Navigation Links
New gene variants raise risk of neuroblastoma, influence tumor progression
Date:9/4/2012

Researchers have discovered two gene variants that raise the risk of the pediatric cancer neuroblastoma. Using automated technology to perform genome-wide association studies on DNA from thousands of subjects, the study broadens understanding of how gene changes may make a child susceptible to this early childhood cancer, as well as causing a tumor to progress.

"We discovered common variants in the HACE1 and LIN28B genes that increase the risk of developing neuroblastoma. For LIN28B, these variants also appear to contribute to the tumor's progression once it forms," said first author Sharon J. Diskin, Ph.D., a pediatric cancer researcher at The Children's Hospital of Philadelphia. "HACE1 and LIN28B are both known cancer-related genes, but this is the first study to link them to neuroblastoma."

Diskin and colleagues, including senior author John M. Maris, M.D., director of the Center for Childhood Cancer Research at Children's Hospital, published the study online Sept. 2 in Nature Genetics.

Striking the peripheral nervous system, neuroblastoma usually appears as a solid tumor in the chest or abdomen. It accounts for 7 percent of all childhood cancers, and 10 to 15 percent of all childhood cancer deaths.

The study team performed a genome-wide association study (GWAS), comparing DNA from 2,800 neuroblastoma patients with that of nearly 7,500 healthy children. They found two common gene variants associated with neuroblastoma, both in the 6q16 region of chromosome 6. One variant is within the HACE1 gene, the other in the LIN28B gene. They exert opposite effects: HACE1 functions as a tumor suppressor gene, hindering cancer, while LIN28B is an oncogene, driving cancer development.

The current study showed that low expression of HACE1, a tumor suppressor gene, and high expression of LIN28B, an oncogene, correlated with worse patient survival. To further investigate the gene's role, the researchers used genetic tools t
'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Genetic variants, tobacco exposure and lung cancer risk
2. Depo-Provera Birth Control Might Raise Breast Cancer Risk
3. Cancer Diagnosis May Raise Odds for Suicide, Heart Attack Death
4. Infection Might Raise Blood Clot Risk for Older Adults: Study
5. Feeling Trapped, Obligated Raises Odds of Job Burnout: Study
6. Spouses of Cancer Patients May Have Raised Risk of Heart Disease, Stroke
7. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
8. Childhood Obesity May Raise Odds of Adult Liver Cancer
9. Wartime Killing May Raise Veterans Thoughts of Suicide
10. Stopping Blood Thinners Raises Stroke Risk for Patients With Irregular Heartbeat
11. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... Dr. Paul Vitenas, one of the most awarded ... Holiday Event for those in the area that would like to ... & Glow will take place on December 11, 2014, from 6:00 ... heart of Houston at 4208 Richmond Ave. , “We want ... will come and celebrate the season with us on December 11, ...
(Date:11/28/2014)... Minnesota (PRWEB) November 28, 2014 ... of the few insurance marketing organizations in the ... income and asset protection marketplace. Secura Consultants is ... partnership with Principal Financial Group, a leading global ... multiple ownership interests. With the ownership interest comes ...
(Date:11/28/2014)... 2014 (HealthDay News) -- Celebration can quickly turn ... Thanksgiving Day, experts say. Over the last decade, ... occurred while people were using turkey fryers, according to ... actually cared for a patient who tried to deep ... done in any circumstances," Dr. Arthur Sanford, a burn ...
(Date:11/28/2014)... Alex Kramer HealthDay Reporter , ... in the kitchen, through cooking classes or at home, may ... a recent review. Cooking programs and classes for children ... to the new research. And, although the review didn,t look ... such programs might help children develop long-lasting healthy habits. ...
(Date:11/28/2014)... PreDiabetes Centers , a national ... learn their risk for type 2 diabetes by ... local school in partnership with the American Diabetes ... As the Presenting Sponsor for the Stop ... co-hosting diabetes-prevention presentations at Austin-area companies with the ...
Breaking Medicine News(10 mins):Health News:Cosmetic Surgeon Dr. Paul Vitenas to Host Glitter & Glow Holiday Event 2Health News:Cosmetic Surgeon Dr. Paul Vitenas to Host Glitter & Glow Holiday Event 3Health News:Secura Consultants Offers Complimentary Buy-Sell Agreement Reviews 2Health News:Turkey Fryer Mishaps Can Cause Serious Burns 2Health News:Want Kids to Eat Better? Get Them Cooking 2Health News:Want Kids to Eat Better? Get Them Cooking 3Health News:PreDiabetes Centers Offers Workplace Diabetes Screening at Local School 2
... To Do the Right Thing and Override the ... Keehan, DC,president and chief executive officer of the ... the following statement:, By vetoing legislation to ... President has just played partisan politics,with the lives ...
... Oct. 3 The Missouri House of Representatives,recognized ... serving the state,s National Guard Service members and ... TriWest beneficiary service and,education representative serving Missouri, in ... time and energy to assisting soldiers,and airmen of ...
... Curative ... Therapy Driving Growth, ARCADIA, Calif., Oct. 3 ... Program for Los Angeles, a,ranking of the 50 fastest growing technology, ... Touche USA LLP, one,of the nation,s leading professional services organizations. Rankings ...
... tags will be on display,throughout Ralphs stores again ... and suppliers to support National Breast Cancer Awareness,month ... can be found on shelves in Ralphs,stores across ... to support breast cancer awareness in their,community. Several ...
... 3 Nowhere are the,consequences of premature birth more ... Wisconsin. In the next week, 151 babies,will be born ... by and watch their babies be admitted into a ... one of the most frightening and overwhelming,experiences a parent ...
... New York Citys infant mortality rate widely regarded as ... in 2006, the Health Department reported today. The rate in ... from 6.0 the previous year. The City has made major ... the rate was double what it is today, but the ...
Cached Medicine News:Health News:Missouri House Recognizes 'Extraordinary' Efforts Supporting National Guard Families 2Health News:StemCyte, Inc. Ranked Number Six in Deloitte's Technology Fast 50 Program for Los Angeles 2Health News:StemCyte, Inc. Ranked Number Six in Deloitte's Technology Fast 50 Program for Los Angeles 3Health News:StemCyte, Inc. Ranked Number Six in Deloitte's Technology Fast 50 Program for Los Angeles 4Health News:Ralphs 'Pink Tag' Campaign to Raise $170,000 for Breast Cancer Awareness in October 2Health News:March of Dimes NICU Family Support(R) Programs Give Wisconsin Families Comfort and Information during a Crisis 2Health News:New York City's infant mortality rate declined in 2006 2Health News:New York City's infant mortality rate declined in 2006 3Health News:New York City's infant mortality rate declined in 2006 4
(Date:11/26/2014)...  Cohen, Placitella & Roth, PC is investigating ... Nymox Pharmaceutical Corporation ("Nymox" or "Company") (NASDAQ: ... 31, 2011 through November 2, 2014 ("Class Period").  ... its officers and directors publically disseminated materially false ... and 20(a) of the Securities Exchange Act of ...
(Date:11/26/2014)... Nov. 26, 2014  Avanir Pharmaceuticals, Inc. (NASDAQ: ... Food and Drug Administration (FDA) has issued a ... (NDA) for AVP-825. AVP-825 is an investigational drug-device ... intranasally utilizing a novel Breath Powered delivery technology. ... and consistent with the preliminary feedback announced on ...
(Date:11/26/2014)... -- BioScrip ® , Inc. (NASDAQ: BIOS ) announced today ... will present at the Bank of America Merrill Lynch 2014 Leveraged ... , , , Wednesday, December 3, 2014 , , , ... , , Location: , , , Boca Raton Resort and Club, ... BioScrip, Inc. is a leading national provider of ...
Breaking Medicine Technology:Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 3Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 2Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 3Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 4
... , Jan. 19 Recognized as one of ... St. Louis Children,s Hospital in St. Louis is further ... a SOMATOM® Definition AS computed tomography (CT) scanner from Siemens Healthcare. ... intelligently adapts, on the fly, to the patient, for aiding in ...
... LOS ANGELES , Jan. 19 With ... money yet they cannot afford to cut live receptionist service. ... center and live answering service that provides customized solutions for ... Los Angeles , Global Messaging Network caters to all ...
Cached Medicine Technology:Siemens Delivers Complete Dose Protection to St. Louis Children's Hospital 2Siemens Delivers Complete Dose Protection to St. Louis Children's Hospital 3Siemens Delivers Complete Dose Protection to St. Louis Children's Hospital 4Global Messaging Network Saves Companies Overhead Costs by Outsourcing Call Processing 2
... Centuries of German ... finest surgical instrumentation in ... makes them available to ... the coveted Meisterbrief certificate, ...
... German Craftsmanship have produced ... in the world. Ocutek ... to you! Only holders ... certificate, which requires and ...
... German Craftsmanship have produced ... in the world. Ocutek ... to you! Only holders ... certificate, which requires and ...
Protects the eye from symptoms caused by "dry eye, medical conditions, drug reactions and environmental factors. Forms a moisture chamber over the eye area during rest....
Medicine Products: