Navigation Links
New gene variants raise risk of neuroblastoma, influence tumor progression
Date:9/4/2012

Researchers have discovered two gene variants that raise the risk of the pediatric cancer neuroblastoma. Using automated technology to perform genome-wide association studies on DNA from thousands of subjects, the study broadens understanding of how gene changes may make a child susceptible to this early childhood cancer, as well as causing a tumor to progress.

"We discovered common variants in the HACE1 and LIN28B genes that increase the risk of developing neuroblastoma. For LIN28B, these variants also appear to contribute to the tumor's progression once it forms," said first author Sharon J. Diskin, Ph.D., a pediatric cancer researcher at The Children's Hospital of Philadelphia. "HACE1 and LIN28B are both known cancer-related genes, but this is the first study to link them to neuroblastoma."

Diskin and colleagues, including senior author John M. Maris, M.D., director of the Center for Childhood Cancer Research at Children's Hospital, published the study online Sept. 2 in Nature Genetics.

Striking the peripheral nervous system, neuroblastoma usually appears as a solid tumor in the chest or abdomen. It accounts for 7 percent of all childhood cancers, and 10 to 15 percent of all childhood cancer deaths.

The study team performed a genome-wide association study (GWAS), comparing DNA from 2,800 neuroblastoma patients with that of nearly 7,500 healthy children. They found two common gene variants associated with neuroblastoma, both in the 6q16 region of chromosome 6. One variant is within the HACE1 gene, the other in the LIN28B gene. They exert opposite effects: HACE1 functions as a tumor suppressor gene, hindering cancer, while LIN28B is an oncogene, driving cancer development.

The current study showed that low expression of HACE1, a tumor suppressor gene, and high expression of LIN28B, an oncogene, correlated with worse patient survival. To further investigate the gene's role, the researchers used genetic tools to decrease LIN28B's activity, and showed that this inhibited the growth of neuroblastoma cells in culture.

The new research builds on previous GWAS work by Children's Hospital investigators implicating other common gene variants as neuroblastoma oncogenes. As in the current study, these gene variants show a double-barreled effect, both initiating cancer and provoking its progression.

"In addition to broadening our understanding of the heritable component of neuroblastoma susceptibility, we think this research may suggest new therapies," Diskin added. "Our follow-up studies will focus on how we may intervene on these genes' biological pathways to develop more effective treatments."


'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Related medicine news :

1. Genetic variants, tobacco exposure and lung cancer risk
2. Depo-Provera Birth Control Might Raise Breast Cancer Risk
3. Cancer Diagnosis May Raise Odds for Suicide, Heart Attack Death
4. Infection Might Raise Blood Clot Risk for Older Adults: Study
5. Feeling Trapped, Obligated Raises Odds of Job Burnout: Study
6. Spouses of Cancer Patients May Have Raised Risk of Heart Disease, Stroke
7. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
8. Childhood Obesity May Raise Odds of Adult Liver Cancer
9. Wartime Killing May Raise Veterans Thoughts of Suicide
10. Stopping Blood Thinners Raises Stroke Risk for Patients With Irregular Heartbeat
11. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... ... expansion of its services to provide one resource, from start to finish, for ... preparation, Life Safety Statement of Condition surveys requested by the Joint Commission, and ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... services today announced a strategic partnership with Five9 (Nasdaq: FIVN), a leading ... one of Avaya’s largest Platinum Business Partners, is a leading provider of ...
(Date:5/24/2016)... ... May 24, 2016 , ... Mental health watchdog ... Church of Scientology and renowned professor of psychiatry Thomas Szasz, is continuing its protest ... An Industry of Death” exhibit in Atlanta, Georgia. The opening of the exhibit follows ...
(Date:5/24/2016)... ... ... Boyd Industries, a leading supplier of dental chairs and cabinetry , will ... dentistry , at AAPD 2016, the annual conference and trade show of the American ... keeps dental hand pieces and other anxiety-provoking pieces of the dental delivery system out ...
(Date:5/24/2016)... ... May 24, 2016 , ... The Radiosurgery ... practice of radiosurgery, is recognizing five medical residents and students for their outstanding ... radiotherapy (SBRT). The awards will be presented at the 2016 SRS/SBRT Scientific Meeting ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016 Les ... la première endoprothèse à double thérapie au ... portant sur les membres inférieurs et la ... entreprise mondiale spécialisée dans la fourniture de ... a élargi son portefeuille pour inclure des ...
(Date:5/23/2016)... PUNE, India , May 23, 2016 ... is spread across 163 pages, profiles 12 companies and ... 280 tables and figures on the industry and its ... study that is comprehensive in nature, details the current ... of the industry including definitions, classifications, applications and industry ...
(Date:5/23/2016)... , May 23, 2016 The World Health ... PrePex device to include adolescents aged 13 years, and ... can be offered for adult and adolescent males in the ... . PrePex was the first male circumcision device to ... MedTech,s CEO, Eddy Horowitz said: " The ...
Breaking Medicine Technology: