Navigation Links
New genetic analysis reveals principles of phenotypic expression
Date:6/22/2010

College Park, MD (June 22, 2010) -- The Human Genome Project, along with numerous parallel efforts to solve the DNA sequences of hundreds of animal, plant, fungal, and microbe genomes in the last few decades, has produced enormous amounts of genetic data with which researchers are struggling to keep pace. Knowing gene sequences, after all, may not directly reveal what roles that genes play in the actual manifestation of physical traits (or phenotypes) of an organism -- including their roles in human diseases. To help navigate the new genomic landscape, researchers are developing experimental approaches and analysis tools to help prioritize and organize complex genetic information with respect to phenotypic effects.

In the journal Chaos, which is published by the American Institute of Physics (AIP), scientists at the University of Alabama at Birmingham report powerful new techniques for studying the phenotypes related to genetic differences in the budding yeast, Saccharomyces cerevisiae. The researchers took yeast cultures from an extensive library of approximately 5,000 mutated strains and subjected them to hydroxyurea -- an anti-cancer drug with known effects on the cell cycle.

Using a method called quantitative high-throughput cellular phenotyping (Q-HTCP), the researchers analyzed growth curves for tens of thousands of individual cultures, "focused on finding all of the genes that modulate the cellular effects of the drug," says study co-author John Hartman, an assistant professor of genetics. The researchers then selected the 300 "most 'hydroxyurea-interactive' genes" and further classified the genes by testing their influence on cell growth after treatment with drugs acting by different mechanisms. To integrate the results from such experiments, the researchers developed a new data mining approach called Recursive Expectation-Maximization Clustering (REMc). The approach, Hartman says, "has advantages over prior methods with
'/>"/>

Contact: Jason Socrates Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New research shows peer drug use may increase an individuals genetic tendency to use drugs
2. University of Utah researchers fight genetic killer of infants and toddlers
3. H1N1 Flu Undergoing Genetic Changes in Pigs
4. Renowned Geneticist Heralds in New Era for People with Down Syndrome
5. Genetics, Insecticides Might Contribute to Parkinsons
6. Research: Major breakthrough will revolutionize the screening and treatment of genetic diseases
7. Genetic markers could predict prostate cancer in younger men, U-M study finds
8. MSU researchers discover potential genetic factor in eating disorders
9. Jews Around the World Linked by Common Genetic Ancestry
10. Sun-induced skin cancer: new discovery permits doctors to assess genetic risk
11. Lifestyle Doesnt Influence Genetic Risks in Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... 2014) ― A new study in the American ... health-related Google searches reveals a recurring pattern that could ... , Investigators from San Diego State University, the Santa ... analyzed "healthy" Google searches (searches that included the term ... in the U.S. from 2005 to 2012. They found ...
(Date:4/18/2014)... scientists could lead to potential new treatments for breaking ... , Fibrosis, or scarring, is a hallmark of ... lungs can lead to serious organ damage and, in ... options centers on findings made by Swati Bhattacharyya, PhD, ... that a specific protein plays in promoting fibrosis. ...
(Date:4/17/2014)... inflammation in non-cancerous prostate tissue may have nearly twice ... with no inflammation, according to results of a new ... Cancer Center. , The link between persistent inflammation and ... prostate cancer those with a Gleason score between ... most aggressive and rapidly growing prostate cancers. , "What ...
(Date:4/17/2014)... pain relief targets that could be used to ... King,s College London made the discovery when researching ... of the body. , Dr Marzia Malcangio said: ... pain generation and our findings could help chemotherapy ... One potential side effect of some chemotherapy drugs ...
(Date:4/17/2014)... today in PLOS Pathogens , children who live ... can mount an immune response to infection with malaria ... of high fever and illness and partially control the ... may help researchers develop future interventions that prevent or ... Each year, approximately 200 million cases of malaria occur ...
Breaking Medicine News(10 mins):Health News:New research shows people are thinking about their health early in the week 2Health News:New clues on tissue scarring in scleroderma 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:New pain relief targets discovered 2Health News:Study sheds light on how the immune system protects children from malaria 2
... ... there are 6 key components of a successful strategic workforce planning process,” stated Jim ... components of strategic workforce planning and provides guidelines for implementing each of those 6 ... Waco, ...
... All Allied ... the health care industry. , ... (PRWEB) August 19, 2009 -- Today, All Allied Health Schools announced the launch of a new ... latest developments in the health care industry--and how these changes will affect health care careers ...
... Computed tomography (CT) scans are responsible for more than ... medical imaging exams. However, a newly adapted low-dose technique ... to reduce patient radiation resulting from CT up to ... September issue of the American Journal of Roentgenology ...
... led to fewer surgical deliveries, review shows , TUESDAY, ... increase the risk of Cesarean section delivery, according to ... Researchers reviewed available data on elective induction, in which ... it for medical reasons. Most of the studies included ...
... , , , ... Pharmaceutical Companies, Inc. (NYSE: PRX ) today announced ... final approval from the U.S. Food and Drug Administration for ... Clonidine TDS is a generic version of Boehringer Ingelheim,s ...
... , CHICAGO, Aug. 18 Synch-Solutions is ... on Inc. magazine,s 2009 list of the 5,000 fastest ... Synch-Solutions, reflecting the company,s strong and steady advancement - even in ... and technology solutions for organizations across multiple industry sectors. "As an ...
Cached Medicine News:Health News:Profiles International Releases New Study Identifying Key Factors for Strategic Workforce Planning 2Health News:All Allied Health Schools Launches "Health Care Community" 2Health News:All Allied Health Schools Launches "Health Care Community" 3Health News:Induced Labor May Prevent Need for Cesarean Section 2Health News:Par Pharmaceutical & Aveva Drug Delivery Systems Receive Final Approval to Market Generic Catapres TTS(R) 2Health News:Par Pharmaceutical & Aveva Drug Delivery Systems Receive Final Approval to Market Generic Catapres TTS(R) 3Health News:Synch-Solutions Named to Inc. Magazine's 2009 Ranking of the Fastest Growing Companies in the United States 2
(Date:1/14/2014)... Animal Emergency Critical Care, a LifeCentre partner practice, located at ... is the first in Loudoun County to ... Susan M. Barnes , Medical Director, is a well-seasoned veterinarian ... Cole Taylor , are avid scuba divers. "As altitude skiers and ...
(Date:1/14/2014)... NineSigma , Inc., the leading innovation partner ... Summit , May 14-16, 2014 at the Global Center ... . This is the premier industry ... achievements through open innovation. Participants will learn how world-changing ...
(Date:1/14/2014)... WASHINGTON, New York , January 14, 2014 ... leading provider of Closed System Transfer Devices (CSTD) for hazardous drugs, today ... growth for the fourth straight year.   ... exposure for pharmacy technicians, pharmacists, nurses and other ...
Breaking Medicine Technology:Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4Equashield's Sales Grow by 60% in 2013 2
Storage temperature: 15 - 30C, linearity: 0 - 20 mg/dL, expected value: male: 3.0 - 7.0 mg/dL and female: 2.2 - 6.2 mg/dL. Available with calibrator and number of tests 125....
For the quantitative determination of Uric Acid in serum. Linearity: 25 mg/dl....
... Engineered for small and medium volume ... Elecsys 1010 System offers the speed, simplicity ... testing requirements. Compact yet powerful, the Elecsys ... from rapid response assays to routine testing ...
Sample throughput of up to 80 tests per hour (4 modules). Low maintenance requirements. Continuous random access. 25 - 100 channels on board. 1008 tests or 6 hours of walkaway operation....
Medicine Products: