Navigation Links
New genetic analysis reveals principles of phenotypic expression
Date:6/22/2010

College Park, MD (June 22, 2010) -- The Human Genome Project, along with numerous parallel efforts to solve the DNA sequences of hundreds of animal, plant, fungal, and microbe genomes in the last few decades, has produced enormous amounts of genetic data with which researchers are struggling to keep pace. Knowing gene sequences, after all, may not directly reveal what roles that genes play in the actual manifestation of physical traits (or phenotypes) of an organism -- including their roles in human diseases. To help navigate the new genomic landscape, researchers are developing experimental approaches and analysis tools to help prioritize and organize complex genetic information with respect to phenotypic effects.

In the journal Chaos, which is published by the American Institute of Physics (AIP), scientists at the University of Alabama at Birmingham report powerful new techniques for studying the phenotypes related to genetic differences in the budding yeast, Saccharomyces cerevisiae. The researchers took yeast cultures from an extensive library of approximately 5,000 mutated strains and subjected them to hydroxyurea -- an anti-cancer drug with known effects on the cell cycle.

Using a method called quantitative high-throughput cellular phenotyping (Q-HTCP), the researchers analyzed growth curves for tens of thousands of individual cultures, "focused on finding all of the genes that modulate the cellular effects of the drug," says study co-author John Hartman, an assistant professor of genetics. The researchers then selected the 300 "most 'hydroxyurea-interactive' genes" and further classified the genes by testing their influence on cell growth after treatment with drugs acting by different mechanisms. To integrate the results from such experiments, the researchers developed a new data mining approach called Recursive Expectation-Maximization Clustering (REMc). The approach, Hartman says, "has advantages over prior methods with
'/>"/>

Contact: Jason Socrates Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New research shows peer drug use may increase an individuals genetic tendency to use drugs
2. University of Utah researchers fight genetic killer of infants and toddlers
3. H1N1 Flu Undergoing Genetic Changes in Pigs
4. Renowned Geneticist Heralds in New Era for People with Down Syndrome
5. Genetics, Insecticides Might Contribute to Parkinsons
6. Research: Major breakthrough will revolutionize the screening and treatment of genetic diseases
7. Genetic markers could predict prostate cancer in younger men, U-M study finds
8. MSU researchers discover potential genetic factor in eating disorders
9. Jews Around the World Linked by Common Genetic Ancestry
10. Sun-induced skin cancer: new discovery permits doctors to assess genetic risk
11. Lifestyle Doesnt Influence Genetic Risks in Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... 2015 WellCare Health Plans, Inc. (NYSE: WCG) ... by the Florida Healthy Kids Corporation (FHKC) to continue to ... as part of the Florida Healthy Kids (FHK) program. Pending ... and may be extended for two additional years at FHKC’s ... in the FHK program who live in Regions 1, 2, ...
(Date:5/21/2015)... May 21, 2015 Ticket Down is a reliable ... USA vs. Guatemala on Friday, July 3rd at LP ... to become a fan of international soccer. The number of chances ... on American soil is growing at a large clip. Over the ... come to the USA to play in front of the American ...
(Date:5/21/2015)... Bird B Gone, the leader in bird ... new sizes of the Bird Spike 2001 to its comprehensive ... bird spike is specifically designed to reduce building maintenance ... lines, parapet walls, I-beams, window ledges and more. It is ... boxes, allowing customers to buy the right amount of spike ...
(Date:5/21/2015)... Amercanex today announced that it is ... electronic marketplace for industrial hemp and associated products. ... which wholesale and retail distributors of hemp can ... a fully disclosed and transparent environment. , Amerhempex ... unique blend of cutting-edge infrastructure, tools, and needs-based ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Shimadzu ... AOC-6000 robotic autosampler, which features new time-saving tools ... standard injection techniques: liquid, headspace, and solid-phase microextraction ... This new tool allows users to seamlessly change ... the GC/MS. , The new autosampler allows for ...
Breaking Medicine News(10 mins):Health News:WellCare Selected to Continue Participating in the Florida Healthy Kids Program, Will Serve Nine Florida Regions Under the New Contract 2Health News:USA vs. Guatemala Tickets: Ticket Down Slashes United States Men's Soccer Team (USMNT) vs. Guatemala Tickets at LP Field in Nashville on 7/3/15 2Health News:Bird B Gone, Inc. Offers New Box Sizes of Stainless Steel Bird Spikes 2Health News:Bird B Gone, Inc. Offers New Box Sizes of Stainless Steel Bird Spikes 3Health News:Amercanex is Revolutionizing Order and Efficiency in the Hemp Industry 2Health News:Shimadzu’s New AOC-6000 Autosampler Makes Automated Sample Introduction Simple and Efficient 2
... for Parkinson,s Research announced awards totaling approximately $10.1 million ... development projects. The funding includes $2.5 million to drive ... one of the Foundation,s Edmond J. Safra Core Programs ... Clinical Intervention Awards are: , Charlotte Keywood, Addex ...
... HealthDay Reporter , TUESDAY, Oct. 5 (HealthDay News) ... who received ,hands-only, cardiopulmonary resuscitation (CPR) from a bystander ... who received no CPR or conventional CPR with mouth-to-mouth ... not only is ,hands-only, CPR -- in which the ...
... Saint Louis University researcher, scientists have identified an important microRNA ... blood. Led by ngel Baldn, Ph.D., assistant professor ... published in a recent issue of Proceedings of the ... America, the study found that the microRNA miR-33, may ...
... The National Institutes of Health has awarded a ... Florida and Tampa-based biotechnology company Saneron-CCEL Therapeutics, Inc., ... human umbilical cord blood cells (HUBC) into animal ... use the pre-clinical data to gain U.S. Food ...
... Oct. 5, 2010 Only about a third of ... recommendations, which means they are likely missing out ... Along with vitamins, minerals and fiber, fruits and vegetables ... suggests help support women,s health including breast and ovarian ...
... 2010 Elsevier, the leading publisher of scientific, ... announced a new version of its online research ... was well received by the neuroscience researcher community ... In the updated version, BrainNavigator 3.0, Elsevier has ...
Cached Medicine News:Health News:MJFF announces over $10 million in funding for clinical and pre-clinical PD research 2Health News:'Hands-Only' CPR May Work Best for Cardiac Arrest 2Health News:'Hands-Only' CPR May Work Best for Cardiac Arrest 3Health News:'Hands-Only' CPR May Work Best for Cardiac Arrest 4Health News:Better cholesterol drugs may follow Saint Louis University researcher's breakthrough 2Health News:USF and Saneron get $2.6 million to develop Alzheimer's treatment using umbilical cord blood cells 2Health News:Shortfalls in carotenoid intake may impact women's health 2Health News:Shortfalls in carotenoid intake may impact women's health 3Health News:Shortfalls in carotenoid intake may impact women's health 4Health News:Elsevier's BrainNavigator 3.0 reflects the next step in enhancing neurological research 2Health News:Elsevier's BrainNavigator 3.0 reflects the next step in enhancing neurological research 3
(Date:5/21/2015)... May 21, 2015 Thirteen winners of ... designed to bring promising medical inventions to market, ... (HPN) in collaboration with the National Institutes of ... (CAI).  The winning teams were selected based on ... and will move forward to phase three of ...
(Date:5/21/2015)...  AbbVie (NYSE: ABBV ) announced today the ... announced offer to acquire each outstanding share of common ... cash and AbbVie common stock, as described in the ... and Exchange Commission by AbbVie on March 23, 2015, ... offer will expire at 5:00 p.m., New ...
(Date:5/21/2015)... Delcath Systems, Inc. (NASDAQ: DCTH ) ... its expanded Global Phase 2 Clinical Trial Program of ... unresectable hepatocellular carcinoma (primary liver cancer, or HCC) has ... conducted at the same hospitals in Europe ... trial, and ICC enrollment is now open at Goethe ...
Breaking Medicine Technology:Neuro Startup Challenge selects 13 winning teams to launch startups for unlicensed NIH technologies to improve brain health 2Neuro Startup Challenge selects 13 winning teams to launch startups for unlicensed NIH technologies to improve brain health 3Neuro Startup Challenge selects 13 winning teams to launch startups for unlicensed NIH technologies to improve brain health 4AbbVie Announces Offer Consideration for Acquisition of Pharmacyclics 2AbbVie Announces Offer Consideration for Acquisition of Pharmacyclics 3AbbVie Announces Offer Consideration for Acquisition of Pharmacyclics 4ICC Cohort Of Delcath's Global Phase 2 Trial Of Melphalan/HDS In Hepatocellular Carcinoma Now Open For Enrollment 2ICC Cohort Of Delcath's Global Phase 2 Trial Of Melphalan/HDS In Hepatocellular Carcinoma Now Open For Enrollment 3ICC Cohort Of Delcath's Global Phase 2 Trial Of Melphalan/HDS In Hepatocellular Carcinoma Now Open For Enrollment 4
... 18 Aida,Pharmaceuticals, Inc. (OTC Bulletin Board: AIDA) ... is developing a potential cancer drug,that seeks to ... a pre-clinical product being developed by Aida,s Shanghai,Qiaer ... the,function of extracted fragments of Vasostatin, an inhibitor ...
... CARLSBAD, Calif., April 18 Isis,Pharmaceuticals, Inc. ... of two studies,designed to assess the impact ... Annual Atherosclerosis, Thrombosis and Vascular Biology (ATVB),Conference ... in a poster,entitled "Antisense Inhibition of Apolipoprotein ...
Cached Medicine Technology:Aida Announces New Anti-Cancer Drug Under Development 2Isis Reports Reduction of apoB-100 Levels in a Murine Model Resulting in Up to 92% Reduction of Atherosclerosis 2Isis Reports Reduction of apoB-100 Levels in a Murine Model Resulting in Up to 92% Reduction of Atherosclerosis 3Isis Reports Reduction of apoB-100 Levels in a Murine Model Resulting in Up to 92% Reduction of Atherosclerosis 4
... IMPACs comprehensive information system designed specifically ... integrate and streamline their diagnostic, management, ... intuitive software solution. Thousands of laboratory ... have proven PowerPaths unique "case-centric model ...
The most compact revolutionary innovation in hematology. 26 paramaters with 5 part DIFF....
... The remote vision controls ... NP-3S chart projector from the ... the autorefraction measurements can be ... via wireless data transfer. The ...
... (threshold) testing provides clinically beneficial information ... conditions. Dark adaptometry is useful in ... degenerations, senile miosis, high myopia, vitamin-A ... while whole-field scotopic sensitivity has been ...
Medicine Products: