Navigation Links
New genes involved in acute lymphoblastic leukemia play fundamental role in prognosis of the disease
Date:2/6/2009

p>

Subgroup with worst prognosis

With this research a set of 13 microRNAs was identified which showed up as epigenetically regulated in 65% of the patients studied with acute lymphoblastic leukaemia, according to Doctor Prsper. Epigenetic regulation is the modulation of the genes expression that does not depend on changes in the sequence of the genetic code and the influence of which in cancer is increasingly being demonstrated. They are, thus, reversible changes in the DNA that manage to get the genes to be expressed or not (to be activated or silent) depending on external conditions.

In the subgroup of patients amongst which this set of genes appears as regulated, it was shown that, although these patients initially responded to treatment, they were the ones who with greater frequency subsequently suffered relapse, disimprove and present the worst prognosis and survival rates. These are the patients amongst whom the disease is much more resistant to treatment and amongst whom a silencing of the expression of the microRNAs is produced, according to the specialist.

Most efficacious pharmaceutical drugs

Given these result, Doctor Prsper concludes that epigenetic regulation plays a fundamental role in the development of this disease. Moreover, he points out, it would seem that the most recent pharmaceutical drugs, capable of producing epigenetic alterations, can be effective in 65% of patients who respond worst to conventional therapies for acute lymphoblastic leukaemia.


'/>"/>

Contact: Oihane Lakar
oihane@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Angiogenesis linked to poor survival in patients with rare type of ovarian cancer
2. Penn study finds link between Parkinsons disease genes and manganese poisoning
3. Genesis Pharmaceuticals Enters Into Agreement to Purchase Hongrui Pharmaceuticals, and Acquire 22 New Traditional Chinese Medicines
4. Cardiogenesis Announces Successful Educational Symposium at Society of Thoracic Surgeons Meeting in San Francisco
5. In Kids, Genes May Affect Leukemia Treatment
6. Popular or Not? Your Genes May Help Decide
7. Common Genes Link Bipolar Disorder, Schizophrenia
8. UCSF Researchers Use New Tools to Move in on Cancer Susceptibility Genes
9. 9 Genes Are Linked to Alzheimers
10. What is the pathogenesis of C. jejuni-related disease?
11. Few DNA repair genes maintain association with cancer in field synopsis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New genes involved in acute lymphoblastic leukemia play fundamental role in prognosis of the disease
(Date:9/2/2014)... By Steven Reinberg ... -- A device intended to help with weight loss by ... to meet expectations in a trial among obese patients. ... between the brain and stomach, researchers hoped to suppress feelings ... they anticipated. "A device that safely blocks the nerve ...
(Date:9/2/2014)... HealthDay Reporter TUESDAY, ... outbreak continues to overwhelm health-care workers in three West ... the United Nations called on Tuesday for a concerted ... often-fatal virus. Dr. Thomas Frieden, director of the ... without a greater global commitment in resources -- both ...
(Date:9/2/2014)... ALEXANDRIA, VAThe latest research on sleep apnea, tonsillectomies, ... otolaryngic topics will be presented in Orlando, FL, ... OTO EXPO℠ of the American Academy of OtolaryngologyHead ... meeting of ear, nose, throat, head and neck ... research to be presented were released today, and ...
(Date:9/2/2014)... When weather conditions are right, tornadoes can occur ... a path of destruction. In fact, the United States leads ... tornadoes per year. Rainbow International offers the following safety tips ... , Select a safe place such as ... with no windows to stay during the storm. If a ...
(Date:9/2/2014)... Ticket Down is a reputable source for ... will be an exciting week for soccer fans in the ... and Bolivia will battle on U.S. soil in friendly exhibition ... 5th - September 9th: , Brazil vs. Ecuador Tickets ... Mexico vs. Chile Tickets at Levi's Stadium on Saturday, ...
Breaking Medicine News(10 mins):Health News:Nerve Blocking Procedure Fails to Impress in Weight Loss Study 2Health News:Nerve Blocking Procedure Fails to Impress in Weight Loss Study 3Health News:More Global Help Needed to Fight Ebola Outbreak 2Health News:More Global Help Needed to Fight Ebola Outbreak 3Health News:Act Quickly in Case of Tornado: Rainbow International® Offers Tips on How to Be Prepared for a Tornado 2Health News:Ticket Down Substantially Slashes Ticket Prices on Brazil vs. Ecuador Tickets, Brazil vs. Colombia Tickets, Mexico vs. Chile Tickets and Mexico vs. Bolivia Tickets 2Health News:Ticket Down Substantially Slashes Ticket Prices on Brazil vs. Ecuador Tickets, Brazil vs. Colombia Tickets, Mexico vs. Chile Tickets and Mexico vs. Bolivia Tickets 3
... said, ‘Self-critical adult who are prone to depression and anxiety, ... abused environment in their childhood years’. ,Verbally abused ... depression and anxiety as those who had not been verbally ... 54, conducted by Florida State University researchers revealed. ...
... Mr.Manmohan Singh today met representatives of the medical students ... The students came from institutions inside Delhi and across the ... demands which they wanted the Prime Minister and the government ... of their fellow students. ,The Prime Minister assured ...
... Health and Family Welfare Department into two wings, namely ... to allow for streamlined health services. ,State ... the step was being taken to ensure that specialist ... will ask 23 doctors who were on deputation with ...
... A politician's daughter in South Africa was embroiled in ... drugs in favour of a diet containing// garlic, olive ... believed to increase the lifetime of HIV victims’, said ... Treatment Action Campaign (TAC), said ‘Instead of objective decision-making ...
... Human Reproduction, researchers have established the first direct ... fertilization and Placenta Previa, a potentially dangerous complication ... a condition in which the placenta covers the ... baby’s passage in the birth canal. ...
... North Tripura district have been suffering from AIDS and 12 ... ,This was found in a survey at the ... ,The department collected blood samples of 120 inmates of ... HIV positive, the sources said., ,Refugee leader R Bhanglo, ...
Cached Medicine News:Health News:Link Established—Assisted Fertilization Can Complicate Pregnanc 2
(Date:9/2/2014)... York , September 2, 2014 ... published by Transparency Market Research "Latin America Home ... Devices, Therapeutic Home Healthcare Devices, Mobility Assist Devices ... Telemedicine, Respiratory Therapy, Infusion Therapy and Unskilled Home ... Trends and Forecast, 2014 - 2020" the Latin ...
(Date:9/2/2014)... -- According to the new market research ... by Material (Metal, Glass, Plastic), by Application [GC, LC ... published by MarketsandMarkets, the Chiral Chromatography Columns Market was ... grow at a CAGR of 5.2% from 2013 to ... 90 market data tables and 15 figures spread through ...
(Date:9/2/2014)... Calif. , Sept. 2, 2014  Avanir Pharmaceuticals, Inc. ... will present an overview of the company at the Morgan ... . , Presentation date: Tuesday September 9, 2014 ... A live webcast and 30-day archive of this presentation ... About Avanir Pharmaceuticals, Inc. Avanir Pharmaceuticals, Inc. is ...
Breaking Medicine Technology:Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 2Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 3Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 4Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 5Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 6Chiral Chromatography Column Market Worth $87.8 Million by 2018 2Chiral Chromatography Column Market Worth $87.8 Million by 2018 3Chiral Chromatography Column Market Worth $87.8 Million by 2018 4
... FRANCISCO, Calif., Aug. 25, 2011 Rigel Pharmaceuticals, Inc. ... M. Gower, chairman and chief executive officer, and Ryan ... Rigel, will present at two separate investor conferences in ... Healthcare Conference 2011Date: Thursday, September 8th at 10:20 a.m. ...
... Nutrastar International Inc. (OTCBB: NUIN; "Nutrastar" or the "Company"), ... Chinese Medicine ("TCM") consumer products, today announced that its ... under which Nutrastar may repurchase up to US$5 million ... 12 months. Under the program, the ...
Cached Medicine Technology:Nutrastar Announces Adoption of Share Repurchase Program 2Nutrastar Announces Adoption of Share Repurchase Program 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: