Navigation Links
New gene therapy proves effective in treating severe heart failure
Date:6/3/2010

Researchers at Mount Sinai School of Medicine have developed a new gene therapy that is safe and effective in reversing advanced heart failure. SERCA2a (produced as MYDICAR) is a gene therapy designed to stimulate production of an enzyme that enables the failing heart to pump more effectively. In a Phase II study, SERCA2a injection through a routine minimally invasive cardiac catheterization was safe and showed clinical benefit in treating this patient population and decreasing the severity of heart failure. The data were presented this week at the Heart Failure Congress of the European Society of Cardiology in Berlin.

"SERCA2a met the primary endpoints and appears to be safe and effective in people with advanced heart failure," said trial investigator Jill Kalman, MD, Associate Professor, Medicine, Cardiology, Director of the Cardiomyopathy Program, Mount Sinai School of Medicine. "There is a significant unmet need for treatments in this patient population, and these data indicate that SERCA2a is a promising option for them."

The CUPID (Calcium Up-regulation by Percutaneous administration of gene therapy In cardiac Disease) trial is a randomized, double-blind, placebo-controlled study, which enrolled 39 patients with advanced heart failure to study the safety and efficacy of SERCA2a. Patients were randomized to receive SERCA2a gene delivery in one of three doses or placebo and were evaluated over six months. The treatment is delivered directly to the patient's heart during a routine outpatient catheterization procedure.

Patients in the SERCA2a group demonstrated improvement or stabilization in symptoms, heart function, and severity of heart failure. They also saw an increase in time between cardiovascular events and a decrease in frequency of events. SERCA2a was found to be safe, with no increases in adverse events, disease-related events, laboratory abnormalities, or arrhythmias compared to placebo.

SERCA2a was developed
'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Career Training College, Pima Medical Institute, Offering Second Bachelor's Degree Program in Respiratory Therapy
2. Interruption of Menstrual Cycle by Chemotherapy Associated with Improved Survival in Early Breast Cancer
3. New Online Physical Therapy Marketing Academy Helps Physical Therapists Conquer The Web
4. Proton therapy carries precise, potent punch against childrens cancers
5. Dual Therapy Best for Preventing Bleeding After Heart Procedures
6. Blocking DNA repair protein could lead to targeted, safer cancer therapy
7. Targeted immunotherapy shows promise for metastatic breast, pancreatic cancers
8. AthletiCo Physical Therapy Enhances Work Rehabilitation Program by Offering Ergonomics and Job Analysis
9. Research finds surgery outperforms drug therapy in treatment of benign prostatic hyperplasia
10. Response to preoperative therapy may predict survival in pancreatic cancer patients
11. Making Your Way Through the Fog of Chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... St. Petersburg, FL (PRWEB) July 30, 2014 Phytceramides ... explains how and why in her new book. , Today is ... Phytoceramides: Anti Aging At Its Best . The book is ... larger skin care book, but felt that Phytoceramides were ... sense to bring out this focused book now," says Kathy Heshelow, ...
(Date:7/29/2014)... Daily Gossip indicates that the new method ... symptoms that hemorrhoids commonly causes. The new method was ... expert. , The author of H Miracle reveals ... symptoms such as itching, burning, pain and swelling, as ... H Miracle by visiting the official website at: ...
(Date:7/29/2014)... 29, 2014 Daily Gossip reveals in its ... program claims that he cured his condition with the use ... share part of his experience. , He claimed that ... naturally in just 4 days. Since his method turned out ... from all around the world. , The Nasal Polyps ...
(Date:7/29/2014)... 29, 2014 DailyGossip.org reveals in its ... is a new method of naturally overcoming sciatica, in ... the new method ensure sufferers that the cure is ... , The new method is described as very ... sciatica with an 8 minutes per day treatment plan. ...
(Date:7/29/2014)... DailyGossip.org reveals in its latest review that ... can perfectly understand patients and what they have to go ... is the author of the new program. Ellie claims that ... suffering, Ellie started her very own research. Four years passed ... author of the Get Rid of Cold Sores program claims ...
Breaking Medicine News(10 mins):Health News:Last Day New Book Is Available at No Cost: Phytoceramides, Anti Aging At Its Best by Sublime Beauty Founder® Kathy Heshelow 2Health News:Last Day New Book Is Available at No Cost: Phytoceramides, Anti Aging At Its Best by Sublime Beauty Founder® Kathy Heshelow 3Health News:H Miracle Review Exposes Natural Method to Cure Hemorrhoids 2Health News:Nasal Polyps Treatment Miracle Review Reveals How to Cure Nasal Polyps Without Surgery 2Health News:Stop Sciatica in 8 Minutes Review Reveals the Way to Cure Sciatica Easily 2Health News:Get Rid of Cold Sores Fast Review Exposes the Way to Stop Outbreaks 2
... apnea, a dangerous medical condition that becomes more prevalent as ... deadly if left// untreated, says an expert. ,The ... irritation, with people being unaware that they are causing more ... the online edition of health portal News Medical. ...
... 'An ounce of prevention is worth a pound of cure.' , ... disease that could wipe the smile// off many faces and cause ... 43% of all cancers are preventable. Sunday, 4 February 2007, is ... will focus on strategies for a cancer free world – a ...
... College of Medicine finds that naltrexone may be beneficial to ... is often used to bring// relief to victims of alcohol ... inflammatory disorder of the intestine that affects an estimated 500,000 ... an early edition of the American Journal of Gastroenterology. ...
... hair dye are increasing as more and younger people dye ... dermatitis on the face and, in severe cases, facial swelling ... dyes currently contain para-phenylenediamine (PPD) and other related agents. During ... serious problem that it was banned from hair dyes in ...
... A promising step forward in the field of AIDS was ... to this 2-5AN6B, a nucleic acid, could actually stop the// ... ,This work was led by Robert J.Suhadolnik, Professor of ... 2-5AN6B in combination with drugs currently used for AIDS treatment ...
... menstrual cycles affect the responsiveness of their brains’ reward ... Mental Health (NIMH), a component of the National Institutes ... women were winning rewards, their circuitry was more active ... and dominated by estrogen, compared to a phase when ...
Cached Medicine News:Health News:'Cancer Prevention' - In Your Hands 2Health News:'Cancer Prevention' - In Your Hands 3Health News:NIMH Studies Woman’s Hormonal Cycl 2
(Date:7/29/2014)... 29, 2014 /PRNewswire-iReach/ -- MHG Medical Management Services, ... its Medical Equipment and X-ray Annual Inspection ... tailored to the cruise industry,s unique requirements.  MHG ... to propose that they should develop a new ... is intended to create standardized processes and raise ...
(Date:7/29/2014)...  Roche (SIX: RO, ROG; OTCQX: RHHBY) launched its ... 2014 Clinical Lab Expo today by unveiling two booths ... is partnering with customers to redefine the value of ... day that they,re looking for a partner to help ... and offices," said Jack Phillips , president and ...
(Date:7/29/2014)... 2014  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ... second quarter 2014 financial results after the Nasdaq market ... host a live conference call and webcast to discuss ... morning, August 7, 2014 at 8:00 a.m. Eastern Time ... the live conference call by dialing 866-952-1907 (US) or ...
Breaking Medicine Technology:MHG Medical Management Services Aims to Change Cruise Industry Standard With New Equipment Maintenance Program 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 3Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 4Neurocrine Biosciences Announces Conference Call And Webcast To Report Second Quarter 2014 Financial Results 2
Steroid-eluting, single-pass lead. CapSure VDD2 optimizes VDD therapy and offers easier handling, proven performance, and choice....
The Guidant Fineline II Sterox Atrial J is a steroid-eluting pacing lead designed for permanent implantation for either atrial or ventricular applications....
The Guidant Fineline II Sterox is a steroid-eluting pacing lead designed for permanent implantation for either atrial or ventricular applications....
... Medtronic presents the Streamline family of ... have taken the gold standard in temporary ... that make them easy to use and ... Model 6491 Unipolar Pediatric Temporary Pacing Lead ...
Medicine Products: