Navigation Links
New gene therapy proves effective in treating severe heart failure
Date:6/3/2010

Researchers at Mount Sinai School of Medicine have developed a new gene therapy that is safe and effective in reversing advanced heart failure. SERCA2a (produced as MYDICAR) is a gene therapy designed to stimulate production of an enzyme that enables the failing heart to pump more effectively. In a Phase II study, SERCA2a injection through a routine minimally invasive cardiac catheterization was safe and showed clinical benefit in treating this patient population and decreasing the severity of heart failure. The data were presented this week at the Heart Failure Congress of the European Society of Cardiology in Berlin.

"SERCA2a met the primary endpoints and appears to be safe and effective in people with advanced heart failure," said trial investigator Jill Kalman, MD, Associate Professor, Medicine, Cardiology, Director of the Cardiomyopathy Program, Mount Sinai School of Medicine. "There is a significant unmet need for treatments in this patient population, and these data indicate that SERCA2a is a promising option for them."

The CUPID (Calcium Up-regulation by Percutaneous administration of gene therapy In cardiac Disease) trial is a randomized, double-blind, placebo-controlled study, which enrolled 39 patients with advanced heart failure to study the safety and efficacy of SERCA2a. Patients were randomized to receive SERCA2a gene delivery in one of three doses or placebo and were evaluated over six months. The treatment is delivered directly to the patient's heart during a routine outpatient catheterization procedure.

Patients in the SERCA2a group demonstrated improvement or stabilization in symptoms, heart function, and severity of heart failure. They also saw an increase in time between cardiovascular events and a decrease in frequency of events. SERCA2a was found to be safe, with no increases in adverse events, disease-related events, laboratory abnormalities, or arrhythmias compared to placebo.

SERCA2a was developed
'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Career Training College, Pima Medical Institute, Offering Second Bachelor's Degree Program in Respiratory Therapy
2. Interruption of Menstrual Cycle by Chemotherapy Associated with Improved Survival in Early Breast Cancer
3. New Online Physical Therapy Marketing Academy Helps Physical Therapists Conquer The Web
4. Proton therapy carries precise, potent punch against childrens cancers
5. Dual Therapy Best for Preventing Bleeding After Heart Procedures
6. Blocking DNA repair protein could lead to targeted, safer cancer therapy
7. Targeted immunotherapy shows promise for metastatic breast, pancreatic cancers
8. AthletiCo Physical Therapy Enhances Work Rehabilitation Program by Offering Ergonomics and Job Analysis
9. Research finds surgery outperforms drug therapy in treatment of benign prostatic hyperplasia
10. Response to preoperative therapy may predict survival in pancreatic cancer patients
11. Making Your Way Through the Fog of Chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 17, 2015 Scientists from the ... team of U.S. and Venezuelan researchers, have discovered ... humans among an isolated tribe of Yanomami Amerindians ... diversity in the Yanomami, previously unexposed to antibiotics ... double that of people living in industrialized countries, ...
(Date:4/17/2015)... Dallas, TX (PRWEB) April 17, 2015 ... hormone specialist and functional medicine advocate with 30 years ... she will be adding another level of service for ... on her website of 10 recommended wellness books with ... , When asked to explain her interest in providing ...
(Date:4/17/2015)... April 17, 2015 Compare-autoinsurance.org has released ... best online auto insurance quotes . , ... financial coverage for their cars. Drivers should always compare ... buy. The insurance market is a competitive one, which ... every hour. , It is now possible to ...
(Date:4/17/2015)... City, NJ (PRWEB) April 17, 2015 ... stored in the posterior pituitary and thought to help ... bonding between couples. To further substantiate this, new studies ... in the journal, Nature, and reported by Medical News ... have a powerful influence over maternal social behavior. The ...
(Date:4/17/2015)... Nomedexamlifeinsurance.com has released a new blog post ... smokers . , Smoking is linked to numerous diseases ... will charge smokers more money for life insurance plans. ... insurance and can qualify for advantageous offers. , ... than for non-smokers. Comparing quotes is the best method ...
Breaking Medicine News(10 mins):Health News:Mount Sinai Scientists Find Unprecedented Microbial Diversity in Isolated Amazonian Tribe Previously Unexposed to Antibiotics or Processed Foods 2Health News:Mount Sinai Scientists Find Unprecedented Microbial Diversity in Isolated Amazonian Tribe Previously Unexposed to Antibiotics or Processed Foods 3Health News:Connie Casad, M.D. Provides Patients Recommended List of Wellness Books on Website 2Health News:The Best Auto Insurance Quotes Are Available Online! 2Health News:Oxytocin Now Found to Help Diet Doc Patients Whose Weight Has Gotten out of Control Due to Emotional Eating Disorders 2Health News:Oxytocin Now Found to Help Diet Doc Patients Whose Weight Has Gotten out of Control Due to Emotional Eating Disorders 3Health News:Life Insurance Quotes for Smokers Available Online 2
... Oct. 30 (HealthDay News) -- Hepatitis C patients who receive ... recurrent hepatitis than those who receive a liver from a ... for black patients who receive a liver from a white ... Hospital in Detroit looked at 165 hepatitis C patients who ...
... involution were at a higher risk for developing breast ... according to a study published online in The ... Apart from age, family history, and age at ... include mammographic breast density and extent of lobular involution. ...
... GALVESTON, Texas When the space shuttle Discovery lifts off ... be joined by 16 rodent passengers on a historic mission ... automatically supply them with food and water, the mice will ... why spaceflight makes humans more vulnerable to infection by viruses ...
... FRIDAY, Oct. 29 (HealthDay News) -- An increasing number ... bouts of constipation, according to experts. Lack of ... may be contributing to the problem, they suggest. ... 30 percent rise in the number of such cases ...
... (NABT) will recognize W. Jason Niedermeyer, a biology teacher ... the 2010 Evolution Education Award during the NABT annual ... in Minneapolis, Minnesota. The Evolution Education Award is ... Biological Sciences Curriculum Study (BSCS). The award is presented ...
... , FRIDAY, Oct. 29 (HealthDay News) -- ... incapacitated or critically ill patients want to have full ... that power to doctors, finds a new study. ... patients dependent on mechanical ventilation who had about a ...
Cached Medicine News:Health News:Breast density, no lobular involution increase breast cancer risk 2Health News:Shuttle mice to boost disease research 2Health News:Chronic Constipation Appears to Be Increasing Among Kids 2Health News:Biologists, educators recognize excellence in evolution education 2Health News:Most Health Proxies Would Make End-of-Life Decisions Themselves: Study 2
(Date:4/17/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kh5kqg/the_corporate ) ... Corporate Reputation of Pharma - The Patient Perspective ... to their offering. The Corporate Reputation ... its fourth edition. This report contains the latest ... annual Corporate Reputation report, the author surveys a ...
(Date:4/17/2015)... -- Bionomics Limited (ASX:BNO, ADR:BMICY), a biopharmaceutical company focused ... the treatment of cancer and diseases of the central ... three of its most advanced oncology programs at the ... Annual Meeting being held from April 18-22, 2015 ... The presentation on the BNC105 program describes ...
(Date:4/16/2015)... , April 16, 2015 Mindray ... developer, manufacturer, and marketer of medical devices worldwide, ... Securities and Exchange Commission an Annual Report on Form ... year ended December 31, 2014. An electronic version of ... on Mindray,s investor relations website at  http://ir.mindray.com  or  ...
Breaking Medicine Technology:The Corporate Reputation of Pharma - The Global Patient Perspective in 2014 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 4Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 5Mindray Files Annual Report on Form 20-F with the U.S. Securities and Exchange Commission 2
Double ended with 0.5mm x 10mm and 1.0mm x 15mm blades; both blades gently curved; round serrated handle, In Titanium....
0.5mm "K" hook. Rounded knurled handle; shaft angled 11mm from tip; overall length 120mm, in Titanium....
Bend with "H" Shaped Tip, Right; Stainless Steel....
The GE e-Speed™scanner, the worlds fastest computed tomography (CT) imaging platform, delivers a new advanced tool for physicians to see and diagnose heart disease....
Medicine Products: