Navigation Links
New genetic analysis reveals principles of phenotypic expression
Date:6/22/2010

College Park, MD (June 22, 2010) -- The Human Genome Project, along with numerous parallel efforts to solve the DNA sequences of hundreds of animal, plant, fungal, and microbe genomes in the last few decades, has produced enormous amounts of genetic data with which researchers are struggling to keep pace. Knowing gene sequences, after all, may not directly reveal what roles that genes play in the actual manifestation of physical traits (or phenotypes) of an organism -- including their roles in human diseases. To help navigate the new genomic landscape, researchers are developing experimental approaches and analysis tools to help prioritize and organize complex genetic information with respect to phenotypic effects.

In the journal Chaos, which is published by the American Institute of Physics (AIP), scientists at the University of Alabama at Birmingham report powerful new techniques for studying the phenotypes related to genetic differences in the budding yeast, Saccharomyces cerevisiae. The researchers took yeast cultures from an extensive library of approximately 5,000 mutated strains and subjected them to hydroxyurea -- an anti-cancer drug with known effects on the cell cycle.

Using a method called quantitative high-throughput cellular phenotyping (Q-HTCP), the researchers analyzed growth curves for tens of thousands of individual cultures, "focused on finding all of the genes that modulate the cellular effects of the drug," says study co-author John Hartman, an assistant professor of genetics. The researchers then selected the 300 "most 'hydroxyurea-interactive' genes" and further classified the genes by testing their influence on cell growth after treatment with drugs acting by different mechanisms. To integrate the results from such experiments, the researchers developed a new data mining approach called Recursive Expectation-Maximization Clustering (REMc). The approach, Hartman says, "has advantages over prior methods with respect to defining cluster number and quantifying cluster quality," which augments biological discovery.

The technique, Hartman adds, "offers a new way for trying to understand how genetic variation -- such as that related to human disease -- is alternatively buffered or expressed." Understanding phenotypic expression at a systems level, he says, would help create a new field of medicine, dubbed "phenomics."


'/>"/>

Contact: Jason Socrates Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Related medicine news :

1. New research shows peer drug use may increase an individuals genetic tendency to use drugs
2. University of Utah researchers fight genetic killer of infants and toddlers
3. H1N1 Flu Undergoing Genetic Changes in Pigs
4. Renowned Geneticist Heralds in New Era for People with Down Syndrome
5. Genetics, Insecticides Might Contribute to Parkinsons
6. Research: Major breakthrough will revolutionize the screening and treatment of genetic diseases
7. Genetic markers could predict prostate cancer in younger men, U-M study finds
8. MSU researchers discover potential genetic factor in eating disorders
9. Jews Around the World Linked by Common Genetic Ancestry
10. Sun-induced skin cancer: new discovery permits doctors to assess genetic risk
11. Lifestyle Doesnt Influence Genetic Risks in Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... Fullerton, California (PRWEB) , ... ... ... Solutions, a nationwide provider of communication enabled solutions and managed services today ... cloud software for the enterprise contact center market. , Altura, one of ...
(Date:5/24/2016)... , ... May 24, 2016 , ... Mental health watchdog ... the Church of Scientology and renowned professor of psychiatry Thomas Szasz, is continuing its ... “Psychiatry: An Industry of Death” exhibit in Atlanta, Georgia. The opening of the exhibit ...
(Date:5/24/2016)... ... ... Boyd Industries, a leading supplier of dental chairs and cabinetry , ... pediatric dentistry , at AAPD 2016, the annual conference and trade show of the ... Unit keeps dental hand pieces and other anxiety-provoking pieces of the dental delivery system ...
(Date:5/24/2016)... ... May 24, 2016 , ... The Radiosurgery Society (RSS), a ... is recognizing five medical residents and students for their outstanding contributions to research ... awards will be presented at the 2016 SRS/SBRT Scientific Meeting taking place June ...
(Date:5/24/2016)... ... May 24, 2016 , ... As reported by MassGeneral.org, on ... penis transplant in the United States . The 64-year-old patient who received the transplant ... transplant could restore not only a natural appearance, but also urinary and sexual function ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... , May 23, 2016 The World Health ... PrePex device to include adolescents aged 13 years, and ... can be offered for adult and adolescent males in the ... . PrePex was the first male circumcision device to ... MedTech,s CEO, Eddy Horowitz said: " The ...
(Date:5/23/2016)... ABU DHABI , UAE, May 23, 2016 ... the importance of Precision Medicine and the role ...     The First International ... under the distinguished patronage and presence of Sheikh ... Development. The conference focused in Precision Medicine, which helps provide ...
(Date:5/23/2016)... , May 23, 2016 ... reach USD 5.0 billion by 2022, according to a ... generation of medical waste coupled with the lack of ... is expected to drive the demand for reprocessed medical ... devices as compared to that of the original device ...
Breaking Medicine Technology: