found that the compound ...
(Date:7/9/2014)... the most important organs in the human body. Its ... properly this is its synthesis function and ... this is its detoxification function. Lack of exercise and ... the liver. The resulting diseased cells can lead to ... failure. According to the German Liver Foundation, over five ...
Breaking Medicine News(10 mins):Health News:Study cracks how the brain processes emotions 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 3Health News:Study predicts ranavirus as potential new culprit in amphibian extinctions 2Health News:Rotten egg gas holds key to healthcare therapies 2Health News:Telemedicine for patients with chronic liver diseases 2Health News:Telemedicine for patients with chronic liver diseases 3
... designs a telemedicine system using interactive digital television. ... of Navarre, Alejandro Fanjul Fernández, has designed a ... This system enables the monitoring and treatment of ... from the comfort and convenience of their homes, ...
... a novel pathway by which estradiol, the primary estrogen ... as it aids in avoiding osteoporosis. // ,It ... bone, and that when the production of estrogen is ... after exposure to radiation or chemotherapeutic drugs, bones become ...
... day give their children a weekly treatment with a nasal ... severe middle //ear infection, based on results of a study. ... use of antibiotics, thereby avoiding the problem of antibiotic resistance. ... is an inflammation of the middle ear space that can ...
... Wisconsin is running a pioneering trial of using stem ... which have //been "encouraging". ,Amish Raval, of ... cardiologists began their trial on March 7. ... it could revolutionize cardiology," said Raval. ,Stem ...
... registered in the US National Marrow Donor Registry// is so ... queue for matching donors. ,Urmi and Girish are ... here. ,Urmi, 5, has been diagnosed with aplastic ... play with her dolls and read stories about Lord Krishna ...
... University College of Dentistry has discovered the first conclusive proof ... human hosts. This can even be ... between 100,000 and 200,000 years ago, say the researchers. ... cariology and comprehensive care at NYUCD, discovered that Streptococcus mutans, ...
Cached Medicine News:Health News:Interactive Digital Television to Monitor Health 2Health News:Interactive Digital Television to Monitor Health 3Health News:Estradiol Guards Against Osteoporosis 2Health News:Viral Enzyme Recruited in Fight Against Ear Infection 2Health News:Viral Enzyme Recruited in Fight Against Ear Infection 3Health News:Tooth Decay Bacteria Evolved Along With Man 2
(Date:1/15/2014)... TORONTO , Jan. 15, 2014  According to ... medical technology market intelligence, the United ... occlusion (TEO) device markets will expand moderately through ... fastest-growing segments. In particular, increasing interest in drug-eluting ...
(Date:1/15/2014)...  Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 ("HSR") ... its indirect wholly-owned subsidiary, Sapphire Subsidiary Corp. ("Purchaser"), for ... Solta Medical, Inc. (NASDAQ: SLTM ) ("Solta") ...
(Date:1/15/2014)...  Zafgen, Inc., a leading biopharmaceutical company dedicated to ... today announced initial results from its Phase 2a ... aminopeptidase 2 (MetAP2), in patients with Prader-Willi syndrome ... results showed improvements in body weight, hunger-related behaviors, ...
Breaking Medicine Technology:US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4
Joseph skin hook is a single end-sharp with 2 prong....
Experience great vision, comfort and durability in a quarterly-replacement lens....
A unique lens system featuring Balanced Progressive Technology for optimum vision quality at every distance....
The proven daily wear spherical soft contact lens....
Medicine Products: