Navigation Links
New genetic analysis reveals principles of phenotypic expression

College Park, MD (June 22, 2010) -- The Human Genome Project, along with numerous parallel efforts to solve the DNA sequences of hundreds of animal, plant, fungal, and microbe genomes in the last few decades, has produced enormous amounts of genetic data with which researchers are struggling to keep pace. Knowing gene sequences, after all, may not directly reveal what roles that genes play in the actual manifestation of physical traits (or phenotypes) of an organism -- including their roles in human diseases. To help navigate the new genomic landscape, researchers are developing experimental approaches and analysis tools to help prioritize and organize complex genetic information with respect to phenotypic effects.

In the journal Chaos, which is published by the American Institute of Physics (AIP), scientists at the University of Alabama at Birmingham report powerful new techniques for studying the phenotypes related to genetic differences in the budding yeast, Saccharomyces cerevisiae. The researchers took yeast cultures from an extensive library of approximately 5,000 mutated strains and subjected them to hydroxyurea -- an anti-cancer drug with known effects on the cell cycle.

Using a method called quantitative high-throughput cellular phenotyping (Q-HTCP), the researchers analyzed growth curves for tens of thousands of individual cultures, "focused on finding all of the genes that modulate the cellular effects of the drug," says study co-author John Hartman, an assistant professor of genetics. The researchers then selected the 300 "most 'hydroxyurea-interactive' genes" and further classified the genes by testing their influence on cell growth after treatment with drugs acting by different mechanisms. To integrate the results from such experiments, the researchers developed a new data mining approach called Recursive Expectation-Maximization Clustering (REMc). The approach, Hartman says, "has advantages over prior methods with respect to defining cluster number and quantifying cluster quality," which augments biological discovery.

The technique, Hartman adds, "offers a new way for trying to understand how genetic variation -- such as that related to human disease -- is alternatively buffered or expressed." Understanding phenotypic expression at a systems level, he says, would help create a new field of medicine, dubbed "phenomics."


Contact: Jason Socrates Bardi
American Institute of Physics

Related medicine news :

1. New research shows peer drug use may increase an individuals genetic tendency to use drugs
2. University of Utah researchers fight genetic killer of infants and toddlers
3. H1N1 Flu Undergoing Genetic Changes in Pigs
4. Renowned Geneticist Heralds in New Era for People with Down Syndrome
5. Genetics, Insecticides Might Contribute to Parkinsons
6. Research: Major breakthrough will revolutionize the screening and treatment of genetic diseases
7. Genetic markers could predict prostate cancer in younger men, U-M study finds
8. MSU researchers discover potential genetic factor in eating disorders
9. Jews Around the World Linked by Common Genetic Ancestry
10. Sun-induced skin cancer: new discovery permits doctors to assess genetic risk
11. Lifestyle Doesnt Influence Genetic Risks in Breast Cancer
Post Your Comments:
(Date:12/1/2015)... ... , ... Royal River Natural Foods — a locally-owned, independent natural health store ... the nutritional supplement creatine, along with resistance training for a year, had more new ... The report is part of the December 2015 issue of Natural Insights for Well ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... oncology and hematology continuing medical education (CME), today announced that the first annual ... Hyatt New York. , “The prevention, detection and treatment of gastrointestinal cancers are ...
(Date:12/1/2015)... Middletown, PA (PRWEB) , ... December 01, 2015 ... ... separate environments; however, there are professionals who believe that with innovative technologies and ... services allows the patient to get the benefit of a dual-approach to his ...
(Date:12/1/2015)... ... December 01, 2015 , ... CloudLIMS ... 2015 Golden Bridge Business Awards under the New Products and Services category for ... based sample management software that helps labs organize data and track ...
(Date:12/1/2015)... ... 2015 , ... The importance of volumetric breast density assessment ... numerous abstracts accepted for presentation here, at the 101st Annual Radiology Society of ... use of Volpara Solutions’ quantitative breast imaging software tools for providing breast imaging ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , Dec. 1, 2015  AccuTEC Blades, a ... new corporate logo and brand identity program. The ... and engineering of bladed products where "the edge ... --> Serving manufacturers and distributors ... auto glass equipment, AccuTEC,s product lines include those ...
(Date:12/1/2015)... , Dec. 1, 2015 Building ... HIV/AIDS, Johnson & Johnson (NYSE: JNJ ) ... Janssen Pharmaceutical Companies to significantly reduce the burden ... make up 74 percent of new HIV infections ... on World AIDS Day, these new initiatives include ...
(Date:12/1/2015)... , December 1, 2015 ... Contraceptive Injectables, Topical Contraceptives, Male Condoms, Female ... Vaginal Rings, Contraceptive Diaphragms, Contraceptive Sponges, Non-Surgical ... Size, Share, Growth, Trends and Forecast 2014 ... Transparency Market Research (TMR).The report states that ...
Breaking Medicine Technology: