Navigation Links
New gateway to treat leukemia and other cancers

This press release is available in French.

Montreal, March 25, 2010 Canadian researchers have discovered a previously hidden channel to attack leukemia and other cancer cells, according to a new study published in the Journal of Biological Chemistry. The findings from the Universit de Montral, Maisonneuve-Rosemont Hospital and Universit Laval may change the way doctors treat cancer patients.

"We found a gateway, which is present in all humans, that allows anti-cancer agents such as Bleomycin to enter the body so they may reach and attack leukemia cells," says senior author Dindial Ramotar, a professor at the Universit de Montral Faculty of Medicine and a scientist at the affiliated Maisonneuve-Rosemont Hospital.

Dr. Ramotar began testing his theory a full decade ago using baker's yeast, which is remarkably similar to human cells. "Our discovery went from that model system to human cells and will soon reach the bedside through translational therapy," he explains. "We are on the brink of testing patients."

The new gateway (SLC22A16) may be a lifesaver for patients with acute myeloid leukemia (AML), a cancer that affects white blood cells. AML patients are extremely difficult to treat, since most are unresponsive to anticancer remedies. "We can now streamline anti-cancer agents to treat AML," says Dr. Ramotar. "For example, we found the anti-cancer agent Bleomycin has positive results on lymphoma cells derived from patients and depends on the presence of the gateway. That's especially good news, since Bleomycin does not act as an immunosuppressant."

The newly identified gateway, Dr. Ramotar cautions, is only "present in some cell types such as those derived from bone marrow." The channel also does not function in colon and breast cancer making it difficult to treat these patients with Bleomycin, he adds. "We must now examine ways to stimulate the gateway to treat a broad range of cancers using Bleomycin and other drugs."


Contact: Sylvain-Jacques Desjardins
University of Montreal

Related medicine news :

1. BMEGateway Celebrates its 20th Anniversary and Welcomes Dr. William Morgan
2. Technology new gateway into treatment for problem alcohol users: Study
3. Djigzo, an Open Source Email Encryption Provider, Today Announced That the Company's Encryption Gateway Now Supports Red Hat Linux
4. Michigan Health Care Providers Select mPay Gateways Point-of-Care Patient Payment System
5. GateWay Community College Receives Strong Endorsement for Re-accreditation
6. Steroids May Be Overrated in Treatment of COPD
7. Untreated, Mild May Become Major Depression
8. Hard to Treat Diseases (HTDS) Comments on Recent Movement Of Its Security
9. Experimental stem cell treatment arrests acute lung injury in mice, study shows
10. American Association of Poison Control Centers: Treat Poinsettias and Mistletoe with Respect Rather Than Fear This Holiday Season
11. Entest BioMedical Enters into LOI with Advanced Light Devices to Develop Laser Platform for Stem Cell / Laser COPD Treatment
Post Your Comments:
(Date:6/26/2016)... ... 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic ... World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. ... some of the world’s leading providers of cereal and other breakfast foods. Its residents ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, ... work on several important health care topics including advance care planning, healthcare costs ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
(Date:6/24/2016)... 24, 2016 The Academy of Managed Care ... that would allow biopharmaceutical companies to more easily ... make formulary and coverage decisions, a move that addresses ... medicines. The recommendations address restrictions in the ... the drug label, a prohibition that hinders decision makers ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... "The World Market for Companion Diagnostic Tests" report to ... World Market for Companion Diagnostics The World ... diagnostic and personalized medicine diagnostics. Market analysis in the report ... Diagnostics Test Market (In Vitro Diagnostic Kits) by Region (N. ...
Breaking Medicine Technology: