Navigation Links
New generation asthma drug could improve metabolism
Date:6/5/2011

Formoterol, a new generation asthma medication, shows great promise for improving fat and protein metabolism, say Australian researchers, who have tested this effect in a small sample of men. The researchers presented their results on Saturday 4 June 2011 at The Endocrine Society's 93rd Annual Meeting in Boston.

The research team comprises members of Professor Ken Ho's lab from Sydney's Garvan Institute of Medical Research as well as Professor Ric Day, a clinical pharmacologist from St. Vincent's Hospital.

Study leader, endocrinologist Dr Paul Lee, focused his PhD research on how various hormones affect metabolism. Of central importance is a class of hormones called catecholamines, which regulate heart rate, metabolism and breathing.

Formoterol is a synthetic catecholamine, the metabolic effects of which have not previously been studied in people. Therapy doses given to animals, however, have shown that it stimulates metabolism without affecting the heart.

"We have known for a long time that catecholamine influences the way the body handles nutrients, in particular fat and protein," said Lee.

"The generation of drugs before formoterol was exploited in the livestock industry around 20 years ago to reduce the fat and increase the protein content of meat. Unfortunately, these older drugs also caused a faster heart rate."

"Formoterol is a new generation of this class of medication. It is highly selective for the kind of catecholamine receptors found in the lungs, and not those in the heart."

"The new drug is also more selective for a similar receptor found in muscle and fat. In theory at least, it should have beneficial metabolic effects like the older class of medication without affecting the heart."

Lee sourced the drug in its oral form, found the dose needed to give a metabolic effect, and gave it to 8 healthy men over a week.

"Energy metabolism increased by more than 10%, fat burning increased by more than 25%, while protein burning fell by 15%," he said.

"So although whole body metabolism increased, these men burned fat while reducing the burning of protein. That's a good thing because in the long run these effects may lead to a loss in fat mass and an increase in muscle.

"In this study, all 8 subjects tolerated the medication well without any significant increase in heart rate."

The next step will be to test the drug over a longer period in a larger sample of people to determine if the beneficial effects translate into improvement in body composition, health and function.


'/>"/>

Contact: Alison Heather
61-292-958-128
Research Australia
Source:Eurekalert

Related medicine news :

1. 30 Years Into the Epidemic, a Generation With HIV Comes of Age
2. Fetal programming of disease risk to next generation depends on parental gender
3. Columbia researchers work to prevent blindness from age-related macular degeneration
4. Targeted regeneration could be key to boosting coalfield communities
5. Mayo Clinic finds new genetic cause of neurodegeneration
6. In vivo RNAi screening identifies new regulators of liver regeneration
7. AACR and Landon Foundation support the next generation of researchers with INNOVATOR Awards
8. Mothers obesity may lead to infertility in the next generation
9. LRI awards wide-ranging research grants to drive next generation of scientific discovery in lupus
10. BNCT, a new-generation radiation treatment, is effective in advanced head and neck cancer
11. In search of cancers common ground: A next-generation view
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, ... editors can give their videos a whole new perspective by using the title ... Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to choose ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified ... be personalized through a fitness app. The fitness app plans to fix the two major ... only offer a one size fits all type program , They don’t eliminate ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the ... AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in ... topics including advance care planning, healthcare costs and patient and family engagement. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 ... brings up a new, often overlooked aspect of head lice: the parasite’s ability to live ... not a common occurrence, but a necessary one in the event that lice have simply ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
Breaking Medicine Technology: