Navigation Links
New function of gene in promoting cancer found by VCU researchers
Date:11/22/2010

Richmond, Va. (Nov. 22, 2010) Researchers at Virginia Commonwealth University have discovered that a gene well known for its involvement in tumor cell development, growth and metastasis also protects cancer cells from being destroyed by chemotherapy. By inhibiting the expression of this gene, doctors may have a new viable and effective approach for treating aggressive cancers such as breast, liver and prostate carcinomas, malignant gliomas and neuroblastomas that result from high expression of this cancer-promoting gene.

The new study was reported the week of Nov. 22 in PNAS Early Edition, an online publishing of the latest scientific research by the Proceedings of the National Academy of Sciences. The work was a collaboration among researchers from VCU Massey Cancer Center, the VCU Institute of Molecular Medicine (VIMM), and the Department of Human and Molecular Genetics of the VCU School of Medicine, and was led by Paul B. Fisher, M.Ph., Ph.D., Thelma Newmeyer Corman Endowed Chair in Cancer Research at VCU Massey.

The involved gene, AEG-1 (astrocyte elevated gene-1), has been known to directly contribute to cancer cell survival, chemotherapeutic drug resistance and tumor cell progression by regulating diverse intracellular processes. This study reveals for the first time a previously unknown aspect of AEG-1 function by identifying the gene as a potential regulator of protective autophagy, which shields cancer cells from destructive agents and environmental insults and is an important feature that may contribute to AEG-1's tumor-promoting properties. The research further shows that protective autophagy also contributes to AEG-1's chemoresistance properties, and that inhibition of AEG-1 enhances tumor cells' response to chemotherapy.

"Understanding how AEG-1 promotes resistance to chemotherapy and enhances cancer cell survival may lead to treatments that inhibit this gene and its regulated pathways, thereby uncovering potentially new therapeutic targets that can be exploited to enhance the ability of anticancer drugs to fight tumors," said Fisher, who is also chair of VCU's Department of Human and Molecular Genetics and director of VIMM. "The potential for translating these findings into beneficial approaches for patients is major, particularly for patients with aggressive cancers that are difficult to treat because of resistance to current therapies."


'/>"/>

Contact: Jenny Owen
jrowen2@vcu.edu
804-628-2111
Virginia Commonwealth University
Source:Eurekalert

Related medicine news :

1. Race Seems to Impact Rate of Kidney Function Decline
2. Noninvasive brain stimulation helps improve motor function in stroke patients
3. Gene Associated With Autism May Alter How Brain Functions
4. Study shows volunteering benefits those with functional limitations
5. Acid reflux, functional dyspepsia have significant impact on disordered sleep
6. Yoga alleviates pain and improves function in fibromyalgia patients
7. Air pollution alters immune function, worsens asthma symptoms
8. Placebo successful in treating women with sexual dysfunction
9. Study identifies underlying dysfunction of seemingly non-critical heart condition
10. Function found for Alzheimers protein
11. Scientists discover the mechanisms and function of a type of mysterious immune cell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... Dickinson Insurance ... community by announcing a new fundraiser in support of a local boy named Barrett, ... the campaign will bring awareness to, and rally support for, all local families dealing ...
(Date:2/11/2016)... ... February 11, 2016 , ... Hoggan Scientific, LLC, a company ... physical therapy, occupational therapy and sports medicine clinics, hospitals, universities and ergonomics applications, ... introduces its new microFET Digital Pinch Gauge. , Hoggan Scientific will debut ...
(Date:2/11/2016)... ... 11, 2016 , ... As part of their 2015 end of year funding ... Foundation (MDRTF), has gifted $10,000 to University of Chicago to support ovarian cancer research ... , “We are honored to support a promising young investigator from Dr. Lengyel’s lab ...
(Date:2/10/2016)... ... ... LaserShip, a regional parcel carrier that services the eastern U.S., donated and delivered ... order to aid in the Flint water crisis. In 2014, LaserShip acquired Prestige Delivery ... only 15 miles away from Flint. , “We have deep roots in the local ...
(Date:2/10/2016)... Washington (PRWEB) , ... February 10, 2016 , ... ... access and Video Remote Interpreting (VRI) within Healthcare, recently partnered with Heart ... remote interpreting (VRI). , For nearly 23 years, Heart City Health Center has ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... Feb. 10, 2016 CSI Specialty Group (CSI) ... launch of the Specialty Pharmacy Podcast. A free, weekly ... at providing real-world education, discussion and context amongst specialty ... --> The Specialty Pharmacy Podcast, ... CSI Specialty Group Suzette DiMascio, CHE, CMCE, CPC, is ...
(Date:2/10/2016)... WOONSOCKET, R.I. , Feb. 10, 2016  CVS ... vaccines to people living in Santa Clara ... of Meningitis B on the Santa Clara University campus. ... vaccines available to protect patients against the disease. Students ... are encouraged to get vaccinated. In addition, anyone who ...
(Date:2/10/2016)... Feb. 10, 2016  Rich Pharmaceuticals, Inc. (OTC Markets: ... 1-for-100 reverse split of its issued and outstanding shares ... on Thursday, February 11, 2016. The Company,s common stock ... number 76303T308 and temporary ticker symbol "RCHAD". After 20 ... the ticker symbol (RCHA).  --> ...
Breaking Medicine Technology: