Navigation Links
New genetic clues to breast and ovarian cancer
Date:5/2/2013

A major international study involving a Simon Fraser University scientist has found that sequence differences in a gene crucial to the maintenance of our chromosomes' integrity predispose us to certain cancers.

Angela Brooks-Wilson, an associate professor in SFU's biomedical physiology and kinesiology department and a Distinguished Scientist at the BC Cancer Agency, is one of more than 600 scientists globally who contributed to this study.

Published in the March 27, 2013 online issue of the science journal Nature Genetics, the study is called Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.

The study found that variations in the sequencing of the TERT gene, which encodes an enzyme crucial to telomere maintenance, influence telomere length and our risk of getting breast and ovarian cancers.

Telomeres are structures that encapsulate our chromosomes' ends and are often compared to the plastic protectors on the ends of shoelaces.

These protective structures shorten in length over our lifespan and chromosomal cells should stop dividing when they become too short.

Scientists have known for a while that if chromosomal ends become exposed this can lead to genetic damage and cancer. They've also estimated that up to 80 per cent of telomere-length variation is inherited.

This is the first study to connect that inheritance to predisposition to breast and ovarian cancer.

"This discovery helps us better understand the biology that underlies these cancers, as well as better predict who is likely to develop them," says Brooks-Wilson.

The SFU researcher is one of four investigators in the Ovarian Cancer in Alberta and British Columbia study (OVAL-BC). The interprovincial ovarian cancer study contributed samples and data to this new international study.

"About 140 individual smaller studies like
'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3035
Simon Fraser University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. International study finds new genetic links to juvenile arthritis
2. More accurate, powerful genetic analysis tool opens new gene-regulation realms
3. Genetic markers linked to the development of lymphedema in breast cancer survivors
4. Genetic variation contributes to pulmonary fibrosis risk
5. Johns Hopkins experts to present genetics advances at international meeting this weekend
6. Effect of medication is affected by copies of genetic information
7. Liver transplantation for patients with genetic liver conditions has high survival rate
8. Mosquito genetic complexity may take a bite out of efforts to control malaria
9. Moffitt Researchers help lead international efforts that find new genetic links to ovarian cancer
10. More Genetic Insights Into 3 Types of Cancer
11. 5 genetic variations increase risk of ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... BALTIMORE, April 30 MDDCcommunity.com would like to announce ... local member company. Over the past few months Dynasplint(R) ... establishing more of a presence online. Their expansion includes ... Twitter account, all of which are intended to provide ...
... April 30 The Missouri House today amended ... funds to go to grants for maternity homes and pregnancy ... being considered by the Missouri Senate. , , ... homes and pregnancy resource centers are essential to helping pregnant ...
... The ,Help is Here Express, bus tour will be stopping ... 8th at various cities in order to help uninsured and ... for free or nearly free. With the state,s unemployment rate ... is ready to help state residents who face layoffs and ...
... YORK and NASSAU, The Bahamas, April 30 ... of Fincor (FINC) through a 1:1 share split. Prospero ... Technologies enlarges thru Fincor its portfolio with the new ... the WETTECH and Advanced Cavitation Technologies. Prospero ...
... are abandoned again! WEST PALM BEACH, Fla., April ... a civil rights and negligence lawsuit in New York ... Welfare Administration and four other agencies for failure to ... state-licensed foster parent.Identified in the filing only by their ...
... and psychological repercussions that impact quality of life and ... ability to remain employed. Compared to individuals with other ... have a more profound effect on a person,s ability ... of those with severe forms of arthritis were not ...
Cached Medicine News:Health News:Dynasplint Systems, Inc. Launches Two New Web Sites Plus Social Media Tools 2Health News:Partnership for Prescription Assistance Prepared to Help Kansan Workers Hurt by Recession 2Health News:Partnership for Prescription Assistance Prepared to Help Kansan Workers Hurt by Recession 3Health News:Partnership for Prescription Assistance Prepared to Help Kansan Workers Hurt by Recession 4Health News:Prospero Group (PRPG) and Fincor (FINC) Made a Share Transfer and Enter the Market with ACTRx a New Malaria and Dengue Fever Treatment 2Health News:Severely Abused Foster Children Sue New York City Child Welfare Agencies After their Failure to Help Them 2Health News:Women with arthritis more likely than men to stop working 2Health News:Women with arthritis more likely than men to stop working 3
(Date:12/15/2014)... FRESH MEADOWS, N.Y. , Dec. 15, 2014 /PRNewswire/ ... using the SPL (Structured Product Labeling) markup language standard, ... need the understanding and skills to work with the ... present a series of three webinars on the benefits ... The three one-hour webinars will be facilitated by ...
(Date:12/14/2014)... 14, 2014  ChartSpan, a consumer platform for patients ... and iPad medical app in the United ... ChartSpan is an iPhone and ... manage and send electronic healthcare records. The product was ... tired of waiting for the healthcare system to deliver ...
(Date:12/13/2014)... 12, 2014 Mindray Medical International Limited ("Mindray", ... and marketer of medical devices worldwide, today announced shareholder ... held in Hong Kong on ... shareholders voted to re-elect incumbent directors Li Xiting and ... shareholders did not re-elect Peter Wan as ...
Breaking Medicine Technology:Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 2Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 3ChartSpan Becomes The Most Downloaded Medical App in America 2ChartSpan Becomes The Most Downloaded Medical App in America 3Mindray Announced Shareholder Resolutions Post 2014 Annual General Meeting 2
... CITY, Calif., April 16, 2007 /PRNewswire-FirstCall/ --,Threshold ... its oncology pipeline, which includes two,preclinical presentations ... research presentations from Threshold's Tubulin,Inhibitor program. The ... Association for Cancer Research (AACR) annual meeting,being ...
... Trial to 9 mg Dosage,Level, HOPKINTON, Mass., April ... that clinical data on its lead,nerve repair therapy, ... Scientific Session at the 75th Annual Meeting of,the ... , The oral presentation, "Results of the Cethrin ...
Cached Medicine Technology:Threshold Pharmaceuticals Announces Multiple Presentations on,Oncology Pipeline at the 2007 American Association for Cancer,Research (AACR) Annual Meeting 2Threshold Pharmaceuticals Announces Multiple Presentations on,Oncology Pipeline at the 2007 American Association for Cancer,Research (AACR) Annual Meeting 3Boston Life Sciences, Inc. Announces Presentation of Cethrin Phase,I/IIa 6-Month Results at 75th Annual Meeting of the American,Association of Neurological Surgeons 2Boston Life Sciences, Inc. Announces Presentation of Cethrin Phase,I/IIa 6-Month Results at 75th Annual Meeting of the American,Association of Neurological Surgeons 3Boston Life Sciences, Inc. Announces Presentation of Cethrin Phase,I/IIa 6-Month Results at 75th Annual Meeting of the American,Association of Neurological Surgeons 4
... Finntips have been designed to optimize the ... of our tip products is widely recognized ... range has been extended over the years ... standard and special tips including filter tips, ...
The BioCheck LH ELISA is intended for the quantitative determination of luteinizing hormone (LH) in human serum. This assay is useful in the diagnosis and treatment of gonadal dysfunction....
... (LH) is a glycoprotein secreted by the ... and TSH, the intact LH molecule is ... These glycoproteins all have homologous alpha-subunits, however ... LH and FSH production and secretion are ...
The NPT7 blood gas analyzer measures pH/blood gases and oximetry on 90 L sample volume with a two-step sampling procedure. Clinical tests compare NPT7 accuracy to that of benchtop analyzers. 30 sampl...
Medicine Products: