Navigation Links
New genetic risk factor for inflammation identified in African-American women
Date:8/30/2012

SEATTLE African Americans have higher blood levels of a protein associated with increased heart-disease risk than European Americans, despite higher "good" HDL cholesterol and lower "bad" triglyceride levels. This contradictory observation now may be explained, in part, by a genetic variant identified in the first large-scale, genome-wide association study of this protein involving 12,000 African American and Hispanic American women.

Lead researcher Alexander Reiner, M.D., an epidemiologist at Fred Hutchinson Cancer Research Center, and colleagues describe their findings online ahead of the Sept. 7 print issue of the American Journal of Human Genetics.

Specifically, the researchers looked for genetic signposts associated with elevated levels of C-reactive protein, or CRP a marker of inflammation that is linked with increased risk of heart disease, diabetes and some cancers.

"Most previous studies examining the genetic determinants of elevated CRP have focused on tens of thousands of white individuals of European descent," said Reiner, a member of the Hutchinson Center's Public Health Sciences Division. "Since minorities African Americans and Hispanic Americans in particular tend to have higher CRP levels than other U.S. racial and ethnic groups, it's important to understand whether genetic factors might contribute to these differences."

Reiner and colleagues identified several genetic factors linked to CRP that are relatively specific to African Americans. They found a variation in TREM2, a family of genes on chromosome 6p21 that are expressed in white blood cells and appear to be important for regulating the degree of inflammation generated when white blood cells respond to infection or tissue injury.

"TREM genes were recognized relatively recently to be involved in inflammation and autoimmune disorders. Our finding adds further support to
'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. URMC researchers connect new genetic signature to leukemia
2. More clues about why chimps and humans are genetically different
3. Mans Best Friend Points the Way in Genetic Research
4. Pre-test genetic counseling increases cancer knowledge for BRCA patients
5. Genetic Studies Give Clues to Tourette Syndrome, OCD
6. Marin Countys high breast cancer rate may be tied to genetics
7. Genetic Research Sheds Light on Jewish Diaspora
8. Genetic analyses reveal novel mutations as causes of startle disease
9. American Society of Human Genetics to hold 2012 annual meeting, Nov. 6 to 10, in San Francisco
10. Fruit flies light the way for A*STAR scientists to pinpoint genetic changes that spell cancer
11. Genetic mutations that cause common childhood brain tumors identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... uncommon these days to find a colored ribbon representing a ... cancer. But what color ribbon does one think of with ... color, for many suffering from the disease, black may be ... study consisting of lung cancer patients, primarily smokers between the ... light on the stigma often felt by these patients, the ...
(Date:4/17/2014)... improves general blood flow and alleviates muscle soreness ... at the University of Illinois at Chicago. , ... in the Archives of Physical Medicine and ... function in people who had not exercised, suggesting ... their level of physical activity. , Improved circulation ...
(Date:4/17/2014)... found that India,s shocking rates of suicide are highest ... clinging to tiny smallholdings less than one hectare ... cotton and coffee, that are highly susceptible to global ... previous case studies that point to a crisis in ... of the nation,s economy during the 90s. Researchers say ...
(Date:4/17/2014)... April 17, 2014 Giving patients adrenaline after they suffer ... increase their prospects of surviving long-term, according to new ... number of patients who have a cardiac arrest get ... cardiac arrest for decades," said Dr. Steve Lin, an ... "Yet, despite advances in medical treatment, long-term survival rates ...
(Date:4/17/2014)... lost its status as the leading weapon against the ... life, with new research indicating it simply needs to ... use of the cheap anti-malarial drug chloroquine in treating ... of more than half a million people each year ... has developed resistance to chloroquine, but research carried out ...
Breaking Medicine News(10 mins):Health News:Unraveling the 'black ribbon' around lung cancer 2Health News:Massage therapy improves circulation, eases muscle soreness 2Health News:New evidence of suicide epidemic among India's 'marginalized' farmers 2Health News:New evidence of suicide epidemic among India's 'marginalized' farmers 3Health News:Adrenaline does little to increase patient's survival after cardiac arrest 2Health News:Scientists find new way to fight malaria drug resistance 2
... published this week in the New England Journal of ... patients with a specific genetic mutation benefit from the drug ... 15.9 months. In patients who responded, the drug stopped cancer ... with a BRAF V600 mutation, this drug is a breakthrough. ...
... emerging field of systems biology, UT Southwestern Medical Center researchers ... cell,s sense of direction and then confirmed those predictions in ... explain how mammalian cells establish the sense of direction necessary ... form of E. coli bacteria employ to hijack ...
... Mo. Many leading causes of death are ... activity. Adults in minority populations have lower levels ... deaths, according to the Department of Health & ... Missouri researchers found that minority adults who received ...
... By Steven Reinberg HealthDay Reporter , ... on Wednesday blocked implementation of an FDA mandate that ... images on packages of cigarettes. The proposed requirement ... set to kick in this September, would have emblazoned ...
... All children can benefit from going to preschool, especially those ... where parents don,t provide much mental stimulation, a new study ... from 600 families who were followed from age 2 until ... went to preschool did better once they started kindergarten than ...
... refuting a hypothesis can be as significant as proving ... elucidating how diseases proceed with a view toward preventing, ... scientists from spending precious years of effort exploring a ... Proceedings of the National Academy of Sciences , Munich-based ...
Cached Medicine News:Health News:Investigators predict, confirm how E. coli bacteria hijack cells' directional mechanism 2Health News:Fitness programs for minority adults lack cultural relevance, MU study finds 2Health News:Judge Blocks Plan for Graphic Cigarette Warnings 2Health News:Preschool Kids Best Prepared for Kindergarten: Study 2Health News:Observations refute widely held view on causal mechanism in ALS 2Health News:Observations refute widely held view on causal mechanism in ALS 3
(Date:1/15/2014)... the leading health care supply chain expertise, analytics and ... national contracts that expand its portfolio to provide hospital ... These include manufacturer product and service agreements, as well ... IT consulting support. New Novation agreements ...
(Date:1/15/2014)... BreedIT Corp (OTC: BRDT), through its Israeli ... sophisticated agro-breeding solutions for plant breeders and researchers, today ... of directors appointed chemistry and pharmaceutical industry expert Dr. ... the board. From 1975 to 2012, Dr. ...
(Date:1/15/2014)... , Jan. 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ... its Symphony® CGM System as a non-invasive, wireless continuous ... Doman , Executive Chairman and Interim CEO of Echo ... Tenth Annual Equity Conference. Mr. Doman ...
Breaking Medicine Technology:New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
... Champions Biotechnology, Inc. (OTC ... with a predictive preclinical platform aimed at accelerating ... drugs, has established an exclusive licensing agreement with ... University,s wholly owned technology transfer company. The licensing ...
... Bellicum Pharmaceuticals, Inc. today announced $4.5 million in Series ... used to complete the company,s ongoing Phase I/IIa trial of ... to prepare for Phase IIb trials. The company anticipates reporting ... , The new funding brings the total raised to date ...
Cached Medicine Technology:Champions Biotechnology, Inc. Signs Exclusive Licensing Agreement with Ramot for TAR-1, a Novel Therapeutic for the Treatment of Cancer 2Champions Biotechnology, Inc. Signs Exclusive Licensing Agreement with Ramot for TAR-1, a Novel Therapeutic for the Treatment of Cancer 3Champions Biotechnology, Inc. Signs Exclusive Licensing Agreement with Ramot for TAR-1, a Novel Therapeutic for the Treatment of Cancer 4Bellicum Pharmaceuticals Announces $4.5 Million in New Funding 2
Finesse electrosurgical generator (100-120 VAC) utilizes a patented design that integrates the electrosurgical generator and smoke evacuation system into a single compact unit....
NS2000 Bipolar Generator provides precise coagulation without tissue sticking....
The Sabre 2400 provides high power performance and key user features to meet today's demanding electrosurgical needs. It is an ideal general-purpose electrosurgical generator....
The ExcaliburPlus PC is the most powerful isolated ESU with 10,000 V PTP in spray coag....
Medicine Products: