Navigation Links
New genes involved in acute lymphoblastic leukemia play fundamental role in prognosis of the disease
Date:2/6/2009

This release is available in Spanish.

The inactivity or "silence" of certain genes plays a fundamental role in the prognosis of acute lymphoblastic leukemia as well as in response to treatment, according to the results of research involving a team made up of specialists from the University Hospital of Navarra and the Center for Applied Medical Research at the same University of Navarra, as well as the Reina Sofa Hospital in Cordoba, Andalusia.

In concrete, the work confirmed that the inactivation of 13 microRNAs (a type of gene) by an epigenetic mechanism (capable of modulating the functions of the genetic code), is associated with higher mortality amongst patients with ALL. In total, the study involved 353 patients - 179 children and 174 adults - with acute lymphoblastic leukaemia). The results open up new therapeutic options on demonstrating the possibility of using these microRNAs as new targets in the treatment of this cancer illness. The conclusions of the research were recently published in the scientific journal with the greatest international impact in its speciality, the Journal of Clinical Oncology.

Involved in the research work was a team made up of specialists from the University Hospital of Navarra and the Centre for Applied Medical Research (CIMA) of the University of Navarra. Specialists from the Reina Sofa Hospital in Crdoba and the Institute of Human Genetics at the Schleswig-Holstein University Hospital, Kiel Campus in Germany also participated in the study and the publication of results.

It is notable that acute lymphoblastic leukaemia is the most common oncological illness amongst children. It makes up 25% of all cancers amongst paediatric patients and approximately 75% of cases of leukemia in infancy, although current survival rates in developed countries stand at about 75% of diagnosed patients.

Subgroup with worst prognosis

With this research a set of 13 microRNAs was identified which showed up as epigenetically regulated in 65% of the patients studied with acute lymphoblastic leukaemia, according to Doctor Prsper. Epigenetic regulation is the modulation of the genes expression that does not depend on changes in the sequence of the genetic code and the influence of which in cancer is increasingly being demonstrated. They are, thus, reversible changes in the DNA that manage to get the genes to be expressed or not (to be activated or silent) depending on external conditions.

In the subgroup of patients amongst which this set of genes appears as regulated, it was shown that, although these patients initially responded to treatment, they were the ones who with greater frequency subsequently suffered relapse, disimprove and present the worst prognosis and survival rates. These are the patients amongst whom the disease is much more resistant to treatment and amongst whom a silencing of the expression of the microRNAs is produced, according to the specialist.

Most efficacious pharmaceutical drugs

Given these result, Doctor Prsper concludes that epigenetic regulation plays a fundamental role in the development of this disease. Moreover, he points out, it would seem that the most recent pharmaceutical drugs, capable of producing epigenetic alterations, can be effective in 65% of patients who respond worst to conventional therapies for acute lymphoblastic leukaemia.


'/>"/>

Contact: Oihane Lakar
oihane@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert  

Related medicine news :

1. Angiogenesis linked to poor survival in patients with rare type of ovarian cancer
2. Penn study finds link between Parkinsons disease genes and manganese poisoning
3. Genesis Pharmaceuticals Enters Into Agreement to Purchase Hongrui Pharmaceuticals, and Acquire 22 New Traditional Chinese Medicines
4. Cardiogenesis Announces Successful Educational Symposium at Society of Thoracic Surgeons Meeting in San Francisco
5. In Kids, Genes May Affect Leukemia Treatment
6. Popular or Not? Your Genes May Help Decide
7. Common Genes Link Bipolar Disorder, Schizophrenia
8. UCSF Researchers Use New Tools to Move in on Cancer Susceptibility Genes
9. 9 Genes Are Linked to Alzheimers
10. What is the pathogenesis of C. jejuni-related disease?
11. Few DNA repair genes maintain association with cancer in field synopsis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New genes involved in acute lymphoblastic leukemia play fundamental role in prognosis of the disease
(Date:3/29/2017)... ... March 30, 2017 , ... CHARM CITY RUN WELCOMES ... has announced that Mercy Medical Center will serve as the official title sponsor of ... On Sunday, June 25, 2017, thousands of women will walk or run the course ...
(Date:3/29/2017)... , ... March 29, 2017 , ... ... several educational opportunities for attending prescribers at the upcoming World Congress, in Hollywood ... “A4M has always been recognized as the visionary leader in the training of ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... in Carnegie, OK, from Dr. Jamie Cameron, with or without a referral. ... to traditional orthodontic treatment. Depending on each patient’s case, treatment with the FASTBRACES ...
(Date:3/29/2017)... ... 2017 , ... Altima Technologies, Inc., the maker of popular ... assets and audio-video devices has recently updated its Visio Stencils library with new ... download shapes and stencils from http://www.VisioStencils.com. , New devices were added ...
(Date:3/29/2017)... ... March 29, 2017 , ... The assembly ... assembly protocols involve many repetitive steps and often scientists require many different versions ... high-throughput needed, and results in a lower error rate and cost saving for ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... Mar. 29, 2017 Research and Markets has announced ... Patients Treated at Proton Therapy Centers & Forecast" report to their ... The South Korean ... current market size in 2016. The Untapped Proton Therapy Market for ... USD in 2016. Proton Therapy plays an important role ...
(Date:3/29/2017)... 29, 2017  The leader in accelerated orthodontics, OrthoAccel ... Sam Daher , Manal Ibrahim , Kenji ... will be the featured microlecture presenters at the AcceleDent ... of Orthodontists (AAO) Annual Session, April 21-25, 2017. Orthodontists ... beginning daily at 11:20 a.m. On the opening morning ...
(Date:3/29/2017)... 2017  Maxor National Pharmacy Services, LLC ("Maxor"), a ... named Leah Bailey as General Counsel.  Bailey will ... company. With more than 13 years of ... focused on health care, Bailey joins the Maxor team ... Bailey advised the PBM, Specialty, and Mail Order business ...
Breaking Medicine Technology: