Navigation Links
New genetic analysis reveals principles of phenotypic expression
Date:6/22/2010

College Park, MD (June 22, 2010) -- The Human Genome Project, along with numerous parallel efforts to solve the DNA sequences of hundreds of animal, plant, fungal, and microbe genomes in the last few decades, has produced enormous amounts of genetic data with which researchers are struggling to keep pace. Knowing gene sequences, after all, may not directly reveal what roles that genes play in the actual manifestation of physical traits (or phenotypes) of an organism -- including their roles in human diseases. To help navigate the new genomic landscape, researchers are developing experimental approaches and analysis tools to help prioritize and organize complex genetic information with respect to phenotypic effects.

In the journal Chaos, which is published by the American Institute of Physics (AIP), scientists at the University of Alabama at Birmingham report powerful new techniques for studying the phenotypes related to genetic differences in the budding yeast, Saccharomyces cerevisiae. The researchers took yeast cultures from an extensive library of approximately 5,000 mutated strains and subjected them to hydroxyurea -- an anti-cancer drug with known effects on the cell cycle.

Using a method called quantitative high-throughput cellular phenotyping (Q-HTCP), the researchers analyzed growth curves for tens of thousands of individual cultures, "focused on finding all of the genes that modulate the cellular effects of the drug," says study co-author John Hartman, an assistant professor of genetics. The researchers then selected the 300 "most 'hydroxyurea-interactive' genes" and further classified the genes by testing their influence on cell growth after treatment with drugs acting by different mechanisms. To integrate the results from such experiments, the researchers developed a new data mining approach called Recursive Expectation-Maximization Clustering (REMc). The approach, Hartman says, "has advantages over prior methods with respect to defining cluster number and quantifying cluster quality," which augments biological discovery.

The technique, Hartman adds, "offers a new way for trying to understand how genetic variation -- such as that related to human disease -- is alternatively buffered or expressed." Understanding phenotypic expression at a systems level, he says, would help create a new field of medicine, dubbed "phenomics."


'/>"/>

Contact: Jason Socrates Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Related medicine news :

1. New research shows peer drug use may increase an individuals genetic tendency to use drugs
2. University of Utah researchers fight genetic killer of infants and toddlers
3. H1N1 Flu Undergoing Genetic Changes in Pigs
4. Renowned Geneticist Heralds in New Era for People with Down Syndrome
5. Genetics, Insecticides Might Contribute to Parkinsons
6. Research: Major breakthrough will revolutionize the screening and treatment of genetic diseases
7. Genetic markers could predict prostate cancer in younger men, U-M study finds
8. MSU researchers discover potential genetic factor in eating disorders
9. Jews Around the World Linked by Common Genetic Ancestry
10. Sun-induced skin cancer: new discovery permits doctors to assess genetic risk
11. Lifestyle Doesnt Influence Genetic Risks in Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... ... ... The NALA, a boutique marketing agency, is proud to announce that it has ... organization providing financial and emotional support to families of children with cancer living in ... hosted a Thanksgiving food drive that resulted in four boxes of donated food. ...
(Date:12/6/2016)... Cary, NC (PRWEB) , ... December 06, 2016 ... ... cancer research charity, is thrilled to formally announce its Not a Moment to ... Moment to Lose will rally supporters dedicated to declaring victory over cancer. The ...
(Date:12/6/2016)... ... 06, 2016 , ... GrekTek LLC, ( http://www.grektek.com ) an ... http://kck.st/2g3a1so ) for the HealthyWatch, a new device to help patients manage their ... watch while sharing these events with caregivers in real time. , ...
(Date:12/6/2016)... ... December 06, 2016 , ... Specialty Technical Publishers (STP) ... Audit Protocol Consortium (IAPC) EHS audit protocol for Great Britain . Leading ... of their EHS regulatory obligations and rapidly collect, share, archive, and export audit ...
(Date:12/5/2016)... ... ... What: Shriners Hospitals for Children, with the help of Dimension Data, will bring ... monitor and web-enabled camera. Santa visits with children through Dimension Data’s program to connect ... is where the video connection to the North Pole will stream. Much like children ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... , Dec. 6, 2016 /PRNewswire/ - InMed Pharmaceuticals, ... today on its R&D program in the use ... pulmonary disease (COPD). In June, 2015 InMed initiated ... to identify the targets and potential active compounds ... COPD. Subsequently, with in vitro assays using human ...
(Date:12/5/2016)... WARSAW, Ind. , Dec. 5, 2016  Zimmer ... "Company") today announced that, pursuant to its previously-announced ... securities identified in the table below (collectively, the ... Notes were validly tendered and not validly withdrawn ... York City time, today, December 5, ...
(Date:12/5/2016)... 5, 2016 Sangamo BioSciences, Inc. (Nasdaq: ... presentation of preclinical and manufacturing data that support SB-525, its ... Annual Meeting of the American Society of Hematology (ASH) ... from December 3-6, 2016. "We have developed an ... we believe is highly competitive, and we remain on track ...
Breaking Medicine Technology: