Navigation Links
New genetic clues to breast and ovarian cancer
Date:5/2/2013

A major international study involving a Simon Fraser University scientist has found that sequence differences in a gene crucial to the maintenance of our chromosomes' integrity predispose us to certain cancers.

Angela Brooks-Wilson, an associate professor in SFU's biomedical physiology and kinesiology department and a Distinguished Scientist at the BC Cancer Agency, is one of more than 600 scientists globally who contributed to this study.

Published in the March 27, 2013 online issue of the science journal Nature Genetics, the study is called Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.

The study found that variations in the sequencing of the TERT gene, which encodes an enzyme crucial to telomere maintenance, influence telomere length and our risk of getting breast and ovarian cancers.

Telomeres are structures that encapsulate our chromosomes' ends and are often compared to the plastic protectors on the ends of shoelaces.

These protective structures shorten in length over our lifespan and chromosomal cells should stop dividing when they become too short.

Scientists have known for a while that if chromosomal ends become exposed this can lead to genetic damage and cancer. They've also estimated that up to 80 per cent of telomere-length variation is inherited.

This is the first study to connect that inheritance to predisposition to breast and ovarian cancer.

"This discovery helps us better understand the biology that underlies these cancers, as well as better predict who is likely to develop them," says Brooks-Wilson.

The SFU researcher is one of four investigators in the Ovarian Cancer in Alberta and British Columbia study (OVAL-BC). The interprovincial ovarian cancer study contributed samples and data to this new international study.

"About 140 individual smaller studies like OVAL-BC contributed samples from more than 150,000 women, data and analysis to make this new study happen. It's a remarkable example of international collaboration. I would say this is big science at its collegial best."


'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3035
Simon Fraser University
Source:Eurekalert

Related medicine news :

1. International study finds new genetic links to juvenile arthritis
2. More accurate, powerful genetic analysis tool opens new gene-regulation realms
3. Genetic markers linked to the development of lymphedema in breast cancer survivors
4. Genetic variation contributes to pulmonary fibrosis risk
5. Johns Hopkins experts to present genetics advances at international meeting this weekend
6. Effect of medication is affected by copies of genetic information
7. Liver transplantation for patients with genetic liver conditions has high survival rate
8. Mosquito genetic complexity may take a bite out of efforts to control malaria
9. Moffitt Researchers help lead international efforts that find new genetic links to ovarian cancer
10. More Genetic Insights Into 3 Types of Cancer
11. 5 genetic variations increase risk of ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... PITTSBURGH, Pa. (PRWEB) , ... October 13, 2017 , ... ... the dark poses a problem. Fortunately, an inventor from Austin, Texas, has identified a ... access to medication in darkness or restricted lighting. As such, it eliminates the need ...
(Date:10/13/2017)... , ... October 13, 2017 ... ... of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ... on guideline updates for the primary prevention of cardiovascular diseases during the ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset ... of specialty vendors and unique items from across the nation, this holiday-themed event will ... services offered by the VNA. The boutique will be open Saturday, November 4 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, ... lowdown on sciatica in a new episode of "Success Files," which is an ... and innovation and investigates each subject in-depth with passion and integrity. , Sciatica ...
(Date:10/12/2017)... ... 12, 2017 , ... First Healthcare Compliance (FHC), an industry ... a range of technology and learning solutions at the 68th Annual American Healthcare ... be held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 West ... in innovative solutions for injectable drug administration, today announced ... the market opens on Thursday, October 26, 2017, and ... results and business expectations at 9:00 a.m. Eastern Time. ... or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)... Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an update ... Puerto Rico , where the company manufactures ... Following a comprehensive onsite assessment, the ... temporary loss of power and minimal water damage due ... have resumed, and the company expects to return to ...
(Date:10/5/2017)... ROSEMONT, Ill. , Oct. 5, 2017 /PRNewswire-USNewswire/ ... American Association of Oral and Maxillofacial Surgeons (AAOMS) ... than opioids – to be used as a ... post-surgical pain. ... relationship, the AAOMS White Paper "Opioid Prescribing: Acute ...
Breaking Medicine Technology: