Navigation Links
New gene offers hope for preventive medicine against fractures
Date:9/18/2012

A big international study has identified a special gene that regulates bone density and bone strength. The gene can be used as a risk marker for fractures and opens up opportunities for preventive medicine against fractures. The study, led by the Sahlgrenska Academy, University of Gothenburg, Sweden, was published in the journal PLoS Genetics.

The international study, which involved more than 50 researchers from Europe, North America and Australia and was led by Associate Professor Mattias Lorentzon and Professor Claes Ohlsson at the Sahlgrenska Academy, University of Gothenburg, is based on extensive genetic analyses of the genetic material of 10,000 patients and experimental studies in mice.

Through the combined studies, researchers have succeeded in identifying a special gene, Wnt16, with a strong link to bone density and so-called cortical bone thickness, which is decisive to bone strength.

The genetic variation studied by the international research network could predict, for example, the risk of a forearm fracture in a large patient group of older women.

"In the experimental study, we could then establish that the gene had a crucial effect on the thickness and density of the femur. In mice without the Wnt16 gene, the strength of the femur was up to 61 per cent lower," according to Mattias Lorentzon at the Institute of Medicine, the Sahlgrenska Academy, University of Gothenburg.

The discovery opens up opportunities to develop new medicines to prevent the most common fractures.

"Low cortical bone mass is a decisive factor in, for example, hip and forearm fractures. Unfortunately, the treatments currently used for brittleness of the bones have very little effect on the cortical bone mass," says Mattias Lorentzon.

"If we can learn to stimulate the signaling routes of the Wnt16 gene, we could strengthen the skeleton in these parts too, thereby preventing the most common and serious fractures. The discovery of Wnt16 and its regulation of cortical bone mass is therefore very important," according to Mattias Lorentzon.


'/>"/>

Contact: Mattias Lorentzon, University of Gothenburg
mattias.lorentzon@medic.gu.se
46-031-342-4929
University of Gothenburg
Source:Eurekalert

Related medicine news :

1. Mayo Clinic offers newly approved treatment for acid reflux disease
2. Wilderness Medicine founder offers health tips for summer season
3. Botox Offers Little Relief for Migraine, Study Finds
4. Prosthetic retina offers simple solution to restoring sight
5. Study Offers Ways to Decrease Use of Restraints at Nursing Homes
6. Skin transplant offers new hope for vitiligo patients
7. New molecular structure offers first picture of a protein family vital to human health
8. US Drug Watchdog Launches Now Calls Transvaginal Mesh A Disaster For 100,000's of US Women Recipients And Offers The Names and Contacts Of The Best Women Attorneys
9. SYNERGY HomeCare Offers Free Home Safety Assessments
10. US Drug Watchdog Now Offers To Get A Free Legal Review For All DePuy ASR Recipients Who Received A Letter From Broadspire About Their Recalled DePuy Hip Implant
11. Webvet.com Offers Free Promotional Pages for Veterinary Professionals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2017)... ... ... The American Hospital Association (AHA) has elected Claire Zangerle, Chief Nurse Executive at ... Trustees for a three-year term beginning January 1, 2018. , The AHA ... committed to the improvement of health in their communities. Founded in 1898, the AHA ...
(Date:8/20/2017)... Sugar Land Texas (PRWEB) , ... August 20, ... ... to announce that the HIPAA ComplyPAK™ Compliance Management System has assisted ... American Institute of Certified Public Accountants, Service Organization Control Level 2 (AICPA SOC ...
(Date:8/19/2017)... ... 18, 2017 , ... Paragon and IOTA ... help the cannabis industry move towards greater legitimacy. By incorporating IOTA’s unique approach ... with lower fees. Paragon will build a fully verifiable database to track prescriptions, ...
(Date:8/19/2017)... ... August 19, 2017 , ... Yesterday, the President of the United States ... two sides. There are not two sides to hatred, bigotry, discrimination, and a white ... and the NPEIV stands against all forms of such hatred and discrimination in this ...
(Date:8/18/2017)... VA (PRWEB) , ... August 18, 2017 , ... More ... the Democratic Republic of Congo (DRC) thanks to an ambitious venture that conjoined the ... well as the generous support of the Liberty community. These shoes will save lives ...
Breaking Medicine News(10 mins):
(Date:8/17/2017)... -- MJAC2017 , the premier cannabis event devoted to ... its leading lineup. MJAC2017 is proud ... specializing in the development of pharmaceutical and consumer products, will ... The Green Organic Dutchman are gold sponsors for the event, ... ...
(Date:8/15/2017)... , Aug. 15, 2017   Mostyn Law and Gulf ... Houston, Texas . The Mostyn Law family ... 2 years. That is why Mostyn Law is partnering ... to show its appreciation. Blood supplies are running ... 5% short of hospital needs in August. That is why the ...
(Date:8/15/2017)... AccuGenomics, Inc., a diagnostic company based in ... the company has provided an AccuKit to the HIV ... Chapel Hill and to Qura Therapeutics for evaluation in ... HIV reservoir and viral expression in human CD4+ T ... Center is a joint initiative between the University of ...
Breaking Medicine Technology: