Navigation Links
New gene therapy technique on iPS cells holds promise in treating immune system disease
Date:4/28/2011

ay eventually lead to serious blood disorders, including blood cancer.

In order to develop a more effective and safer gene therapy for X-CGD, researchers from the National Institute of Allergy and Infectious Disease (NIAID) at the National Institutes of Health (NIH) and The Johns Hopkins University School of Medicine embarked on a study using a more precise method for performing gene therapy that did not use viruses for the gene correction. Researchers removed adult stem cells from the bone marrow of a patient with X-CGD and genetically reprogrammed them to become induced pluripotent stem cells (iPS cells). Like embryonic stem cells, these patient-specific iPS cells can be grown and manipulated indefinitely in culture while retaining their capacity to differentiate into any cell type of the body, including HSCs.

"HSCs that are derived from gene corrected iPS cells are tissue-compatible with the patient and may create a way for the patient's own cells to be used in a transplant to cure the disease, removing the risk of GVHD or the need to find a compatible donor," said Harry L. Malech, MD, senior study author, Chief of the Laboratory of Host Defenses and Head of the Genetic Immunotherapy Section of NIAID at the NIH. "However, turning iPS cells into a large number of HSCs that are efficently transplantable remains technically difficult; therefore, our study aimed at demonstrating that it is possible to differentiate gene corrected iPS cells into a large number of corrected neutrophils. These corrected neutrophils, grown in culture, are tissue-compatible with the patient and may be used to manage the life-threatening infections that are caused by the disease."

Typically, iPS cells from a patient with an inherited disorder do not express disease traits, despite the fact that the iPS cell genome contains the expected mutation. The researchers were able to prove, in culture, that iPS cells from a patient with X-CGD could be differentiated int
'/>"/>

Contact: Claire Gwayi-Chore
webmaster@hematology.org
202-552-4914
American Society of Hematology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Nicotine replacement therapy is over-promoted since most ex-smokers quit unassisted
2. Social Anxiety and Panic - Alternative Treatment to Drugs and Therapy
3. Longview Therapy Center, PLLC, Unveils Its Definition Of Hope
4. Short-term radiation therapy successful on breast cancer
5. ASCROs Response to NY Times Articles on Radiation Therapy Incidents
6. Children With Cerebral Palsy Benefitting From New Physical Therapy Regimen
7. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
8. Behavioral therapy improves sleep and lives of patients with pain
9. WHI data confirm short-term heart disease risks of combination menopausal hormone therapy
10. Promising therapy for relapsing multibple sclerosis
11. Split-course palliative radiotherapy confirmed as effective treatment for advanced NSCLC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... December 20, 2014 As Risperdal ... forward in U.S. courts, Bernstein Liebhard LLP notes ... that children treated with the medication may experience ... breast development and lactation. The study, which appears ... and adolescents who began treatment with risperidone, an ...
(Date:12/20/2014)... The aftermath of the November 24th hack on Sony ... Hollywood, but worldwide. As reported in the Los ... attack are starting a finger-pointing game which could put some ... are not the only ones affected, regular employees who had ... times ahead, agents and lawyers could be in for some ...
(Date:12/20/2014)... 20, 2014 Developers of FCPX ... a new plugin for Final Cut Pro X entitled ... Volume 5 allows users to create hand drawn text ... Christina Austin, CEO of Pixel Film Studios. “TranSlice Volume ... while maintaining an easy to use interface.” , TranSlice ...
(Date:12/20/2014)... 20, 2014 The Twin Cities DI ... event in the nation! Over 250 financial professionals come ... information on the industry, get motivated to protect their ... people facing and overcoming the challenges of disability. , ... the nation came together to attend The 13th Annual ...
(Date:12/20/2014)... Today, Balfleet.com, one of the most outstanding dressmakers in ... on its Mother of the Bride Dresses ... bride dresses from Balfleet.com feature gorgeous looks and delicate ... pride in providing high quality dresses to its clients ... on our mother of the bride dresses, and we ...
Breaking Medicine News(10 mins):Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 3Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 3Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 5Health News:Pixel Film Studios released a new transition entitled TranSlice Volume 5 exclusively for Final Cut Pro X 2Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3Health News:Balfleet.com is Offering 50%-70% Off of its Mother of the Bride Dresses 2
... or no sunscreen in spite of staying under direct sunlight ... sports spend a significant amount of time practicing and competing ... they are spending so much time in the sun, they ... of them regularly use any form of sunscreen, according to ...
... Immunization (IFFIm) will be providing life saving vaccines for ... project costing $4 billion to be funded by the ... the scheme, the International Finance Facility for Immunization (IFF), ... over the next 10 years and another five million ...
... daily stress in their life have less risk of developing ... in the British Medical Journal. The study was conducted in ... The estrogen which is responsible for growth ... have found that stress reduced the production of oestrogen and ...
... In a study, published in the recent issue of The ... Hospital, Michigan, had concluded that obesity is a risk factor ... are below the age of 40years.// ,Since 1927, ... fatal pulmonary embolism (PE). Because of the high proportion of ...
... a married couple in West Bengal. The duo preferred to ... everyday. ,In an act driven// by social ostracism, a 29-year-old ... hanged himself in the Durgapur industrial town of south Bengal's ... Sarkar were a happy couple since their love marriage four ...
... in people may accelerate the heart conditions by releasing the ... study of 32 people with heart failure, the 14 patients ... of this protein in their blood. ,The protein, tumor ... family of proteins called cytokines, chemical messengers that are mobilized ...
Cached Medicine News:Health News:People Still Neglect To Use Sunscreen In Spite Of Cancer Warnings 2Health News:European Countries To Fund $4 Billion For Vaccination For Poor Children’ 2
(Date:12/19/2014)... , Dec. 18, 2014 Somewhere between ... hearing health was forgotten. But Audicus , a ... hear better this new year. Hearing loss ... the aging population, though it is often unaddressed. Forty-eight ... four has a hearing aid, mainly due to price. ...
(Date:12/19/2014)... CITY, Calif., Dec. 18, 2014 Capnia, ... the development of medical diagnostics based on its ... gas flow, today announced financial results for the ... 2014. "Following the completion of our ... positioned to maximize the recently initiated CoSense® commercial ...
(Date:12/19/2014)... , Dec. 18, 2014   Aratana Therapeutics, ... biopharmaceutical company focused on the licensing, development and ... announced positive results from its pivotal field study ... treating pain in dogs with osteoarthritis.  In the ... assessment scores that were statistically significant compared to ...
Breaking Medicine Technology:Audicus Will Help People Resolve to Hear Better in 2015 2Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5
... , , , ... majority-owned subsidiary of Speedus Corp. (Nasdaq: SPDE ), ... the U.S. FDA, has cleared the Zargis Cardioscan(TM) device ... analysis software connects wirelessly to a Bluetooth®-enabled electronic stethoscope ...
... NATICK, Mass., Jan. 8 Boston Scientific Corporation (NYSE: ... from the Japanese Ministry of Health, Labor and Welfare (MHLW) ... treatment of coronary artery disease. The Company plans to ... which is expected in the coming weeks. , The PROMUS ...
Cached Medicine Technology:Zargis Cardioscan Cleared for Sale in Canada 2Zargis Cardioscan Cleared for Sale in Canada 3Boston Scientific Announces Japanese Approval for PROMUS(R) Everolimus-Eluting Coronary Stent System 2Boston Scientific Announces Japanese Approval for PROMUS(R) Everolimus-Eluting Coronary Stent System 3Boston Scientific Announces Japanese Approval for PROMUS(R) Everolimus-Eluting Coronary Stent System 4
... nebulizer system offers an affordable and ... COPD or other respiratory conditions. The ... gives patients the ability to take ... Its unique nebulizer design delivers powerful ...
Pediatric Compressor Nubulizer...
... very popular and competitively priced SportNeb ... compressor. Design enhancements include a neb ... optional black carry bag. The color ... The SportNeb also offers private labeling ...
... is an important part of managing the ... convenient products mean delivering the aerosolized medication ... while minimizing medication waste. Aerosol delivery with ... of Nebulizers, including the new NebuTech® HDN®, ...
Medicine Products: